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Kuo, Yuh-Chi,Wu, Chia-Lin,Tasi, Wei-Jern,Wang, Jir-Yenn,Chang, Shi-Chung,Lin, Ching-Yuang,Shiao, Ming-Shi 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1
Yuh-Chi Kuo¹,Chia-Lin Wn¹,Wei-jern Tasi¹,Jir-Yenn Wang²,Shi-Chung Chang₃,Ching-Yung Lin⁴,and Ming-Shi Shiao⁴¹National Research Institute of Chinese Medicine, ²Department of Biology,Fu Jen University, ³Department of Chest, ⁴Department of Pediatrics, □De[art,amt of Medical Research and Education. Taipei Veterans General Hospital, Taipei, Taiwan Yuh-Chi Kuo¹,Chia-Lin Wn¹,Wei-jern Tasi¹,Jir-Yenn Wang²,Shi-Chung Chang²,Ching-Yung Lin³,and Ming-Shi Shiao⁴.¹National Research Institute of Chinese Medicine, ²Department of Biology,Fu Jen University, ³Department of Chest, ⁴Department of Pediatrics, □De[art,amt of Medical Research and Education. Taipei Veterans General Hospital, Taipei, Taiwan. Blocking of Cell Proliferation, Cytokines Production and Genes Expression Following Administration of Cordyceps sinensis in the Bronchoalveolar Lavage Fluids Cells. Proceedings of international Symposium on East-West Medicine, Seoul. 44-64, 1999.-Cordyceps sinensis is a major parasitic fungus on larva of Lepidoptera. It is one of the well know fungi used in traditional Chinese medicine for treatment asthma, lung and kideney diseases. Many fungi belonging to the genus Cordyceps have been demonstrated to produce natural products with various biological activities. Reported biological activities of genus cordyceps include:(a)inhibition of DNA and RNA synthesis;(b)enhancement of cell differentiation;(c)restruction of cytoskeleton;(d)inhibition of protein kinase activity;(e)antitumor activity on bladder, colon, lung carcinoma as well as fibroblastoma;(f)inhibition of the infection and revers transciptase activity of human immunodeficiency virus type 1; and(g) inhibition of methylation of nucleic acid. Thus, it is suggested that the extracts of Cordyceps sp. Contain antitumor, antiviral, and many other biological activities. In our previous studies, we proved that C. sinensis contains the antitumor and immunomodulatory agents. In the present studies, effects of C. sinensis on bronchoalveolar lavage fluids(BAL)cells were demonstrated. The crude methanolic extracts of C. sinensis were fractionated into 15 fractions by silica gel column chromatography. Effects of various fraction on BAL cells proliferation and lipopolysaccharide(LPS) stimulated interleukin-1β(IL-8),platelet activating factor(PAF), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α),and interleukin-8(IL-8) production on BAL cells were determined. The result indicated that the CS-19-22 fraction suppressed BAL cells proliferation activated by LPS. The median inhibitory concentration(IC50) was 6㎍/ml. The CS-19-22 fraction also decreased IL-1β,PAF,IL-6, TNF-αand IL-8 production.The results of revers transcription-polymerase chain reaction(RT-PCR) demonstrated that the CS-19-22 fraction did not affect IL-1β,PAF,IL-6, TNF-α,and IL-8 mRNAs expression in BAL cells activated by LPS. By contrast, it inhibited the IL-10 mRNA expression but enhanced IFN-γand IL-12 mRNAs expression in activated BAL cells. Moreover, the CS-19-22 fraction blocked PAF-induced platelet aggregation. It is unlikely that cytotoxicity was involved. Because no cell deths were observable. We hypothesize that inhibitory mechanisms of CS-19-22 on BAL cells proliferation may be related to the impairments of gene expression and production of cytokines in BAL cells. The explanation of C. sinensis antiasthma function may involved the following(1)C.sinenesis contained immunomodulatory agents that stimulated IFN-γand IL-12 expression in TH1cells.(2)Enhanced secretion of IFN-γand IL-12 will inhibit the Tγcells immune responses Ex. Decreasing of IL-6 and IL-10 production.(3) The impairments of cytokines production in TH2 cells suppressed th BAL cells proliferation then more cytokines production Ex.IL-1β,PAF,IL-6,TNF-αand IL-8 in activated BAL cells were decreased. (4)The suppression of TH2cells immune responses will inhibit the growth and differentiation of B cells then IgE production will be decreased. (5)Reduced production of IgE will decreased asthma attack occurring in individuals. However, the results of the present study suggested that C. sinensis may also have acted to treat asthma in part by inhibiting BAL cells proliferation and cytokine gene expression and production. Future, experiments with treatment of animals with asthma with C. sinensis will be necessary to defined whether C. sinensis can reduce asthma injury. Plans are underway for the isolation of pure principal growth inhibitors and their mechanisms of action are subjected for further study.
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Wei, Guo,Nie, Ming-Ming,Shen, Xiao-Jun,Xue, Xu-Chao,Ma, Li-Ye,Du, Cheng-Hui,Wang, Shi-Liang,Bi, Jian-Wei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Objective: To observe local and systemic toxicity after sustained-release 5-fluorouracil (5-Fu) implantation in canine peritoneum and para-aortic abdominalis and the changes of drug concentration in the local implanted tissue with time. Methods: 300 mg sustained-release 5-Fu was implanted into canine peritoneum and para-aorta abdominalis. Samples were taken 3, 5, 7 and 10 days after implantation for assessment of changes and systemic reactions. High performance liquid chromatography was applied to detect the drug concentrations of peritoneal tissue at different distances from the implanted site, lymphatic tissue of para-aortic abdominalis, peripheral blood and portal venous blood. Results: 10 days after implantation, the drug concentrations in the peritoneum, lymphatic tissue and portal vein remained relatively high within 5 cm of the implanted site. There appeared inflammatory reaction in the local implanted tissue, but no visible pathological changes such as cell degeneration and necrosis, and systemic reaction like anorexia, nausea, vomiting and fever. Conclusions: Sustained-release 5-Fu implantation in canine peritoneum and para-aortic abdominalis can maintain a relatively high tumour-inhibiting concentration for a longer time in the local implanted area and portal vein, and has mild local and systemic reactions. Besides, it is safe and effective to prevent or treat recurrence of gastrointestinal tumours and liver metastasis.
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Shi Wei Huang,Yuan Yin,Ya Juan Zheng,Ya Ru Dong 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.1
Exposure to ischemia/reperfusion leads to the development and progression of retinal degenerative diseases. However, the exact mechanisms are not fully understood. In this article, the role of CIC-3 chloride channel in OGD-R (oxygen-glucose deprivation followed by reperfusion)-induced retinal damage was examined. Mouse photoreceptor-derived 661W cells were treated with the CIC-3 antisense oligonucleotide before exposure to OGD-R. Cell viability, mitochondrial membrane potential, cytochrome-c level, DNA fragmentation, caspase activity and protein expression were detected. Pretreatment of 661W cells with CIC- 3 antisense oligonucleotide significantly decreased OGD-R-mediated toxicity. In addition, apoptosis-related biochemical indicators showed that pre-incubation of CIC-3 antisense oligonucleotide would elevate the mitochondrial membrane potential, decrease the release of cytochrome-c as well as formation of DNA fragmentation, and inhibit activities of caspase-3 and caspase- 9 in exogenous OGD-R-treated 661W cells. Moreover, treatment with CIC-3 antisense oligonucleotide changed the expression of apoptosis-related protein. These results suggest that CIC-3 chloride channel mediates OGD-R-induced apoptosis, at least partially through mitochondrial membrane potential pathway and increasing the levels of proapoptotic molecules in 661W cells. CIC-3 chloride channel blockade may provide a new therapeutic approach for preventing ischemia/reperfusion- induced retinal neural damage.
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Soil-Structure Interaction on the Response of Jacket-Type Offshore Wind Turbine
Wei Shi,박현철,Chin Wah Chung,신현경,김상훈,이성수,김창완 한국정밀공학회 2015 International Journal of Precision Engineering and Vol.2 No.2
Jacket structures are still at the early stage of their development for use in the offshore wind industry. The aim of this paper is to investigate the effect of the soil-structure interaction on the response of an offshore wind turbine with a jacket-type foundation. For this purpose, two different models of flexible foundation-the p-y model and the p-y model considering pile groups effect-are employed to compare the dynamic responses with the fixed-base model. The modal analysis and the coupled dynamic analysis are carried out under deterministic and stochastic conditions. The influence of the soil-structure interaction on the response of the jacket foundation predicts that the flexible foundation model is necessary to estimate the loads of the offshore wind turbine structure well. It is suggested that during fatigue analysis the pile group effect should be considered for the jacket foundation.
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Wei Dong,Hai Bo Shi,Heng Ma,Yan Bo Miao,Tong Jun Liu,Wei Wang 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.5
Protein glycation inhibitors from Polygonatum odoratum rhizomes were investigated using a bioassay-guided procedure to characterize active compounds for preventing and treating diabetic complications. The EtOH extract and soluble fractions were evaluated using an in vivo model of renal advanced glycation end-product (AGE) accumulation in streptozotocin-induced diabetic rats and an in vitro bovine serum albumin-glucose assay. Three homoisoflavanones 3-(4’-hydroxybenzyl)-5,7-dihydroxy-6-methyl-8-methoxychroman-4-one (1), 3-(4’-hydroxybenzyl)-5,7-dihydroxy-6,8-dimethylchroman-4-one (2), and 3-(4’-methoxybenzyl)-5,7-dihydroxy-6-methyl-8-methoxychroman-4-one (3), isolated from the active CHCl3-soluble fraction of the EtOH extract, were subjected to in vitro bioassays to evaluate their inhibitory activities against AGE formation. All the isolates inhibited AGE formation more effectively than the positive control, aminoguanidine. These results indicate that pending further study these compounds could be used as novel natural product drug for mitigating diabetic complications.
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Shi, Wei,Han, Jonghoon,Kim, Changwan,Lee, Daeyong,Shin, Hyunkyoung,Park, Hyunchul Elsevier 2015 RENEWABLE ENERGY Vol.74 No.-
<P><B>Abstract</B></P> <P>Korea has huge potential for offshore wind energy and the first Korean offshore wind farm has been initiated off the southwest coast. With increasing water depth, different substructures of the offshore wind turbine, such as the jacket and multipile, are the increasing focus of attention because they appear to be cost-effective. However, these substructures are still in the early stages of development in the offshore wind industry. The aim of the present study was to design a suitable substructure, such as a jacket or multipile, to support a 5 MW wind turbine in 33 m deep water for the Korean Southwest Offshore Wind Farm. This study also aimed to compare the dynamic responses of different substructures including the monopile, jacket and multipile and evaluate their feasibility. We therefore performed an eigenanalysis and a coupled aero-hydro-servo-elastic simulation under deterministic and stochastic conditions in the environmental conditions in Korea. The results showed that the designed jacket and multipile substructures, together with the modified monopile, were well located at soft–stiff intervals, where most modern utility-scale wind turbine support structures are designed. The dynamic responses of the different substructures showed that of the three substructures, the performance of the jacket was very good. In addition, considering the simple configuration of the multipile, which results in lower manufacturing cost, this substructure can provide another possible solution for Korean’s first offshore wind farm. This study provides knowledge that can be applied for the deployment of large-scale offshore wind turbines in intermediate water depths in Korea.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A jacket as well as a multipile substructure was designed to support 5MW OWT for Korean offshore demonstration project in 33 m water depth. </LI> <LI> A fully coupled dynamic analysis was conducted based on Korean environmental conditions. </LI> <LI> The dynamic responses of the three substructures were compared to find their feasibility. </LI> <LI> The jacket had the best performance in terms of the investigated loads. </LI> <LI> The multipile results were comparable with the jacket substructure. </LI> </UL> </P>
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A 60GHz Wireless Cooperative Communication System Based on Switching Beamforming
( Wei Shi ),( Jingjing Wang ),( Yun Liu ),( Qiuna Niu ),( Hao Zhang ),( Chunlei Wu ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.4
The challenge of penetrating obstacles along with impact from weak multipath effects makes 60GHz signal very difficult to be transmitted in non-line of sight (NLOS) channel. So 60GHz system is vulnerable to obstructions and thus likely results in link interruption. While the application of cooperative technology to solve link blockage problemin 60GHz system should consider the characteristic of directional transmission for 60GHz signal. Therefore in this paper a system is proposed to solve the link blockage problem in 60GHz NLOS communication environment based on the concept of cooperation and also the beamforming technology, which is the basis of directional transmission for 60GHz communication system. The process of anti-blockage solution with cooperative communication is presented in detail, and the fast switching and recovery schemes are well designed. The theoretical values of symbol error rate (SER) using decode and forward (DF) cooperation and amplify and forward (AF) cooperation are presented respectively when the common channel interference exists. Simulation results demonstrate that the performance based on DF cooperation is better than the performance based on AF cooperation when directional transmission is used.
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