Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis

Seunghee Jun(Seunghee Jun),Hyunjin Park(Hyunjin Park),Ui-Jeong Kim(Ui-Jeong Kim),Eun Jeong Choi(Eun Jeong Choi),Hye Ah Lee(Hye Ah Lee),Bomi Park(Bomi Park),Soon Young Lee(Soon Young Lee),Sun Ha Jee(Su 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis. METHODS: Our systematic review aimed to investigate the associations between different levels of alcohol consumption and the risk of several cancer types. We focused on analyzing prospective associations using data from 139 cohort studies. Among them, 106 studies were included in the meta-analysis after a quantitative synthesis. RESULTS: Our analysis did not find a significant association between light alcohol consumption and all-cause cancer risk (relative risk, 1.02; 95% confidence interval, 0.99 to 1.04), but we observed a dose-response relationship. Light alcohol consumption was significantly associated with higher risks of esophageal, colorectal, and breast cancers. Light to moderate drinking was associated with elevated risks of esophageal, colorectal, laryngeal, and breast cancers. Heavy drinking was also found to contribute to the risk of stomach, liver, pancreas, and prostate cancers, thereby increasing the risk of almost all types of cancer. Additionally, females generally had lower cancer risks compared to males. CONCLUSIONS: Our findings highlight that cancer risks extend beyond heavy alcohol consumption to include light alcohol consumption as well. These findings suggest that there is no safe level of alcohol consumption associated with cancer risk. Our results underscore the importance of public health interventions addressing alcohol consumption to mitigate cancer risks.

Rewritable, Printable Conducting Liquid Metal Hydrogel

Park, Jung-Eun,Kang, Han Sol,Baek, Jonghyek,Park, Tae Hyun,Oh, Seunghee,Lee, Hyungsuk,Koo, Min,Park, Cheolmin American Chemical Society 2019 ACS NANO Vol.13 No.8

<P>The development of high-performance printable electrical circuits, particularly based on liquid metals, is fundamental for device interconnection in flexible electronics, motivating numerous attempts to develop a variety of alloys and their composites. Despite their great potential, rewritable and printable electronic circuits based on liquid metals are still manufactured on demand. In this study, we demonstrate liquid metal-based hydrogels suitable for rewritable, printable electrical circuits. Our liquid metal hydrogels are based on sedimentation-induced composites of eutectic gallium-indium (EGaIn) particles in poly(ethylene glycol) diacrylate (PEGDA). The EGaIn particles are vertically phase-segregated in the PEGDA. When a composite surface with high EGaIn content is gently scratched, the surface covering PEGDA is removed, followed by the rupture of the native oxide layers of the particles, and the exposed EGaIn becomes conductive. The subsequent water-driven swelling of PEGDA on the scratched surface completely erases the conductive circuit, causing the system to reset. Our friction-responsive liquid metal hydrogel exhibits writing-erasing endurance for 20 cycles, with a dramatic change in the electrical resistance from metal (∼1 Ω) to insulator (∼10<SUP>7</SUP> Ω). By employing surface friction pen printing, we demonstrate mechanically flexible, rewritable, printable electrical conductors suitable for displays.</P> [FIG OMISSION]</BR>

Health monitoring of steel structures using impedance of thickness modes at PZT patches

Park, Seunghee,Yun, Chung-Bang,Roh, Yongrae,Lee, Jong-Jae Techno-Press 2005 Smart Structures and Systems, An International Jou Vol.1 No.4

This paper presents the results of a feasibility study on an impedance-based damage detection technique using thickness modes of piezoelectric (PZT) patches for steel structures. It is newly proposed to analyze the changes of the impedances of the thickness modes (frequency range > 1 MHz) at the PZT based on its resonant frequency shifts rather than those of the lateral modes (frequency range > 20 kHz) at the PZT based on its root mean square (RMS) deviations, since the former gives more significant variations in the resonant frequency shifts of the signals for identifying localities of small damages under the same measurement condition. In this paper, firstly, a numerical analysis was performed to understand the basics of the NDE technique using the impedance using an idealized 1-D electro-mechanical model consisting of a steel plate and a PZT patch. Then, experimental studies were carried out on two kinds of structural members of steel. Comparisons have been made between the results of crack detections using the thickness and lateral modes of the PZT patches.

Atmospheric deposition of anthropogenic inorganic nitrogen in airborne particles and precipitation in the East Sea in the northwestern Pacific Ocean

Park, Geun-Ha,Lee, Seon-Eun,Kim, Young-il,Kim, Dongseon,Lee, Kitack,Kang, Jeongwon,Kim, Yeo-Hun,Kim, Haryun,Park, Seunghee,Kim, Tae-Wook Elsevier 2019 Science of the Total Environment Vol.681 No.-

<P><B>Abstract</B></P> <P>The atmospheric deposition of anthropogenic nitrogen is an increasingly important new source of nitrogen to the ocean. Coastal areas east of the Korean Peninsula are suitable for the investigation of the effects of atmospheric anthropogenic nitrogen on the ocean nutrient system because of the low riverine discharge rates and the prevailing influence of the East Asian outflow. Thus, we measured the concentrations of nitrate (NO<SUB>3</SUB> <SUP>−</SUP>) and ammonium (NH<SUB>4</SUB> <SUP>+</SUP>) in airborne particles and in precipitation from March 2014 to February 2016 at a coastal site (37.08°N, 129.41°E) on the east coast of Korea. The dry deposition of NO<SUB>3</SUB> <SUP>−</SUP> (27–30 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP>) was far greater than that of NH<SUB>4</SUB> <SUP>+</SUP> (6–8 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP>). The greater rate of dry NO<SUB>3</SUB> <SUP>−</SUP> deposition was associated with air masses traveling over northeastern China and central Korea. In contrast, the rates of wet deposition of NO<SUB>3</SUB> <SUP>−</SUP> (17–24 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP>) and NH<SUB>4</SUB> <SUP>+</SUP> (14–27 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP>) were comparable and were probably associated with in-cloud scavenging of these ions. The results indicate that the total deposition of NO<SUB>3</SUB> <SUP>−</SUP> and NH<SUB>4</SUB> <SUP>+</SUP> combined could contribute to ~2.4% and ~1.9% of the primary production in the coastal areas east of the Korean Peninsula and in the East Asian marginal seas, respectively, which would be a lower bound because the dry deposition of reactive nitrogen gas was not included. Our study shows that the atmospheric input of anthropogenic NO<SUB>3</SUB> <SUP>−</SUP> and NH<SUB>4</SUB> <SUP>+</SUP> may substantially increase phytoplankton biomass in the coastal waters of the East Sea near the Korean Peninsula.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Atmospheric Nitrogen Deposition (AND) was 64–89 mmol N m<SUP>−2</SUP> yr<SUP>−1</SUP> in the East Sea. </LI> <LI> AND was enhanced in air masses traveling over northeastern China and central Korea. </LI> <LI> AND could contribute to ~1.9% of the primary production of East Asian seas. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

A study on development of car seat thermal comfort evaluation system

( Seunghee Hong ),( Daee Kim ),( Young Seo ),( Baekhee Lee ),( Hyunkyu Park ),( Yeongsik Kim ),( Se Jin Park ) 한국감성과학회 2017 한국감성과학회 국제학술대회(ICES) Vol.2017 No.-

In the automobile industry, the technical characteristic of each component has been exploding improved. The technology level is capable of benchmarking from many manufacturers and it is possible to maintain a similar level, so recently, the sensitivity aspect given to users has emerged as an important part. Among them, the seat is in contact with the passenger's body during boarding, and it has a very close relationship to judging the comfort or discomfort. In this research, we tried to develop a seat thermal comfort evaluation method to evaluate the influence of the characteristic on the real environment and the human sensibility, based on the physical properties of the seat cover. In addition, by using the qualitative data (subjective assessment questionnaire) and quantitative evaluations (temperature / humidity, physiological signal; EEG, ECG, GSR), the validity of the evaluation method was verified. As a result, it was observed that the variation of the temperature and humidity of the seat cushion with the change of the seasons had a very significant effect on the comfort of the seat. In addition, it proved that the seat thermal comfort evaluation system satisfying the sensitivity from the physical property is valid.

MFC-Based Structural Health Monitoring Using a Miniaturized Impedance Measuring Chip for Corrosion Detection

Park, Seunghee,Grisso, Benjamin L.,Inman, Daniel J.,Yun, Chung-Bang SPRINGER VERLAG KG 2007 RESEARCH IN NONDESTRUCTIVE EVALUATION Vol.18 No.2

<P> This article presents an experimental study using an active sensing device that consists of a miniaturized impedance-measuring chip (AD5933) and a self-sensing macrofiber composite (MFC) patch to detect corrosion in aluminum structures widely used for aerospace, civil, and mechanical systems. A simple beam structure made from a 6063 T5 aluminum alloy was selected for corrosion-detection testing. Four different corrosion cases with two different locations and two different degrees at each location were artificially inflicted on the beam using hydrochloric (HCI) acid. To identify the degrees and locations of the corrosion, the electromechanical impedance-based damage-detection technique using the proposed active sensing device was investigated. Root-mean-square deviation (RMSD) metric of the real part of the impedances obtained from the MFC patch was selected as a damage-sensitive feature. Experimental results have verified that the proposed approach can be an effective tool for detection and quantification of corrosion in aluminum structures.</P>

Occupational Characteristics of Semiconductor Workers with Cancer and Rare Diseases Registered with a Workers' Compensation Program in Korea

Park, Dong-Uk,Choi, Sangjun,Lee, Seunghee,Koh, Dong-Hee,Kim, Hyoung-Ryoul,Lee, Kyong-Hui,Park, Jihoon Occupational Safety and Health Research Institute 2019 Safety and health at work Vol.10 No.3

Background: The aim of this study was to describe the types of diseases that developed in semiconductor workers who have registered with the Korea Workers' Compensation and Welfare Service (KWCWS) and to identify potential common occupational characteristics by the type of claimed disease. Methods: A total of 55 semiconductor workers with cancer or rare diseases who claimed to the KWCWS were compared based on their work characteristics and types of claimed diseases. Leukemia, non-Hodgkin lymphoma, and aplastic anemia were grouped into lymphohematopoietic (LHP) disorder. Results: Leukemia (n = 14) and breast cancer (n = 10) were the most common complaints, followed by brain cancer (n = 6), aplastic anemia (n = 6), and non-Hodgkin lymphoma (n = 4). LHP disorders (n = 24) accounted for 43%. Sixty percent (n = 33) of registered workers (n = 55) were found to have been employed before 2000. Seventy-six percent (n = 42) of registered workers and 79% (n = 19) among the registered workers with LHP (n = 24) were found to be diagnosed at a relatively young age, ${\leq}40years$. A total of 18 workers among the registered semiconductor workers were finally determined to deserve compensation for occupational disease by either the KWCWS (n = 10) or the administrative court (n = 8). Eleven fabrication workers who were compensated responded as having handled wafers smaller than eight inches in size. Eight among the 18 workers compensated (44 %) were found to have ever worked at etching operations. Conclusion: The distribution of cancer and rare diseases among registered semiconductor workers was closely related to the manufacturing era before 2005, ${\leq}8$ inches of wafer size handled, exposure to clean rooms of fabrication and chip assembly operations, and etching operations.

Electro-Mechanical Impedance-Based Wireless Structural Health Monitoring Using PCA-Data Compression and <i>k</i>-means Clustering Algorithms

Park, Seunghee,Lee, Jong-Jae,Yun, Chung-Bang,Inman, Daniel J. Sage Publications 2008 Journal of intelligent material systems and struct Vol.19 No.4

<P>This article presents a practical method for an electro-mechanical impedance-based wireless structural health monitoring (SHM), which incorporates the principal component analysis (PCA)-based data compression and k-means clustering-based pattern recognition. An on-board active sensor system, which consists of a miniaturized impedance measuring chip (AD5933) and a self-sensing macro-fiber composite (MFC) patch, is utilized as a next-generation toolkit of the electromechanical impedance-based SHM system. The PCA algorithm is applied to the raw impedance data obtained from the MFC patch to enhance a local data analysis-capability of the on-board active sensor system, maintaining the essential vibration characteristics and eliminating the unwanted noises through the data compression. Then, the root-mean square-deviation (RMSD)-based damage detection result using the PCA-compressed impedances is compared with the result obtained from the raw impedance data without the PCA preprocessing. Furthermore, the k-means clustering-based unsupervised pattern recognition, employing only two principal components, is implemented. The effectiveness of the proposed methods for a practical use of the electromechanical impedance-based wireless SHM is verified through an experimental study consisting of inspecting loose bolts in a bolt-jointed aluminum structure.</P>

Identical twin with discordant classification of pituitary adenoma, and different GNAS gene sequence

( Seunghee Han ),( Hye-sun Park ),( Ji-yeon Lee ),( Sehee Park ),( Cheol Ryong Ku ),( Dong Yeob Shin ),( Young Suk Jo ),( Sun Ho Kim ),( Eun Jig Lee ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1

The majority of pituitary adenomas are sporadic tumors with recognized genetic mutations seldom being found. And familial pituitary tumors account for about 5%, carrying germline mutations in predisposition genes, including MEN1, PRKAR1A, and AIP. But, about 85% of familial pituitary adenoma kindred have unknown genetic cause. Meanwhile, the concordant occurrence of pituitary adenoma in identical twins is extremely rare. This case which report different subtypes of pituitary adenoma occurred in identical twins could contribute to elucidate the tumorogenesis of pituitary adenoma. A 26-year-old woman visited hospital with amenorrhea for 1.5 years. Her initial serum prolactin level was 141.0 ng/mL. Sella magnetic resonance imaging (MRI) showed a 0.6 cm sized right pituitary adenoma. After transsphenoidal surgery, serum prolactin level normalized and her menstruation returned regularly. Her twin sister had acromegalic features, such as enlarged face, hands and feet. Basal serum insulin-like growth factor (IGF-1) levelwas 770.9 ng/mL. Sella MRI showed a 1.5 cm sized left pituitary adenoma.. Serum growth hormone (GH) level was not suppressed by 75g oral glucose tolerance test (OGTT). After tumor removal, serum GH level was suppressed by OGTT. Their pathologic results consisted with prolactinoma andgrowth hormone secreting tumor, respectively. In evaluating family history, their father’s brother had pituitary adenoma. Short tandem repeat (STR)analysis results consisted with identical twins. Because of their family history and early onset of pituitary adenoma, genetic test was done for determining familial pituitary adenoma. And, genetic alterations in sporadic pituitary tumor also evaluated, because different subtypes of pituitary tumor was occurred in identical twins. We found GNAS gene mutation only in acromegaly patient. But the primary oncogenic potential of GNAS mutations remains a matter of debate. Thus, a better understanding of the causative genes and the pathogenic mechanisms of pituitary tumorogenesis is needed to improve the diagnosis and management of pituitary tumor patients.

Metabolic complications of obesity in children and adolescents

Park Hyunjin,Choi Jung Eun,Jun Seunghee,Lee Hyelim,Kim Hae Soon,Lee Hye Ah,Park Hyesook 대한소아청소년과학회 2024 Clinical and Experimental Pediatrics (CEP) Vol.67 No.7

The global prevalence of childhood and adolescent obesity, exacerbated by the coronavirus disease 2019 pandemic, affects school-aged children and preschoolers. Early-onset obesity, which carries a high risk of metabolic complications, may contribute to a lower age at the onset of cardiovascular disease. As metabolic diseases such as diabetes, dyslipidemia, and nonalcoholic fatty liver disease observed in adulthood are increasingly recognized in the pediatric population, there is an emphasis on moving disease susceptibility assessments from adulthood to childhood to enable early detection. However, consensus is lacking regarding the definition of metabolic diseases in children. In response, various indicators such as the pediatric simple metabolic syndrome score, continuous metabolic syndrome score, single-point insulin sensitivity estimator, and fatty liver index have been proposed in several studies. These indicators may aid the early detection of metabolic complications associated with pediatric obesity, although further validation studies are needed. Obesity assessments are shifting in perspective from visual obesity to metabolic health and body composition considerations to fill the gap in health impact assessments. Sarcopenic obesity, defined as the muscle- to-fat ratio, has been proposed in pediatric populations and is associated with metabolic health in children and adolescents. The National Health Screening Program for Children in Korea has expanded but still faces limitations in laboratory testing. These tests facilitate timely intervention by identifying groups at a high risk of metabolic complications. Early detection and intervention through comprehensive health screening are critical for mitigating long-term complications of childhood obesity.