Diagnostic Availability of Estrogen Receptor Alpha mRNA on Cervical Cancer Tissue

Geehyuk Kim,Kwangmin Yu,Jungho Kim,Seoyong Kim,Sunyoung Park,Sungwoo Ahn,이지영,Sunghyun Kim,박호현,이동섭 대한임상검사과학회 2018 대한임상검사과학회지(KJCLS) Vol.50 No.4

Cervical cancer is the fourth most frequently diagnosed cancer in women worldwide. In lower Human Development Index countries, it has the second highest incidence and mortality among cancer in women. Therefore, better diagnosis and treatment systems are needed. Among them, estrogen receptor alpha (ER-α) mRNA expression has been analyzed with RT-qPCR since several studies reported that ER-α is necessary in the maturation of the uterus and is related to cervical cancer. In this study, ER-α quantitative analysis was performed on various lesions and normal tissue samples. Based on the receiver operating characteristic (ROC) curve, its sensitivity and specificity were 85% and 75%, respectively, showing higher or similar results to those of conventional HPV tests. In addition, its expression level was analyzed with clinical information. With regression analysis, the R square value between the ER-α mRNA expression level and menopause status was 0.5041, indicating a strong correlation. This study was performed as part of a pilot study and suggests that ER-α is related to carcinogenesis. Future studies will examine other hormones and menopausal factors with a larger sample size.

Exploring the Effect of Four Factors on Affirmative Action Programs for Women

KIM, Sunhee,KIM, Seoyong 이화여자대학교 아시아여성학센터 2014 Asian Journal of Women's Studies(AJWS) Vol.20 No.1

Our study aims to explore determinants and mechanisms that support affirmative action programs (AAPs). Managing the programs and enhancing women’s well-being in organizational life requires knowledge about support for AAPs. Although many studies have examined attitudes toward these, they have confined their scope of research to their particular theoretical disciplines. Our study analyzes the impact of four primary factors―gender, political factors, psychological factors, and social structure on support for the programs. These in turn consist of eight variables, as we shall see, and we examine the varieties of causal mechanisms that are concerned with moderation and mediation, as well as the causal relationships within the variables. Our findings suggest that the four factors have comparative strengths in explaining support for AAPs and have moderating, mediating, and causal impact on them. 본 연구의 목적은 적극적 고용평등프로그램(AAPs: Affirmative Action Programs)에 대한 지지에 영향을 미치는 결정요인과 관련된 기제를 탐구하는 데 있다. 조직내 여성들의 삶의 질을 제고하고 적극적 고용평등과 관련된 프로그램을 관리하기 위해서는 적극적 고용평등 지지에 대한 지식과 연구가 필요하다. 기존에 이에 대한 연구가 존재하지만 특정 이론적 시각에서 연구하고 있다는 한계가 있다. 본 연구에서는 젠더, 정치적 요소, 심리적 요소, 사회적 구조 등 4개의 요소가 적극적 평등 지지에 미치는 영향을 분석한다. 이들 네 요소는 다시 8개의 변수로 구체화된다. 아울러 본 연구는 이들 변수들간 인과관계와 조절, 매개와 관련된 인과기제의 다양한 측면을 분석한다. 본 연구는 적극적 평등을 지지하는데 있어 네 가지 요소들이 가지는 상대적 설명력, 이들이 가진 조절, 매개, 인과적 효과를 파악했다는데 의의가 있다.

Government's Role and Conditions for Cooperation in Collaborative Technology Innovation : Case of CDMA technology development

Kim, Seoyong 고려대학교 2000 虎院論集 Vol.8 No.-

This paper focuses on searching for government's role to assure the conditions of cooperation in collaborative technology innovation including the government and private actors. Collaborative projects inherently have the potential risk of cooperation collapse cause by the opportunistic or free-riding behaviors of private collaborators. Wheter or not collaborative project succeed therefore depends on the extent of cooperation among collaborators. Three propositions of conditions to induce the cooperation among collaborators were drawn from theories of CA (Collective Action), PD (Prisoner Dilemma), and TC (Tragedy of the Commons). After assumed the collaborative project of CDMA as one of collective action related to problems of free-riding and opportunistic behaviors by private firms, we analyze the case of CDMA technology development process by utilizing the three propositions. Finally the research will identify government's roles and policy tools to induce the success of JVs (Joint Ventures) through assuring conditions for cooperation.

Comparison of multiplex real-time PCR and PCR-reverse blot hybridization assay for the direct and rapid detection of bacteria and antibiotic resistance determinants in positive culture bottles

Kim, Jungho,Uh, Young,Park, Soon Deok,Kim, Seoyong,Lee, Hyeyoung,Wang, Hye-Young,Kim, Hyo Youl Microbiology Society 2016 Journal of medical microbiology Vol.65 No.-

원자력 수용성 태도변화에 대한 탐색적 분석

Seoyong Kim 위기관리 이론과 실천 2015 Crisisonomy Vol.11 No.11

정부가 추진하는 많은 정책은 국민들의 태도변화를 그 목표로 하는 경우가 많다. 원자력과 관련된 정책도 원자력 수용성과 관련된 대중들의 태도변화를 목적에 두는 경우가 많다. 그러나 다양한 정책도구가 실제 정책대상인 국민들의 태도변화를 가져올 수 있는지에 대한 실증연구는 소수에 불과하다. 본 연구의 목적은 대중들의 태도변화 가능성과 변화과정에서 개입하는 변수들의 영향력을 다섯 가지 조건적 자극문항 제공을 통해 분석하는데 있다. 조건적 자극문항 제공에 기초한 분석결과를 볼 때 첫째, 태도변화와 관련해 조건적 자극별로 태도변화 정도가 달라진다는 점을 알 수 있었으며, 특히 신뢰와 안전규제 자극이 태도변화를 위한 효과적 자극이 될 수 있음을 알 수 있었다. 둘째, 태도변화에 개입하는 영향요인을 볼 때 조건적 자극 유형별로 영향력의 정도와 유의미한 변수구조가 달라지고 있다. 특히 기존 태도와 낙인이 태도변화 과정에서 핵심적인 역할을 수행하고 있었다. 아울러자극 제공 前 기존 태도는 찬성과 반대, 반동과 반응, 중립을 결정하는 데 구조적 영향을 행사하고 있었다 Like many other governmental public policies, nuclear power policies often aim to change the attitudes of people on nuclear power's acceptability. However, very few empirical studies have demonstrated how policy instruments change people’s attitudes. Our study addresses this topic using five conditional stimuli questions. The results of the data analysis show that the degree of attitude change varies by the types of conditional stimuli. In particular, the stimuli stressing trust and safety regulation were found to be more effective in attitude change. As for independent variables influencing attitude change, there are variations in both degree of impact and statistical significance. Among others, the existing attitude and stigma take a critical role in changing attitudes, and the previous attitude prior to receiving stimuli has an important influence in determining ‘agree or disagree’ and ‘reactance, response or neutrality’.

Determinants for the Social Acceptance of New Emerging Science and Technology

Seoyong Kim 과학기술정책연구원 2013 STI Policy Review Vol.4 No.2

This study identifies the structural determinants of the social acceptance of genetically modified (GM) foods across European countries. Toward this end, we suggest an integrated theoretical model to explain the social acceptance of GM foods by including both perception factors (perceived benefit, perceived risk, feelings, trust, and knowledge) and value factors (ethical concerns, science optimism, religiosity, and ideology). This model is then tested by analyzing survey data collected from 18,634 Europeans in 32 countries. The results indicate that first, not only perception factors but also value factors significantly contribute to explaining the acceptance of GM foods. Second, perceived benefits, perceived risk, feelings, and ethical concerns tend to be the four biggest determinants for acceptance. Third, this two-factor model could be generalized even with variation across countries. Finally, ethical concerns and scientific optimism play a moderating role between predictors and outcomes in the acceptance of GM foods.

Evaluation of the Punch-it™ NA-Sample kit for detecting microbial DNA in blood culture bottles using PCR-reverse blot hybridization assay

Kim, Jungho,Wang, Hye-young,Kim, Seoyong,Park, Soon Deok,Yu, Kwangmin,Kim, Hyo Youl,Uh, Young,Lee, Hyeyoung Elsevier Biomedical 2016 Journal of microbiological methods Vol.128 No.-

<P><B>Abstract</B></P> <P>DNA extraction efficiency affects the success of PCR-based method applications. The Punch-it™ NA-Sample kit for extracting DNA by using paper chromatography is technically easy to use and requires just two reagents and only 10min to complete. The Punch-it™ NA-Sample kit could be offered as a rapid, accurate, and convenient method for extracting bacterial and fungal DNA from blood culture bottles. We compared the efficiencies of the commercial kit (Punch-it™ NA-Sample kit) and an in-house conventional boiling method with Chelex-100 resin for DNA extraction from blood culture bottles. The efficiency of the two DNA extraction methods was assessed by PCR-reverse blot hybridization assay (PCR-REBA, REBA Sepsis-ID) for detecting Gram positive (GP) bacteria, Gram negative (GN) bacteria, and <I>Candida</I> species with 196 positive and 200 negative blood culture bottles. The detection limits of the two DNA extraction methods were 10<SUP>3</SUP> CFU/mL for GP bacteria, 10<SUP>3</SUP> CFU/mL for GN bacteria, and 10<SUP>4</SUP> CFU/mL for <I>Candida</I>. The sensitivity and specificity of the Punch-it™ NA-Sample kit by REBA Sepsis-ID were 95.4% (187/196) and 100% (200/200), respectively. The overall agreement of the two DNA extraction methods was 98.9% (392/396). Three of four samples showing discrepant results between the two extraction methods were more accurately matched up with the Punch-it™ NA-Sample kit based on conventional culture methods. The results indicated that the Punch-it™ NA-Sample kit extracted bacterial and fungal DNA in blood culture bottles and allowed extracted DNA to be used in molecular assay.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Punch-it™ NA-Sample kit and boiling method for DNA extraction were compared. </LI> <LI> Punch-it™ NA-Sample kit extracted bacterial and fungal DNA in blood culture bottles. </LI> <LI> The Punch-it™ NA-Sample kit does not require enzyme to digest cell walls. </LI> </UL> </P>

A Conceptual Study on Radioactive Waste Solidification Treatment Using Plasma Torch Melter

Jihyun Kim,HyungJun Kim,Seoyong Choi 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.2

KHNP-CRI has developed Mega-Watt Class PTM (Plasma Torch Melter) for the purpose of reducing the volume of radioactive waste and immobilizing or solidifying radioactive materials. About 1 MW PTM is a treatment technology that operates a plasma torch and puts drum-shaped waste into a melter and radioactive waste in the form of slag is discharged into a waste container. Since only the overflowing slag is discharged from the melter, the discharge is intermittent. Therefore, solidification occurs in the process of discharging the melt. It is difficult to accumulate evenly in the waste container, and there is also an empty space. Solid radioactive waste must be disposed of to meet the acceptance criteria for radioactive waste. Plasma-treated solid waste raised concerns about the requirements. The waste solidification output in a slag container gave us some concerns for the waste package’s solidification and encapsulation requirements. The plasma-treated solid waste process to meet the acceptance criteria will be cost and need time consuming. Thus, a induction heating will be introduced to meet solidification requirements and test criteria of the solidification waste for the waste package disposal.

COVID-19 위기상황과 정부신뢰 - 신뢰대상 차이와 집계 여부에 따른 정부신뢰 결정구조 변화를 중심으로 -

김서용 ( Seoyong Kim ) 한국정책학회 2021 韓國政策學會報 Vol.30 No.4

본 연구의 목적은 COVID-19 위기상황에서 정부신뢰 영향요인을 분석하는 데 있다. 이를 위해 종속변수를 구성하는 정부신뢰 대상차이, 집계여부에 따라 영향요인(정부요인, 非정부대상 신뢰요인, 위험요인, 자원요인)의 구조와 설명력이 어떻게 달라지는지 분석하였다. 설문조사자료(N=1,525)를 분석한 결과, 첫째, COVID-19과 관련성이 높은 위험요인 외에 정부요인, 非정부대상 신뢰요인이 신뢰 설명에 유의한 역할을 수행하고 있었다. 둘째, 변수수준에서는 전문가집단신뢰, 정부소통이 모든 신뢰대상에 영향을 미치고, 지식, 정보량은 문재인 대통령 신뢰에, 정책선호, 이념은 이재명 경기도지사 신뢰에 영향을 미쳤다. COVID-19 재난상황이라는 점에서 전문가집단에 대한 신뢰의 설명력이 높았으며, 정부소통, 新舊매체 신뢰도 상당한 설명력을 보였다. 셋째, 신뢰구조에서 각 신뢰대상별로 다른 결정구조를 가지고 있었으나 정은경 본부장과 질병관리본부간 신뢰의 결정구조가 유사하게 나타났다. 아울러 종속변수의 값을 개별로 하는 경우, 집계하는 경우에 따라 신뢰의 결정구조에 차이가 발생하였다. The purpose of this study is to analyze the factors affecting public trust in government under COVID-19 crisis. To this end, we analyzed how the determinant structure and explanatory power of the independent variables (government factor, trust factor, risk factor, and resource factor) change depending on the difference in the target of trust in the government and whether or not they are aggregated. As a result of analyzing the survey data (N=1,525), first, not only risk factors highly related to COVID-19 but also government factors and trust factors played a significant role in explaining trust in government. At the second variable level, trust in expert and government communication variables affected all trustees, knowledge and information amount affected the trust in President Moon Jae-in, and policy preferences and ideology affected the trust in Gyeonggi Governor Lee Jae-myung. In the context of the COVID-19 disaster, the explanatory power of trust in expert on government trust was high. Also government communication and trust in new media showed considerable explanatory power. Third, in the trust structure, each trust object has a different determinant structure, but the determinant structure of Jung Eun-kyung and the Korea Centers for Disease Control and Prevention was similar. In addition, there was a difference in the determinant structure of trust in government depending on the case where the dependent variables were individually or aggregately counted.

환경주의 결정구조의 보편성과 특수성 -32개국 비교분석과 정책적 함의-

김서용 ( Seoyong Kim ),김선희 ( Sunhee Kim ) 한국정책학회 2014 韓國政策學會報 Vol.23 No.4

지구 온난화로 인한 기상이변 속출은 전세계적으로 환경주의의 성장과 확산을 가져오고 있다. 이와 같은 환경주의 확산은 환경정책의 근본적 변화를 야기하고 있다. 본 연구의 목적은 32개국 국민을 대상으로 수집된 설문조사자료를 바탕으로 환경정책의 근간이 되는 환경주의 결정요인과 관련된 인과적 법칙들의 보편성과 특수성을 분석하는데 있다. 핵심적 분석결과를 살펴보면 첫째, 환경주의 설명에서 사회인구학적 요인 보다는 가치적 요인과 환경심리적 요인이 높은 설명력을 가지고 있었으며, 특히 회의적 환경주의, 자기 효능감, 과학적 낙관주의 등의 변수가 환경주의 설명에 결정적으로 기여하고 있다. 둘째, 각 변수들의 영향력에서 연령, 성, 교육, 소득, 과학적 낙관주의, 환경위험지각, 환경지식, 자기 효능감 등은 환경주의에 正(+)의 영향을, 회의적 환경주의는 負(-)의 영향을 미치고 있었다. 셋째, 세 가지 요인들(사회인구학적 요인, 가치적 요인, 환경심리적 요인)로 구성된 전체 모형의 설명력은 국가에 따라 차이를 보이고 있다. 이와 같은 환경주의와 관련된 구조적 법칙들은 향후 환경정책 설계와 환경갈등의 원인 진단을 위한 유용한 정보로 활용될 것으로 예상된다. The catastrophic disaster caused by climate change is bring out the growth and expansion of environmentalism across countries. Such growth in environmentalism has been bringing out the change in environmental policy. Based on survey data collected from people across 32 countries, our study aims to analyze the determinants for environmentalism, by which we confirm the universal or particular rule underlying environmentalism. The results show first that the environmental psychological factors and value factor explain the environmentalism more than the social structural variables. In particular, skeptical environmentalism, efficacy, scientific optimism mainly explain the variance of environmentalism. Second, age, gender, education, scientific optimism, risk perception, knowledge and efficacy have positive impact on environmentalism whereas skeptical environmentalism does negative on it. Third, the explanation power of model based on three factors is varying across countries.