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Seon-Hui Jang,Soo-Joung Park,Chang-Jin Lee,Dong-Kuk Ahn,Seong-Kyu Han 대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.5
Botulinum toxin type A (BoNT/A) has been used therapeutically for various conditions including dystonia, cerebral palsy, wrinkle, hyperhidrosis and pain control. The substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc) receive orofacial nociceptive information from primary afferents and transmit the information to higher brain center. Although many studies have shown the analgesic effects of BoNT/A, the effects of BoNT/A at the central nervous system and the action mechanism are not well understood. Therefore, the effects of BoNT/A on the spontaneous postsynaptic currents (sPSCs) in the SG neurons were investigated. In whole cell voltage clamp mode, the frequency of sPSCs was increased in 18 (37.5%) neurons, decreased in 5 (10.4%) neurons and not affected in 25 (52.1%) of 48 neurons tested by BoNT/A (3 nM). Similar proportions of frequency variation of sPSCs were observed in 1 and 10 nM BoNT/A and no significant differences were observed in the relative mean frequencies of sPSCs among 1-10 nM BoNT/A. BoNT/A-induced frequency increase of sPSCs was not affected by pretreated tetrodotoxin (0.5 mM). In addition, the frequency of sIPSCs in the presence of CNQX (10 mM) and AP5 (20 mM) was increased in 10 (53%) neurons, decreased in 1 (5%) neuron and not affected in 8 (42%) of 19 neurons tested by BoNT/A (3 nM). These results demonstrate that BoNT/ A increases the frequency of sIPSCs on SG neurons of the Vc at least partly and can provide an evidence for rapid action of BoNT/A at the central nervous system.
Jang, Seon-Hui,Park, Soo-Joung,Lee, Chang-Jin,Ahn, Dong-Kuk,Han, Seong-Kyu The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.5
Botulinum toxin type A (BoNT/A) has been used therapeutically for various conditions including dystonia, cerebral palsy, wrinkle, hyperhidrosis and pain control. The substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc) receive orofacial nociceptive information from primary afferents and transmit the information to higher brain center. Although many studies have shown the analgesic effects of BoNT/A, the effects of BoNT/A at the central nervous system and the action mechanism are not well understood. Therefore, the effects of BoNT/A on the spontaneous postsynaptic currents (sPSCs) in the SG neurons were investigated. In whole cell voltage clamp mode, the frequency of sPSCs was increased in 18 (37.5%) neurons, decreased in 5 (10.4%) neurons and not affected in 25 (52.1%) of 48 neurons tested by BoNT/A (3 nM). Similar proportions of frequency variation of sPSCs were observed in 1 and 10 nM BoNT/A and no significant differences were observed in the relative mean frequencies of sPSCs among 1-10 nM BoNT/A. BoNT/A-induced frequency increase of sPSCs was not affected by pretreated tetrodotoxin ($0.5{\mu}M$). In addition, the frequency of sIPSCs in the presence of CNQX ($10{\mu}M$) and AP5 ($20{\mu}M$) was increased in 10 (53%) neurons, decreased in 1 (5%) neuron and not affected in 8 (42%) of 19 neurons tested by BoNT/A (3 nM). These results demonstrate that BoNT/A increases the frequency of sIPSCs on SG neurons of the Vc at least partly and can provide an evidence for rapid action of BoNT/A at the central nervous system.
Seon-Hui Jang,Dong-Hyu Cho,Seong-Kyu Han 조선대학교 치의학연구원 2023 Oral Biology Research (Oral Biol Res) Vol.47 No.2
The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) receives orofacial nociceptive information from primary afferent neurons and transmits this information to higher brain centers. Resveratrol (3, 5, 4′-trihydroxystilbene) is a polyphenolic compound found in various plant species and have been reported to have various biological activities, including analgesic effects. Although many studies have investigated the mechanism of action of resveratrol in terms of its antinociceptive effect, limited research has been conducted on the effects of resveratrol on SG neurons involved in orofacial pain transmission, especially to understand its relevance to glutamate receptors. To address this research gap, the present study investigated the effect of resveratrol on glutamate receptor activity in SG neurons using the whole-cell patch-clamp technique. The results showed that resveratrol significantly inhibited glutamate-mediated inward currents in SG neurons. Notably, there were no changes in α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid- or kainic acid-mediated inward currents in the presence of resveratrol, although N-methyl-D-aspartate (NMDA)-mediated inward currents were markedly suppressed. Taken together, these results suggest that resveratrol may be involved in orofacial pain transmission in SG neurons of the Vc by inhibiting the activity of NMDA receptors, among ionotropic glutamate receptors.
장선희(Jang Seon Hui),안숙이(An Sug I) 한국음악교육학회 2003 음악교육연구 Vol.24 No.-
The purpose of this study was to develop a portfolio assessment program for elementary school third grade music classes. For the purpose, the study inquired theories of portfolio development and explored how to (1) setting goals and objectives for developing the portfolio assessment program, (2) devising contents of portfolio assessment and evaluation an developing assessment tools, (3) planning evaluation results from the portfolio, and application of the portfolio. The procedure of the portfolio program development was as follows: (1) A preliminary program for portfolio assessment was designed for the third grade classes of E elementary school, based on the content of the Curriculum of Music for Elementary Schools, and the students` musical experience. (2) The preliminary program for portfolio assessment was applied to the third grade music classes at E elementary school, and revised on the results of the applications. (3) The final portfolio assessment program was completed by amending the preliminary program through the results of the second procedure. This study found certain conclusion from developing a portfolio assessment program. Using the portfolio it allows teachers to improve their instruction through integrating teaching and evaluation simultaneously. It also provides a chance to practice a variety of learning methods such as individual learning, group learning, or interaction learning. Portfolio assessment also allows students to participate more actively in learning by various types of interaction. It also stimulates more reflective thinking so that the students have an insight into their learning process.