http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
황적준,한길로,김윤신,서정욱 大韓法醫學會 1998 대한법의학회지 Vol.22 No.1
The corrected transposition of the great arteries is a rare congenital heart anomaly consisting of the discordant connections of both the atria to ventricles and the ventricles to the great arteries. But its circulation is physiologically corrected and therefore it is compatible with life unless there are associated lesions. Our case was associated with VSD, COA, and PDA. He was slightly cyanotic and irritable. Despite of oxygen supply, his symptoms were not improved and he eventually died in 52 hours after delivery. Medical record revealed severe respiratory and metabolic acidosis.
우성일,서한길 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2
The sequencing of the amino acids in the β-amyloid and the cloning of the amyloid precursor protein(APP) gene were the breakthrough event in the molecular biologic researches about the Alzheimer’is disease. After then, the mutations in the APP gene, presenilin 1 gene and presenilin 2 *gene associated with the familial Alzheimer’s disease(FAD) were found. Also, the roles of APOLEε 4 as a risk allele and APOLE ε2 as a protective allele in late onset AD, were demonstrated. All of the mutations causing FAD were known to function through a common final pathway which involves the increase on fibrillogenic form af Aβ. The APOLE allele seems to influence the production, distribution and clearance of Aβ. Such expansion in the understanding of AD molecular genetics give hopes to the development of novel therapeutic modalities.
Han Gil Seo 대한연하장애학회 2018 대한연하장애학회지 Vol.8 No.2
Dysphagia after radiotherapy for head and neck cancer is a common problem that affects the nutritional status and quality of life of patients. In particular, although radiation-induced dysphagia associated with late fibroatrophy is often progressive and intractable, there have been only few studies on the therapeutic options, and preventive efforts are not performed well in clinics. This review summarizes the management of radiation-induced dysphagia and suggests possible medical treatments based on the current evidence and reported pathophysiologic mechanisms.
Effect of Focal Muscle Vibration on Calf Muscle Spasticity: A Proof-of-Concept Study
Seo, Han Gil,Oh, Byung-Mo,Leigh, Ja-Ho,Chun, Changmook,Park, Cheol,Kim, Choong Hyun Elsevier 2016 PM&R Vol.8 No.11
<P>Background: Focal vibration has been studied for its ability to reduce spasticity in patients with upper motor neuron lesions, but adequate stimulation parameters remain unclear. Focal muscle vibration with adequate parameters may facilitate gait rehabilitation in patients with lower limb spasticity. Objective: To determine focal muscle vibration parameters that effectively inhibit the H-reflex of the gastrocnemius in healthy subjects. Design: A proof-of-concept exploratory study. Setting: University hospital laboratory. Subjects: Thirteen healthy volunteers. Methods: Focal muscle vibrations of 40, 80, and 120 Hz and amplitudes of 0.1, 0.3, and 0.5 mm were tested on the calf muscles of 10 healthy subjects, respectively. The H-reflex and M-response were recorded baseline, during vibration, and after vibration for each stimulation parameter. The mean vibratory inhibition index (VII) during vibration, the maximum amplitude of the H-reflex and M-response (H-max and M-max), minimal onset latency of the H-reflex, and the ratio of H-max to M-max (HMR) at each time point were measured. Results: No significant difference was found among mean VIIs at 40, 80, and 120 Hz in the healthy subjects. However, a relatively consistent reduction of H-max and HMR was observed at 80 Hz. Mean VI's at 0.3 and 0.5 mm were significantly lower than that at 0.1 mm (P < .001). Conclusion: This study suggests that focal muscle vibration may be an adjuvant therapy during gait rehabilitation in patients with calf muscle spasticity. Focal vibration at 80 Hz and 0.3 mm amplitude applied to the gastrocnemius effectively inhibits the segmental reflex pathway. A future clinical trial on this topic is warranted.</P>
Park, Seo Kyoung,Choi, Han Gil,Nam, Ki Wan 한국환경생태학회 2015 한국환경생태학회지 Vol.29 No.1
To examine the relationship between competition and environmental factors, the germlings of Ascophyllum nodosum (L) Le Jolis and Fucus vesiculosus L. were cultured in monocultures and mixtures of the two species under two different exposure and nutrient levels. Both intra- and inter-specific competition were examined in comparison of the mortality and growth of germlings in monocultures and mixtures of the two species. The mortality of germlings increased with increasing density and emergence periods both in the monoculture and mixtures of the two species, and the mortality of Ascophyllum was significantly higher than that of Fucus both in submerged and emerged treatments. The growth of germlings of both species reduced with increasing density but F. vesiculosus always grew faster than Ascophyllum. The values of log output ratio were more than 0.1, indicating that Fucus 'won' in the competitive battles with Ascophyllum under two nutrient- and air-exposure levels. Log output ratio was greater in high than in low nutrients, indicating that the growth of Fucus is more enhanced than that of Ascophyllum in high nutrients. In the present study, the outcome of inter specific competition between germlings of Fucus vesiculosus and Ascophyllum nodosum was slightly altered by duration of emergence and nutrient concentration, but not to such an extent as to change the outcome.
Lee, Han Gil,Kim, So Young,Kim, Du Sik,Seo, Su Ryeon,Lee, Syng-Ill,Shin, Dong Min,De Smet, Patrick,Seo, Jeong Taeg Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of neuroscience research Vol.87 No.1
<P>The effect of the potent soluble guanylyl cyclase (sGC) inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) on neurite outgrowth and retraction was investigated in PC12 cells and SH-SY5Y human neuroblastoma cells. ODQ inhibited neurite outgrowth and triggered neurite retraction in the cells stimulated with nerve growth factor (NGF), staurosporine, or Y-27632. The nitric oxide (NO) scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide (PTIO) had little effect on neurite outgrowth induced by Y-27632 or staurosporine. In the presence of ODQ, treatment of the cells with the cell-permeable cGMP analogue 8-bromo-cGMP failed to retrigger Y-27632- and staurosporine-induced neurite outgrowth. Furthermore, the depletion of sGC by RNA interference failed to prevent Y-27632- and staurosporine-induced neurite outgrowth. These results indicate that the NO/sGC/cGMP signaling cascade is not critically involved in ODQ-induced neurite remodeling. The MEK inhibitor PD98059 did not inhibit neurite outgrowth, and Y-27632 and staurosporine did not induce ERK phosphorylation, suggesting that the inhibitory effect of ODQ on neurite outgrowth is independent of the ERK signaling pathway. In contrast, pretreatment with dithionite or a hemin-glutathione mixture reversed the inhibitory effect of ODQ on Y-27632- and staurosporine-induced neurite outgrowth, indicating that ODQ might act on an intracellular redox-sensitive molecule. We conclude that ODQ inhibits Y-27632- and staurosporine-induced neurite outgrowth and triggers neurite retraction in an sGC-independent manner in neuronal cells and suggest that oxidation of unidentified redox-sensitive protein could be responsible for these effects. © 2008 Wiley-Liss, Inc.</P>