http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Current issues of pediatric inflammatory bowel disease in Korea
Oh, Seak Hee,Kim, Kyung Mo The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.11
Inflammatory bowel disease (IBD) is a chronic relapsing disorder of unknown etiology, which is believed to be multifactorial. Recently, the incidence of pediatric IBD has steeply increased in Korea since 2000. Poorly controlled disease activity can result in complications such as intestinal fistulae, abscess, and stricture, as well as growth retardation and delayed puberty in children. Because of a lack of confirmative tests, various diagnostic modalities must be used to diagnose IBD. Onset age, location, behavior, and activity are important in selecting treatments. Monogenic IBD must be excluded among infantile and refractory very-early-onset IBD. Early aggressive therapy using biologics has recently been proposed for peripubertal children to prevent growth failure and malnutrition.
Sedation in Pediatric Esophagogastroduodenoscopy
Seak Hee Oh 대한소화기내시경학회 2018 Clinical Endoscopy Vol.51 No.2
Pediatric esophagogastroduodenoscopy (EGD) has become an established diagnostic and therapeutic modality in pediatric gastroenterology. Effective sedation strategies have been adopted to improve patient tolerance during pediatric EGD. For children, safety is a fundamentalconsideration during this procedure as they are at a higher risk of severe adverse events from procedural sedation compared toadults. Therefore, a detailed risk evaluation is required prior to the procedure, and practitioners should be aware of the benefits and risksassociated with sedation regimens during pediatric EGD. In addition, pediatric advanced life support by endoscopists or immediate interventionby anesthesiologists should be available in the event that severe adverse events occur during pediatric EGD.
Is Whole Exome Sequencing Clinically Practical in the Management of Pediatric Crohn’s Disease?
( Seak Hee Oh ),( Jiwon Baek ),( Kyung Mo Kim ),( Eun-ju Lee ),( Yusun Jung ),( Yeoun Joo Lee ),( Hyun-seung Jin ),( Byong Duk Ye ),( Suk-kyun Yang ),( Jong-keuk Lee ),( Eul-ju Seo ),( Hyun Taek Lim ) 대한소화기학회 2015 Gut and Liver Vol.9 No.6
Background/Aims: The aim of this study was to identify the profile of rare variants associated with Crohn’s disease (CD) using whole exome sequencing (WES) analysis of Korean children with CD and to evaluate whether genetic profiles could provide information during medical decision making. Methods: DNA samples from 18 control individuals and 22 patients with infantile, very-early and early onset CD of severe phenotype were used for WES. Genes were filtered using panels of inflammatory bowel disease (IBD)-associated genes and genes of primary immunodeficiency (PID) and monogenic IBD. Results: Eighty-one IBD-associated variants and 35 variants in PID genes were revealed by WES. The most frequently occurring variants were carried by nine (41%) and four (18.2%) CD probands and were ATG16L2 (rs11235604) and IL17REL (rs142430606), respectively. Twenty-four IBD-associated variants and 10 PID variants were predicted to be deleterious and were identified in the heterozygous state. However, their functions were unknown with the exception of a novel p.Q111X variant in XIAP (X chromosome)of a male proband. Conclusions: The presence of many rare variants of unknown significance limits the clinical applicability of WES for individual CD patients. However, WES in children may be beneficial for distinguishing CD secondary to PID. (Gut Liver 2015,9:767-775)
MICRO WAVE OVEN용 마그네트론 구동을 위한 전원장치개발에 관한 연구
오덕진(Duck-Jin Oh),김희준(Hee-Jun Kim),오원석(Won-Seak Oh),정진홍(Jin-Hong Jung),김석기(Seak-Gi Kim),송종화(Jung-Hwa Song) 전력전자학회 1999 전력전자학술대회 논문집 Vol.- No.-
HVT<High Voltage Transformer) have been used to drive a magnetron in a microwave oven, but they have some problems such as heavy weight and low efficiency. To solve such problems of microwave oven power source, voltage resonant ZVS-PFM inverters have been developed. This paper presents a high-frequency high-voltage AC-DC converter incorporating high-frequency transformer resonant ZVS-PFM inverter with three-wmdmg transformer and voltage doubler type rectifier for drive high power magnetron. The new power supply makes it possible to realize light weight and high efficiency
Hee Gyung Lee,Kyung Mo Kim,Seak Hee Oh,Yeoun Joo Lee,Jae Seung Kim,Kyoung Hyo Choi,Young Ah Cho 대한소아소화기영양학회 2012 Pediatric gastroenterology, hepatology & nutrition Vol.15 No.3
Purpose: To compare the abilities of radionuclide salivagrams (RS) and videofluoroscopic swallow studies (VFSS) to diagnose aspiration in children with aspiration pneumonia. Methods: The records of children who were referred to the Asan Medical Center between April, 2006 and April, 2012 and who underwent both VFSS and RS to evaluate their recurrent aspiration pneumonia were reviewed (n=67). The aspiration positivity rates of the two tests were determined. The agreement between the tests was assessed by using the kappa statistic. Results: VFSS was more frequently positive (n=26, 39%) than RS (n=23, 34%) (p=0.68). In the 11 children who repeat two test, Repeated examination increased positive rate in each tests (n=11), repeated RS (54%, p=1) is more frequent positive than repeated VFSS (46%, p=0.37). If a cumulative positive test had been defined as at least one positive result, the positive rate of two test was 56% (p<0.05). There was a fair agreement between RS and VFSS (kappa=0.26). Conclusion: The RS and VFSS positivity rates in children with aspiration pneumonia were similar but there was fair agreement between the two tests. This result suggests that these investigations to demonstrate aspiration are not interchangeable but complementary.
Lee, Eun,Oh, Seak-Hee,Kwon, Ji-Won,Kim, Byoung-Ju,Yu, Jin-Ho,Park, Chan-Jeoung,Hong, Soo-Jong The Korean Pediatric Society 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.6
Chronic granulomatous disease (CGD) is an uncommon inherited disorder caused by mutations in any of the genes encoding subunits of the superoxide-generating phagocyte NADPH oxidase system, which is essential for killing catalase producing bacteria and fungi, such as $Aspergillus$ species, $Staphylococcus$ $aureus$, $Serratia$ $marcescens$, $Nocardia$ species and $Burkholderia$ $cepacia$. In case of a history of recurrent or persistent infections, immune deficiency should be investigated. Particularly, in the case of uncommon infections such as aspergillosis in early life, CGD should be considered. We describe here a case of CGD that presented with invasive pulmonary aspergillosis in a 2-month-old girl. We confirmed pulmonary aspergillosis noninvasively through a positive result from the culture of bronchial alveolar lavage fluid, positive serological test for $Aspergillus$ antigen and radiology results. She was successfully treated with Amphotericin B and recombinant IFN-${\gamma}$ initially. Six weeks later after discharge, she was readmitted for pneumonia. Since there were infiltrates on the right lower lung, which were considered as residual lesions, voriconazole therapy was initiated. She showed a favorable response to the treatment and follow-up CT showed regression of the pulmonary infiltrates.