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Lee, Meesun,Lee, Sangmi,Jeong, Hohyn,Park, Manyong,Kim, Dong-Woung,Song, Bong-Keun,Lee, Jong-Deok,Lee, Ho Sub,Kim, Sungchul KOREAN PHARMACOPUNCTURE INSTITUTE 2013 Journal of pharmacopuncture Vol.16 No.1
Objective: The aim of this experiment was to investigate the effect and the mechanism of Geumgoeshingi-whan (GGSGW) Pharmacopuncture at the acupoint GV 4 on the blood pressure in spontaneously hypertensive rats (SHR). Methods: SHR were injected with normal saline solution (Control-SHR group)or GGSGW Pharmacopuncture (GGSGW-SHR group) at the acupoint GV 4. The systolic arterial blood pressure and renal parameters were measured for two weeks. Results: The systolic arterial blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR, followed by a significant rise in creatine clearance. The plasma levels of aldosterone were decreased significantly after GGSGW Pharmacopunctureas were the plasma levels of atrial natriuretic peptide (ANP). Conclusion: These results suggest that the blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR and that the depressor response of the blood pressure was related to decreases in the plasma levels of aldosterone and ANP.
Lee, Sukjun,Lim, Donghyun,Lee, Eunyoung,Lee, Nakyung,Lee, Hong-gun,Cechetto, Jonathan,Liuzzi, Michel,Freitas-Junior, Lucio H.,Song, Jin Sook,Bae, Myung Ae,Oh, Sangmi,Ayong, Lawrence,Park, Seung Bum American Chemical Society 2014 Journal of medicinal chemistry Vol.57 No.17
<P>New antimalarial agents that exhibit multistage activities against drug-resistant strains of malaria parasites represent good starting points for developing next-generation antimalarial therapies. To facilitate the progression of such agents into the development phase, we developed an image-based parasitological screening method for defining drug effects on different asexual life cycle stages of <I>Plasmodium falciparum</I>. High-throughput screening of a newly assembled diversity-oriented synthetic library using this approach led to the identification of carbohybrid-based 2-aminopyrimidine compounds with fast-acting growth inhibitory activities against three laboratory strains of multidrug-resistant <I>P. falciparum</I>. Our structure–activity relationship study led to the identification of two derivatives (<B>8aA</B> and <B>11aA</B>) as the most promising antimalarial candidates (mean EC<SUB>50</SUB> of 0.130 and 0.096 μM against all three <I>P. falciparum</I> strains, selectivity indices >600, microsomal stabilities >80%, and mouse malaria ED<SUB>50</SUB> values of 0.32 and 0.12 mg/kg/day, respectively), targeting all major blood stages of multidrug-resistant <I>P. falciparum</I> parasites.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2014/jmcmar.2014.57.issue-17/jm5009693/production/images/medium/jm-2014-009693_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm5009693'>ACS Electronic Supporting Info</A></P>
Child-rearing experiences of mothers with early adolescents in Korean multicultural families
Sangmi Lee,Hyun Young Koo 한국아동간호학회 2021 Child Health Nursing Research Vol.27 No.2
Purpose: This study was conducted to explore the child-rearing experiences of mothers with early adolescents in Korean multicultural families. Methods: The participants were six mothers with early adolescents in Korean multicultural families. Data were collected through in-depth interviews. The main question was, "Could you tell me about your child-rearing experiences with your adolescent child?" The data were analyzed using qualitative content analysis. Results: Four categories resulted from the analysis of child-rearing experiences of mothers with early adolescents in Korean multicultural families, as follows: "separation between myself and others", "distance between myself and my adolescent child", "making efforts to bridge the gap between myself and others", and "trying to connect with my adolescent child closely". Conclusion: These findings indicate that mothers in Korean multicultural families made many efforts to bridge the gap between themselves and other people, and tried to connect with their children closely. The findings of this study emphasize specific aspects of how mothers with early adolescents experienced child-rearing in Korean multicultural families.
( Sangmi Lee ),( Eun Jin Kwon ),( Young-ah You ),( Ji Eun Du ),( Inho Jo ),( Young Ju Kim ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.3
Objective Maternal malnutrition affects the growth and metabolic health of the offspring. Little is known about the longterm effect on metabolic indices of epigenetic changes in the brain caused by maternal diet. Thus, we explored the effect of maternal food restriction during pregnancy on metabolic profiles of the offspring, by evaluating the DNA methylation of hypothalamic appetite regulators at 3 weeks of age. Methods Sprague-Dawley rats were divided into 2 groups: a control group and a group with a 50% food-restricted (FR) diet during pregnancy. Methylation and expression of appetite regulator genes were measured in 3-week-old offspring using pyrosequencing, real-time polymerase chain reaction, and western blotting analyses. We analyzed the relationship between DNA methylation and metabolic profiles by Pearson’s correlation analysis. Results The expression of pro-opiomelanocortin (POMC) decreased, whereas DNA methylation significantly increased in male offspring of the FR dams, compared to the male offspring of control dams. Hypermethylation of POMC was positively correlated with the levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol in 3-week-old male offspring. In addition, there were significant positive correlations between hypermethylation of POMC and the levels of triglycerides, HDL-C, and leptin in 6-month-old male offspring. Conclusion Our findings suggest that maternal food restriction during pregnancy influences the expression of hypothalamic appetite regulators via epigenetic changes, leading to the development of metabolic disorders in the offspring.
Lee, Sangmi,Kim, Sungchul Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Respiratory dysfunction and complications are the most common causes of death in amyotrophic lateral sclerosis. This is a pilot study to observe the changes in respiratory physiology parameters after Sa-am acupuncture treatment. Eighteen ALS patients received Sa-am acupuncture treatment twice a day for 5 days. The EtCO<SUB>2</SUB>, SpO<SUB>2</SUB>, RR, and pulse rate were measured for 15 min before and during treatment, using capnography and oximetry. Correlation of K-ALSFRS-R scores against measured parameters showed that patients who had high K-ALSFRS-R scores had greater changes in pulse rate after acupuncture stimulation; they also showed a decrease in EtCO<SUB>2</SUB>, RR, and pulse rate and an increase in SpO<SUB>2</SUB>. A comparison of the mean values of these different parameters before and after Sa-am acupuncture stimulation revealed statistically significant differences (<I>P</I> < 0.05) in SpO<SUB>2</SUB> and pulse rate, but none in EtCO<SUB>2</SUB> and RR. Sa-am acupuncture treatment on ALS patients seems to be more effective in the early stages of the disease. In light of increased SpO<SUB>2</SUB> values, Sa-am acupuncture appears to have a greater effect on inspiration rather than on expiration. As a pilot study of acupuncture on ALS patients, this study could be used as a basis for future research.</P>
Lee, Jungryun,Song, Kiyeong,Lee, Kyoobin,Hong, Joohyeon,Lee, Hyojung,Chae, Sangmi,Cheong, Eunji,Shin, Hee-Sup National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.50
<P>T-type Ca<SUP>2+</SUP> channels in thalamocortical (TC) neurons have long been considered to play a critical role in the genesis of sleep spindles, one of several TC oscillations. A classical model for TC oscillations states that reciprocal interaction between synaptically connected GABAergic thalamic reticular nucleus (TRN) neurons and glutamatergic TC neurons generates oscillations through T-type channel-mediated low-threshold burst firings of neurons in the two nuclei. These oscillations are then transmitted from TC neurons to cortical neurons, contributing to the network of TC oscillations. Unexpectedly, however, we found that both WT and KO mice for <I>Ca<SUB>V</SUB>3.1</I>, the gene for T-type Ca<SUP>2+</SUP> channels in TC neurons, exhibit typical waxing-and-waning sleep spindle waves at a similar occurrence and with similar amplitudes and episode durations during non-rapid eye movement sleep. Single-unit recording in parallel with electroencephalography in vivo confirmed a complete lack of burst firing in the mutant TC neurons. Of particular interest, the tonic spike frequency in TC neurons was significantly increased during spindle periods compared with nonspindle periods in both genotypes. In contrast, no significant change in burst firing frequency between spindle and nonspindle periods was noted in the WT mice. Furthermore, spindle-like oscillations were readily generated within intrathalamic circuits composed solely of TRN and TC neurons in vitro in both the KO mutant and WT mice. Our findings call into question the essential role of low-threshold burst firings in TC neurons and suggest that tonic firing is important for the generation and propagation of spindle oscillations in the TC circuit.</P>