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Lee, Sangkwan,Kim, Seon-jong Williams & Wilkins Co 2018 Medicine Vol.97 No.12
<P><B>Abstract</B></P><P><B>Background:</B></P><P>Arthritis is the most common disease in elderly individuals. Many medications for osteoarthritis treatment have the potential for side effects. Using a bioinformatics tool and preclinical studies, ChondroT, 5 herbal complexes, was identified from Ganghwaljetongyeum, which is a18 herbal complex, which has often used to treat osteoarthritis. The goal of this study is to evaluate short-term safety of ChondroT.</P><P><B>Methods:</B></P><P>This will be a multicenter, randomized, double-blind, and placebo-controlled trial. There will be a 2-week run-in period before random allocation to 3 groups, ChondroT 1.0 g, 2.0 g, and placebo groups. Total duration of the clinical trial will be 14 weeks including a 4-week washout follow-up. Participants will be followed-up every 4 weeks, and the effect and the safety will be assessed at visit 2, 3, and 4. All participants are asked to maintain the medication schedule in this protocol. The primary outcome will be measured using pain visual analog scale (VAS) after 8 week treatment and secondary outcomes will include pain VAS score after 4 week treatment, SF-36 survey score, patient's global assessment, physical function test, and the change of erythrocyte sedimentation rate, and C-reactive protein. The repeated-measure analysis will be used for the primary efficacy based on full analysis set and per-protocol.</P><P><B>Discussion:</B></P><P>This study has restrictive inclusion, exclusion criteria, and a well-controlled intervention, and it will be the first randomized controlled trial to evaluate the efficacy and safety of ChondroT formula in osteoarthritis patients. The trial according to this protocol may provide a new intervention in the treatment of osteoarthritis.</P>
Molecular Monolayer Nonvolatile Memory with Tunable Molecules
Lee, Junghyun,Chang, Hojong,Kim, Sangkwan,Bang, Gyeong Sook,Lee, Hyoyoung WILEY-VCH Verlag 2009 Angewandte Chemie Vol.48 No.45
<B>Graphic Abstract</B> <P>An unforgettable monolayer: Dialkylthiolate-tethered metal complex self-assembled monolayers (see picture; thickness 3 nm) provide stable and reproducible molecular monolayer nonvolatile memory (MMNVM) characterized by its hysteretic current–voltage (I–V) properties and retention time for write–multiple read–erase–multiple read pulse cycles. This is the first known voltage-driven MMNVM using only a molecular monolayer. <img src='wiley_img/14337851-2009-48-45-ANIE200902990-content.gif' alt='wiley_img/14337851-2009-48-45-ANIE200902990-content'> </P>
청각자극(Rhythmic Auditory Stimulation)을 이용한 훈련이 뇌졸중 환자의 보행에 미치는 효과
박기언,이인성,오재건,이일석,최산호,이상관,성강경,Park, Kee-eon,Lee, Insung,Oh, Jaegun,Lee, Ilsuk,Choi, Sanho,Lee, Sangkwan,Sung, Kang-keyng 대한중풍순환신경학회 2013 대한중풍.순환신경학회지 Vol.14 No.1
■ Objectives The goal of this pilot study is to observe the change of stroke gait by auditory cue training. ■ Methods An intracranial hemorrhage patient was trained for 4 weeks. For the 1<sup>st</sup> consecutive 6days(the 1<sup>st</sup> week), the patient was trained to walk with auditory cue, what was called auditory cue gait training condition. For the 2<sup>nd</sup> consecutive 6days(the 2<sup>nd</sup> week), the patient was trained to walk naturally without auditory cue, what was called free gait training condition. For the 3<sup>rd</sup> consecutive 6days(the 3<sup>rd</sup> week), the patient was trained to walk under auditory cue gait training condition. For the 4<sup>th</sup> consecutive 6days(the 4<sup>th</sup> week), the patient was trained to walk under free gait training condition. We analyzed the gait using a treadmill gait analysis system 3 hours after the 6<sup>th</sup> gait training. ■ Results Auditory cue gait training showed effects on gait parameters, which were increasing walking velocity, step length, stride length, decreasing cadence, step time and stride time. ■ Conclusion Auditory cue gait training improved gait parameters of a stroke patient.
박상관(SangKwan Park),박건우(Gunwoo Park),이상훈(Sanghoon Lee) 한국정보과학회 2008 한국정보과학회 학술발표논문집 Vol.35 No.2
웹 상에 존재하는 정보의 량이 방대해 질수록 사용자가 원하는 정보를 찾는데 더 많은 노력이 필요하게 되었다. 따라서 보다 원하는 정보를 정확하고 효율적으로 검색하기 위한 많은 검색 방법들이 연구되어 왔다. 하지만 이와 같은 방법들은 웹 검색자들의 검색의도를 파악하는데 어려움이 있다. 따라서 검색자들의 검색 의도에 맞는 정보를 효율적으로 검색하기에 적절하지 않는 단점을 가지고 있다. 따라서 본 논문에서는 사용자의 검색 질의와 가장 유사한 커뮤니티를 검색하고 신뢰 정도를 분석하여 신뢰 할 수 있는 커뮤니티를 기반으로 검색을 함으로써 보다 사용자의 검색 의도에 정확하고 효율적인 검색 결과를 획득하기 위한 방법을 제안한다.
Subcutaneous Injection of Myrrh Essential Oil in Mice: Acute and Subacute Toxicity Study
Lamichhane, Ramakanta,Lee, Kyung-Hee,Pandeya, Prakash Raj,Sung, Kang-Kyung,Lee, SangKwan,Kim, Yun-Kyung,Jung, Hyun-Ju Hindawi 2019 Evidence-based Complementary and Alternative Medic Vol.2019 No.-
<P>Myrrh essential oil (MEO) is widely used as remedies for the different human ailment in different parts of the world. The misuse of this natural product in higher doses may lead to fever, inflammation, and liver and kidney problems. In this study, we performed the acute and subacute toxicity analysis of MEO in mice model after subcutaneous injection and evaluated the safe dose to prevent the possible risk and side effects. Initially (first phase study) higher dose of MEO (20, 40, and 80 <I>μ</I>L) was injected, and later in the second phase study lower dose of MEO (1, 5, and 10 <I>μ</I>L) was injected for three days in each group of mice. Blood samples were taken for the investigation of hematological parameters and activity of various enzymes. The liver, kidney, spleen, lungs, and heart were excised for histological study. The body weight and skin abnormalities were also evaluated. In the first phase study, the mice showed granuloma formation at the site of injection. The liver showed dilated sinusoids and enlarged central vein. In the spleen the distinction between red and white pulp was lost. The kidney showed the degeneration of glomerulus. The enzyme activity and body weight were also decreased by the higher dose. The WBC count also increased nearly by twofold. Pruritus and self-trauma were also evident. Later in the second phase study, the skin abnormalities (granuloma) and damage in the structure of tissue (in liver, spleen, and kidney) were absent along with no change in enzyme levels, blood parameters, and body weight compared to the control. The MEO was toxic to liver, spleen, and kidney in the higher doses. The safe volume of MEO useful for various studies in mice was evaluated. The safe use of MEO should be assured, it should not be misused, being considered as a natural remedy, and there should be awareness of its toxicity and side effects.</P>
Youn, Jong-In,Lee, Ho Sub,Lee, Sangkwan The Society of Physical Therapy Science 2016 JOURNAL OF PHYSICAL THERAPY SCIENCE Vol.28 No.8
<P>[Purpose] This study used electromyography to measure the effective treatment duration of interferential current therapy for muscle fatigue. [Subjects and Methods] Fifteen healthy adult men volunteered to participate in the study (age: 24.2 ± 1.3 years; weight: 67.6 ± 4.92 kg; height: 176.4 ± 4.92 cm). All subjects performed 5 min of isometric back extension exercise to produce muscle fatigue, and were then treated with interferential current therapy for 15 min, with electromyography monitoring (treatment group). After sufficient rest, the exercise was repeated for 5 min and an electromyography signal was acquired for 15 min with no treatment (control group). [Results] In the treatment group, the median frequency shifted to a higher level; the root mean square decreased over time, and then maintained a minimum amplitude. However, there were few changes in the electromyography signal after exercise in the control group. [Conclusion] Electromyography signals can provide information about the effective duration for muscle fatigue treatment as well as the muscle characteristics during treatment. This study should be helpful for clinicians by demonstrating the appropriate duration of therapy for relief of muscle stiffness.</P>
이상관,최산호,오재건,이일석,박기언,홍해진,성강경,Lee, Sangkwan,Choi, Sanho,Oh, Jaegun,Lee, Ilsuk,Park, Kee-eon,Hong, Haejin,Sung, Kang-keyng 대한중풍순환신경학회 2013 대한중풍.순환신경학회지 Vol.14 No.1
The following study reviewed the walking patterns of stroke patients with hemiplegia, which is called hemiplegic gait of stroke patients. Focusing is given to the changes in the distance and temporal factors of walking, which is called spatiotemporal characteristics, throughout the walking cycle. First, we introduced the definitions of essential terms related to gait and its measure. Second, we reviewed the spatiotemporal characteristics of hemiplegic gait. A main issue was that hemiplegic gait showed significant deviations from normal healthy gait. Although hemiplegia is primarily associated with unilateral motor disorder, changes in almost all spatiotemporal parameters used to assess walking were evident on both the involved and uninvolved sides of the body. Last, we reviewed the changes of spatiotemporal parameters of hemiplegic gait according to the prognosis or status of stroke patients, which may help to give a specific intervention for rehabilitation of stroke.
편마비 환자의 운동수행능력과 질량중심 변화의 상관 관계
이일석,임형문,최산호,오재건,성강경,이상관,Lee, Ilsuk,Lim, Hyungmoon,Choi, Sanho,Oh, Jaegun,Sung, Kang-keyng,Lee, Sangkwan 대한중풍순환신경학회 2013 대한중풍.순환신경학회지 Vol.14 No.1
■ Objectives The aim of this study is to look into the correlation between motor performance and displacement of center of pressure(CoP) in hemiplegic patients with cerebral stroke. ■ Methods We measured manual muscle test(MMT) as motor performance value and, anterior/posterior position(Ant./Post. position) and lateral symmetry of CoP as displacement of CoP values from 129 stroke patients. The gait analysis was carried out using treadmill gait analysis equipment. ■ Results In terms of motor performance, MMT of upper extremity negatively correlated with Ant/Post position of CoP, however, one of lower extremity did not. In addition, MMT of both extremities negatively correlated with lateral symmetry of CoP. ■ Conclusion Displacement of CoP was negatively correlated with hemiplegic patient's motor performance.