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Park, Jong Il,Han, sang seop,Jeong, Tae Cheon,Roh, Jung Koo,Kim, Hyoung Chin,Kim, Jeong Hwan,Jeon, Yeong Joong,Kim, Dal Hyun,Kim,Je Hak,Park, Kwan Ha 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.1
The antigenic potential of CFA-001, cefazolin, a cephalosporin derivative produced by an enzymatic semisynthesis, was determined in Hartley guinea pigs. A battery of tests employed consisted of active systemic anaphylaxis (ASA), passive cutaneous anaphylaxis (PCA), and indirect hemagglutination test (IHA). The results were as follows: 1) In ASA, no signs attributable to anaphylaxis was observed in guinea pigs sensitized with CFA-001, whereas OVA-sensitized animals induced severe anaphylactic symptoms; 2) guinea pigs did not produce antibodies against CFA-001 when sensitized with or without Freund's complete adjuvant (FCA) in homologous PCA tests. Meanwhile, antibodies against ovalbumin (OVA) were clearly detected; 3) No CFA-001-specific hemagglutination was observed in the IHA using sera obtained from CFA-001-sensitized guinea pigs. These results suggest that CFA-001 has no antigenicity potential in guinea pigs.
Ha Jiyeon,Park Seong Ho,Son Jung Hee,Kang Ji Hun,Ye Byong Duk,박소현,Kim Bohyun,Choi Sang Hyun,Park Sang Hyoung,Yang Suk-Kyun 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.1
Objective: Computed tomography enterography (CTE) and magnetic resonance enterography (MRE) are considered substitutes for each other for evaluating Crohn’s disease (CD). However, the adequacy of mixing them for routine periodic follow-up for CD has not been established. This study aimed to compare MRE alone with the mixed use of CTE and MRE for the periodic follow-up of small bowel inflammation in patients with CD. Materials and Methods: We retrospectively compared two non-randomized groups, each comprising 96 patients with CD. One group underwent CTE and MRE (MRE followed by CTE or vice versa) for the follow-up of CD (interval, 13–27 months [median, 22 months]), and the other group underwent MRE alone (interval, 15–26 months [median, 21 months]). However, these two groups were similar in clinical characteristics. Three independent readers from three different institutions determined whether inflammation had decreased, remained unchanged, or increased within the entire small bowel and the terminal ileum based on sequential enterography of the patients after appropriate blinding. We compared the two groups for inter-reader agreement and accuracy (terminal ileum only) using endoscopy as the reference standard for enterographic interpretation. Results: The inter-reader agreement was greater in the MRE alone group for the entire small bowel (intraclass correlation coefficient [ICC]: 0.683 vs. 0.473; p = 0.005) and the terminal ileum (ICC: 0.656 vs. 0.490; p = 0.030). The interpretation accuracy was higher in the MRE alone group without statistical significance (70.9%–74.5% vs. 57.9%–64.9% in individual readers; adjusted odds ratio = 3.21; p = 0.077). Conclusion: The mixed use of CTE and MRE was inferior to MRE alone in terms of inter-reader reliability and could probably be less accurate than MRE alone for routine monitoring of small bowel inflammation in patients with CD. Therefore, the consistent use of MRE is favored for this purpose.
Ha, Min Gwan,Na, Youngseung,Park, Hee Young,Kim, Hyoung-Juhn,Song, Juhun,Yoo, Sung Jong,Kim, Yong-Tae,Park, Hyun S.,Jang, Jong Hyun The Korean Electrochemical Society 2021 Journal of electrochemical science and technology Vol.12 No.4
Electrochemical devices are constructed for continuous syngas (CO + H<sub>2</sub>) production with controlled selectivity between CO<sub>2</sub> and proton reduction reactions. The ratio of CO to H<sub>2</sub>, or the faradaic efficiency toward CO generation, was mechanically manipulated by adjusting the space volume between the cathode and the polymer gas separator in the device. In particular, the area added between the cathode and the ion-conducting polymer using 0.5 M KHCO<sub>3</sub> catholyte regulated the solution acidity and proton reduction kinetics in the flow cell. The faradaic efficiency of CO production was controlled as a function of the distance between the polymer separator and cathode in addition to that manipulated by the electrode potential. Further, the electrochemical CO<sub>2</sub> reduction device using Au NPs presented a stable operation for more than 23 h at different H<sub>2</sub>:CO production levels, demonstrating the functional stability of the flow cell utilizing the mechanical variable as an important operational factor.
A Simple New Method for Identifying the Proximal Cut End in Lower Canalicular Laceration
( Sang Hyoung Cho ),( Dong Won Hyun ),( Hyo Jeong Kang ),( Myung Sook Ha ) 대한안과학회 2008 Korean Journal of Ophthalmology Vol.22 No.2
Purpose: We report a simple and effective method of identifying the medial cut end of lower canalicular laceration cases. Methods: Twenty-seven eyes with lower canalicular lacerations as a result of trauma were involved in the study. Surgery was performed within 48 hours after injury for canalicular reconstruction. Upper canalicular probing was utilized to identify the medial cut end of deep canalicular lacerations when difficulties were encountered. Total time from the initiation of the probing procedure to the identification of the medial cut end of the lower canaliculus was measured. Results: A total of 27 eyes with lower canalicular lacerations were reconstructed. In 20 eyes, the medial lacerated end was located by upper canalicular probing. The mean time from initiation of the probing procedure to identification of the medial cut end of the lacerated canaliculus was 2 minutes. Conclusions: We conclude that upper canalicular probing in patients with lower canalicular lacerations significantly reduces the time from the initiation of the operation to the identification of the medial cut end of the lower canaliculus.
Ha, InHo,Park, Hyoung-Joon,Han, Sang-Kook Elsevier 2019 OPTICS COMMUNICATIONS - Vol.437 No.-
<P><B>Abstract</B></P> <P>We propose a spectral power shaping technique for use in intermediate frequency (IF) over fiber systems. The technique redistributes the power of nonlinear components by adjusting the spectral power of the signal. Experiments performed using 10 km distance transmission system show that the proposed technique effectively controls the power of the nonlinear components in a broadband system. The feasibility of the proposed technique was experimentally verified in terms of the error vector magnitude (EVM) and degree of channel linearity.</P>