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( Sung Hee Lim ),( Jong-mu Sun ),( Joohyun Hong ),( Dongryul Oh ),( Yong Chan Ahn ),( Man Ki Chung ),( Han-sin Jeong ),( Young-ik Son ),( Myung-ju Ahn ),( Chung-hwan Baek ),( Keunchil Park ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.0
Background/Aims: Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over current chemoradiotherapy (CRT) in patients with hypopharynx and BOT cancer. Methods: Treatment-naïve patients with stage III/IV (M0) hypopharynx or BOT cancer were randomly assigned to receive CRT alone (CRT arm: cisplatin 100 mg/m<sup>2</sup> on D1 3-weekly, two times plus radiotherapy 68.4 Gy/30 fractions on weekdays) versus two 21-day cycles of IC with TPF (docetaxel & cisplatin 75 mg/m<sup>2</sup> on D1, and fluorouracil 75 mg/m<sup>2</sup> on D1-4) followed by the same CRT regimen (IC arm). The primary endpoint was progression-free survival (PFS). Results: This study closed early after enrollment of 36 patients (19 in the CRT arm, 17 in the IC arm). After a median follow-up of 47.2 months, there was no significant difference in PFS: the median PFS was 26.8 months for the CRT arm and was not reached for the IC arm (p = 0.13). However, the survival curves were widely separated with a plateau after 3 years, suggesting a potential survival benefit from IC: 3-year PFS rates were 45% and 68%, and 3-year overall survival rates were 56% and 86%, in the CRT and IC arms, respectively. Conclusions: This study failed to demonstrate that induction TPF chemotherapy improves survival in patients with BOT and hypopharynx cancer. However, it suggested a favorable outcome with IC to this population.
Baek, Seung Ki,Kwak, Sung Soo,Kim, Joo Sung,Kim, Sang Woo,Cho, Hyung Koun American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.34
<P>The high performance of ZnO-based piezoelectric nanogenerators (NGs) has been limited due to the potential screening from intrinsic electron carriers in ZnO. We have demonstrated a novel approach to greatly improve piezoelectric power generation by electrodepositing a high quality p-type Cu2O layer between the piezoelectric semi: conducting film and the metal electrode. The p-n heterojunction using only oxides suppresses the screening effect by forming an intrinsic depletion region, and thus sufficiently enhances the piezoelectric potential, compared to the pristine ZnO piezoelectric NG. Interestingly, a Sb-doped Cu2O layer has high mobility and low surface trap states. Thus, this doped layer is an attractive p-type material to significantly improve piezoelectric performance. Our results revealed that p-n junction NGs consisting of Au/ZnO/Cu2O/indium-tin oxide with a Cu2O:Sb (cuprous oxide with a small amount of antimony) layer of sufficient thickness (3 mu m) exhibit an extraordinarily high piezoelectric potential of 0.9 V and a maximum output current density of 3.1 mu A/cm(2).</P>
Exogenous Tryptophan Aggravates Experimental Lung Fibrosis Through Activation of AKT-mTORC1 Pathway
( Ki Sung Song ),( Jisu Hong ),( Ae-rin Baek ),( Susie Chin ),( An Soo Jang ),( Do Jin Kim ),( Sung Woo Park ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Using the metabolomic approach, we previously reported that lung tryptophan levels were significantly increased in IPF. However, the role of tryptophan in IPF pathogenesis remains unclear. we investigated whether regulation of tryptophan modulates the severity of lung fibrosis and to find its possible mechanism. Methods We measured the expression of main extracellular matrix components in MRC-5 cells with or without tryptophan. IPF primary fibroblasts were used to perform proliferation assay and measurement of tryptophan hydroxylase (TPH-1). Exogenous tryptophan was administrated in the bleomycin (BLM) exposed mice. Results In IPF lung lysates and fibroblast, TPH-1 protein levels were significantly increased than controls. Treatment of tryptophan increased collagen, fibronectin, and a-SMA expressions in MRC5 cells. Tryptophan dramatically augments fibroblast proliferation. Treatment of tryptophan activates AKT-mTOR C1 pathway molecules in IPF fibroblast. Exogenous tryptophan promotes BLM-induced lung damage and fibrosis in mice. Conclusions These findings suggest that overproduction of tryptophan may contribute to the IPF pathogenesis and regulation of the tryptophan pathway may have therapeutic potential in preventing lung fibrosis. This study was supported by National research foundation of Korea grant 2019R1A2C1006351.
Initial Stemness Maintenance of Pig Epiblast Stem Cells (pEpiSCs)
Sang-Ki Baek,Sang-Hoon Park,Mi-Ran Lee,Hye-Ju Eun,Song-Yi Moon,Joon-Hee Lee 한국동물번식학회 2012 Reproductive & Developmental Biology(Supplement) Vol.36 No.2s
Since embryonic stem cells (ESCs) were first established from explant cultures of in vivo day 3.5 mouse embryos, the establishment of ESCs from species such as primates and rat has been developed. However, this success relies on the development of culture medium suitable for human and rat cells, which has different requirements from the murine ESC. In general, the establishment of ESC from pig and cow is of great interest both the agricultural perspective and for biomedical application. Large animal models, particularly pig, are likely to provide models of human genetic diseases and transplantation research where rodent models are inappropriate. However, establishment of ESCs establishment from pigs has remained an elusive goal. In the present study, we focused on signaling transduction regulation in pig epiblast stem cells (pEpiSCs). Pig epiblasts were isolated from early tubular stage embryos collected in vivo day 10.5~12 after insemination. Epiblasts were separated from trophoblast and underlying primitive endoderm using 21G needles and fine forceps. Epiblasts were cultured on mitomycin C (10 μl/ml) treated mouse embryonic feeder cells in Dulbecco’s modified Eagle’s medium (DMEM) containing 1% minimal essential medium (MEM) nonessential amino acids, 1% penicillin/ streptomycin, 1% glutamine, 0.007% β-mercaptoethanol, 5 ng/ml bFGF and 1 ng/ml LIF. After plating rapid differentiation of isolated epiblasts to extraembryonic cell types was visualized in most cultures but stem cells were enclosed by these differentiated cells. We have established seven pig epiblast stem cells lines (pEpiSC1-7) from Days 10.5-12 pig embryos. pEpiSC expressed the pluripotent markers including OCT4, NANOG, SOX2 and NODAL at 3-5 passage. In addition, the modification of culture condition by the inclusion of particular protein kinase inhibitor such as Akt inhibitor, PD0325091(PD), delyed rapid differentiation of pEpiSCs. These results showed that stemness of pEpiSCs can be maintained by regulation of signaling pathway. * This work was partly supported by a grant from the NPR (2011-0013703) and the Next-Generation BioGreen 21 Program (No. PJ008209), Rural Development Administration, Republic of Korea.