http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sang-Hyun Kang,Shin Hwang,Tae Yong Ha,Gi Won Song,Dong-Hwan Jung,Chul-Soo Ahn,Deok-Bog Moon,Ki-Hun Kim,Gil-Chun Park,Young-In Yoon,Yo Han Park,Hui-Dong Cho,권재현,Yong-Kyu Chung,Jin-Uk Choi,Sung Gyu Lee 대한이식학회 2019 Korean Journal of Transplantation Vol.33 No.4
Background: The mammalian target of the rapamycin inhibitor has dual inhibitory effects on cell growth and angiogenesis. This study aimed to analyze the usage of everolimus on actual immunosuppression (IS) regimens through a cross-sectional study in a high-volume liver transplantation (LT) center. Methods: Our institutional LT database was searched for adult patients who underwent primary LT surgery between January 2010 and December 2016. We identified 2,093 LT recipients with observation periods of 1 to 8 years. Results: We divided the 2,093 recipients into three groups according to the posttransplant follow-up period as follows: group A (12–36 months; n=680), group B (37–60 months; n=560), and group C (>60 months; n=853). The individual IS agents were tacrolimus in 1,807 patients (86.3%), cyclosporine in 169 patients (8.1%), mycophenolate mofetil (MMF) in 1,310 patients (62.6%), and everolimus in 115 patients (5.5%). The most common IS regimens were tacrolimus-MMF combination and tacrolimus monotherapy, regardless of the posttransplant period. Patients with pretransplant malignancies were administered everolimus more frequently than those without pretransplant malignancies (P<0.001). In 102 patients with hepatocellular carcinoma recurrence or de novo malignancies, IS regimens included everolimus-tacrolimus in 41 patients (40.2%), tacrolimus-MMF in 27 patients (26.4%), tacrolimus in 20 patients (19.6%), MMF in 10 patients (9.8%), cyclosporine in three patients (2.9%), and cyclosporine-MMF in one patient (1.0%). Conclusions: Administration of everolimus after LT has been gradually increasing with the expansion of indications in our institutional practice. Currently, the role of everolimus is minimal and not comparable to that of tacrolimus, but it has a unique position in the field of IS after LT.
Sang Hun Kim,Ki Tae Jung,Ji Ho Song 조선대학교 의학연구원 2018 The Medical Journal of Chosun University Vol.43 No.1
Extravasation is the accidental injection or leakage of fluid into the subcutaneous or perivascular tissues. Some drugs can cause serious injury such as severe tissue injury, necrosis, and etc. Here we report a case of chemical burn by sodium bicarbonate extravasation due to accidental venous puncture during arterial cannulation. A 42-years-old woman has taken emergency laparotomy surgery due to a stab wound to the abdomen. Massive blood loss has developed, and consequently vital signs were unstable and metabolic acidosis has developed. Sodium bicarbonate has administered via a peripheral intravenous line on the dorsal vein of a right hand that runs to the cephalic vein. However, the cephalic vein that runs by the side of the radial artery has punctured accidentally during the attempt of right radial artery cannulation. Second degree superficial and deep chemical burn by sodium bicarbonate extravasation has developed. Skin lesion about 3 × 4 cm2 with erythema and bullae formation has developed. There were no necrotic changes and the digital sensation was intact. Wet dressing and silicon foam dressing were prescribed. After two weeks, she was discharged. Until then, dermis exposure about 1 × 1 cm2 remained although the skin lesions became getting well.
Sung-Hee Kim,홍석윤,Jee-Hun Song,Won-Ho Joo 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.4
Noise from construction equipment affects not only surrounding residents, but also the operators of the machines. Noise that affects drivers must be evaluated during the preliminary design stage. This paper suggests an interior noise analysis procedure for construction equipment cabins. The analysis procedure, which can be used in the preliminary design stage, was investigated for airborne and structureborne noise. The total interior noise of a cabin was predicted from the airborne noise analysis and structure-borne noise analysis. The analysis procedure consists of four steps: modeling, vibration analysis, acoustic analysis and total interior noise analysis. A mesh model of a cabin for numerical analysis was made at the modeling step. At the vibration analysis step, the mesh model was verified and modal analysis and frequency response analysis are performed. At the acoustic analysis step, the vibration results from the vibration analysis step were used as initial values for radiated noise analysis and noise reduction analysis. Finally, the total cabin interior noise was predicted using the acoustic results from the acoustic analysis step. Each step was applied to a cabin of a middle-sized excavator and verified by comparison with measured data. The cabin interior noise of a middle-sized wheel loader and a large-sized forklift were predicted using the analysis procedure of the four steps and were compared with measured data. The interior noise analysis procedure of construction equipment cabins is expected to be used during the preliminary design stage.
Analysis of Several Digital Network Technologies for Hard Real-time Communications in Nuclear Plant
Song, Ki-Sang,No, Hee-Cheon,Kim, Dong-Hun,Koo, In-Soo Korean Nuclear Society 1999 Nuclear Engineering and Technology Vol.31 No.2
Applying digital network technology for advanced nuclear plant requires deterministic communication for tight safety requirements, timely and reliable data delivery for operation-critical and mission-critical characteristics of nuclear plant. Communication protocols, such as IEEE 802/4 Token Bus, IEEE 802/5 Token Ring, FDDI, and ARCnet, which have deterministic communication capability are partially applied to several nuclear power plants. Although digital communication technologies have many advantages, it is necessary to consider the noise immunity from electromagnetic interference (EMI), electrical interference, impulse noise, and heat noise before selecting specific digital network technology for nuclear plant. In this paper, we consider the token frame loss and data frame loss rate due to the link error event, frame size, and link data rate in different protocols, and evaluate the possibility of failure to meet the hard real-time requirement in nuclear plant.
Sang-Yeon Lee,Kye-Hwan Lee,Keun-Chul Lee,Keun-Chul Lee,Buem-hun Song,Chul-Won Lee 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10
Rice as a typical silicified plants needs the intemal absorption of silica, especially during the growing period. The leaves and culm of plant are erected up by uptake of silicic acid. Sun light could reach the bottom leaves in the plant communities. In addition, the nitrogen uptake would be physiologically controlled by the application of silica and the quality of rice could be improved by reducing the quantity of protein in grian. In the field experiment designed, the rice cultivar was DonhjinⅠho, Daeanbyeo and transplanting day was May 25, 2007. N levels per ha were 100 and 200kg, respectively and liquid silica(ai 11%, manufactureed by Dongbuhiteck Co.) was sprayed on flag leaves according to 500fold and 1000fold with distilled water and 3 times at an interval of 1week from 30 days before heading. The rice culms treated with each liquid silica levels were shortened and panicle length were increase as compare with the control in the level of each N. The lodging was reduced in the plot that treated with the higher liquid silica application of 100kg as compared with 200kg plot in the filed. The rice yields of the plots treated with silica application were more increased than in the control plot. All yield components, except of panicle number in DongjinⅠ, increased as compare with 200kg plot in the filed. Changes measured by 2-DE in display expression of flag leaves and seed in relation to nitrogen treatment level and silica trements were similar in fashion, yet still displayed distinguishable differences in display strength spots.
Gene Expression of Heme Oxygenase-1 and Nitric Oxide Synthase on Trophoblast of Preeclampsia
( Song Kwon Choi ),( Jong Yun Hwang ),( Ji Yeon Lee ),( Sung Hun Na ),( Joong Gyu Ha ),( Hyang Ah Lee ),( Dong Hun Lee ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.7
The aim of this study was to evaluate the gene expression of heme oxygenase-1 (HO-1), inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) in placenta of preeclampsia. Methods Placenta were obtained from women with normal pregnancies (n=15) and severe preeclamptic (n=15) after informed consent and under the approval of IRB of Kangwon National University Hospital. The severe preeclampsia was diagnosed as high blood pressure and proteinuria. High blood pressure was defined as systolic blood pressure of >160 mm Hg or diastolic pressure of >110 mm Hg and proteinuria was defined as urine protein of >2 g/24 hr. We investigated mRNA expression of HO-1, iNOS and eNOS in both groups by real time polymerase chain reaction and immunohistochemistry. The Student`s t-test was used for statistical analysis with SPSS ver. 12.0. P<0.05 was considered to be statistically significant. Results There were no significant differences in maternal age ( P=1.181) and gestational age ( P=0.30) between the two groups. Fetal birth weight from women with preeclampsia was significantly lower than that from normal pregnant women ( P=0.002). We detected differences in mRNA expression of placenta between both groups. Expression of HO-1 was decreased in placenta of preelamptic pregnancies compared to that from normal. However, expression of iNOS and eNOS was higher in preeclamptic group compared to normal. Conclusion We suggest that preeclampsia is associated with a decreased expression of HO-1 and increased expressions of iNOS and eNOS in placenta.
Song, Hyun Seok,Jin, Hye Jun,Ahn, Sae Ryun,Kim, Daesan,Lee, Sang Hun,Kim, Un-Kyung,Simons, Christopher T.,Hong, Seunghun,Park, Tai Hyun American Chemical Society 2014 ACS NANO Vol.8 No.10
<P>The sense of taste helps humans to obtain information and form a picture of the world by recognizing chemicals in their environments. Over the past decade, large advances have been made in understanding the mechanisms of taste detection and mimicking its capability using artificial sensor devices. However, the detection capability of previous artificial taste sensors has been far inferior to that of animal tongues, in terms of its sensitivity and selectivity. Herein, we developed a bioelectronic tongue using heterodimeric human sweet taste receptors for the detection and discrimination of sweeteners with human-like performance, where single-walled carbon nanotube field-effect transistors were functionalized with nanovesicles containing human sweet taste receptors and used to detect the binding of sweeteners to the taste receptors. The receptors are heterodimeric G-protein-coupled receptors (GPCRs) composed of human taste receptor type 1 member 2 (hTAS1R2) and human taste receptor type 1 member 3 (hTAS1R3), which have multiple binding sites and allow a human tongue-like broad selectivity for the detection of sweeteners. This nanovesicle-based bioelectronic tongue can be a powerful tool for the detection of sweeteners as an alternative to labor-intensive and time-consuming cell-based assays and the sensory evaluation panels used in the food and beverage industry. Furthermore, this study also allows the artificial sensor to exam the functional activity of dimeric GPCRs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-10/nn502926x/production/images/medium/nn-2014-02926x_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn502926x'>ACS Electronic Supporting Info</A></P>