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유승열(Yu Seung Yeol),정지훈(Jeong Ji Hoon),백동현(Baek Dong Hyun),김동산(Kim Dong san),윤완철(Yoon Wan Chul) 한국철도학회 2009 한국철도학회 학술발표대회논문집 Vol.2009 No.11월
The purpose of this study is to develop a framework for Simulator Training based on Human Error Analysis. The goal of training is to reduce the damage of railroad accident and incidents by improving the capacity of trainee's error management in normal situation and error-producing condition. The framework process is composed of five phase(set the training objective, set the training scenario, briefing, execution, de-briefing). Also, the training provides training manual for Instructor and trainee.
Smart Nanocarrier Based on PEGylated Hyaluronic Acid for Cancer Therapy
Choi, Ki Young,Yoon, Hong Yeol,Kim, Jong-Ho,Bae, Sang Mun,Park, Rang-Woon,Kang, Young Mo,Kim, In-San,Kwon, Ick Chan,Choi, Kuiwon,Jeong, Seo Young,Kim, Kwangmeyung,Park, Jae Hyung American Chemical Society 2011 ACS NANO Vol.5 No.11
<P>Tumor targetability and site-specific drug release of therapeutic nanoparticles are key factors for effective cancer therapy. In this study, poly(ethylene glycol) (PEG)-conjugated hyaluronic acid nanoparticles (P-HA-NPs) were investigated as carriers for anticancer drugs including doxorubicin and camptothecin (CPT). P-HA-NPs were internalized into cancer cells (SCC7 and MDA-MB-231) <I>via</I> receptor-mediated endocytosis, but were rarely taken up by normal fibroblasts (NIH-3T3). During <I>in vitro</I> drug release tests, P-HA-NPs rapidly released drugs when incubated with cancer cells, extracts of tumor tissues, or the enzyme Hyal-1, which is abundant in the intracellular compartments of cancer cells. CPT-loaded P-HA-NPs (CPT-P-HA-NPs) showed dose-dependent cytotoxicity to cancer cells (MDA-MB-231, SCC7, and HCT 116) and significantly lower cytotoxicity against normal fibroblasts (NIH-3T3) than free CPT. Unexpectedly, high concentrations of CPT-P-HA-NPs demonstrated greater cytotoxicity to cancer cells than free CPT. An <I>in vivo</I> biodistribution study indicated that P-HA-NPs selectively accumulated into tumor sites after systemic administration into tumor-bearing mice, primarily due to prolonged circulation in the blood and binding to a receptor (CD44) that was overexpressed on the cancer cells. In addition, when CPT-P-HA-NPs were systemically administrated into tumor-bearing mice, we saw no significant increases in tumor size for at least 35 days, implying high antitumor activity. Overall, P-HA-NPs showed promising potential as a drug carrier for cancer therapy.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2011/ancac3.2011.5.issue-11/nn202070n/production/images/medium/nn-2011-02070n_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn202070n'>ACS Electronic Supporting Info</A></P>
시뮬레이터 기반 인적오류 저감훈련(SBET)의 프레임워크 설계
정지훈(Ji Hoon Jeong),김동산(Dong San Kim),유승열(Seung Yeol Yu),백동현(Dong Hyun Baek),윤완철(Wan Chul Yoon) 대한인간공학회 2009 대한인간공학회 학술대회논문집 Vol.2009 No.5
본 논문은 철도 기관사의 인적오류 발생 및 그 피해를 저감하기 위한 시뮬레이터 훈련의 프레임워크를 제시한다. 이 프레임워크는 시뮬레이터 기반 인적오류 저감훈련의 목적, 훈련의 단계를 포함한다. 또한, 운전 중인 기관사의 인적오류를 유발할 수 있는 주요한 조건들을 체계적으로 정리하고 이들을 시뮬레이터 훈련에 도입할 수 있는 방법을 제시한다.
Liver‐Specific and Echogenic Hyaluronic Acid Nanoparticles Facilitating Liver Cancer Discrimination
Min, Hyun Su,Son, Sejin,Lee, Tae Woong,Koo, Heebeom,Yoon, Hong Yeol,Na, Jin Hee,Choi, Yongseok,Park, Jae Hyung,Lee, Jaeyoung,Han, Moon Hee,Park, Rang‐,Woon,Kim, In‐,San,Jeong, Seo Young,Rh WILEY‐VCH Verlag 2013 Advanced Functional Materials Vol.23 No.44
<P><B>Abstract</B></P><P>With the increasing demand for instant real‐time ultrasound (US) imaging of a specific organ, target‐specific and long‐circulating ultrasound contrast agents are of special interest. A new species of echogenic hyaluronic acid nanoparticles is presented as an ultralong‐acting, liver‐specific, US contrast agent that is distinct from conventional gas‐filled microbubbles. Using an oil‐in‐water (O/W) emulsification method, bioinert and hydrophobic perfluoropentane (PFP) is encapsulated as an ultrasound gas precursor into hyaluronic acid nanoparticles (HANPs) using hydrophobic interactions. HANPs are formulated by self‐assembly, with amphiphilic hyaluronic acid‐5β‐cholanic acid (HA‐CA) conjugating in aqueous conditions. The resulting echogenic PFP‐encapsulated HANPs (Echo‐NPs) show solid nanostructures, differentiated from core‐empty conventional microbubbles, and exhibiting outstanding physical properties as an ultrasound contrast agent. They are more stable and robust echogenic solid bodies with an in vivo favorable hydrodynamic size and because PFPs vaporize gradually, their expansion process is very slow in body conditions. After several systemic circulations, echo‐NPs generated intense and ultralong echo signals for US imaging at the target site. The echogenic properties of Echo‐NPs show a significantly increased half‐life and echo persistence, compared with conventional microbubbles. The results clearly show that echo‐NPs outperform conventional microbubbles in terms of both physical and echogenic in vitro and in vivo properties.</P>