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Antiinflammatory Evaluation of Leucas lavandulaefolia Rees. Extract
Saha, Kakali,Mukherjee, Pulok K.,Das, J.,Mandal, Subhash C.,Saha, B.P.,Pal, M. The Korean Society of Pharmacognosy 1996 Natural Product Sciences Vol.2 No.2
The antiinflammatory activity of the methanol extract of Leucas lavandulaefolia Rees was evaluated on different experimental models of inflammation in rats. The extract has been found to possess significant, inhibitory activity against carrageenin, histamine, serotonin, and dextran induced hind paw oedema in rats. The effect produced by extract was comparable to that of phenylbutazone and a prototype, nonsteroidal antiinflammatory agent.
Saha, Leton C.,Mian, Shabeer A.,Kim, Hyo-Jeong,Saha, Joyanta K.,Matin, Mohammad A.,Jang, Joon-Kyung Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.2
We investigated how temperature influences the structural and energetic dynamics of carbon nanotubes (CNTs) undergoing a high-speed impact with a Si (110) surface. By performing molecular dynamics simulations in the temperature range of 100 - 300 K, we found that a low temperature CNT ends up with a higher vibrational energy after collision than a high temperature CNT. The vibrational temperature of CNT increases by increasing the surface temperature. Overall, the structural and energy relaxation of low temperature CNTs are faster than those of high temperature CNTs.
Saha, P.K.,Chowdhury, S.D.,Das, S.C.,Saha, S.K. Asian Australasian Association of Animal Productio 1999 Animal Bioscience Vol.12 No.5
Two Bangladeshi varieties of yellow corn-'Barnali' and 'Khaibhutta' were chemically analysed and used in the diet of laying chicken to determine their replacement value for wheat. Both the new varieties of yellow corn were found to be good sources of energy and the CP contents were comparable to wheat. Forty two, 29-week old randomly selected Starcross Brown commercial pullets were assigned to 7 dietary treatments with 6 replicates, each being an experimental unit. Diets were formulated replacing wheat quantitatively by two varieties of yellow corn either 0, 50, 75 or 100 per cent from a wheat based control diet. The production performance of laying hens fed diets formulated with Barnali or Khaibhutta at different dietary levels during an experimental period of 16 weeks was satisfactory and comparable to wheat based diet. Except egg yolk colour, the other internal arid external egg quality characteristics at 8th and 16th weeks of the experiment did not differ significantly. The egg yolk colour improved significantly (p<0.01) by feeding both the new varieties of corn and the degree of pigmentation of yolk increased as the dietary levels of corn increased at the expense of wheat. Considering laying performance, the new varieties of yellow corn, Barnali or Khaibhutta can be used in layer diet as replacement of wheat. Such a replacement would better that wheat-based diet in terms of egg yolk pigmentation.
Nabaneeta Saha,Goutam K. Saha,Gautam Aditya 한국응용곤충학회 2009 Journal of Asia-Pacific Entomology Vol.12 No.4
The effects of alternative prey and structural complexity of habitat on the selection of mosquito larvae by aquatic insect predators were evaluated in the laboratory. The water bugs Anisops bouvieri, Diplonychus (=Sphaerodema) rusticus, and D. annulatus, and the odonate nymphs, Ceriagrion coromandelianum and Brachydiplax chalybea chalybea, selected mosquito larvae based on their abundance relative to chironomid larvae and on the levels of habitat complexity. The effect of one prey species on the other was asymmetrical, as indicated through prey selectivity values. Compared to open habitat, the presence of macrophytes reduced the vulnerability of mosquito larvae while the effect was reverse in the presence of sediments. When both sediment and macrophytes were present in habitats, all the predators except D. annulatus consumed more mosquito larvae than chironomid larvae. The clearance rate, an indicator of predatory efficiency, varied among the predator species and habitat types. The results suggest that the outcome of the interactions between insect predators and mosquito immatures was context-dependent and that it was mediated by the presence of alternative controphic species and the habitat complexity. The effects of alternative prey and structural complexity of habitat on the selection of mosquito larvae by aquatic insect predators were evaluated in the laboratory. The water bugs Anisops bouvieri, Diplonychus (=Sphaerodema) rusticus, and D. annulatus, and the odonate nymphs, Ceriagrion coromandelianum and Brachydiplax chalybea chalybea, selected mosquito larvae based on their abundance relative to chironomid larvae and on the levels of habitat complexity. The effect of one prey species on the other was asymmetrical, as indicated through prey selectivity values. Compared to open habitat, the presence of macrophytes reduced the vulnerability of mosquito larvae while the effect was reverse in the presence of sediments. When both sediment and macrophytes were present in habitats, all the predators except D. annulatus consumed more mosquito larvae than chironomid larvae. The clearance rate, an indicator of predatory efficiency, varied among the predator species and habitat types. The results suggest that the outcome of the interactions between insect predators and mosquito immatures was context-dependent and that it was mediated by the presence of alternative controphic species and the habitat complexity.
Leton C. Saha,Shabeer A. Mian,김효정,Mohammad A. Matin,Joyanta K. Saha,장준경 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.2
We investigated how temperature influences the structural and energetic dynamics of carbon nanotubes (CNTs) undergoing a high-speed impact with a Si (110) surface. By performing molecular dynamics simulations in the temperature range of 100 - 300 K, we found that a low temperature CNT ends up with a higher vibrational energy after collision than a high temperature CNT. The vibrational temperature of CNT increases by increasing the surface temperature. Overall, the structural and energy relaxation of low temperature CNTs are faster than those of high temperature CNTs.
Prognostic role of EGR1 in breast cancer: a systematic review
( Subbroto Kumar Saha ),( S. M. Riazul Islam ),( Tripti Saha ),( Afsana Nishat ),( Polash Kumar Biswas ),( Minchan Gil ),( Lewis Nkenyereye ),( Shaker El-sappagh ),( Saiful Islam ),( Ssang-goo Cho ) 생화학분자생물학회 2021 BMB Reports Vol.54 No.10
EGR1 (early growth response 1) is dysregulated in many cancers and exhibits both tumor suppressor and promoter activities, making it an appealing target for cancer therapy. Here, we used a systematic multi-omics analysis to review the expression of EGR1 and its role in regulating clinical outcomes in breast cancer (BC). EGR1 expression, its promoter methylation, and protein expression pattern were assessed using various publicly available tools. COSMIC-based somatic mutations and cBioPortal-based copy number alterations were analyzed, and the prognostic roles of EGR1 in BC were determined using Prognoscan and Kaplan-Meier Plotter. We also used bc-GenEx-Miner to investigate the EGR1 co-expression profile. EGR1 was more often downregulated in BC tissues than in normal breast tissue, and its knockdown was positively correlated with poor survival. Low EGR1 expression levels were also associated with increased risk of ER+, PR+, and HER2- BCs. High positive correlations were observed among EGR1, DUSP1, FOS, FOSB, CYR61, and JUN mRNA expression in BC tissue. This systematic review suggested that EGR1 expression may serve as a prognostic marker for BC patients and that clinicopathological parameters influence its prognostic utility. In addition to EGR1, DUSP1, FOS, FOSB, CYR61, and JUN can jointly be considered prognostic indicators for BC. [BMB Reports 2021; 54(10): 497-504]
Ghosh, Sumanta K.,Saha, Rumpa,Ghosh, Aniruddha,Basu, Ankita,Mukherjee, Kakali,Saha, Indrajit,Saha, Bidyut Korean Chemical Society 2012 대한화학회지 Vol.56 No.6
Under pseudo-first order conditions, the monomeric species of Cr(VI) was found to be kinetically active in the absence of phenanthroline (phen) whereas in the phen-promoted path, the Cr(VI)-phen complex undergoes a nucleophilic attack by etane-1,2-diol to form a ternary complex which subsequently experience a redox decomposition leading to hydroxy ethanal and Cr(III)-phen complex. The effect of the cationic surfactant (CPC), anionic surfactant (SDS) and neutral surfactant (TX-100) on the unpromoted and phen-promoted path have been studied. Micellar effects have been explained by considering the preferential partitioning of reactants between the micellar and aqueous phase. Combination of TX-100 and phenanthroline will be the ideal for chromic acid oxidation of ethane-1,2-diol in aqueous media.
Σ-nucleus potential studied with the(π−,K+)reaction on medium-to-heavy nuclear targets
Saha, P. K.,Noumi, H.,Abe, D.,Ajimura, S.,Aoki, K.,Bhang, H. C.,Dobashi, K.,Endo, T.,Fujii, Y.,Fukuda, T.,Guo, H. C.,Hashimoto, O.,Hotchi, H.,Imai, K.,Kim, E. H.,Kim, J. H.,Kishimoto, T.,Krutenkova, A American Physical Society 2004 PHYSICAL REVIEW C - Vol.70 No.4
Saha, S K,Choi, H Y,Kim, B W,Dayem, A A,Yang, G-M,Kim, K S,Yin, Y F,Cho, S-G Macmillan Publishers Limited 2017 Oncogene Vol.36 No.3
<P>Studies have reported that interactions between keratins (KRTs) and other proteins initiate signaling cascades that regulate cell migration, invasion, and metastasis. In the current study, we found that expression of KRT19 was specifically high in breast cancers and significantly correlated with their invasiveness. Moreover, knockdown of KRT19 led to increased proliferation, migration, invasion, drug resistance, and sphere formation in breast cancer cells via an upregulated NOTCH signaling pathway. This was owing to reduced expression of NUMB, an inhibitory protein of the NOTCH signaling pathway. In addition, we found that KRT19 interacts with beta-catenin/RAC1 complex and enhances the nuclear translocation of beta-catenin. Concordantly, knockdown of KRT19 suppressed the nuclear translocation of beta-catenin as well as beta-catenin-mediated NUMB expression. Furthermore, modulation of KRT19mediated regulation of NUMB and NOTCH1 expression led to the repression of the cancer stem cell properties of breast cancer patient-derived CD133(high)/CXCR4(high)/ALDH1(high) cancer stem-like cells (CSLCs), which showed very low KRT19 and high NOTCH1 expression. Taken together, our study suggests a novel function for KRT19 in the regulation of nuclear import of the beta-catenin/RAC1 complex, thus modulating the NUMB-dependent NOTCH signaling pathway in breast cancers and CSLCs, which might bear potential clinical implications for cancer or CSLC treatment.</P>
Dual channel closed-loop supply chain coordination with a reward-driven remanufacturing policy
Saha, S.,Sarmah, S.P.,Moon, Ilkyeong Institution of Production Engineers 2016 International journal of production research Vol.54 No.5
<P>This paper investigates a reward-driven policy, employed in a closed-loop supply chain (CLSC), for acquiring used products earmarked for remanufacture. Under the examined model, a single manufacturer sells products through a retailer as well as directly to end users in a forward supply chain. In the reverse supply chain, three different modes of collection are employed to capture used products for remanufacture: they are through a third party, directly by the manufacturer and from the retailer. Mathematical models for both non-cooperative and centralised scenarios are developed to characterise the pricing decisions and remanufacturing strategies that indicate individual and overall supply chain performance. Optimality of all the proposed models is examined with theory. To coordinate and achieve a win-win outcome for channel members, we proposed a three-way discount mechanism for the manufacturer. Extended numerical investigation provides insights on ways to manage an efficient reward-driven CLSC in a dual-channel environment.</P>