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Heng, D. Y. C.,Choueiri, T. K.,Rini, B. I.,Lee, J.,Yuasa, T.,Pal, S. K.,Srinivas, S.,Bjarnason, G. A.,Knox, J. J.,MacKenzie, M.,Vaishampayan, U. N.,Tan, M. H.,Rha, S. Y.,Donskov, F.,Agarwal, N.,Kollma Oxford University Press 2014 ANNALS OF ONCOLOGY Vol.25 No.1
<P>This study focuses on the outcomes of a large international cohort of patients with metastatic RCC who would not have met the eligibility criteria for clinical trials and compares these to those that would have eligible. The proportion of patients who would have been ineligible and the reason for ineligibility are also discussed.</P>
First-, second-, third-line therapy for mRCC: benchmarks for trial design from the IMDC
Ko, J J,Choueiri, T K,Rini, B I,Lee, J-L,Kroeger, N,Srinivas, S,Harshman, L C,Knox, J J,Bjarnason, G A,MacKenzie, M J,Wood, L,Vaishampayan, U N,Agarwal, N,Pal, S K,Tan, M-H,Rha, S Y,Yuasa, T,Donskov, Nature Publishing Group 2014 The British journal of cancer Vol.110 No.8
<P><B>Background:</B></P><P>Limited data exist on outcomes for metastatic renal cell carcinoma (mRCC) patients treated with multiple lines of therapy. Benchmarks for survival are required for patient counselling and clinical trial design.</P><P><B>Methods:</B></P><P>Outcomes of mRCC patients from the International mRCC Database Consortium database treated with 1, 2, or 3+ lines of targeted therapy (TT) were compared by proportional hazards regression. Overall survival (OS) and progression-free survival (PFS) were calculated using different population inclusion criteria.</P><P><B>Results:</B></P><P>In total, 2705 patients were treated with TT of which 57% received only first-line TT, 27% received two lines of TT, and 16% received 3+ lines of TT. Overall survival of patients who received 1, 2, or 3+ lines of TT were 14.9, 21.0, and 39.2 months, respectively, from first-line TT (<I>P</I><0.0001). On multivariable analysis, 2 lines and 3+ lines of therapy were each associated with better OS (HR=0.738 and 0.626, <I>P</I><0.0001). Survival outcomes for the subgroups were as follows: for all patients, OS 20.9 months and PFS 7.2 months; for those similar to eligible patients in the first-line ADAPT trial, OS 14.7 months and PFS 5.6 months; for those similar to patients in first-line TIVO-1 trial, OS 24.8 months and PFS 8.2 months; for those similar to patients in second-line INTORSECT trial, OS 13.0 months and PFS 3.9 months; and for those similar to patients in the third-line GOLD trial, OS 18.0 months and PFS 4.4 months.</P><P><B>Conclusions:</B></P><P>Patients who are able to receive more lines of TT live longer. Survival benchmarks provide context and perspective when interpreting and designing clinical trials.</P>
Good Scalability of Study of Spin Torque Transfer MRAMs with Perpendicular Magnetization MTJs
H. Yoda,T. Kishi,T. Nagase,M. Yoshikawa,E. Kitagawa,T. Daibou,K. Nishiyama,T. Kai,N. Shimomura,M. Nakayama,M. Amano,H. Aikawa,S. Takahashi,S. Ikegawa,M. Nagamine,J. Ozeki,S. Yuasa,Y. Nakatani,M. Oogan 한국자기학회 2008 한국자기학회 학술연구발표회 논문개요집 Vol.- No.-
You, C.Y.,Yoon, J.,Park, S.Y.,Yuasa, S.,Jung, M.H. Elsevier 2011 Current Applied Physics Vol.11 No.2
We investigate magnetic thermal noise spectra in magnetic tunneling junction with spin transfer torque. The basic structure of the examined magnetic tunneling junction is PtMn/F<SUB>3</SUB>/Ru/F<SUB>2</SUB>/MgO/F<SUB>1</SUB>, where F<SUB>1,2,3</SUB> are ferromagnetic layers. F<SUB>1</SUB> acts as a soft free layer, while PtMn/F<SUB>3</SUB>/Ru/F<SUB>2</SUB>, an exchange biased synthetic ferrimagnet structure, serves as a fixed reference layer. With the assumption of rigid fixed reference layer, the magnetic thermal noise is only related with the thermal motion of the free layer spins. However, we find additional resonance peaks in the magnetic noise spectra, which correspond to the thermal motion of the reference layer spins. Furthermore, the magnetic noise spectra show intricate field dependences, which are related with the spin dynamics of the reference layer induced by spin transfer torque.
MgO Overlayer Thickness Dependence of Perpendicular Magnetic Anisotropy in CoFeB Thin Films
D. D. Lam,F. Bonell,S. Miwa,Y. Shiota,K. Yakushiji,H. Kubota,T. Nozaki,A. Fukushima,S. Yuasa,Y. Suzuki 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.10
The dependence of the magnetization and perpendicular magnetic anisotropy (PMA) of Ta/CoFeB/MgO/Ta on the thicknesses of the CoFeB layer and the MgO overlayer was investigated by vibrating sample magnetometer. The magnetization is found to be small for samples with a thin MgO overlayer. The PMA strongly depends on the MgO overlayer (hereafter, MgO) thickness and its maximum value of 1.74 erg/cm2 is achieved for a 1.0 nm thick MgO overlayer with annealing at 300 ◦C. The volume anisotropy of the CoFeB layer is found to be independent of the MgO thickness,which suggest that only the interface anisotropy depends on the MgO thickness. The possible mechanisms that may influence the interface magnetization and anisotropy are discussed herein.
D. D. Lam,F. Bonell,S. Miwa,Y. Shiota,K. Yakushiji,H. Kubota,T. Nozaki,A. Fukushima,S. Yuasa,Y. Suzuki 한국자기학회 2013 Journal of Magnetics Vol.18 No.1
The perpendicular magnetic anisotropy of sputtered CoFeB thin films covered by MgO was investigated by vibrating sample magnetometry. Three different CoxFe80-xB₂? alloys were studied. Under out-of plane magnetic field, the saturation field was found to increase with increasing the Co content. The magnetization and interface anisotropy energy were obtained for all samples. Both showed a marked dependence on the MgO overlayer thickness. In addition, their variations were found to be non-monotonous as a function of the Co concentration.