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RISS 인기검색어
- 검색키워드
- 저자 : S. Manju (검색결과 12 건)
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Function space formulation of the 3-noded distorted Timoshenko metric beam element
S. Manju,Somenath Mukherjee 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.69 No.6
The 3-noded metric Timoshenko beam element with an offset of the internal node from the element centre is used here to demonstrate the best-fit paradigm using function space formulation under locking and mesh distortion. The best-fit paradigm follows from the projection theorem describing finite element analysis which shows that the stresses computed by the displacement finite element procedure are the best approximation of the true stresses at an element level as well as global level. In this paper, closed form best-fit solutions are arrived for the 3-noded Timoshenko beam element through function space formulation by combining field consistency requirements and distortion effects for the element modelled in metric Cartesian coordinates. It is demonstrated through projection theorems how lock-free best-fit solutions are arrived even under mesh distortion by using a consistent definition for the shear strain field. It is shown how the field consistency enforced finite element solution differ from the best-fit solution by an extraneous response resulting from an additional spurious force vector. However, it can be observed that when the extraneous forces vanish fortuitously, the field consistent solution coincides with the best-fit strain solution.
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Strain induced structural transformation, mechanical and phonon stability in silicene derived 2D-SiB
Manju M.S.,Siby Thomas,Anees P.,Sang Uck Lee,Ajith K. M. 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.90 No.-
Two-dimensional monolayer SiB is a silicene derivative exhibiting buckling of atoms similar to that seenin silicene. This manuscript presents a systematic study of the strain-dependent variation of thestructural, mechanical, and dynamical properties of SiB. Strain was applied in the uniaxial armchair,uniaxial zigzag, and biaxial directions within the range of0.2 to 0.3. The resultant strain energy plotindicates anisotropic behavior of SiB in these directions. The SiB showed a mechanical strength that washigher than its counterpart, silicene, by an order of 30%. The elastic constant data from the undeformedSiB indicated an anisotropic nature, which was also seen with all the strain directions. Charge densitycontours, along with Bader charge analysis, confirmed the ionic nature of SiB in its original form. Thisnature became covalent as the strain varied from the compressive to the tensile regime in the uniaxialzigzag and biaxial directions. The majorfinding described in this manuscript is a newflat conformationhaving orthorhombic symmetry in contrast to the buckled structure. In addition, this material wasobserved to attain stability with the application of uniaxial tensile armchair and zigzag directionalstrains. Ab-initio molecular dynamics simulation confirmed the thermal stability of SiB in its newconformation.
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Manju Pandey,Prabhash Mishra,Debdulal Saha,K. Sengupta,S. S. Islam 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.2
Porous alumina thin film has been investigated in order to find its sensitivity in the trace moisture level. Alumina, with two different phases were obtained using sol-gel process and fired between 400°C to 1000°C. FESEM, BET, AFM and XRD techniques were employed for microstructural characterization of the sintered thin film in two phases. A detailed analysis is done to assess the superiority of gamma (γ) - over alpha (α) phase using impedance spectroscopy. It was observed that gamma phase is more sensitive towards trace level moisture sensing.
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Karthi, N.,Karthiga, A.,Kalaiyarasu, T.,Stalin, A.,Manju, V.,Singh, S.K.,Cyril, R.,Lee, S.M. Pergamon 2017 Computational biology and chemistry Vol.70 No.-
<P>Pelargonidin is an anthocyanidin isolated from plant resources. It shows strong cytotoxicity toward various cancer cell lines, even though the carcinogenesis-modulating pathway of pelargonidin is not yet known. One of our previous reports showed that pelargonidin arrests the cell cycle and induces apoptosis in HT29 cells. Flowcytometry and immunoblot analysis confirmed that pelargonidin specifically inhibits the activation of CDK1 and blocks the G2-M transition of the cell cycle. In addition, DNA fragmentation was observed along with induction of cytochrome c release-mediated apoptosis. Hence, the aim of the present study was to investigate the molecular mechanism of pelargonidin's action on cell cycle regulators CDK1, CDK4, and CDK6 as well as the substrate-binding domain of DNMT1 and DNMT3A, which regulate the epigenetic signals related to DNA methylation. The results of docking analysis, binding free energy calculation, and molecular dynamics simulation correlated with the experimental results, and pelargonidin showed a specific interaction with CDK1. In this context, pelargonidin may also inhibit the recognition of DNA and catalytic binding by DNMT1 and DNMT3A. The HOMO-LUMO analysis mapped the functional groups of pelargonidin. Prediction of pharmacological descriptors suggested that pelargonidin can serve as a multitarget inhibitor for cancer treatment. (C) 2017 Elsevier Ltd. All rights reserved.</P>
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The unsymmetric finite element formulation and variational incorrectness
G. Prathap,S. Manju,V. Senthilkumar 국제구조공학회 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.26 No.1
The unsymmetric finite element formulation has been proposed recently to improve predictions from distorted finite elements. Studies have also shown that this special formulation using parametric functions for the test functions and metric functions for the trial functions works surprisingly well because the former satisfy the continuity conditions while the latter ensure that the stress representation during finite element computation can retrieve in a best-fit manner, the actual variation of stress in the metric space. However, a question that remained was whether the unsymmetric formulation was variationally correct. Here we determine that it is not, using the simplest possible element to amplify the principles.
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Mukherjee, Somenath,Manju, S. Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.38 No.3
A new method of formulation of a class of elements that are immune to mesh distortion effects is proposed here. The simple three-noded bar element with an offset of the internal node from the element center is employed here to demonstrate the method and the principles on which it is founded upon. Using the function space approach, the modified formulation is shown here to be superior to the conventional isoparametric version of the element since it satisfies the completeness requirement as the metric formulation, and yet it is in agreement with the best-fit paradigm in both the metric and the parametric domains. Furthermore, the element error is limited to only those that are permissible by the classical projection theorem of strains and stresses. Unlike its conventional counterpart, the modified element is thus not prone to any errors from mesh distortion. The element formulation is symmetric and thus satisfies the requirement of the conservative nature of problems associated with all self-adjoint differential operators. The present paper indicates that a proper mapping set for distortion immune elements constitutes geometric and displacement interpolations through parametric and metric shape functions respectively, with the metric components in the displacement/strain replaced by the equivalent geometric interpolation in parametric co-ordinates.
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Somenath Mukherjee,S. Manju 국제구조공학회 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.38 No.3
A new method of formulation of a class of elements that are immune to mesh distortion effects is proposed here. The simple three-noded bar element with an offset of the internal node from the element center is employed here to demonstrate the method and the principles on which it is founded upon. Using the function space approach, the modified formulation is shown here to be superior to the conventional isoparametric version of the element since it satisfies the completeness requirement as the metric formulation, and yet it is in agreement with the best-fit paradigm in both the metric and the parametric domains. Furthermore, the element error is limited to only those that are permissible by the classical projection theorem of strains and stresses. Unlike its conventional counterpart, the modified element is thus not prone to any errors from mesh distortion. The element formulation is symmetric and thus satisfies the requirement of the conservative nature of problems associated with all self-adjoint differential operators. The present paper indicates that a proper mapping set for distortion immune elements constitutes geometric and displacement interpolations through parametric and metric shape functions respectively, with the metric components in the displacement/strain replaced by the equivalent geometric interpolation in parametric co-ordinates.
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The unsymmetric finite element formulation and variational incorrectness
Prathap, G.,Manju, S.,Senthilkumar, V. Techno-Press 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.26 No.1
The unsymmetric finite element formulation has been proposed recently to improve predictions from distorted finite elements. Studies have also shown that this special formulation using parametric functions for the test functions and metric functions for the trial functions works surprisingly well because the former satisfy the continuity conditions while the latter ensure that the stress representation during finite element computation can retrieve in a best-fit manner, the actual variation of stress in the metric space. However, a question that remained was whether the unsymmetric formulation was variationally correct. Here we determine that it is not, using the simplest possible element to amplify the principles.
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Gayathri Rajamanickam,S. L. Manju 한국고분자학회 2023 Macromolecular Research Vol.31 No.1
Niruriflavone (NF) a natural flavonoid isolated from Phyllanthus niruri Linn through bio-guided isolation, demonstrated significant neuroprotective efficacy by inhibiting oxidative stress, acetylcholinesterase, and 5-lipoxygenase which were beneficial for the treatment of Alzheimer’s disease (AD). It was further confirmed by in-vivo studies. Natural product usage in AD therapy has a lot of limitations. Nanotechnology addresses the challenges in natural product drug delivery for AD. Hence, the goal of this study was to develop an oral delivery system for the controlled release of niruriflavone. Also, the neuroprotective and antioxidant properties of niruriflavone-loaded chitosan nanoparticles (NFLC) were evaluated in aluminium chloride-induced AD rats. NFLC was prepared by the ionic gelation method and characterized by particle size, zeta potential, morphology, encapsulation efficacy, in vitro drug release kinetics, and stability. The particle size of synthesized NFLC was 192.3 nm with a zeta potential of + 20.7 mV and a polydispersity index of 0.509. The microcrystalline aggregate of nanoparticles and the rough surface was revealed by transmission and scanning electron microscopies. The cytotoxicity study of NFLC is conducted in neuroblastoma cell line SH-SY5Y which was evaluated by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. NFLC was discovered to be biocompatible and cell viability by about 85%. It showed improved antioxidative enzyme levels and decreased oxidative products. The ability of NFLC to target the blood–brain barrier and treat AD will be validated with in-vivo studies.
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