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Assessment of Cervical Cancer with a Parameter-Free Intravoxel Incoherent Motion Imaging Algorithm
Anton S. Becker,Jose A. Perucho,Moritz C. Wurnig,Andreas Boss,Soleen Ghafoor,Pek-Lan Khong,Elaine Y. P. Lee 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.3
Objective: To evaluate the feasibility of a parameter-free intravoxel incoherent motion (IVIM) approach in cervical cancer, to assess the optimal b-value threshold, and to preliminarily examine differences in the derived perfusion and diffusion parameters for different histological cancer types. Materials and Methods: After Institutional Review Board approval, 19 female patients (mean age, 54 years; age range, 37–78 years) gave consent and were enrolled in this prospective magnetic resonance imaging study. Clinical staging and biopsy results were obtained. Echo-planar diffusion weighted sequences at 13 b-values were acquired at 3 tesla field strength. Single-sliced region-of-interest IVIM analysis with adaptive b-value thresholds was applied to each tumor, yielding the optimal fit and the optimal parameters for pseudodiffusion (D*), perfusion fraction (Fp) and diffusion coefficient (D). Monoexponential apparent diffusion coefficient (ADC) was calculated for comparison with D. Results: Biopsy revealed squamous cell carcinoma in 10 patients and adenocarcinoma in 9. The b-value threshold (median [interquartile range]) depended on the histological type and was 35 (22.5–50) s/mm2 in squamous cell carcinoma and 150 (100–150) s/mm2 in adenocarcinoma (p < 0.05). Comparing squamous cell vs. adenocarcinoma, D* (45.1 [25.1–60.4] x 10-3 mm2/s vs. 12.4 [10.5–21.2] x 10-3 mm2/s) and Fp (7.5% [7.0–9.0%] vs. 9.9% [9.0–11.4%]) differed significantly between the subtypes (p < 0.02), whereas D did not (0.89 [0.75–0.94] x 10-3 mm2/s vs. 0.90 [0.82–0.97] x 10-3 mm2/s, p = 0.27). The residuals did not differ (0.74 [0.60–0.92] vs. 0.94 [0.67–1.01], p = 0.32). The ADC systematically underestimated the magnitude of diffusion restriction compared to D (p < 0.001). Conclusion: The parameter-free IVIM approach is feasible in cervical cancer. The b-value threshold and perfusion-related parameters depend on the tumor histology type.
대학생의 정서적 데이트 폭력 인식과 이성관계 만족도의 상관관계
구은정,권민지,김소라,류연수,신지연,유현아,장민주,홍자인,Lanjingjing,배성희,도지영 이화여자대학교 간호과학대학 2019 이화간호학회지 Vol.- No.53
Purpose: This study aims to identify the correlation between perception of emotional dating violence and satisfaction of relationship of college students to provide objective data for college students to improve perception of emotional dating violence and satisfaction of relationship. Methods: Data was collect using questionaries between November 3rd to November 20th, 2018. Participants of this study were 110 male college students and 127 female college student who are currently attending universities aged 18 to 29 years old. Data were analyzed using average, standard deviation, t-test, ANOVA, and Pearson’s correlation using the SPSS 21.0 program. Result: The study has established the negative correlation between perception of emotional dating violence and satisfaction of relationship(R=-.587, p<.001). As the level of perception of emotion dating violence is lower, satisfaction of relationship is higher. The number of relationships recognized by oneself, experience of dating violence, and severity of dating violence also demonstrated significant difference in perception of emotional dating violence and satisfaction of relationship. Conclusion: The result of the study suggests that perception of emotional dating violence is negatively related to satisfaction of relationship. Furthermore, this study suggests that it is important to increasing perception of dating violence for healthier and better quality of relationships.
A Review of the Development of Spatial Structures in China
Shen, S.Z.,Lan, T.T. Korean Association for Spatial Structures 2001 한국공간구조학회지 Vol.1 No.1
The development of contemporary spatial structures for long-span roofs in China was initiated in the 19505. Space trusses, reticulated shells and cable suspended structures have been developing rapidly since 1980s. Recently there has been a growing interest in tensile membrane structures. Comprehensive theoretical study has been carried out parallel to the engineering application, which provided necessary theoretical support to the development of different types of spatial structures.
432-μm Laser’s Beam-waist Measurement for the Polarimeter/Interferometer on the EAST Tokamak
Z. X. Wang,H. Q. Liu,Y. X. Jie,M. Q. Wu,T. Lan,X. Zhu,Z. Y. Zou,Y. Yang,X. C. Wei,L. Zeng,G. S. Li,X. Gao 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.8
A far-infrared (FIR) polarimeter/interferometer (PI) system is under development for measurementsof the current-density and the electron-density profiles in the EAST tokamak. The systemwill utilize three identical 432-μm CHCOOH lasers pumped by a CO2 laser. Measurements of thelaser beam’s waist size and position are basic works. This paper will introduce three methods witha beam profiler and several focusing optical elements. The beam profiler can be used to show thespatial energy distribution of the laser beam. The active area of the profiler is 12.4 × 12.4 mm2. Some focusing optical elements are needed to focus the beam in order for the beam profiler toreceive the entire laser beam. Two principles and three methods are used in the measurement. Thefirst and the third methods are based on the same principle, and the second method adopts an otherprinciple. Due to the fast and convenient measurement, although the first method is a special formof the third and it can only give the size of beam waist, it is essential to the development of theexperiment and it can provide guidance for the choices of the sizes of the optical elements in the nextstep. A concave mirror, a high-density polyethylene (HDPE) lens and a polymethylpentene (TPX)lens are each used in the measurement process. The results of these methods are close enough forthe design of PI system’s optical path.
Cho, S.Y.,Kim, H.J.,Lan, N.T.,Han, H.J.,Lee, D.C.,Hwang, J.Y.,Kwon, M.G.,Kang, B.K.,Han, S.Y.,Moon, H.,Kang, H.A.,Kim, H.J. Elsevier Scientific Pub. Co 2017 Veterinary microbiology Vol.204 No.-
<P>Nervous necrosis viruses (NNV) cause serious economic losses in marine fish cultivation. The red-spotted grouper NNV (RGNNV) is the most common species of NNV worldwide. There have been many efforts to develop prophylactic NNV vaccines, and various types of vaccine candidate have been suggested. However, most were designed as injectable vaccines, which are not suitable for large-scale vaccination and cause too much stress to the fish. Oral vaccination through voluntary feeding is an ideal way to provide protective immunity to fish. In the present study, recombinant Saccharomyces cerevisiae producing RGNNV capsid protein was used as oral vaccine. The recombinant yeast was prepared in freeze-dried form after disruption. Convict groupers were divided into three groups, control, and oral and parenteral vaccination groups, each consisting of 700 fishes. The control group received no treatment, the parenteral group received one intraperitoneal injection of RGNNV virus-like particles, and the oral vaccination group consumed feed containing the lysed recombinant yeast; voluntary intake was allowed four times at one-week intervals. Both vaccination groups produced serum RGNNV neutralizing antibody titers of > 10(3) (log 2, 9.96), sustained for at least 95 days post-immunization. In addition, in response to challenge with RGNNV both groups suffered significantly reduced mortality and had reduced brain RGNNV titers. These results indicate that recombinant yeast-based oral fish vaccines have great potential for large-scale vaccination.</P>