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Roque Calvo,Emilio Gómez,Rosario Domingo 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.
Flatness and planar straightness are fundamental form tolerances in engineering design and its materialization through manufacturing processes. Minimum zone tolerance is a preferred approach of flatness and straightness for widely accepted ISO and ANSI standards. In this paper, we propose a novel accurate method of minimum zone tolerance based on vectorial calculus of point coordinates. The non-linear minimax formulation of the original flatness or straightness problem is transformed into a set of linear problems. Next, the optimal solution of the envelop planes or lines is reached through vectorial calculus for both flatness and planar straightness. Then, the developed algorithms are compared to a selection of methods with published tests in recent and classic literature on the topic, reaching the best attained accuracies or outperforming them in the trials. Finally, we propose a new decomposition of the uncertainty contributions for analysis and the improvement of sampling strategy. We conclude remarking the practical contributions of the proposals.
Endoscopic Ablation Therapy for Biliopancreatic Malignancies
Jason Roque,Shiaw-Hooi Ho,Nageshwar Reddy,Khean-Lee Goh 대한소화기내시경학회 2015 Clinical Endoscopy Vol.48 No.1
Biliopancreatic malignancies such as cholangiocarcinoma (CCA) has notoriously been diagnosed late. As such most therapy have been palliative in nature. Cholangioscopy allows for an earlier diagnosis to be made. Brachytherapy with the insertion of catheter with iridium-132 seeds, percutaneously or through endoscopic retrograde cholangiopancreatography (ERCP) was the earliest ablative techniques used. It has been shown to have a beneficial effect only in prolonging survival. Photodynamic therapy (PDT) has also been used for several years. stenting with PDT versus stenting alone for unresectable CCA showed a marked survival benefit with the addition of PDT. However the most exciting endoscopic ablative modality appears to be intraductal radiofrequency ablation using the Habib catheter and device. Several case series have shown the effectiveness of this technique in ablating tumors. This technique is evolving and coupled with early diagnosis of CCA through cholangioscopy will allow for a curative therapy. The crux to the effective treatment of early cancerous lesions in the bile or pancreatic duct is the early diagnosis of such lesions. Effective endoscopic ablative therapy is now available with the advent of radiofrequency ablation probes that can be passed through the duodenoscope via ERCP.
Katharine Roque,신경민,조지훈,김형아,허용 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.2
Hazardous biochemical agents in animal husbandry indoor environments are known to promote the occurrence of various illnesses among workers and animals. The relationship between endotoxin levels in dust collected from chicken farms and various immunological markers was investigated. Peripheral blood was obtained from 20 broiler chickens and 20 laying hens from four different chicken farms in Korea. Concentrations of total or respirable dust in the inside the chicken farm buildings were measured using a polyvinyl chloride membrane filter and mini volume sampler. Endotoxin levels in the dust were determined by the Limulus Amebocyte Lysate Kinetic method. Interferon-γ production by peripheral blood mononuclear cells stimulated with concanavalin A was significantly lower in broilers or layers from the farms with higher endotoxin concentrations than the chickens from the farms with lower endotoxin levels. An opposite pattern was observed for plasma cortisol concentrations with higher cortisol levels found in chickens from the farms with higher endotoxin levels. When peripheral lymphocytes were examined, the percentage of CD3–Ia+ B cells was lower in layers from farms with higher endotoxin levels than those from locations with lower endotoxin levels. Overall, these results suggest a probable negative association between dust endotoxin levels and cell-mediated immunity in chickens.
Katharine Roque,임경동,송은섭,Ravi Gautam,이재희,김연경,조아랑,신소정,김창열,김형아,허용 계명대학교 자연과학연구소 2016 Quantitative Bio-Science Vol.35 No.2
Hazardous biochemical agents in indoor animal husbandry environments promote the occurrence of various illnesses among husbandry workers and industrial animals. The relationship between endotoxin levels in dust collected from Korean beef cattle farms and markers of bovine cellular immunity was investigated. Peripheral blood was obtained from 25 cattle from five cattle farms in Korea. Endotoxin levels present in total or respirable dust were determined by the Limulus Amebocyte Lysate Kinetic method. Cytokine production was evaluated following the stimulation of peripheral mononuclear cells with concanavalin A for 72 h in a 5% CO2 incubator. Production of both interleukin (IL)-4 and interferon (IFN)γ was significantly higher in the high endotoxin exposure group (100.9±70.6 EU/m3) compared with the low endotoxin exposure group (17.7±18.6 EU/m3), with a lower IFNγ/IL-4 ratio in animals from the high endotoxin farms, indicating immunity skewed toward a type-2 response. The proportion of γδ T lymphocyte, important bovine immune cells involved in protection against microbial infection, was lower in cattle from the high endotoxin farms than in those from the low endotoxin farms. The numbers of white blood cells, red blood cells, lymphocytes, eosinophils, and basophils were significantly downregulated in cattle from the high endotoxin farms. Overall, these results suggest a probable negative association between dust endotoxin levels and cell-mediated immunity in Korean beef cattle.
Katharine Roque,Kyung-Min Shin,Ji-Hoon Jo,임경동,송은섭,신소정,Ravi Gautam,Jae Hee Lee,김연경,조아랑,김창열,Hyun Ji Kim,Myung Sook Lee,Hyeong-Geu Oh,Byung-Chul Lee,Jung Hee Kim,Hyun Kyu Jeong,김형아,허용,Kwang-Ho Kim 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.3
Indoor animal husbandry environments are inevitably contaminated with endotoxins. Endotoxin exposure is associated with various inflammatory illnesses in animals. This cross-sectional study evaluated the relationship between the degree of endotoxin exposure and the cellular and humoral immune profiles of fattening pigs. Blood samples were taken from the jugular vein of 47 pigs from ten pig farms in Korea. Whole blood cell counts and plasma immunoglobulin (Ig) classes were determined. Peripheral-blood mononuclear cells were stimulated in vitro with concanavalin A for 48 h, and cytokines released into culture supernatants were measured. The barns in which the pigs lived were assessed for endotoxin levels in the total and respirable dust by using the limulus amebocyte lysate kinetic QCL method. Low and high endotoxin exposures were defined as ≤ 30 and > 30 EU/m3, respectively. Compared to pigs with low endotoxin exposure (n = 19), highly exposed pigs (n = 28) had higher circulating neutrophil and lymphocyte (particularly B cells) counts, IgG and IgE levels, interferon-gamma (IFNg) and interleukin (IL)-4 productions, and lower IgA levels and tumor necrosis factor-alpha (TNFa) production. The IL-4, IFN, and TNFa levels significantly correlated with endotoxin level and/or pig age. Constant exposure of pigs to high levels of airborne endotoxins can lead to aberrant immune profiles.