http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Katharine Roque,Kyung-Min Shin,Ji-Hoon Jo,임경동,송은섭,신소정,Ravi Gautam,Jae Hee Lee,김연경,조아랑,김창열,Hyun Ji Kim,Myung Sook Lee,Hyeong-Geu Oh,Byung-Chul Lee,Jung Hee Kim,Hyun Kyu Jeong,김형아,허용,Kwang-Ho Kim 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.3
Indoor animal husbandry environments are inevitably contaminated with endotoxins. Endotoxin exposure is associated with various inflammatory illnesses in animals. This cross-sectional study evaluated the relationship between the degree of endotoxin exposure and the cellular and humoral immune profiles of fattening pigs. Blood samples were taken from the jugular vein of 47 pigs from ten pig farms in Korea. Whole blood cell counts and plasma immunoglobulin (Ig) classes were determined. Peripheral-blood mononuclear cells were stimulated in vitro with concanavalin A for 48 h, and cytokines released into culture supernatants were measured. The barns in which the pigs lived were assessed for endotoxin levels in the total and respirable dust by using the limulus amebocyte lysate kinetic QCL method. Low and high endotoxin exposures were defined as ≤ 30 and > 30 EU/m3, respectively. Compared to pigs with low endotoxin exposure (n = 19), highly exposed pigs (n = 28) had higher circulating neutrophil and lymphocyte (particularly B cells) counts, IgG and IgE levels, interferon-gamma (IFNg) and interleukin (IL)-4 productions, and lower IgA levels and tumor necrosis factor-alpha (TNFa) production. The IL-4, IFN, and TNFa levels significantly correlated with endotoxin level and/or pig age. Constant exposure of pigs to high levels of airborne endotoxins can lead to aberrant immune profiles.