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Kim, Hyunsook,Kim, Dong-Hyeon,Seo, Kun-ho,Chon, Jung-Whan,Nah, Seung-Yeol,Bartley, Glenn E.,Arvik, Torey,Lipson, Rebecca,Yokoyama, Wallace American Chemical Society 2015 Journal of agricultural and food chemistry Vol.63 No.5
<P>The relationship between the intestinal microbiota and the hypocholesterolemic and antiobesity effects of whole grape seed flour from white and red winemaking was evaluated. Male Golden Syrian hamsters were fed a high-fat (HF) control diet or a HF diet supplemented with 10% partially defatted grape seed flours from either Chardonnay (ChrSd) or Cabernet Sauvignon (CabSd) grapes for 3 weeks. The numbers of total bacteria and relative abundances of <I>Bifidobacterium</I> spp., <I>Lactobacillus</I> spp., and <I>Firmicutes</I> in feces were significantly lower, while the relative abundance of <I>Bacteroides fragilis</I> was greater than the control from feeding the ChrSd diet. The ratio of <I>Firmicutes</I>/<I>Bacteroidetes</I> (F/B) was lower in the ChrSd diet. There were significantly positive correlations between <I>Lactobacillus</I> spp., ratio of F/B, and plasma total- and LDL-cholesterol and liver weight. The reduction of <I>Lactobacillus</I> spp. by the ChrSd diet was accompanied by inhibition of Farnesoid X receptor (FXR) signaling in the intestine as expression of intestinal fibrablast growth factor (FGF)15, positively regulated by FXR, was decreased. Expression of CYP7A1, negatively regulated by FGF15, was up-regulated in the liver, which indicates that alteration of the intestinal microbiota may regulate bile acid and lipid metabolism. These findings suggest that beneficial health effects of Chardonnay grape seed flour on HF-induced metabolic disease relate in part to modulation of intestinal microbiota and their metabolic processes.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2015/jafcau.2015.63.issue-5/jf5026373/production/images/medium/jf-2014-026373_0005.gif'></P>
Kim, Juyoung,Jung, Jin Hee,Lee, Saet Buyl,Go, Young Sam,Kim, Hae Jin,Cahoon, Rebecca,Markham, Jonathan E.,Cahoon, Edgar B.,Suh, Mi Chung American Society of Plant Biologists 2013 PLANT PHYSIOLOGY - Vol.162 No.2
<P><I>KCS9 is involved in the elongation of C22 to C24 fatty acids, which are essential precursors for the biosynthesis of cuticular waxes, aliphatic suberins, and membrane lipids, including sphingolipids and phospholipids.</I></P>
Kim, Sujin,Lee, Seonyeong,Shin, Chorong,Lee, Jangwoo,Kim, Sunmi,Lee, Aram,Park, Jeongim,Kho, Younglim,Moos, Rebecca K.,Koch, Holger M.,Kim, Sungkyoon,Choi, Kyungho Elsevier 2018 International journal of hygiene and environmental Vol.221 No.4
<P><B>Abstract</B></P> <P>Parabens and triclosan have been widely used in many personal care products and cosmetics. The endocrine disrupting potential of these compounds is of increasing public health concern. The aim of this study is to understand the current exposure profile of these chemicals in last void before bedtime (night-time) and first-morning void (first-morning) urines among a Korean population and to characterize their exposure sources and pathways.</P> <P>A total of 261 people, including infants (0–2 years), toddlers (3–6 years), children (7–12 years), adolescents (13–18 years), and adults (≥19 years), were recruited, and sampled for night-time urine and first-morning urine of the following day. Methyl (MeP), ethyl (EtP), propyl (PrP) and butyl paraben (BuP), and triclosan were measured in urine. The demographic characteristics, use of personal care products, and food consumption were obtained through a questionnaire.</P> <P>Among the target compounds, EtP and MeP were most frequently detected at the highest concentrations. The median concentration of EtP in night-time urine was 32.4 μg/L (interquartile range: 8.37–82.8 μg/L), which is higher than previously reported worldwide. Unlike other test compounds, compared to those measured from first-morning urine, the EtP concentrations were significantly higher in night-time urine, suggesting the presence of different exposure sources. Among adults, the MeP and PrP concentrations in night-time urine were associated with frequent use of skin care products, colored cosmetics, bath products, toothpaste, vinyl food packaging, or consumption of canned food. The MeP and PrP concentrations were higher in females than in males, especially in night-time urine. The results of this study also show that multiple urine samples are necessary to capture the diurnal variation of non-occupational exposure to environmental chemicals, such as parabens.</P>
miR-218 and miR-129 regulate breast cancer progression by targeting Lamins
Setijono, Stephanie Rebecca,Park, Mikyung,Kim, Goeun,Kim, Yongjo,Cho, Kae Won,Song, Su Jung Elsevier 2018 Biochemical and biophysical research communication Vol.496 No.3
<P><B>Abstract</B></P> <P>Breast cancer is the most frequently diagnosed life-threatening cancer in women. Triple-negative breast cancer (TNBC) has an aggressive clinical behavior, but the treatment of TNBC remains challenging. MicroRNAs (miRNAs) have emerged as a potential target for the diagnosis, therapy and prognosis of breast cancer. However, the precise role of miRNAs and their targets in breast cancer remain to be elucidated. Here we show that miR-218 is downregulated and miR-129 is upregulated in TNBC samples and their expressions confer prognosis to patients. Gain-of-function and loss-of-function analysis reveals that miR-218 has a tumor suppressive activity, while miR-129 acts as an oncomir in breast cancer. Notably, miR-218 and miR-129 directly target Lamin B1 and Lamin A, respectively, which are also found to be deregulated in human breast tumors. Finally, we demonstrate Lamins as the major factors in reliable miR-218 and miR-129 functions for breast cancer progression. Our findings uncover a new miRNA-mediated regulatory network for different Lamins and provide a potential therapeutic target for breast cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> miR-218 is downregulated and miR-129 is upregulated in breast cancer. </LI> <LI> miR-218 inhibits and miR-129 promotes breast cancer proliferation and migration. </LI> <LI> Lamins are identified as a novel target of miR-218 and miR-129. </LI> <LI> miR-218 and miR-129 play their biological functions by Lamins in breast cancer. </LI> </UL> </P>
김리브가,김유철,김광수,Rebecca Kim,MD,Yu Cheol Kim,MD,Kwang Soo Kim,MD,PhD 대한안과학회 2014 대한안과학회지 Vol.55 No.2
Purpose: To evaluate the causes of secondary macular hole after vitrectomy and the possibility of their prevention. Methods: 27 patients (28 eyes) who experienced macular hole formation after vitrectomy were reviewed retrospectively. Age, sex, operation methods, duration between the vitrectomy and the secondary macular hole surgery and causes of the primary vitrectomy were recorded. Best-corrected visual acuity (BCVA) before and after primary vitrectomy; preoperative and postoperative macular findings with optical coherence tomography and fundus examination; and BCVA before and after macular hole surgery were analyzed. Results: Of the 2945 eyes that had undergone vitrectomy, 28 eyes (0.96%) experienced macular hole formation. As causes of primary vitrectomy, 12 eyes had proliferative diabetic retinopathy, 6 eyes had rhegmatogenous retinal detachment, 2 eyes had branch retinal vein occlusion, 3 eyes had age-related macular degeneration and 5 eyes had trauma such as eyeball rupture or intraocular foreign body. The mean duration between primary vitrectomy and macular hole formation was 20.4 months (4 days-115 months). The estimated causes of macular hole formation included cystoid macular edema (CME) (n = 13), thinning of the macula (n = 6), thickening of internal limiting membrane or recurrence of preretinal membrane (PRM) (n = 7), recurrence of subretinal hemorrhage (n = 1) and macular damage during vitrectomy (n = 2). Final BCVA after macular hole surgery decreased in most cases compared to BCVA before macular hole formation except in 7 eyes (25%). Conclusions: Close observation of the macula after primary vitrectomy especially in eyes with continuous CME, and recurrent PRM and proper management on them including timely removal of the tangential traction force are necessary for preventing macular hole formation. In addition, surgeons should make efforts not to exert excessive tractional force on the macula to avoid iatrogenic damage during removal of the preretinal membrane. J Korean Ophthalmol Soc 2014;55(2):230-236
Kim, Hyunsook,Bartley, Glenn E.,Arvik, Torey,Lipson, Rebecca,Nah, Seung-Yeol,Seo, Kunho,Yokoyama, Wallace American Chemical Society 2014 Journal of agricultural and food chemistry Vol.62 No.8
<P>The mechanisms for the hypocholesterolemic and antiobesity effects of grape seed flours derived from white and red winemaking processing were investigated using male Golden Syrian hamsters fed high-fat (HF) diets supplemented with 10% partially defatted grape seed flours from Chardonnay (ChrSd), Cabernet Sauvignon (CabSd), or Syrah (SyrSd) pomace as compared to a HF control diet for 3 weeks. Hamsters fed the ChrSd diet had significantly lowered plasma total-, VLDL-, and LDL-cholesterol concentrations compared to the CabSd, SyrSd, and control diets. The improved plasma cholesterol after ChrSd was correlated with the up-regulation of hepatic genes related to cholesterol (CYP51) and bile acid (CYP7A1) synthesis as well as LDL-cholesterol uptake (LDLR). A reduction of hepatic lipid content was associated with altered expression of the genes related to lipid metabolism. However, fecal total lipid content was not changed. Expression of ileal apical sodium bile acid transporter (ASBT) was not affected by ChrSd, indicating unchanged ileal bile acid reabsorption. The antiobesity effect of the ChrSd diet appears to be related to expression of adipogenesis- and inflammation-related genes in adipose tissue. These findings suggest that flavonoid-rich Chardonnay grape seed flour induced cholesterol-lowering, antiobesity, and anti-inflammatory health benefits and attenuation of hepatic steatosis via regulation of gene expression related to cholesterol, bile acid, and lipid metabolism in liver and adipose tissue.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2014/jafcau.2014.62.issue-8/jf404832s/production/images/medium/jf-2013-04832s_0005.gif'></P>
EXPANDING UNDERSTANDING OF CUSTOMER ENGAGEMENT: A SUBTLE CO-CREATION PROCESS AT RESTAURANTS
Eojina Kim,Liang (Rebecca) Tang 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07
Value co-creation has become an emerging venue of the customer engagement research. The purpose of the study is to investigate a model that represents the process (behavior and value) and consequence (satisfaction) of customer co-creation in the restaurant context. Specifically, with the theoretical support of service-dominant logic, the present study explores customer co-creation behavior as a key predictor of co-created value, which in turn leads to customer satisfaction. The results of the study confirm that customer value cocreation is a subtle process by examining the relationship between customer co-creation behavior at the “co-production” stage and co-created value at the “co-creation of value” stage. The findings of the study contribute to the evolving knowledge of customer cocreation of value, and offer practitioners in the hospitality and tourism industry effective marketing strategies based on re-examining customer relationships and engagement, thereby maximizing customer value.