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Taylor R. Cushman,Waqar Haque,Hari Menon,Chad G. Rusthoven,E. Brian Butler,Bin S. Teh,Vivek Verma 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.6
Objective: Women with cervical cancer (CC) found to have positive surgical margins, positive lymph nodes, and/or parametrial invasion receive a survival benefit from postoperative chemoradiotherapy (CRT) vs. radiation therapy (RT) alone. However, older women may not benefit to the same extent, as they are at increased risk of death from non-oncologic causes as well as toxicities from oncologic treatments. This study sought to evaluate whether there was a survival benefit of CRT over RT in elderly patients with cervical cancer. Methods: The National Cancer Database was queried for patients ≥70 years old with newly diagnosed IA2, IB, or IIA CC and positive margins, parametrial invasion, and/or positive nodes on surgical resection. Statistics included logistic regression, Kaplan-Meier overall survival (OS), and Cox proportional hazards modeling analyses. Results: Altogether, 166 patients met inclusion criteria; 62 (37%) underwent postoperative RT and 104 (63%) underwent postoperative CRT. Younger patients and those living in areas of higher income were less likely to receive CRT, while parametrial invasion and nodal involvement were associated with an increased likelihood (p<0.05 for all). There were no OS differences by treatment type. Subgroup analysis by number of risk factors, as well as each of the 3 risk factors separately, also did not reveal any OS differences between cohorts. Conclusion: In the largest such study to date, older women with postoperative risk factor(s) receiving RT alone experienced similar survival as those undergoing CRT. Although causation is not implied, careful patient selection is paramount to balance treatment-related toxicity risks with theoretical outcome benefits.
Endovascular Therapy for Ischemic Stroke
Ramana M R Appireddy,Andrew M Demchuk,Mayank Goyal,Bijoy K Menon,Muneer Eesa,Philip Choi,Michael D. Hill 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.1
The utility of intravenous tissue plasminogen activator (IV t-PA) in improving the clinical outcomes after acute ischemic stroke has been well demonstrated in past clinical trials. Thoughmultiple initial small series of endovascular stroke therapy had shown good outcomes as compared to IV t-PA, a similar beneficial effect had not been translated in multiple randomizedclinical trials of endovascular stroke therapy. Over the same time, there have been parallel advances in imaging technology and better understanding and utility of the imaging in therapy ofacute stroke. In this review, we will discuss the evolution of endovascular stroke therapy followed by a discussion of the key factors that have to be considered during endovascular stroketherapy and directions for future endovascular stroke trials.
K. B. Padmakumar,B. R. Smitha,Lathika Cicily Thomas,C. L. Fanimol,G. SreeRenjima,N. R. Menon,V. N. Sanjeevan 한국해양과학기술원 2010 Ocean science journal Vol.45 No.3
This study presents in situ evidence for the blooms of Trichodesmium erythraeum observed in the shelf waters of the South Eastern Arabian Sea (SEAS) during the onset of the southwest monsoon in June 2009. Evidence showed that water surface discoloration was caused by the accumulation of T. erythraeum, and that the water column contained a colony of T. thiebautii. The surface water color in the bloom region varied from pale brown to pinkish red. Pale brown indicated healthy algae at the peak of its photosynthetic activity, while pinkish red indicated the presence of photosynthetically less active filaments. Zooplankton abundance, especially copepodites, in the bloom area substantiated the theory that Trichodesmium filaments are excellent epiphytes to which the copepodites cling. The bloom area was very fertile with copious quantities of dissolved oxygen (6.85 ml L-1), PO4-P (0.108 μmol L-1) and SiO4 (1.29 μmol L-1). Lower NO3-N (0.028 μmol L-1) values in the bloom area did not appear to affect Trichodesmium growth from molecular nitrogen fixation. However, lower NO3-N values altered the normal phytoplankton composition of this area.
ULAM STABILITIES FOR IMPULSIVE INTEGRO-DIFFERENTIAL EQUATIONS
S. D. Kadam,R. Menon,R. S. Jain,B. S. Reddy 경남대학교 수학교육과 2024 Nonlinear Functional Analysis and Applications Vol.29 No.1
In the present paper, we establish Ulam-Hyres and Ulam-Hyers-Rassias stabilities for nonlinear impulsive integro-differential equations with non-local condition in Banach space. The generalization of Grownwall type inequality is used to obtain our results.
EXISTENCE AND CONTROLLABILITY OF MILD SOLUTION OF IMPULSIVE INTEGRO-DIFFERENTIAL INCLUSIONS
S. D. Kadam,Surendranath Reddy,Radhika Menon,R. S. Jain 경남대학교 수학교육과 2020 Nonlinear Functional Analysis and Applications Vol.25 No.4
In this work, existence results for impulsive integro-differential inclusion by us-ing Martelli and Covitz-Nadler xed point theorems (FPT) has been studied and proposedimprovement for some of the results with the help of impulsive inequality. Also controllabil-ity results has been investigated for impulsive integro-dierential inclusion problems. This study will provide useful insights for design problems in engineering leading to controllability solutions of Integro dierential equation subjected to impulsive perturbations taking intoconsideration of nonlocal and delay conditions.
Sushanth Rao Aroor,Kaiz S. Asif,Jennifer Potter-Vig,Arun Sharma,Bijoy K. Menon,Violiza Inoa,Cynthia B. Zevallos,Jose G. Romano,Santiago Ortega-Gutierrez,Larry B. Goldstein,Dileep R. Yavagal 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.1
Mechanical thrombectomy (MT) is the most effective treatment for selected patients with an acute ischemic stroke due to emergent large vessel occlusions (LVOs). There is an urgent need to identify and address challenges in access to MT to maximize the numbers of patients who can benefit from this treatment. Barriers in access to MT include delays in evaluation and accurate diagnosis of LVO leading to inappropriate triage, logistical delays related to availability of facilities and trained interventionalists, and financial hurdles that affect treatment reimbursement. Collection of regional data related to these barriers is critical to better understand current access gaps and a measurable access score to thrombectomy could be useful to plan local public health intervention.