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- 저자 : Qidong Chen (검색결과 6 건)
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Chen Kun,Chen Xi,Lang Chuandong,Yuan Xingshi,Huang Junming,Li Zhi,Xu Mingyou,Wu Kerong,Zhou Chenhe,Li Qidong,Zhu Chen,Liu Lianxin,Shang Xifu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The identification of key regulatory factors that control osteoclastogenesis is important. Accumulating evidence indicates that circular RNAs (circRNAs) are discrete functional entities. However, the complexities of circRNA expression as well as the extent of their regulatory functions during osteoclastogenesis have yet to be revealed. Here, based on circular RNA sequencing data, we identified a circular RNA, circFam190a, as a critical regulator of osteoclast differentiation and function. During osteoclastogenesis, circFam190a is significantly upregulated. In vitro, circFam190a enhanced osteoclast formation and function. In vivo, overexpression of circFam190a induced significant bone loss, while knockdown of circFam190a prevented pathological bone loss in an ovariectomized (OVX) mouse osteoporosis model. Mechanistically, our data suggest that circFam90a enhances the binding of AKT1 and HSP90β, promoting AKT1 stability. Altogether, our findings highlight the critical role of circFam190a as a positive regulator of osteoclastogenesis, and targeting circFam190a might be a promising therapeutic strategy for treating pathological bone loss.
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Research on damage of 3D random aggregate concrete model under ultrasonic dynamic loading
Lixiao Wang,Qidong Chen,Xin Liu,Bin Zhang,Yichen Shen 사단법인 한국계산역학회 2020 Computers and Concrete, An International Journal Vol.26 No.1
Concrete are the most widely used manmade materials for infrastructure construction across the world. These constructions gradually aged and damaged due to long-term use. However, there does not exist an efficient concrete recycling method with low energy consumption. In this study, concrete was regarded as a heterogeneous material composed of coarse aggregate and cement mortar. And the failure mode of concrete under ultrasonic dynamic loading was investigated by finite element (FE) analysis. Simultaneously, a 3D random aggregate concrete model was programmed by APDL and imported into ABAQUS software, and the damage plastic constitutive model was applied to each phase to study the damage law of concrete under dynamic loading. Meanwhile, the dynamic damage process of concrete was numerically simulated, which observed ultrasonic propagating and the concrete crushing behavior. Finally, the FE simulation considering the influence of different aggregate volume and aggregate size was carried out to illustrate the damage level of concrete.
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Tingfang Zhang,Qidong Wang,Linfeng Zhao,Wuwei Chen,Bixin Cai,Mingyue Yan 한국자동차공학회 2024 International journal of automotive technology Vol.25 No.2
In the longitudinal driving of a heterogeneous platoon, external disturbances of local vehicles can cause safety problemsof the intended functionality. Therefore, a cooperative control method based on situation assessment is proposed. First, theminimum safe distance is determined according to the state of adjacent vehicles. A novel situation assessment model isestablished to characterize the stability of the platoon. Vehicle spacing, speed, and acceleration are selected as evaluationindicators. Then, an improved active disturbance rejection controller (IADRC) is designed to improve platoon stabilitythrough feedback compensation control. In addition, considering the unnecessary continuous involvement of the IADRC,its intervention time is determined by the situation assessment results. Finally, simulation and hardware-in-the-loop (HIL)experiments are carried out under two communication topologies. The results show that the proposed method can eff ectivelyimprove the stability and safety of the platoon.
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Preparation and properties of CNTs-Cu hybrids/epoxy superhydrophobic and anticorrosive coatings
Zhongbo Zhu,Shumei Kang,Hua Chen,Qingping Zhao,Zhaokang Huo,Pengyu Li,Qidong Cao,Chenshuo Lu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-
In this work, hydrophobized copper powders combined siloxane-modified carbon nanotubes(SHMWCNTs) to obtain intertwined hybrids of carbon nanotubes and copper (CNTs-Cu hybrids), andsuperhydrophobic CNTs-Cu hybrids/epoxy coatings were prepared on the surface of AH36 carbon steelby drop coating. The surface morphology and wettability of coatings were changed by adjusting the ratiosof SHMWCNTs to hydrophobized copper powders. The obtained coating can show a water contact angleof 167.2, a water sliding angle of 2.9, a plant oil contact angle of 134.3, and self-cleaning properties. Thecoating maintains superhydrophobicity after 300 tape-peeling times, exhibiting excellent mechanicaldurability. The fouled area percentages of chlorella on the coating and a pure epoxy resin were 0.23(±0.07)% and 12.18(±1.22)%, respectively, displaying anti-biofouling resistances. The coating has excellentcorrosion resistance, and its corrosion current density reached 9.55 10-8 A/cm2.
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Jin Yong,Wang Zhilin,Zhang Zhenxin,Lin Bo,Ge Zhengjun,You Qidong,Chen Hao,Liu Xiliang,Xu Chenghao,Gao Shuaiqiang,Wu Yi,Abro Zafar 한국자원공학회 2023 Geosystem engineering Vol.26 No.4
CO2 flooding is a significant technology for oil recovery, to reveal the microcosmic mechanism of CO2 flooding, CO2 slim tube experiments, long core CO2 flooding experiments, gas chromatography analysis experiments, and numerical simulations were carried out. The results show that the miscibility increase can improve the effect of dissolution and diffusion in the CO2-crude oil system, easing the CO2 finger entry phenomena, and delaying gas breakthrough time. Besides, the CO2 -crude oil interaction is enhanced by increasing the pressure difference between the injection well and the production well, which improves the oil recovery of CO2 flooding. Besides, CO2 carries the light and medium components (C4 ~ 25) forward to cross the first miscible zone, which makes the CO2-crude oil system form double miscible zones. This study reveals the rule of CO2 front and light components front under different miscibility degrees of CO2 flooding from the microscopic perspective and deepens the theory of CO2 flooding in low-permeability sandstone reservoirs.
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Qi Dong,Dan Zu,Lingqiang Kong,Sunfang Chen,Jun Yao,Jiawei Lin,Lei Lu,Bing Wu,Bin Fang 한국생체재료학회 2022 생체재료학회지 Vol.26 No.3
Background: Hydrogels loaded with antimicrobial agents have been widely used for treating infected wound defects. However, hydrogels derived from a porcine dermal extracellular matrix (PADM), containing silver nanoparticles (AgNPs), have not yet been studied. Therefore, we investigated the therapeutic effect of an AgNP-impregnated PADM (AgNP–PADM) hydrogel on the treatment of infected wounds. Methods: An AgNP–PADM hydrogel was synthesized by embedding AgNPs into a PADM hydrogel. We examined the porosity, moisture retention, degradation, antibacterial properties, cytotoxicity, antioxidant properties, and ability of the PADM and AgNP–PADM hydrogels to treat infected wounds in animals. Results: The PADM and AgNP–PADM hydrogels were pH sensitive, which made them flow dynamically and solidify under acidic and neutral conditions, respectively. The hydrogels also exhibited porous network structures, satisfactory moisture retention, and slow degradation. Additionally, the AgNP–PADM hydrogel showed a slow and sustained release of AgNPs for at least 7 days without the particle size changing. Thus, the AgNPs exhibited adequate antibacterial ability, negligible toxicity, and antioxidant properties in vitro. Moreover, the AgNP–PADM hydrogel promoted angiogenesis and healed infected skin defects in vivo. Conclusions: The AgNP–PADM hydrogel is a promising bioderived antibacterial material for clinical application to infected wound dressings
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