학술발표회 : 5 ) 양식분야 : 포스터발표 ; Effects of The Different Dietary Arginine Levels on Plasma Free Amino Acid Concentrations in rainbow trout

(S . C . Bai),(I . H . Ok),(S . S . O . Hung),(Q . R . Rogers) 한국국제경제학회 2001 춘계 수산관련학회 공동학술대회발표 요지집 Vol.0 No.-

Maximizing the Selection Response by Optimal Quantitative Trait Loci Selection and Control of Inbreeding in a Population with Different Lifetimes between Sires and Dams

Tang, G.Q.,Li, X.W.,Zhu, L.,Shuai, S.R.,Bai, L. Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.11

A rule was developed to constrain the annual rate of inbreeding to a predefined value in a population with different lifetimes between sires and dams, and to maximize the selection response over generations. This rule considers that the animals in a population should be divided into sex-age classes based on the theory of gene flow, and restricts the increase of average inbreeding coefficient for new offspring by limiting the increase of the mean additive genetic relationship for parents selected. The optimization problem of this rule was formulated as a quadratic programming problem. Inputs for the rule were the BLUP estimated breeding values, the additive genetic relationship matrix of all animals, and the long-term contributions of sex-age classes. Outputs were optimal number and contributions of selected animals. In addition, this rule was combined with the optimization of emphasis given to QTL, and further increased the genetic gain over the planning horizon. Stochastic simulations of closed nucleus schemes for pigs were used to investigate the potential advantages obtained from this rule by combining the standard QTL selection, optimal QTL selection and conventional BLUP selection. Results showed that the predefined rates of inbreeding were actually achieved by this rule in three selection strategies. The rule obtained up to 9.23% extra genetic gain over truncation selection at the same rates of inbreeding. The combination of the extended rule and the optimization of emphasis given to QTL allowed substantial increases in selection response at a fixed annual rate of inbreeding, and solved substantially the conflict between short-term and long-term selection response in QTL-assisted selection schemes.

Inbreeding and Genetic Diversity in Three Imported Swine Breeds in China Using Pedigree Data

Tang, G.Q.,Xue, J.,Lian, M.J.,Yang, R.F.,Liu, T.F.,Zeng, Z.Y.,Jiang, A.A.,Jiang, Y.Z.,Zhu, L.,Bai, L.,Wang, Z.,Li, X.W. Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.6

The accumulation of inbreeding and the loss of genetic diversity is a potential problem in the modern swine breeds in China. Therefore, the purpose of this study was to analyze the pedigrees of Chinese Duroc (CD), Landrace (CL) and Yorkshire (CY) swine to estimate the past and current rates of inbreeding, and to identify the main causes of genetic diversity loss. Pedigree files from CD, CL and CY containing, 4529, 16,776 and 22,600 records, respectively, were analyzed. Pedigree completeness indexes of the three breeds, accounting for one generation back, were 83.72, 93.93 and 93.59%, respectively. The estimated average annual inbreeding rates for CD, CL and CY in recent three years were 0.21, 0.19 and 0.13%, respectively. The estimated average percentage of genetic diversity loss within each breed in recent three years was about 8.92, 2.19, and 3.36%, respectively. The average relative proportion of genetic diversity loss due to unequal contributions of founders in CD, CL and CY was 69.09, 57.95 and 60.57%, and due to random genetic drift was 30.91, 42.05 and 39.43%, respectively. The estimated current effective population size for CD, CL and CY was 76, 117 and 202, respectively. Therefore, CD has been found to have lost considerable genetic diversity, demanding priority for optimizing the selection and mating to control future coancestry and inbreeding. Unequal contribution of founders was a major cause of genetic diversity loss in Chinese swine breeds and random genetic drift also showed substantial impact on the loss of diversity.

Computational Screening of Nanoporous Materials for Hexane and Heptane Isomer Separation

Chung, Yongchul G.,Bai, Peng,Haranczyk, Maciej,Leperi, Karson T.,Li, Peng,Zhang, Hongda,Wang, Timothy C.,Duerinck, Tim,You, Fengqi,Hupp, Joseph T.,Farha, Omar K.,Siepmann, J. Ilja,Snurr, Randall Q. American Chemical Society 2017 Chemistry of materials Vol.29 No.15

<P>Computational high-throughput screening was carried out to assess a large number of-experimentally reported metal-organic frameworks (MOFs) and zeolites for their utility in hexane isomer separation. Through the work, we identified many MOFs and zeolites with high selectivity (SL+M > 10) for the group of n-hexane, 2-methylpentane, and 3-methylpentane (linear and monobranched isomers) versus 2,2-dimethylbutane and 2,3-dimethylbutane (dibranched isomers). This group of selective sorbents includes VICDOC (Fe-2(BDP)(3)), a MOF with triangular pores that is known to exhibit high isomer selectivity and capacity. For three of these structures, the adsorption isotherms for a 10-component mixture of hexane and heptane isomers were calculated. Subsequent simulations of column breakthrough curves showed that the DEYVUA MOF exhibits a longer process cycle time than VICDOC MOF or MRE zeolite, which are previously reported, high-performing materials, illustrating the importance of capacity in designing MOFs for practical applications. Among the identified candidates, we synthesized and characterized a MOF in a new copper form with high predicted adsorbent capacity (q(L+M) > 1.2 mol/L) and moderately high selectivity (SL+M approximate to 10). Finally, we examined the role of pore shape in hexane isomer separations, especially of triangular-shaped pores. We show through the potential energy surface and three-dimensional siting analyses that linear alkanes do not populate the corners of narrow triangular channels and that structures with nontriangular pores can efficiently separate hexane isomers. Detailed thermodynamic analysis illustrates how differences in the free energy of adsorption contribute to shape selective separation in nanoporous materials.</P>

High-efficiency p–i–n organic light-emitting diodes with a novel n-doping electron transport layer

Wei Xu,M.A. Khan,Yu Bai,X.Y. Jiang,Z.L. Zhang,W.Q. Zhu 한국물리학회 2009 Current Applied Physics Vol.9 No.4

We demonstrate p–i–n organic light-emitting diodes (OLEDs) incorporating an n-doping transport layer which comprises 8-hydroxy-quinolinato lithium (Liq) doped into 4'7-diphyenyl-1,10-phenanthroline (Bphen) as ETL and a p-doping transport layer which includes tetrafluro-tetracyano-quinodimethane (F4-TCNQ) doped into 4,4',4''-tris(3-methylphenylphenylamono) triphenylamine (m-MTDATA). In order to examine the improvement in the conductivity of transport layers, hole-only and electron-only devices are fabricated. The current and power efficiency of organic light-emitting diodes have been improved significantly after introducing a novel n-doping (Bphen: 33 wt% Liq) layer as an electron transport layer (ETL) and a p-doping layer composed of m-MTDATA and F4-TCNQ as a hole transport layer (HTL). Compared with the control device (without doping), the current efficiency and power efficiency of Device C (most efficient) is enhanced by approximately 51% and 89%, respectively, while driving voltage is reduced by 29%. This improvement is attributed to the improved conductivity of the transport layers that leads to the efficient charge balance in the emission zone. We demonstrate p–i–n organic light-emitting diodes (OLEDs) incorporating an n-doping transport layer which comprises 8-hydroxy-quinolinato lithium (Liq) doped into 4'7-diphyenyl-1,10-phenanthroline (Bphen) as ETL and a p-doping transport layer which includes tetrafluro-tetracyano-quinodimethane (F4-TCNQ) doped into 4,4',4''-tris(3-methylphenylphenylamono) triphenylamine (m-MTDATA). In order to examine the improvement in the conductivity of transport layers, hole-only and electron-only devices are fabricated. The current and power efficiency of organic light-emitting diodes have been improved significantly after introducing a novel n-doping (Bphen: 33 wt% Liq) layer as an electron transport layer (ETL) and a p-doping layer composed of m-MTDATA and F4-TCNQ as a hole transport layer (HTL). Compared with the control device (without doping), the current efficiency and power efficiency of Device C (most efficient) is enhanced by approximately 51% and 89%, respectively, while driving voltage is reduced by 29%. This improvement is attributed to the improved conductivity of the transport layers that leads to the efficient charge balance in the emission zone.

Development of the 3.7 GHz LHCD System on HL-2A

B. Lu,M. Huang,H. Zeng,X. Y. Bai,X. H. Mao,Z. H. Lu,J. Liang,Z. H. Kang,M. W. Wang,K. Feng,H. Wang,C. Wang,J. Q. Wang,S. Wei,T. Yao,Y. N. Bu,J. Feng,G. Y. Cheng,S. D. Song,D. H. Xia,J. Rao 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.8

A 2 MW-3.7 GHz lower hybrid current drive (LHCD) system is under development for physicsexperiments on the HL-2A device. The RF Power is generated by four TH2103A klystron amplifiersand propagates in the TE10 mode through WR284 waveguides. The transmission lines with a lengthof 20 m to 30 m are pressurized with 2 bars of nitrogen to decrease the possibility of arcing. Thelauncher, based on the passive-active multi-junction (PAM) concept, has been developed and iscurrently being realized. It was designed for a power spectrum peaked at Nk = 2.75 with goodcoupling properties over a wide range of plasma parameters. The four klystrons are fed by ahigh-voltage power supply (HVPS) based on the pulse step modulation (PSM) concept with a fastswitch-off time of less than ten μs. This system is expected to be in operation within 1 years and willexplore many international thermonuclear experimental reactor (ITER) related LH experiments inthe following years.

MicroRNA-375 is a therapeutic target for castration-resistant prostate cancer through the PTPN4/STAT3 axis

Gan Junqing,Liu Shan,Zhang Yu,He Liangzi,Bai Lu,Liao Ran,Zhao Juan,Guo Madi,Jiang Wei,Li Jiade,Li Qi,Mu Guannan,Wu Yangjiazi,Wang Xinling,Zhang Xingli,Zhou Dan,Lv Huimin,Wang Zhengfeng,Zhang Yanqiao,Q 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

The functional role of microRNA-375 (miR-375) in the development of prostate cancer (PCa) remains controversial. Previously, we found that plasma exosomal miR-375 is significantly elevated in castration-resistant PCa (CRPC) patients compared with castration-sensitive PCa patients. Here, we aimed to determine how miR-375 modulates CRPC progression and thereafter to evaluate the therapeutic potential of human umbilical cord mesenchymal stem cell (hucMSC)-derived exosomes loaded with miR-375 antisense oligonucleotides (e-375i). We used miRNA in situ hybridization technique to evaluate miR-375 expression in PCa tissues, gain- and loss-of-function experiments to determine miR-375 function, and bioinformatic methods, dual-luciferase reporter assay, qPCR, IHC and western blotting to determine and validate the target as well as the effects of miR-375 at the molecular level. Then, e-375i complexes were assessed for their antagonizing effects against miR-375. We found that the expression of miR-375 was elevated in PCa tissues and cancer exosomes, correlating with the Gleason score. Forced expression of miR-375 enhanced the expression of EMT markers and AR but suppressed apoptosis markers, leading to enhanced proliferation, migration, invasion, and enzalutamide resistance and decreased apoptosis of PCa cells. These effects could be reversed by miR-375 silencing. Mechanistically, miR-375 directly interfered with the expression of phosphatase nonreceptor type 4 (PTPN4), which in turn stabilized phosphorylated STAT3. Application of e-375i could inhibit miR-375, upregulate PTPN4 and downregulate p-STAT3, eventually repressing the growth of PCa. Collectively, we identified a novel miR-375 target, PTPN4, that functions upstream of STAT3, and targeting miR-375 may be an alternative therapeutic for PCa, especially for CRPC with high AR levels.

Structure and Magnetic Properties for Bulk Fe<SUB>73-x</SUB>Zr₂Y₄B₂₁ Nd<SUB>x</SUB> (x=0, 2, 5, 7) Alloys Prepared by Suction Casting

X. H. Tan,H. Xu,W. J. Zhao,Q. Bai,Y. D. Dong 한국자기학회 2007 한국자기학회 학술연구발표회 논문개요집 Vol.- No.-

Vitamin E improves antioxidant status but not lipid metabolism in laying hens fed a aged corn-containing diet

Ding, X.M.,Mu, Y.D.,Zhang, K.Y.,Wang, J.P.,Bai, S.P.,Zeng, Q.F.,Peng, H.W. Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.2

Objective: The objective of this study was to determine whether a dietary vitamin E (VE) supplement could alleviate any detrimental effects of aged corn on lipid metabolism and antioxidant status in laying hens. Methods: The experiment consisted of a 2×3 factorial design with two corn types (normal corn and aged corn (stored for 4 yr) and three concentrations of VE (0, 20, and 100 IU/kg). A total of 216 Lohmann laying hens (50 wk of age) were randomly allocated into six treatment diets for 12 wk. Each treatment had 6 replicates of 6 hens per replicate. Results: The results show that aged corn significantly decreased the content of low-density lipoprotein cholesterol (p<0.05), and reduced chemokine-like receptor 1 (CMKLR1) mRNA expression (p<0.05) in the liver compared to controls. Diet with VE did not alter the content of crude fat and cholesterol (p>0.05), or acetyl-CoA carboxylase, lipoprotein lipase, fatty acid synthase or CMKLR1 mRNA expression (p>0.05) in the liver among treatment groups. Aged corn significantly increased the content of malondialdehyde (MDA) (p<0.05) and decreased superoxide dismutase (SOD) activity (p<0.05) in the liver. The VE increased the content of MDA (p<0.05) but decreased glutathione peroxidase (GSH-Px) activity in serum (p<0.01) and in the ovaries (p<0.05). Adding VE at 20 and 100 IU/kg significantly increased GSH-Px activity (p<0.05) in liver and in serum (p<0.01), 100 IU/kg VE significantly increased SOD activity (p<0.05) in serum. Aged corn had no significant effects on GSH-Px mRNA or SOD mRNA expression (p<0.01) in the liver and ovaries. Addition of 100 IU/kg VE could significantly increase SOD mRNA expression (p<0.01) in the liver and ovary. Conclusion: Aged corn affected lipid metabolism and decreased the antioxidant function of laying hens. Dietary VE supplementation was unable to counteract the negative effects of aged corn on lipid metabolism. However, addition of 100 IU/kg VE prevented aged corninduced lipid peroxidation in the organs of laying hens.

Precision measurement of the branching fractions of J/ψ→π⁺π^-π⁰ and ψ^'→π⁺π^-π⁰

BESIII Collaboration,Ablikim, M.,Achasov, M.N.,Alberto, D.,Ambrose, D.J.,An, F.F.,An, Q.,An, Z.H.,Bai, J.Z.,Baldini Ferroli, R.B.F.,Ban, Y.,Becker, J.,Berger, N.,Bertani, M.B.,Bian, J.M.,Boger, E.,Bon North-Holland Pub. Co 2012 Physics letters: B Vol.710 No.4

We study the decays of the J/ψ and ψ<SUP>'</SUP> mesons to π<SUP>+</SUP>π<SUP>-</SUP>π<SUP>0</SUP> using data samples at both resonances collected with the BES III detector in 2009. We measure the corresponding branching fractions with unprecedented precision and provide mass spectra and Dalitz plots. The branching fraction for J/ψ→π<SUP>+</SUP>π<SUP>-</SUP>π<SUP>0</SUP> is determined to be(2.137+/-0.004 (stat.)<SUB>-0.056</SUB><SUP>+0.058</SUP> (syst.)<SUB>-0.026</SUB><SUP>+0.027</SUP> (norm.))x10<SUP>-2</SUP>, and the branching fraction for ψ<SUP>'</SUP>→π<SUP>+</SUP>π<SUP>-</SUP>π<SUP>0</SUP> is measured as(2.14+/-0.03 (stat.)<SUB>-0.07</SUB><SUP>+0.08</SUP> (syst.)<SUB>-0.08</SUB><SUP>+0.09</SUP> (norm.))x10<SUP>-4</SUP>. The J/ψ decay is found to be dominated by an intermediate ρ(770) state, whereas the ψ<SUP>'</SUP> decay is dominated by di-pion masses around 2.2 GeV/c<SUP>2</SUP>, leading to strikingly different Dalitz distributions.