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Ana L. Popovic,Jelena D. Rusmirovic,Zlate Velickovic,Tihomir Kovacevic,Aleksandar Jovanovic,Ilija Cvijetic,Aleksandar D. Marinkovic 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.93 No.-
In-depth kinetic and column adsorption study for diclofenac, DCF, heavy-metal and oxyanions adsorptionon highly effective amino-functionalized lignin-based microsphere adsorbent (A-LMS) is examined. TheA-LMS was synthesized via inverse suspension copolymerization of industrial kraft lignin with the aminocontaining grafting-agent (polyethylene imine), and an epoxy chloropropane cross-linker. The batchadsorption results indicated process spontaneity and feasibility of a high removal capacity: DCF(151.13)>>Cd2+(74.84)>Cr(VI)(54.20)>As(V)(53.12)>Ni2+(49.42 mg g 1). The quantum chemical calculatedinteraction energies reveal stabilization of the A-LMS/DCF complex through the electrostatics and vander Waals interactions. The results from the pseudo-second order and Weber-Morrisfitting indicate a fastremoval rate; thus, column tests were undertaken. The single resistance mass transfer model, i.e. themass transfer (kfa) and diffusion coefficient (Deff), shows pore diffusional transport as a rate limiting step. Thefitting of thefixed bed column data with empirical models demonstrates the influences offlow rateand adsorbate inlet concentration on the breakthrough behavior. Pore surface diffusion modeling (PSDM)expresses mass transport under applied hydraulic loading rates, calculated breakthrough pointadsorption capacities: Cd2+(58.1)>Cr(VI)(54.1)>As(V)(50.9)>>Ni2+(42.9 mg g 1)), without performingthe experimentation on a full pilot-scale level, further confirms the high applicability of the A-LMS biobasedadsorbent.
Ivanovic, Zarko,Perovic, Tatjana,Popovic, Tatjana,Blagojevic, Jovana,Trkulja, Nenad,Hrncic, Snjezana The Korean Society of Plant Pathology 2017 Plant Pathology Journal Vol.33 No.1
Citrus blast caused by bacterium Pseudomonas syringae is a very important disease of citrus occuring in many areas of the world, but with few data about genetic structure of the pathogen involved. Considering the above fact, this study reports genetic characterization of 43 P. syringae isolates obtained from plant tissue displaying citrus blast symptoms on mandarin (Citrus reticulata) in Montenegro, using multilocus sequence analysis of gyrB, rpoD, and gap1 gene sequences. Gene sequences from a collection of 54 reference pathotype strains of P. syringae from the Plant Associated and Environmental Microbes Database (PAMDB) was used to establish a genetic relationship with our isolates obtained from mandarin. Phylogenetic analyses of gyrB, rpoD, and gap1 gene sequences showed that P. syringae pv. syringae causes citrus blast in mandarin in Montenegro, and belongs to genomospecies 1. Genetic homogeneity of isolates suggested that the Montenegrian population might be clonal which indicates a possible common source of infection. These findings may assist in further epidemiological studies of this pathogen and for determining mandarin breeding strategies for P. syringae control.
Aleksandra Petrovic,Nebojsa Cvetkovic,Dragica Popadic,Radmila Popovic,Svetlana Ibric,Svetlana Trajkovic,Zorica Djuric 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.12
Using mixture experimental design, the effect of carbomer (Carbopol® 971P NF) and hydroxypropylmethylcellulose (Methocel® K100M or Methocel® K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.
Aleksandra Petrovic,Svetlana Ibric,Svetlana Trajkovic,Radmila Popovic,Zorica Djuric,Dragica Popadic 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.7
The purpose of this study was to investigate the effect of various in vitro test conditions, on the release properties of theophylline (TP) from aminophylline (AP) matrices based on different hydroxypropylmethylcellulose (HPMC) ratio and viscosity grades. The General full factorial experimental design 3 × 3 × 3 was used, based on three independent variables: applied in vitro test (X1), HPMC/drug ratio (X2) and polymer viscosity grade (X3). The drug release percent at 2h (Y2h), 4h (Y4h) and 8 h (Y8h) and time for 50% of TP release from matrices (YT50%) were response variables. Three in vitro tests were used: Test 1 and Test 4 (Theophylline Extended-release Capsules, USP 30) and Half-change method. According to factorial design analyses, in vitro test was the most significant factor influencing mechanism and amount of drug release. For Half Change method erosion was the predominant mechanism indicating Case – II transport, while for Test 1 the release mechanism were followed by both diffusion and erosion. The lowest release exponent n values, obtained from Ritger-Pepass equation, for Test 4 indicate diffusion process inclining from Fickian diffusion to Anomalous transport. Therefore, it is in the stage of development, useful to consider the influence of various in vitro test conditions on the formulation, in order to choose an optimal test for the purpose of future drug release examination.
Soluble ST2 Levels and Left Ventricular Structure and Function in Patients With Metabolic Syndrome
Vera Celic,Anka Majstorovic,Biljana Pencic-Popovic,Aleksandra Sljivic,Natalia Lopez-Andres,Ignacio Roy,Elena Escribano,Maite Beunza,Amaia Melero,Federico Floridi,Laura Magrini,Rossella Marino,Gerardo 대한진단검사의학회 2016 Annals of Laboratory Medicine Vol.36 No.6
Background: A biomarker that is of great interest in relation to adverse cardiovascular events is soluble ST2 (sST2), a member of the interleukin family. Considering that metabolic syndrome (MetS) is accompanied by a proinflammatory state, we aimed to assess the relationship between sST2 and left ventricular (LV) structure and function in patients with MetS. Methods: A multicentric, cross-sectional study was conducted on180 MetS subjects with normal LV ejection fraction as determined by echocardiography. LV hypertrophy (LVH) was defined as an LV mass index greater than the gender-specific upper limit of normal as determined by echocardiography. LV diastolic dysfunction (DD) was assessed by pulse-wave and tissue Doppler imaging. sST2 was measured by using a quantitative monoclonal ELISA assay. Results: LV mass index (β=0.337, P<0 .001, linear regression) was independently associated with sST2 concentrations. Increased sST2 was associated with an increased likelihood of LVH [Exp (B)=2.20, P=0.048, logistic regression] and increased systolic blood pressure [Exp (B)=1.02, P=0.05, logistic regression]. Comparing mean sST2 concentrations (adjusted for age, body mass index, gender) between different LV remodeling patterns, we found the greatest sST2 level in the group with concentric hypertrophy. There were no differences in sST2 concentration between groups with and without LV DD. Conclusions: Increased sST2 concentration in patients with MetS was associated with a greater likelihood of exhibiting LVH. Our results suggest that inflammation could be one of the principal triggering mechanisms for LV remodeling in MetS.
An additive manufacturing benchmark artifact and deviation measurement method
Nikola Vorkapic,Milos Pjevic,Mihajlo Popovic,Nikola Slavkovic,Sasa Zivanovic 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.7
Additive manufacturing (AM) is established as a new class for fabricating 3D physical prototypes layer by layer. Given that a large number of different 3D printers (AM machines) are present now (as a product of renowned manufacturers or custom-made products), the design of a benchmark artifact for evaluation of the AM processes is very important. This implies quality evaluation of the capabilities and limitations of each AM process and also the geometrical testing of the 3D printers. The paper proposes a benchmark artifact, according to the criteria for modeling of the benchmark artifact, with a large number of basic features for its geometrical evaluation. Although there are a large number of commercial software packages, this paper also proposes a low-cost developed measurement method of geometrical deviation that could be also adjustable for requirements in an easy way. Verification of the proposed deviation measurement method has been done by several experiments. The experiments include fabrication of the proposed benchmark artifact on available 3D printers by an FFF (fused filament fabrication) process also known as FDM (fused deposition modeling), and after that its scanning. Verification is done by comparing quality evaluation of each fabricated part by developed method and commercial software.
Optimal Utilization of Low Voltage GaN HEMT in High Frequency Boost Converter
Wenbo Wang,Frans Pansier,Jelena Popovic,J.A. Ferreira 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
In this paper, investigations on optimal topology and operation mode for low voltage GaN HEMT are performed. Analytical loss model of GaN HEMT, in which influences of circuit and package parasitics are accounted for, is developed as a tool to analyze losses in GaN HEMT in different switching conditions. Analysis results shows that when applied in both Vout〈2Vin and Vout〉2Vin situations in Boundary Conduction Mode with Valley Switching(BCM-VS) in a boost converter, where GaN HEMT is switched on when voltage across it is lowered, switching loss can be greatly reduced. Switching loss reduction results not only from the exemption of discharging the large output capacitance of GaN HEMT at high voltage, but also from the fact that parasitic inductance has much less effects on switching loss in GaN HEMT in BCM-VS than in Continuous Conduction Mode (CCM). Limitations and design tradeoffs when GaN HEMT is applied in BCM-VS are also revealed. Forward voltage of GaN HEMT in reverse conduction is high and its conduction should be prevented when Vout〉 to achieve conduction loss reduction. This further loss reduction can be realized by switching on transistor before valley point. Besides, in BCM-VS, overvoltage on GaN HEMT is larger and oscillatory energy dissipation in circuit is higher than in CCM due to higher turn off current. Paralleling external capacitor to the transistor helps to ease voltage stress; however turn on loss will be increased. This loss increase is more severe in the case of Vout〈2Vin than Vout〉2Vin. Trade-offs on the selection of proper external capacitor value exists between increased switching loss and reduced voltage stress. Experimental setup is built to verify and demonstrate the analysis.