A Strategy for Signal Recognition under Adverse Conditions

Peter Holstein,Michael Koch,Diane Hirschfeld,Rudiger Hoffmann,Daniel Bader,Klaus Augsburg 한국소음진동공학회 2003 한국소음진동공학회 국제학술대회논문집 Vol.2003 No.8

System Strategies for Time-Domain Emission Measurements above 1 GHz

Christian Hoffmann,Hassan Hani Slim,Peter Russer 한국전자파학회JEES 2011 Journal of Electromagnetic Engineering and Science Vol.11 No.4

The application of time-domain methods in emission measurement instruments allows for a reduction in scan time by several orders of magnitude and for new evaluation methods to be realized such as the real-time spectrogram to characterize transient emissions. In this paper two novel systems for time-domain EMI measurements above 1 GHz are presented. The first system combines ultra-fast analog-to-digital-conversion and real-time digital signal processing on a field-programmable-gate-array (FPGA) with ultra-broadband multi-stage down-conversion to enable measurements in the range from 10 Hz to 26 GHz with high sensitivity and full-compliance with the requirements of CISPR 16-1-1. The required IF bandwidths were added to allow for measurements according to MIL-461F and DO-160F. The second system realizes a system of time-interleaved analog-to-digital converters (ADCs) and has an upper bandwidth limit of 4 GHz. With the implementation of an automatic mismatch calibration, the system fulfills CISPR 16-1-1 dynamic range requirements. Measurements of the radiated emissions of electronic consumer devices and household appliances like the non-stationary emissions of a microwave oven are presented. A measurement of a personal computer’s conducted emissions on a power supply line according to DO-160F is given.

Liquid Injection ALD of Pb(Zr,Ti)O[sub x] Thin Films by a Combination of Self-Regulating Component Oxide Processes

Watanabe, Takayuki,Hoffmann-Eifert, Susanne,Peter, Frank,Mi, Shaobo,Jia, Chunlin,Hwang, Cheol Seong,Waser, Rainer The Electrochemical Society 2007 Journal of the Electrochemical Society Vol.154 No.12

Bilateral Hypertrophic Olivary Degeneration in Wilson Disease

Josephin Otto,Peter Guenther,Karl-Titus Hoffmann 대한영상의학회 2013 Korean Journal of Radiology Vol.14 No.2

Hypertrophic olivary degeneration resulting from lesions of the dento-rubro-olivary pathway, also called Guillain-Mollarettriangle, has been described previously in a number of cases. Reports about bilateral hypertrophic olivary degeneration of the inferior olivary nuclei are very limited, and the magnetic resonance imaging findings of hypertrophic olivary degeneration in Wilson disease have not yet been described to the best of our knowledge. Herein, we present the first report of bilateral hypertrophic olivary degeneration diagnosed by magnetic resonance imaging in a patient suffering from Wilson disease.

Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potential

Arne Warth,Esther Herpel,Sabine Krysa,Hans Hoffmann,Philipp A. Schnabel,Peter Schirmacher,Gunhild Mechtersheimer,Hendrik Bläker 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.5

Pulmonary carcinoids are infrequent neoplasms of the lung that normally display a less aggressive biological behavior compared to small cell and non-small cell lung cancers. Approximately 15-25% of carcinoids, in particular atypical carcinoids, show lymph node metastasis and have a worse prognosis than their non-metastasized counterparts. To date, there is no morphological or molecular marker that may help to differentiate between carcinoids that metastasize and carcinoids of identical differentiation that show only local tumor growth. In this study, we analyzed 7 metastasized and 10 non-metastasized pulmonary carcinoids for chromosomal and microsatellite instability in order to determine whether microsatellite instability or chromosomal imbalances are associated with metastasis. Due to the rare occurrence of metastasized carcinoids we compared our results of chromosomal instability with the hitherto published comparative genomic hybridization (CGH) profiles of pulmonary carcinoids, for which information about the absence or presence of metastasis was available. While microsatellite instability was not detected we found chromosomal instability as a common event in pulmonary carcinoids with an increase of frequency and extent of chromosomal alterations in atypical and metastasized carcinoids. These findings are in accordance with the collected and herein compiled data of previous studies and indicate increasing numbers of chromosomal imbalances to play a role in the sequential process of tumor development and metastasis. Pulmonary carcinoids are infrequent neoplasms of the lung that normally display a less aggressive biological behavior compared to small cell and non-small cell lung cancers. Approximately 15-25% of carcinoids, in particular atypical carcinoids, show lymph node metastasis and have a worse prognosis than their non-metastasized counterparts. To date, there is no morphological or molecular marker that may help to differentiate between carcinoids that metastasize and carcinoids of identical differentiation that show only local tumor growth. In this study, we analyzed 7 metastasized and 10 non-metastasized pulmonary carcinoids for chromosomal and microsatellite instability in order to determine whether microsatellite instability or chromosomal imbalances are associated with metastasis. Due to the rare occurrence of metastasized carcinoids we compared our results of chromosomal instability with the hitherto published comparative genomic hybridization (CGH) profiles of pulmonary carcinoids, for which information about the absence or presence of metastasis was available. While microsatellite instability was not detected we found chromosomal instability as a common event in pulmonary carcinoids with an increase of frequency and extent of chromosomal alterations in atypical and metastasized carcinoids. These findings are in accordance with the collected and herein compiled data of previous studies and indicate increasing numbers of chromosomal imbalances to play a role in the sequential process of tumor development and metastasis.

High-Resolution Simulations for Vietnam - Methodology and Evaluation of Current Climate

Jack Katzfey,Kim Nguyen,John McGregor,Peter Hoffmann,Suppiah Ramasamy,Hiep Van Nguyen,Mai Van Khiem,Thang Van Nguyen,Kien Ba Truong,Thang Van Vu,Hien Thuan Nguyen,Tran Thuc,Doan Ha Phong,Bang Thanh Ng 한국기상학회 2016 Asia-Pacific Journal of Atmospheric Sciences Vol.52 No.2

To assist the government of Vietnam in its efforts to better understand the impacts of climate change and prioritise its adaptation measures, dynamically downscaled climate change projections were produced across Vietnam. Two Regional Climate Models (RCMs) were used: CSIRO’s variable-resolution Conformal-Cubic Atmospheric Model (CCAM) and the limited-area model Regional Climate Model system version 4.2 (RegCM4.2). First, global CCAM simulations were completed using bias- and variance-corrected sea surface temperatures as well as sea ice concentrations from six Coupled Model Intercomparison Project Phase 5 (CMIP5) global climate models. This approach is different from other downscaling approaches as it does not use any atmospheric fields from the GCMs. The global CCAM simulations were then further downscaled to 10 km using CCAM and to 20 km using RegCM4.2. Evaluations of temperature and precipitation for the current climate (1980-2000) were completed using station data as well as various gridded observational datasets. The RCMs were able to reproduce reasonably well most of the important characteristics of observed spatial patterns and annual cycles of temperature. Average and minimum temperatures were well simulated (biases generally less than 1oC), while maximum temperatures had biases of around 1oC. For precipitation, although the RCMs captured the annual cycle, RegCM4.2 was too dry in Oct.-Nov. (−60% bias), while CCAM was too wet in Dec.- Mar. (130% bias). Both models were too dry in summer and too wet in winter (especially in northern Vietnam). The ability of the ensemble simulations to capture current climate increases confidence in the simulations of future climate.

Five-fold Gastrointestinal Electrical Stimulation With Electromyography-based Activity Analysis: Towards Multilocular Theranostic Intestinal Implants

Jonas F Schiemer,Axel Heimann,Karin H Somerlik-Fuchs,Roman Ruff,Klaus-Peter Hoffmann,Jan Baumgart,Manfred Berres,Hauke Lang,Werner Kneist 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.3

Background/AimsMotility disorders are common and may affect the entire gastrointestinal (GI) tract but current treatment is limited. Multilocularsensing of GI electrical activity and variable electrical stimulation (ES) is a promising option. The aim of our study is to investigate theeffects of adjustable ES on poststimulatory spike activities in 5 GI segments. MethodsSix acute porcine experiments were performed with direct ES by 4 ES parameter sets (30 seconds, 25 mA, 500 microseconds or1000 microseconds, 30 Hz or 130 Hz) applied through subserosal electrodes in the stomach, duodenum, ileum, jejunum, and colon. Multi-channel electromyography of baseline and post-stimulatory GI electrical activity were recorded for 3 minutes with hook needleand hook-wire electrodes. Spike activities were algorithmically calculated, visualized in a heat map, and tested for significance byPoisson analysis. ResultsPost-stimulatory spike activities were markedly increased in the stomach (7 of 24 test results), duodenum (8 of 24), jejunum (23 of24), ileum (18 of 24), and colon (5 of 24). ES parameter analysis revealed that 80.0% of the GI parts (all but duodenum) required apulse width of 1000 microseconds, and 60.0% (all but jejunum and colon) required 130 Hz frequency for maximum spike activity. Fivereaction patterns were distinguished, with 30.0% earlier responses (type I), 42.5% later or mixed type responses (type II, III, and X),and 27.5% non-significant responses (type 0). ConclusionsMultilocular ES with variable ES parameters is feasible and may significantly modulate GI electrical activity. Automatedelectromyography analysis revealed complex reaction patterns in the 5 examined GI segments.

The Influence of IgE on Cultured Human Mast Cells

Pernille Munk Frandsen,Inge Jacoba Maria Kortekaas Krohn,Hans Jürgen Hoffmann,Peter Oluf Schiøtz 대한천식알레르기학회 2013 Allergy, Asthma & Immunology Research Vol.5 No.6

Purpose: The mast cell plays a pivotal role in the human immune response. Crosslinking of 2 IgE molecules bound to the high affinity IgE receptor(FcεRI) on the surface of the mast cell results in mast cell degranulation and the release of several proinflammatory mediators. Patients with type-I allergyhave increased levels of IgE in the blood compared to healthy individuals. Methods: In a 6-week culture system of stem cells to human mastcells we investigated the effect of the concentration of IgE. The mast cells were cultured with different concentrations of IgE for the last 10 days ofthe maturation period. It was observed how the IgE concentration affects the histamine release, FcεRI density on the mast cell surface and the concentrationof other mediators. Results: A clear correlation between IgE concentration in culture medium and the release of histamine upon activationwas observed. It showed a bell-shaped dose response curve, with maximal response around an IgE-concentration of 250 ng/mL. Furthermore,the sensitivity of the mast cells and surface density of FcεRI on mast cell surface was also influenced by the IgE concentration in the culture medium. Conclusions: IgE in the culture medium during the last 10 days of mast cell maturation influences the release of the preformed mediator histamineafter mast cell activation and the density of FcεRI on the mast cell surface. The release of the de novo synthetized mediator prostaglandin D2and the expression of chymase and tryptase are not influenced by IgE in culture medium.

Whither systems medicine?

Rolf Apweiler,Tim Beissbarth,Michael R Berthold,Nils Blüthge,Yvonne Burmeister,Olaf Dammann,Andreas Deutsch,Friedrich Feuerhake,Andre Franke,Jan Hasenauer,Steve Hoffmann,Thomas Höfer,Peter LM Jansen,L 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

New technologies to generate, store and retrieve medical and research data are inducing a rapid change in clinical and translational research and health care. Systems medicine is the interdisciplinary approach wherein physicians and clinical investigators team up with experts from biology, biostatistics, informatics, mathematics and computational modeling to develop methods to use new and stored data to the benefit of the patient. We here provide a critical assessment of the opportunities and challenges arising out of systems approaches in medicine and from this provide a definition of what systems medicine entails. Based on our analysis of current developments in medicine and healthcare and associated research needs, we emphasize the role of systems medicine as a multilevel and multidisciplinary methodological framework for informed data acquisition and interdisciplinary data analysis to extract previously inaccessible knowledge for the benefit of patients.