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Park, Hee-Jin,Son, Changmin,Park, Sang-Hu Korean Society for Precision Engineering 2014 International Journal of Precision Engineering and Vol.15 No.11
We proposed a new process to fabricate micro-scale polymer wrinkles on a curved surface. A UV-curable resin layer on a substrate is weakly polymerized by a small dose of UV-light. By the exposure, there is a curing gradient through the thickness in the resin layer; fully-polymerized zone on the surface and sol-gel inside. Then, it is cured completely under temperature of <TEX>$28^{\circ}C$</TEX>. According to the different states between surface and inside of the layer, a compressive force is generated on the surface zone during a fully-curing process. Through this work, regular surface wrinkles are generated on the surface with a width of around <TEX>$20{\mu}m$</TEX>. To reduce the total processing time, an approach of thermal curing after weak-polymerization is proposed. We believed that the proposed method can be applied to make wrinkles on arbitrary-shaped surface for applications to diverse research fields such as heat transfer and catalyst enhancement.
HPLC–MS/MS analysis of mesupron and its application to a pharmacokinetic study in rats
Park, Changmin,Ha, Joong Gyu,Choi, Seungmok,Kim, Eunyoung,Noh, Keumhan,Shin, Beom Soo,Kang, Wonku Elsevier 2018 Journal of pharmaceutical and biomedical analysis Vol.150 No.-
<P><B>Abstract</B></P> <P>Mesupron, the first-in-class inhibitor of urokinase-type plasminogen activator (uPA) is known to regulate cell proliferation and migration, and is under investigation for the treatment of metastatic breast cancer. In this study, a quantification method was developed for the determination of mesupron in rat plasma using liquid chromatography with a tandem mass spectrometry (LC–MS/MS). After protein precipitation with acetonitrile including itraconazole (internal standard, IS), the analytes were chromatographed on a reversed phased column with a mobile phase of acetonitrile and water (7:3, v/v, including 0.1% formic acid). The ion transitions of the precursor to the product ion were principally protonated ion [M+H]<SUP>+</SUP> at <I>m</I>/<I>z</I> 630.4→398.3 for mesupron and 705.2→392.1 for the IS. The accuracy and precision of the assay were in accordance with FDA regulations for the validation of bioanalytical methods This method was successfully applied to a pharmacokinetic study of mesupron after intravenous administration in rats.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mesupron is the first-in-class inhibitor of urokinase-type plasminogen activator. </LI> <LI> Mesupron is under investigation for the treatment of metastatic breast cancer. </LI> <LI> A sensitive determination method of mesupron was developed using LC–MS/MS. </LI> <LI> This method was successfully applied to a pharmacokinetic study of mesupron after intravenous administration in rats. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Light Quality Effects on the Growth, Phytochemicals and Ion Contents of Red Beet (Beta vulgaris L.)
Changmin Oh,Jai-Eok Park,Yang-Ju Son,Nam-Il Park,Chu Won Nho,Gyhye Yoo 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10
Red beet (Beta vulgaris L.), one of the plants of the Chenopodiaceae family, consumed and cultivated all of the world. It contains a plenty of inorganic nitrates and a variety of secondary metabolites including betalains, flavonoids, and polyphenols, which known to improve human health. Because most red beets are cultivated in open field, the concentration of their ingredients are affected by their surrounding environments (drought, cold, pests etc.). A Vertical Farm (VF), an indoor facility to raise plants in multiple layers with artificial environment, provides constant and planned environment to plants, leading to supplementation of stable plants with high concentrated components. In the present study, we investigated the effect of light quality on red beets and its components in a vertical farm. The light used in the experiment was Control (CON, Red:Blue-White = 2:1), RED (RED, Red:Blue-White = 4:1) and Blue-White (BW, Red:Blue-White = 2: 3) was set. At the 13 Weeks after sowing (WAS), RED treated shoots significantly elevated Total phenolic contents (TPC) compared to other treatments and antioxidative property was increased 3 times higher in shoots of RED treated than in shoots of CON treated at 13WAS. The fructose and glucose content of shoot and root increased significantly in RED treated beets than in CON treated one, while the sucrose content in the roots was decreased by RED or BW treatment at the 12 WAS and 13 WAS. RED treated roots had significantly higher betanin level at the 13 WAS compared to CON treated one. Vulgaxanthin-1 content of shoots was increased in plants subjected to RED treatment but decreased in plants influenced to BW treatment compared to CON treatment, respectively. Inorganic nitrates and Chloride was increased by BW treatment not RED compared to CON. In conclusion, light quality alters the concentration of beet components and RED light elevated TPC, sugars and betalains. Therefore, the elevation of RED light when growing red beets could be a way to produce improved red beets for human health.
박창민(Changmin Park),조구연(Guyeon Jo),황용기(Hwang Yonggi),김재정(Jayjeong kim) 한국정보과학회 2011 한국정보과학회 학술발표논문집 Vol.38 No.2C
메타볼(metaball)로 대표되는 음함수곡면(implicit surface)은 불규칙하고 부드러운 형상의 물체를 모델링하는데 널리 쓰이지만 그 골격요소(skeletal element)의 형태에 따라 다양한 변화를 보인다. 그 중 나무와 같은 식물의 표현에는 직선이나 곡선이 적절하지만 균일한 굵기(유효반경)로서는 표현이 다소 제한적이다. 이에 본 논문에서는 굵기가 가변적인 선분이나 원호를 사용할 수 있는 방법을 제안하며 interval method에 의한 광선추적법으로 렌더링한다. 가변 굵기의 골격요소의 도입은 고정 굵기에 비해 난이도가 훨씬 높은 바 성능이 크게 떨어지지 않으면서도 적은 수의 골격요소를 이용하여 자연스런 식물의 형태를 표현하는 것이 가능함을 보인다.
Residual stress and crack initiation in laser clad composite layer with Co-based alloy and WC+NiCr
Lee, Changmin,Park, Hyungkwon,Yoo, Jaehong,Lee, Changhee,Woo, WanChuck,Park, Sunhong Elsevier 2015 APPLIED SURFACE SCIENCE - Vol.345 No.-
<P><B>Abstract</B></P> <P>Although laser cladding process has been widely used to improve the wear and corrosion resistance, there are unwanted cracking issues during and/or after laser cladding. This study investigates the tendency of Co-based WC+NiCr composite layers to cracking during the laser cladding process. Residual stress distributions of the specimen are measured using neutron diffraction and elucidate the correlation between the residual stress and the cracking in three types of cylindrical specimens; (i) no cladding substrate only, (ii) cladding with 100% stellite#6, and (iii) cladding with 55% stellite#6 and 45% technolase40s. The microstructure of the clad layer was composed of Co-based dendrite and brittle eutectic phases at the dendritic boundaries. And WC particles were distributed on the matrix forming intermediate composition region by partial melting of the surface of particles. The overlaid specimen exhibited tensile residual stress, which was accumulated through the beads due to contraction of the coating layer generated by rapid solidification, while the non-clad specimen showed compressive. Also, the specimen overlaid with 55wt% stellite#6 and 45wt% technolase40s showed a tensile stress higher than the specimen overlaid with 100% stellite#6 possibly, due to the difference between thermal expansion coefficients of the matrix and WC particles. Such tensile stresses can be potential driving force to provide an easy crack path ways for large brittle fractures combined with the crack initiation sites such as the fractured WC particles, pores and solidification cracks. WC particles directly caused clad cracks by particle fracture under the tensile stress. The pores and solidification cracks also affected as initiation sites and provided an easy crack path ways for large brittle fractures.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Major problem, clad cracking in laser cladding process, was researched. </LI> <LI> Residual stress measurements were performed quantitatively by neutron diffraction method along the surface of specimens. </LI> <LI> Relationship between the residual stress and crack initiation was showed clearly. </LI> <LI> Ceramic particle effect in the metal matrix was showed from the results of residual stress measurements. </LI> <LI> Initiation sites of generating clad cracks were specifically studied in MMC coatings. </LI> </UL> </P>
Curved Roller Blind 개발을 통한 Headroom 공간 최적 설계
박창민(Changmin Park),정선기(Sunkee Jung),최수윤(Suyun Choi) 한국자동차공학회 2017 한국자동차공학회 부문종합 학술대회 Vol.2017 No.5
Normally, the Panorama Roof is mounted on the ceiling of the vehicle. From the driving point of the vehicle, it’s divided into the Roof Glass that gives passengers a feeling of refreshment through the exchange of inside / outside air and the sense of openness that is exposed to the surrounding environment from the closed interior space of the vehicle and the Roller Blind that blocks light transmitted from the outside of the vehicle and maintains the internal temperature. The Roof Glass has a composite curvature in the full width direction on the outside of the vehicle, while the Roller Blind of interior has the full width direction linear structure. As a result, the interior of vehicle equipped with the Panorama Roof giving the passenger the sense of openness, while has a disadvantage that the interior space is narrowed by the existence of the dead area between the Roof Glass and the Roller Blind when the Roller Blind is closed. This paper describes the development of Curved Roller Blind with similar to curvature of Roof Glass in full length and full width direction for minimizing the dead area between the Roof Glass and the Roller Blind, which will contribute to the optimal design of the headroom space and will give the passengers a greater sense of openness.