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      • KCI등재후보

        Reliability analysis for lateral stabilityof tongwamen bridge

        Pan Sheng-Shan,Shi Lei,Tan Yong-Gang,Zhang Zhe 국제구조공학회 2011 Steel and Composite Structures, An International J Vol.11 No.5

        Tongwamen Bridge is a critical link between Dongmen Island and the land in Shipu town, Zhejiang province, China. It is a 238 m span, half-through, concrete-filled steel tubular (CFST) X-type arch bridge. The width of the deck is only 10 m, yielding a width-to-span ratio of 1/23.8. The plane truss type section rib was adopted, which made of two CFST chords and web member system. The lateral stability is the key issue to this bridge. However, the existing researches on Tongwamen Bridge’s lateral stability are all the deterministic structural analysis. In this paper, a new strategy for positioning sampling points of the response surface method (RSM), based on the composite method combining RSM with geometric method for structural reliability analysis, is employed to obtain the reliability index of lateral stability. In addition the correlated parameters were discussed in detail to find the major factors. According to the analysis results, increasing the stiff of lateral braces between the arch ribs and setting the proper inward-incline degree of the arch rib can enhance obviously the reliability of lateral stability. Moreover, the deck action of non-orienting force is less than the two factors above. The calculated results indicate that the arch ribs are safe enough to keep excellent stability, and it provides the foundation that the plane truss rib would be a competitive solution for a long-span, narrow, CFST arch bridge.

      • SSCISCIESCOPUSKCI등재
      • KCI우수등재

        The Fingerprinting of Huangjinju Powder for Injection on Chinese Patent Medicine by XRD Fourier

        Pan, Yan-Li,Zhang, Gui-Jun,Gong, Ning-Bo,Wu, Yun-Shan,Lu, Yang,Luo, Rong,Choi, Ho-Young The Korean Society of Medicinal Crop Science 2006 한국약용작물학회지 Vol.14 No.2

        The purpose is to study the identification method of Huangjinju powder for injection and the medicinal materials by the fingerprint off-ray Diffraction Fourier (XRDF). We used the same method on both the studying of Huangjinju and the medicinal materials. Then we selected a few components alignment to compare. We analyzed the data by setting up the deviation $d({\AA})$ as ${\pm}0.05$ to calculate the rate of special mark on the sample (Px) and on the patent (P). The special XRDF of Huangjinju$[d({\AA})/(I/I_0)]$ have 5 peaks that have not expressed in medicinal materials. Therefore Px is 22.73%. Flos Trollii Chinensis has 3 special marks and Px is 17.65%. Flos Chrysanthemi Indici has 1 special mark and Px is 3.57%. Its coincided interplanar spacing with the patent is $2.907{\AA}$. Flos Lonicerae Japonicae has 6 special marks and Px is 23.08%. Its special mark in the patent are 4.95/14 and 4.50/15, respectively. The P is 9.09%. Its coincided interplanar spacing with the patent is $2.910{\AA}\;and\;3.05{\AA}$, respectively. The number of special XRDF mark peaks of baicalin is 9 and Px is 18.37%. Its coincided interplanar spacing with the patent is $2.910{\AA}$. It has visible mark and specificity adopting XRDF fingerprint to identify Huangjinju and medicinal materials. Establishing the quality standard is a synthetic index that depends both on special marks in the medicinal materials of the patent and on the coincidence peak data.

      • KCI등재

        A Research on the Paradigm of Interaction Based on Attributes

        Shan Shu Ya,Pan Young Hwan 한국융합학회 2021 한국융합학회논문지 Vol.12 No.5

        본 연구의 목표는 인터렉션이 하나의 영역으로서 묘사 가능성을 증명하는 것이다. 또한 패러다임화된 시각으로 인터렉션을 이해하려고 시도하는 것이다. 일반적으로 통용되는 규칙에 기초하여 이론모델을 구축하고, 디자이너들에게 인터렉션의 본질을 효과적으로 이해하도록 돕고, 현재 인터렉션 설계가 주로 기초적인 수단으로 의존하게 됨으로써 파생되는 인력과 시간비용의 낭비를 방지하는 것이다. 2000년도에 처음으로 인터렉션 패러다임화의 개념을 제시한 이래 지금까지 관련된 연구에는 일부 결함이 존재한다. 예를들어 제시된 이론 모델들이 서로 다른 척도에서 만들어졌 거나, 혹은 접근하는 시각에 객관성이 결여된 것, 그리고 주로 연구자의 개인적 경험 등에서 오는것 등이다. 본 연구의 가치와 뛰어난 성과는 그 전체적 기초가 파일검색이라는 토대위에 구축되었다. 최근 2000년 이래 현재까지의 인터렉 션 패러다임화에 관한 연구 총 21편의 수집을 통하여 인터렉션 속성 모델 19개,인터렉션 속성 포함 총 174개를 추출 하였다. 또한 이 174개 속성에 대하여 보다 통일된 표준 척도에 근거를 두고 집합류의 연구수단을 이용하여 재분류 귀납함으로써 두 개의 이론 모델을 한 조로 만들었다. 이 두 모형은 각각 인터렉션 운용과 인터렉션 체험의 시각으로 접근하며, 그중 각 모델은 각각 6개의 독립된 속성을 포함한다. 이 인터렉션 모델의 제시 및 집합류 데이터의 분석은 각 인터렉션 속성이 인터렉션 설계에서 얼마만큼의 주목을 받고 중요한지 밝히는데 도움이 될것이다. 이런 데이터는 디자이너가 디자인 과정에서 힘 분배를 합리적으로 할 수 있게 도와주며, 또한 미래에 인터렉션 설계에 관해 발전공간 을 설계하기 위한 이론적 근거를 제공한다. The aim of this study is to demonstrate interaction as a describable field and tries to understand interaction from the perspective of attributes, thus building a theoretical to help interactive designer understand this field by common rule, rather than waste huge time and labor cost on iteration. Since the concept of interaction language has been brought out in 2000, there are varies of related academical studies, but all with defect such as proposed theoretical models are built on a non-uniform scale, or the analyzing perspective are mainly based on researcher’s personal experience and being too unobjective. The value of this study is the clustered resource of research which mainly based on academical review. It collected 21 papers researched on interaction paradigm or interaction attributes published since 2000, extracting 19 interaction attribute models which contains 174 interaction attributes. Furthermore, these 174 attributes were re-clustered based on a more unified standard scale, and the two theoretical models summarized from it are respectively focuses on interaction control and interaction experience, both of which covered 6 independent attributes. The propose of this theoretical models and the analyzation of the cluster static will contribute on further revealing of the importance of interaction attribute, or the attention interaction attribute has been paid on. Also, in this regard, the interactive designer could reasonably allocate their energy during design process, and the future potential on various direction of interaction design could be discussed.

      • KCI등재

        Endovascular Repair of Blunt Popliteal Arterial Injuries

        Shan Zhong,Xiquan Zhang,Zhong Chen,Peng Dong,Yequan Sun,Wei Zhu,Xiaolin Pan,Deming Qi 대한영상의학회 2016 Korean Journal of Radiology Vol.17 No.5

        Objective: To evaluate the feasibility and effectiveness of endovascular repair for blunt popliteal arterial injuries. Materials and Methods: A retrospective analysis of seven patients with clinical suspicion of popliteal arterial injuries that were confirmed by arteriography was performed from September 2009 to July 2014. Clinical data included demographics, mechanism of injury, type of injury, location of injury, concomitant injuries, time of endovascular procedures, time interval from trauma to blood flow restoration, instrument utilized, and follow-up. All patients were male (mean age of 35.9 ± 10.3 years). The type of lesion involved intimal injury (n = 1), partial transection (n = 2), complete transection (n = 2), arteriovenous fistula (n = 1), and pseudoaneurysm (n = 1). All patients underwent endovascular repair of blunt popliteal arterial injuries. Results: Technical success rate was 100%. Intimal injury was treated with a bare-metal stent. Pseudoaneurysm and popliteal artery transections were treated with bare-metal stents. Arteriovenous fistula was treated with bare-metal stent and coils. No perioperative death and procedure-related complication occurred. The average follow-up was 20.9 ± 2.3 months (range 18–24 months). One patient underwent intra-arterial thrombolysis due to stent thrombosis at 18 months after the procedure. All limbs were salvaged. Stent migration, deformation, or fracture was not found during the follow-up. Conclusion: Endovascular repair seems to be a viable approach for patients with blunt popliteal arterial injuries, especially on an emergency basis. Endovascular repair may be effective in the short-term. Further studies are required to evaluate the long-term efficacy of endovascular repair.

      • KCI등재

        Refolding and Purification of Recombinant Human Interferon-g Expressed as Inclusion Bodies in Escherichia coli Using Size Exclusion Chromatography

        Shan-Jing Yao,Yi-Xin Guan,Hai-Xue Pan,Yong-Gui Gao,Man-Gi Cho 한국생물공학회 2005 Biotechnology and Bioprocess Engineering Vol.10 No.2

        A size exclusion chromatography (SEC) process, in the presence of denaturant in the refolding buffer was developed to refold recombinant human interferon- (rhIFN-) at a high concentration. The rhIFN- was overexpressed in E. coli, resulting in the formation of inactive inclusion bodies (IBs). The IBs were first solubilized in 8 M urea as the denaturant, and then the refolding process performed by decreasing the urea concentration on the SEC column to suppress protein aggregation. The effects of the urea concentration, protein loading mode and column height during the refolding step were investigated. The combination of the buffer-exchange effect of SEC and a moderate urea concentration in the refolding buffer resulted in an efficient route for producing correctly folded rhIFN-, with protein recovery of 67.1% and specific activity up to 1.2 107 IU/mg.

      • KCI등재

        Contributed Mini Review : New paradigms on siRNA local application

        ( Meng Pan ),( Jin Wen Ni ),( Hui Ming He ),( Shan Gao ),( Xiao Hong Duan ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.3

        Small interfering RNA (siRNA) functions through pairing with specific mRNA sequences and results in the mRNA`s degradation. It is a potential therapeutic approach for many diseases caused by altered gene expression. The delivery of siRNA is still a major problem due to its rapid degradation in the circulation. Various strategies have been proposed to help with the cellular uptake of siRNA and short or small hairpin RNA (shRNA). Here, we reviewed recently published data regarding local applications of siRNA. Compared with systemic delivery methods, local delivery of siRNA/shRNA has many advantages, such as targeting the specific tissues or organs, mimicking a gene knockout effect, or developing certain diseases models. The eye, brain, and tumor tissues are ‘hot’ target tissues/ organs for local siRNA delivery. The siRNA can be delivered locally, in naked form, with chemical modifications, or in formulations with viral or non-viral vectors, such as liposomes and nanoparticles. This review provides a comprehensive overview of RNAi local administration and potential future applications in clinical treatment. [BMB Reports 2015; 48(3): 147-152]

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