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Coping with Dementia in the Middle of the COVID-19 Pandemic
Nayoung Ryoo,Jung-Min Pyun,백민재,Jeewon Suh,Min Ju Kang,Min Jeong Wang,Young Chul Youn,양동원,Seong Yoon Kim,박영호,김상윤 대한의학회 2020 Journal of Korean medical science Vol.35 No.42
Multiple neurological complications have been associated with the coronavirus disease-19 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2. This is a narrative review to gather information on all aspects of COVID-19 in elderly patients with cognitive impairment. First, the following three mechanisms have been proposed to underlie the neurological complications associated with COVID-19: 1) direct invasion, 2) immune and inflammatory reaction, and 3) hypoxic brain damage by COVID-19. Next, because the elderly dementia patient population is particularly vulnerable to COVID-19, we discussed risk factors and difficulties associated with cognitive disorders in this vulnerable population. We also reviewed the effects of the patient living environment in COVID-19 cases that required intensive care unit (ICU) care. Furthermore, we analyzed the impact of stringent social restrictions and COVID-19 pandemic-mediated policies on dementia patients and care providers. Finally, we provided the following strategies for working with elderly dementia patients: general preventive methods; dementia care at home and nursing facilities according to the activities of daily living and dementia characteristics; ICU care after COVID-19 infection; and public health care system and government response. We propose that longitudinal follow-up studies are needed to fully examine COVID-19 associated neurological complications, such as dementia, and the efficacy of telemedicine/telehealth care programs.
Guillain–Barré Syndrome After COVID-19 Infection in Korea: A Case Series
Ryoo Nayoung,Son Hyoshin,Kim Jean Hee,Bae Dae Woong,An Jae Young 대한의학회 2024 Journal of Korean medical science Vol.39 No.5
Guillain–Barré syndrome (GBS) is an autoimmune-driven condition characterized by acute polyneuropathy, often emerging as a sequel to prior infections or vaccinations. This study presents the first reported cases of GBS emerging after the full recovery from coronavirus disease 2019 (COVID-19) infection in Korea. Despite experiencing mild acute COVID-19 symptoms, these patients faced substantial weakness attributed to GBS, significantly affecting their daily lives. The timely administration of intravenous immunoglobulin treatment halted the progression of symptoms, underscoring the critical importance of early intervention. These cases highlight the potential for neurological complications associated with COVID-19 and underscore the necessity for continuous monitoring and timely medical care.
Harnessing the Power of Voice: A Deep Neural Network Model for Alzheimer’s Disease Detection
Park Chan-Young,Kim Minsoo,Shim YongSoo,Ryoo Nayoung,Choi Hyunjoo,Jeong Ho Tae,Yun Gihyun,Lee Hunboc,Kim Hyungryul,Kim SangYun,Youn Young Chul 대한치매학회 2024 Dementia and Neurocognitive Disorders Vol.23 No.1
Background and Purpose: Voice, reflecting cerebral functions, holds potential for analyzing and understanding brain function, especially in the context of cognitive impairment (CI) and Alzheimer’s disease (AD). This study used voice data to distinguish between normal cognition and CI or Alzheimer’s disease dementia (ADD). Methods: This study enrolled 3 groups of subjects: 1) 52 subjects with subjective cognitive decline; 2) 110 subjects with mild CI; and 3) 59 subjects with ADD. Voice features were extracted using Mel-frequency cepstral coefficients and Chroma. Results: A deep neural network (DNN) model showed promising performance, with an accuracy of roughly 81% in 10 trials in predicting ADD, which increased to an average value of about 82.0%±1.6% when evaluated against unseen test dataset. Conclusions: Although results did not demonstrate the level of accuracy necessary for a definitive clinical tool, they provided a compelling proof-of-concept for the potential use of voice data in cognitive status assessment. DNN algorithms using voice offer a promising approach to early detection of AD. They could improve the accuracy and accessibility of diagnosis, ultimately leading to better outcomes for patients.
Growth Factor Supplementation in Culture Medium Leads to Active Proliferation of Porcine Fibroblast
Keon Bong Oh,Bella Kim,Nayoung Ko,Seong-soo Hwang,Dong-Hoon Kim,Gi-Sun Im,Byoung-Chul Yang,Jae-Seok Woo,Zae Young Ryoo,Jin-Ki Park 한국동물번식학회 2011 Reproductive & Developmental Biology(Supplement) Vol.35 No.2s
Growth Factor Supplementation in Culture Medium Leads to Active Proliferation of Porcine Fibroblast
Keon Bong Oh,Bella Kim,Nayoung Ko,Seong-soo Hwang,Dong-Hoon Kim,Gi-Sun Im,Byoung-Chul Yang,Jae-Seok Woo,Zae Young Ryoo,Jin-Ki Park 한국동물생명공학회(구 한국동물번식학회) 2011 Reproductive & developmental biology Vol.35 No.2
Dong-Hwan Jung,Shin Hwang,Gi-Won Song,Baek-Yeol Ryoo,Nayoung Kim,Eunyoung Tak,Hea-Nam Hong 한국간담췌외과학회 2015 한국간담췌외과학회지 Vol.19 No.1
Backgrounds/Aims: Vitamin K may plays a role in controlling hepatocellular carcinoma (HCC) cell growth. In this study, we intended to present 5-year experience of 72 patients receiving oral vitamin K with or without sorafenib. Its end-point was to evaluate the safety of combination therapy using sorafenib and vitamin K. Methods: An interim analysis was performed as a single-arm cross-sectional study, including 72 HCC patients who underwent liver resection or transplantation and administered oral vitamin K2 alone (n=47) or with sorafenib (n=25). Results: In all patients, administration of vitamin K2 analog 45 mg/day did not show any noticeable adverse side-effect during vitamin K therapy of 23.3±10.6 months, except for one patient who experienced skin rash at the third day of vitamin K therapy. In 25 patients receiving sorafenib and vitamin K for 6 months or longer, any noticeable adverse side-effect suspected of vitamin K origin was not identified yet. A small proportion of patients showed unexpectedly favorable anti-tumor effects after use of vitamin K with or without sorafenib. Conclusions: Because add-on of oral vitamin K did not increase the adverse side-effects of sorafenib, a combination therapy with these two agents appears to be worthy of further clinical trial with an expectation of synergistic therapeutic effects.
Yu Hyeona,Yoon Joohyun,Lee Chan Woo,Park Ji Yoon,Jang Yoonjeong,Park Yun Seong,Ryoo Hyun A,Cho Nayoung,Oh Sunghee,Kim Won,Woo Jong-Min,Kang Hyo Shin,Ha Tae Hyon,Myung Woojae 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.9
Objective The Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A) has been validated in more than 30 languages and is noted for its broad application in research and clinical settings. This study presents the first attempt to examine the reliability and validity of the TEMPS-A in Korea.Methods A total of 540 non-clinical participants completed the Korean TEMPS-A, which was adapted from the original English version via a comprehensive translation procedure. Reliability was assessed using Cronbach’s α, and associations between temperaments were examined using Spearman’s correlation coefficient. Exploratory factor analysis (EFA) was performed, and differences in TEMPS-A scores between the gender- and age-based groups were examined using Kruskal-Wallis analysis.Results The Korean TEMPS-A exhibited excellent internal consistency (0.70–0.91) and significant correlations between subscales. EFA resulted in a two-factor structure: Factor I (depressive, cyclothymic, irritable, and anxious) and Factor II (hyperthymic). Gender and age group differences were observed.Conclusion Overall, our results suggest that TEMPS-A is a reliable and valid measure of affective temperaments for the Korean population. This study opens new possibilities for further research on affective temperaments and their related traits.