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[PG-0009] Antioxidant activities and phytochemical contents of diverse representative tea germplasm
Gi-An Lee(Gi-An Lee),Nayoung Ro(Nayoung Ro),Do Yoon Hyun(Do Yoon Hyun),Gwang-Yeon Gi(Gwang-Yeon Gi),Kyung Jun Lee(Kyung Jun Lee),Weilan Li(Weilan Li),Eun Ae Yoo(Eun Ae Yoo),SooKyeong Lee(SooKyeong Lee 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Comprehensive somatic genome alterations of urachal carcinoma
Lee, Seungchul,Lee, Jingu,Sim, Sung Hoon,Lee, Yeonghun,Moon, Kyung Chul,Lee, Cheol,Park, Woong-Yang,Kim, Nayoung KD,Lee, Se-Hoon,Lee, Hyunju BMJ Publishing Group Ltd 2017 Journal of medical genetics Vol.54 No.8
<P>Conclusions Our genome-wide analysis of urachal cancer suggests that molecular characteristics may be important for the treatment of urachal cancer.</P>
The Role of CDX2 in Intestinal Metaplasia Evaluated Using Immunohistochemistry
Lee, Byoung Hwan,Kim, Nayoung,Lee, Hye Seung,Kang, Jung Mook,Park, Hyun Kyung,Jo, Hyun Jun,Shin, Cheol Min,Lee, Sang Hyub,Park, Young Soo,Hwang, Jin Hyeok,Kim, Jin-Wook,Jeong, Sook-Hyang,Lee, Dong Ho The Korean Society of Gastroenterology; the Korean 2012 Gut and Liver Vol.6 No.1
<P><B>Background/Aims</B></P><P>Intestinal metaplasia (IM) has been regarded as a premalignant condition. This study evaluated the role of the transforming factor CDX2 according to the severity and type of IM.</P><P><B>Methods</B></P><P>This analysis was performed on 383 subjects with IM in the antrum and/or body, with diagnoses that were categorized as controls, dysplasias, and gastric cancers. The IM grades were classified into four groups as negative, mild, moderate or severe using the updated Sydney scoring system. The IM subtypes were categorized as type I, type II, and type III using high iron diamine and alcian blue (pH 2.5) staining. The CDX2 expression in the IM foci was evaluated using immunohistochemistry in specimens from the antrum and/or body.</P><P><B>Results</B></P><P>CDX2 expression increased according to IM severity (p=0.001) but was not associated with the IM subtype (p=0.881) in the antrum specimens. Similarly, CDX2 expression increased according to the IM grade (p=0.001) but was not associated with the IM subtype (p=0.755) in the body specimens. CDX2 expression was also increased according to baseline disease in the antrum, especially dysplastic and GC group (p=0.003), but not in the body (p=0.582). However, status of <I>Helicobacter pylori</I> infection was not associated with CDX2 expression in the antrum (p=0.692) and body (p=0.271).</P><P><B>Conclusions</B></P><P>These results show that CDX2 expression is associated with the IM grade regardless of the IM subtype and that it was more frequent in the dysplasia group. These results suggest that CDX2 expression might play an important role in the progression of IM in various environments that can affect neoplastic change.</P>
Lee, Jun Haeng,Kim, Jae J,Hahm, Ki-Baik,Lee, Dong Ho,Kim, Nayoung,Kim, Sung Kook,Park, Jong Jae,Choi, Seok Reyol,Lee, Jong Hun,Lee, Soo Teik,Lee, Eun Hyun,Rhee, Jong Chul WJG Press 2006 World journal of gastroenterology Vol.12 No.17
<P>To compare ecabet sodium and cimetidine in relieving symptoms of functional dyspepsia.</P>
Sukyeung Lee,Myeongchul Lee,Yumi Choi,Nayoung Ro,Jong-wook Chung 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
This study is to raise the utilization of genetic resource of wheat (Triticum aestivum) landrace by evaluating genetic variation related to end use quality of the Far East. Allelic composition of HMW-glutenin subunits encoded by genes of Glu-1 loci associated with bread baking quality was investigated in 324 wheat landrace genetic resources originated from Korea, China, and Japan. The most frequent combination of HMW-glutenin subunits were Glu-A1c, Glu-B1b in Korean and Japanese resources, but Glu-A1a and Glu-B1c were the most in Chinese resources. By using the Glu-1 score system, 24 accessions were evaluated as 10 out of 10. As for genetic diversity, represented by polymorphic information content(PIC) index, the level of variation of Korean landrace(0.245) was lower than that in China(0.569) and Japan(0.294). When it comes to unique composition, Glu-B1f(13+16) and Glu-D1f(2+10) subunits are only in Chinese resources. Glu-B1d(6+8), Glu-B1e(20), Glu-D1b(7+8), and Glu-D1c (7+9) subunits are only in Korean resources. Consequently, this study showed that Chinese landrace collection was the most highly diverse and had distinctive characteristics compared to Korean and Japanese one. Especially, some resources having preferable genetic stock or high Glu-1 score can be valuable for wheat breeding program.
Jong-Wook Lee(Jong-Wook Lee),Nayoung Kwak(Nayoung Kwak),Euna Han(Euna Han),Hye-Young Kang(Hye-Young Kang) 대한약학회 2023 약학회지 Vol.67 No.2
Visual impairment (VI) and hearing impairment (HI) are common disabilities whose prevalence increases with age, potentially presenting a major challenge in the future. Identifying the types of obstacles which they encounter during drug administration is essential to improve health outcomes. This systematic literature review aimed to identify types of medication barriers encountered by individuals with VI or HI to improve their health outcomes. Combination of keywords indicating VI or HI, barrier, challenge, or difficulty, and drug or medication were used to identify potential studies up to May 31, 2021, from Ovid Medline, Embase, and Cochrane. Overall, 20 and 17 articles met the predefined eligibility criteria for VI and HI, respectively. Individuals with VI were found to encounter difficulties in the entire process of pharmaceutical therapy, including drug identification, medication management, access to pharmacies, medication instructions, drug information (labeling), and communication. Individuals with HI were found to experience challenges in communication, health literacy, and negative experiences and emotions toward doctors/pharmacists. The drug management needs of individuals with VI and HI remain unmet. For safe and effective medication in individuals with VI and HI, it is essential to establish practical solutions, such as providing identification tools for tablets for those with VI, deploying sign language interpreters at designated healthcare institutions and pharmacies for individuals with HI, utilizing novel technologies, including audio prescription labeling systems or mobile applications, and providing education for both healthcare providers and individuals with disabilities to improve their partnership in drug therapy.
Sang-Yeon Lee,Hyun Been Choi,Mina Park,Il Soon Choi,Jieun An,Ami Kim,Eunku Kim,Nahyun Kim,Jin Hee Han,Min young Kim,Seung min Lee,Doo-Yi Oh,Bong Jik Kim,Nayoung Yi,Nayoung, K. D. Kim,Chung Lee,Woong-Y 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Loss-of-function variant in the gene encoding the KCNQ4 potassium channel causes autosomal dominant nonsyndromic hearing loss (DFNA2), and no effective pharmacotherapeutics have been developed to reverse channel activity impairment. Phosphatidylinositol 4,5-bisphosphate (PIP2), an obligatory phospholipid for maintaining KCNQ channel activity, confers differentialpharmacological sensitivity of channels to KCNQ openers. Through whole-exome sequencing of DFNA2 families, we identified three novel KCNQ4 variants related to diverse auditory phenotypes in the proximal C-terminus (p.Arg331Gln), the C-terminus of the S6 segment (p.Gly319Asp), and the pore region (p.Ala271_Asp272del). Potassium currents in HEK293T cells expressing each KCNQ4 variant were recorded by patch-clamp, and functional recovery by PIP2 expression or KCNQ openers was examined. In the homomeric expression setting, the three novel KCNQ4 mutant proteins lost conductance and were unresponsive to KCNQ openers or PIP2 expression. Loss of p.Arg331Gln conductance was slightly restored by a tandem concatemer channel (WT-p.R331Q), and increased PIP2 expression further increased the concatemer current to the level of the WT channel. Strikingly, an impaired homomeric p.Gly319Asp channel exhibited hyperactivity when a concatemer (WT-p.G319D), with a negative shift in the voltage dependence of activation. Correspondingly, a KCNQ inhibitor and chelation of PIP2 effectively downregulated the hyperactive WTp. G319D concatemer channel. Conversely, the pore-region variant (p.Ala271_Asp272del) was nonrescuable under any condition. Collectively, these novel KCNQ4 variants may constitute therapeutic targets that can be manipulated by the PIP2 level and KCNQregulating drugs under the physiological context of heterozygous expression. Our research contributes to the establishment of a genotype/mechanism-based therapeutic portfolio for DFNA2.
( Sun Min Lee ),( Nayoung Kim ),( Hyun Jin Jo ),( Ji Hyun Park ),( Ryoung Hee Nam ),( Hye Seung Lee ),( Hyun Jin Kim ),( Moon Young Lee ),( Yong Sung Kim ),( Dong Ho Lee ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.4
Background/Aims Neuronal degeneration and changes in interstitial cells of Cajal (ICCs) are important mechanisms of age-related constipation. This study aims to compare the distribution of ICCs and neuronal nitric oxide synthase (nNOS) with regard to age-related changes between the ascending colon (AC) and descending colon (DC) in 6-, 31-, and 74-week old and 2-year old male Fischer-344 rats. Methods The amount of fecal pellet and the bead expulsion times were measured. Fat proportion in the muscle layer of the colon was analyzed by hematoxylin and eosin staining. Proto-oncogene receptor tyrosine kinase (KIT) and neuronal nitric oxide synthase (nNOS) expression were analyzed with Western blotting and immunohistochemistry. Isovolumetric contractile measurements and electrical field stimulation were used to assess smooth muscle contractility. Results Colon transit and bead expulsion slowed with senescence. Fat in the muscle layer accumulated with age in the AC, but not in the DC. The proportion of KIT-immunoreactive ICCs in the submucosal and myenteric plexus was higher in the DC than in the AC, and it declined with age, especially in the AC. In contrast, the proportion of NOS-immunoreactive neurons in the myenteric plexus was higher in the AC than in the DC, and both decreased in older rats. Nitric oxide levels declined with age in the DC. Muscle strip experiments showed that the inhibitory response mediated by nitric oxide in the circular direction of the DC was reduced in 2-year old rats. Conclusion The AC and DC differ in their distribution of ICCs and nNOS, and age-related loss of nitrergic neurons more severely affects the DC than the AC. (J Neurogastroenterol Motil 2017;23:592-605)
위점막 순응 및 소장 손상으로 인한 만성 비스테로이드성 소염제 유발 위염증 백서 모델 수립의 어려움
이병환 ( Byoung Hwan Lee ),김나영 ( Nayoung Kim ),남령희 ( Ryoung Hee Nam ),이주엽 ( Ju Yup Lee ),이혜승 ( Hye Seung Lee ),이창희 ( Chang Hee Lee ),박지현 ( Ji Hyun Park ),이동호 ( Dong Ho Lee ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.6
Background/Aims: The prevalence of peptic ulcer disease has not decreased mainly due to an increase in the use of NSAIDs. This study was conducted in order to determine whether a chronic NSAID-induced gastric inflammation model could be established by repeated administration of NSAID. Methods: Indomethacin (10 mg/kg) was administered once per week for six weeks in 8- and 26-week rats and animals were sacrificed every week after administration. Gross ulcer index, histologic damage index, myeloperoxidase (MPO) activity, and mucus (glucosamine) levels were measured. Small bowel damage was also evaluated. Results: Gross gastric damage index showed a peak level at three weeks and then decreased slowly in the 26-week indomethacin group. Gastric mucosal glucosamine level increased in both the 8-week (p=0.038) and 26-week groups (p=0.007). In addition, gastric mucosal MPO level decreased in the 8-week group (p=0.018) but did not show a decrease in the 26-week group. Small bowel damage began to occur at three weeks during the schedule and eight of 36 rats (22.2%) died due to perforation or peritonitis of the small bowel in the 8- and 26-week indomethacin groups, respectively. Conclusions: Due to gastric adaptation and small bowel damage, repeated administration of NSAID to experimental animals may not be an adequate method for establishment of the chronic gastric inflammation model. (Korean J Gastroenterol 2014;63:341-347)