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Regulation of lubricin for functional cartilage tissue regeneration: a review
이윤섭,Jae-Hoon Choi,Nathaniel Suk-Yeon Hwang 한국생체재료학회 2018 생체재료학회지 Vol.22 No.2
Background: Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM) attachment, lubricin is recommended as a novel biotherapeutic protein that restore functional articular cartilage. Likewise, malfunction of lubrication in damaged articular cartilage caused by complex and multifaceted matter is a major concern in the field of cartilage tissue engineering. Main body: Although a noticeable progress has been made toward cartilage tissue regeneration through numerous approaches such as autologous chondrocyte implantation, osteochondral grafts, and microfracture technique, the functionality of engineered cartilage is a challenge for complete reconstruction of cartilage. Thus, delicate modulation of lubricin along with cell/scaffold application will expand the research on cartilage tissue engineering. Conclusion: In this review, we will discuss the empirical analysis of lubricin from fundamental interpretation to the practical design of gene expression regulation.
Application of magnetic nanoparticle for controlled tissue assembly and tissue engineering
이은지,임현구,허지승,김환,정기영,Nathaniel Suk-Yeon Hwang 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1
Magnetic nanoparticles have been subjected toextensive studies in the past few decades owing to theirpromising potentials in biomedical applications. The versatileintrinsic properties of magnetic nanoparticles enable theiruse in many biomedical applications. Recently, magneticnanoparticles were utilized to control the cell’s function. Inaddition, intracellular delivery of magnetic nanoparticlesallowed cell’s positioning by appropriate use of magneticfield and created cellular cluster. Furthermore, magneticnanoparticles have been utilized to assemble more complextissue structures than those that are achieved by conventionalscaffold-based tissue engineering strategies. This reviewaddresses recent work in the use magnetic nanoparticle forcontrolled tissue assembly and complex tissue formation.
Gelatin-based extracellular matrix cryogels for cartilage tissue engineering
한민의,강병재,김수환,Hwan D. Kim,Nathaniel Suk-Yeon Hwang 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.45 No.-
In this study, gelatin-based cryogels were fabricated by mixing methacrylated gelatin (GelMA) withmethacrylated hyaluronic acid (MeHA) or methacrylated chondroitin sulfate (MeCS) for cartilage tissueengineering. In vitro revealed that MeCS incorporated gelatin-based cryogel (G-MeCS) showed significantcartilaginous tissue stimulation. Furthermore, the cell-laden gelatin-based ECM cryogels were implantedinto mouse subcutaneous tissue for 6 weeks and displayed uniform distribution of cells with normalphenotype maintenance. Finally, when these cryogels were implanted into osteochondral defect of NewZealand white rabbit, full integration with host tissue and increased cellularity were observed with GMeCScryogel.
이은서,박정하,Jane Wang,이화진,Nathaniel Suk-Yeon Hwang 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.37 No.-
In this study, mesenchymal progenitor-like cells (MPLCs) were derived from human induced pluripotentstem cells (hiPSCs) by retinoic acid (RA) treatment. In particular, RA induced hiPSC–derived MPLCs wereable to efficiently committed into osteogenic lineage cells. In addition, hiPSC–MPLCs were seeded ontothree-dimensional biomimetic scaffolds composed of hydroxyapatite and poly(L-lactic acid)/poly(lactic-co-glycolide) for assessing osteoinductivity, and enhanced osteogenic activities were perceived in RA-treatedcells in vitro and in vivo. In conclusion, addition of RA increased the osteogenic commitment potential ofhiPSCs–MPLCs and further applications with biomimetic composite scaffolds showed a promisingcombination for bone tissue engineering applications.