Concurrent Relations of Commodity Futures

Namkoong,Hongseok,Kim, Woochang 대한산업공학회 2011 대한산업공학회 추계학술대회논문집 Vol.2011 No.11

Literatures have focused on the relationship between basis, cost of storage and convenience yield, as given by the Theory of Storage. However, the relations among futures contracts should be considered as a whole, upon discussion of futures-spot relationships: futures curve reflects inventory level and the risk premium and thus the dynamics of future spot price. Here the predictive ability of the futures curve over future spot price dynamics is empirically proven. When the futures curve is highly volatile, market participants’ expectation on inventory and risk premium vary. As this discrepancy widen, spot inventory is deemed unstable. Thus, spot price rises for a short time. But then, as inventory restores itself, spot mean reverts, making a sharp market correction. An investment strategy that predicts spot price crashes using the futures curve is devised. Equal weight portfolio of 26 commodities is used. Results corroborate the conjecture; it predicts major market crashes. Result indicates that contemporary relations among futures contracts are crucial in futures-spot relationships. This result expands the view offered by the Theory of Storage by highlighting the importance of relationship among futures contracts.

MoSi2 의 초음파에 관한 기초적 연구

김유철,남궁재관 한국산업안전학회 1994 한국안전학회지 Vol.9 No.1

Ultrasonic for MoSi₂/Y. C. Kim, C. K. Namkoong/MoSi₂ in the silicides has excellence in the oxidation and corrosion resistence. When the solid state bonding sintered-MoSi₂/metal or the thermal sprayed coating by powder-MoSi₂ on the metal are carried out, the defects may be occured at the bonded surface. So, the method for evaluating the existence of the defects by non-destructive inspection is strongly desired. Here, the characteristics of ultrasonic for sintered-MoSi₂ are elucidated and the possibility of the detection of defects using by ultrasonic is investigated.

Detection of c-K-ras Point Mutation in Ovarian Cancer

Namkoong, Sung Eun,Lee, Joon Mo,Kim, Jin Woo,Han, Sang Kyun,Kim, Heung Kee,Park, Jong Sup,Kim, Seung Jo CATHOLIC MEDICAL CENTER 1994 Bulletin of the Clinical Research Institute Vol.22 No.1

To detect the point mutation of c-k-ras in ovarian cancer, GGT of codon 12 was replaced by GAT, AGT, TGT and GTT, then we performed polymerase chain reaction and agarose gel electrophoresis and confirmed it using Southern blot hybrization with digoxygenin detection system. The frequency of c-k-ras point mutation was compared with the clinico-pathological characteristics of 37 ovarian cancer patients. The incidences of four-typed point mutations of K-ras oncogene in 37 ovarian cancers were 35.1%(13/37) and distribution were 32.4%(12/37), 2.7%(1/37), 0%(O/37) and 0%(O/37) in GGT to GAT, GGT to AGT, GGT to TGT, and GGT to GTT, respectively. The incidence of K-ras point mutations on codon 12 among 37 patients with ovarian cancer according to histological type was 35.5%(8/22) with serous cystadenocarcinomns, 28.6%(2/7) with mucinous cystadenocarcinomas. Comparing the positive rate of K-ras point mutations on code 12 among 37 patients with ovarian cancer in different clinical stages, point mutation was detected in 14.3%(1/7) with stage Ⅰ, 28.6%(2/7) with stage Ⅱ, and 43.5%(10/23) with stage Ⅲ/Ⅳ and there was statistically significant increasement of point mutations of K-ras oncogene with advance of the clinical stage of ovarian cancer (P<0.05). The incidence of K-ras point mutntions on codon 12 among 33 patients with ovarian cancer who were performed pelvic lymph node dissection was 52.4%(l1/21) of the patients with positive pelvic lymph node metastases and 16.7%(2/12) of the patients without pelvic lymph node metastasis and the difference was statistically significant (P<0.05). The activation of ras oncogene seems to be a major implication of the multistep process of ovarian carcinogenesis and tumor progression. Furthermore, the point mutation of c-K-ras gene could occur more frequently in the patients of ovarian cancer in far advance stage, and the those with pelvic lymph node metastases than in those without pelvic lymph node metastases, suggesting the role in tumor invasion and metastases.

Contour machining error in NC milling process

Namkoong, Chaikwan,Yellowley, I. 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.6

The comprehensive system analysis for contour milling operation has performed in this study, which combined the each element with proper connectivity into closed loop system, and determined the system response by numerical simulation technique. The obtained simulated results were then compared with the experimental results from the practical points of view, and so forth, the governing equations were formulated into the estimation model, which predicted the total contour machining error within 25% accuracy. Through the procedural evaluation, it could ascertain the characteristics of generation mechanics in circular contour machining error, and the weight of each factor.

Precancerous Conditions of Uterine Cervix and its Relation to Trichomonal Infection

Namkoong, Sung Eun,Kim, Seung Jo,Lee, Yong Seon,Kim, Yoon Ho,Kim, Sun Moo CATHOLIC MEDICAL CENTER 1979 Bulletin of the Clinical Research Institute Vol.7 No.1

Trichomonas Vaginalis, first described by Donne, 1836, for many years has been associated with lesions of the female genital tract.

Effect of anti-muscarinic autoantibodies on leukocyte function in Sjögren’s syndrome

Namkoong, Eun,Lee, Sang-woo,Kim, Nahyun,Choi, Youngnim,Park, Kyungpyo 3M Company 2017 Molecular immunology Vol.90 No.-

<P>Our results suggest that anti-M3R autoantibodies in primary Sjogren's syndrome induce downregulation of plasma membrane-resident M3R and MHC class I molecules in leukocytes followed by NK cell-mediated cell death. This mechanism may explain the frequency of leukopenia occurrence in patients with primary Sjogren's syndrome.</P>

A Study on Circular Contour Machining Error

Namkoong, Chaikwan 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.5

The comprehensive system analysis for contour milling operation and its error has performed in this study. The obtained experimental results were from the practical points of view. In down-milling operation the contour error curve illustrates bigger thean actual workpiece radius. The contour error increased when the cutter loads increased. Through the procedural evaluation, it could ascertain the characteristics of generation mechanics in circular contour machining error, and the weight of each factors.

Chemogenetic manipulation of parasympathetic neurons (DMV) regulates feeding behavior and energy metabolism

NamKoong, Cherl,Song, Woo Jin,Kim, Chang Yeon,Chun, Duck Hyeon,Shin, Soonho,Sohn, Jong-Woo,Choi, Hyung Jin Elsevier 2019 Neuroscience Letters Vol.712 No.-

<P><B>Abstract</B></P> <P>Parasympathetic nervous system (PNS) innervates with several peripheral organs such as liver, pancreas and regulates energy metabolism. However, the direct role of PNS on food intake has been poorly understood. In the present study, we investigated the role of parasympathetic nervous system in regulation of feeding by chemogenetic methods. Adeno associated virus carrying DREADD (designer receptors exclusively activated by designer drugs) infused into the target brain region by stereotaxic surgery. The stimulatory hM3Dq or inhibitory hM4Di DREADD was over-expressed in selective population of dorsal motor nucleus of the vagus (DMV) neurons by Cre-recombinase-dependent manners. Activation of parasympathetic neuron by intraperitoneal injection of the M3-muscarinic receptor ligand clozapine<I>-N-o</I>xide (CNO) (1 mg/kg) suppressed food intake and resulted in body weight loss in ChAT-Cre mice. Parasympathetic neurons activation resulted in improved glucose tolerance while inhibition of the neurons resulted in impaired glucose tolerance. Stimulation of parasympathetic nervous system by injection of CNO (1 mg/kg) increased oxygen consumption and energy expenditure. Within the hypothalamus, in the arcuate nucleus (ARC) changed AGRP/POMC neurons. These results suggest that direct activation of parasympathetic nervous system decreases food intake and body weight with improved glucose tolerance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Activation of parasympathetic neuron by intraperitoneal injection of the clozapine-N-oxide (CNO) suppressed food intake and body weight loss. </LI> <LI> Parasympathetic neurons activation in improved glucose tolerance while inhibition of the neurons resulted in impaired glucose tolerance. </LI> <LI> Stimulation of the parasympathetic nervous system by injection of CNO increased oxygen consumption and energy expenditure. </LI> </UL> </P>

The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase

Namkoong, Sim,Lee, Kang Il,Lee, Jin I,Park, Rackhyun,Lee, Eun-Ju,Jang, Ik-Soon,Park, Junsoo TaylorFrancis 2015 AUTOPHAGY Vol.11 No.5

<P>The PKA-CREB signaling pathway is involved in many cellular processes including autophagy. Recent studies demonstrated that PKA-CREB inhibits autophagy in yeast; however, the role of PKA-CREB signaling in mammalian cell autophagy has not been fully characterized. Here, we report that the integral membrane protein ITM2A expression is positively regulated by PKA-CREB signaling and ITM2A expression interferes with autophagic flux by interacting with vacuolar ATPase (v-ATPase). The <I>ITM2A</I> promoter contains a CRE element, and mutation at the CRE consensus site decreases the promoter activity. Forskolin treatment and PKA expression activate the <I>ITM2A</I> promoter confirming that ITM2A expression is dependent on the PKA-CREB pathway. ITM2A expression results in the accumulation of autophagosomes and interferes with autolysosome formation by blocking autophagic flux. We demonstrated that ITM2A physically interacts with v-ATPase and inhibits lysosomal function. These results support the notion that PKA-CREB signaling pathway regulates ITM2A expression, which negatively regulates autophagic flux by interfering with the function of v-ATPase.</P>

Politics over National Health Insurance System in the United States : Lessons from the Past History

Namkoong Keun(남궁근),Kim, Yeoung-ki(김영기) 경상대학교 사회과학연구원(사회과학연구) 1988 사회과학연구 Vol.6 No.-