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Synergistically Combined Gene Delivery for Enhanced VEGF Secretion and Antiapoptosis
Won, Young-Wook,Lee, Minhyung,Kim, Hyun Ah,Nam, Kihoon,Bull, David A.,Kim, Sung Wan American Chemical Society 2013 MOLECULAR PHARMACEUTICS Vol.10 No.10
<P>With current pharmacological treatments, preventing the remodeling of the left ventricle and the progression to heart failure is a difficult task. Gene therapy is considered to provide a direct treatment to the long-term complications of ischemic heart diseases. Although current gene therapies that use single molecular targets seem potentially possible, they have not achieved success in the treatment of ischemic diseases. With an efficient polymeric gene carrier, PAM-ABP, we designed a synergistically combined gene-delivery strategy to enhance vascular endothelial growth factor (VEGF) secretion and to prolong its antiapoptotic effects. A hypoxia-inducible plasmid expressing both hypoxia-inducible heme oxygenase-1 (HO-1) and the Src homology domain-2 containing tyrosine phosphatase-1 microRNA (miSHP-1) as well as a hypoxia-responsive VEGF plasmid were combined in this study. The positive feedback circuit between HO-1 and VEGF and the negative regulatory role of SHP-1 in angiogenesis enhance VEGF secretion synergistically. The synergy in VEGF secretion as a consequence of the gene combination and prolonged HO-1 activity was confirmed in hypoxic cardiomyocytes and cardiomyocyte apoptosis under hypoxia and was decreased synergistically. These results suggest that the synergistic combination of VEGF, HO-1, and miSHP-1 may be promising for the clinical treatment of ischemic diseases.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/mpohbp/2013/mpohbp.2013.10.issue-10/mp400178m/production/images/medium/mp-2013-00178m_0010.gif'></P>
Won-Hyuk Lee,Kyung-Ho Lee,Jung-Min Lee,Byeong-Wook Nam 한국CDE학회 2020 Journal of computational design and engineering Vol.7 No.6
The importance of operations and maintenance (O&M) and piping inspection in shipbuilding and offshore plant industries has significantly increased recently. Therefore, this study proposes a system that uses augmented reality (AR) to support these operations. AR in O&M and inspection systems can increase work comprehension and efficiency by utilizing 3D graphics, instead of drawings, to describe specific work functions. To realize this improvement, the augmented model should correspond to the reality; if accurate registration is not achieved, it can disrupt the work functions. Therefore, marker-based AR is used to generate specific recognition objects and correct the location of the augmented model. However, owing to certain characteristics of the shipbuilding and offshore plant industries, the markers are likely to be damaged, and thus the cameras fail to clearly detect them. In this study, a 3D camera was used to generate a point cloud based on 3D image information. Accordingly, the area around the model to be detected was designated as the region of interest (ROI). Furthermore, it is difficult to support a high-end device environment because it is tested as a portable device that can be used in a working environment; therefore, superfluous data were removed by detecting the 3D edges in the ROI, thereby minimizing data operation. The scalability of this work was enhanced using the computer-aided design (CAD) file information extracted from the CAD tool (used in the shipbuilding industry) and converting it into a point cloud. The proposed system is expected to eliminate the issues related to understanding the O&M work by addressing registration errors that might occur in constrained environments and to improve the torsional phenomenon of the augmented models.
Transformation behaviour of Ti–Ni and Ti–Ni–Cu alloy ribbons with nano Ti<sub>2</sub>Ni particles
Nam, Tae-hyun,Lee, Jae-hwa,Jung, Dae-won,Yu, Cheol-am,Liu, Yinong,Kim, Yeon-wook Elsevier 2007 Materials science & engineering. properties, micro Vol.449 No.-
<P><B>Abstract</B></P><P>Ti–Ni and Ti–Ni–Cu alloy ribbons have been prepared by single roll melt spinning, and then martensitic transformation behaviours were investigated by means of transmission electron microscopy, differential scanning calorimetry and X-ray diffraction. In 51Ti–49Ni(at.%) alloy ribbons, Ti<SUB>2</SUB>Ni particles of a size less than 50nm with the coherent interface with the matrix were found, while they were not found in 50Ti–50Ni alloy ribbons. In 49Ti–46Ni–5Cu and 50Ti–45Ni–5Cu alloy ribbons, Ti<SUB>2</SUB>Ni particles of size less than 30nm with coherent interface with the matrix were found. Coherent Ti<SUB>2</SUB>Ni particles induced the R phase transformation in Ti–Ni alloys, and consequently transformation occurred in two-stages, i.e., B2–R–B19. Coherent Ti<SUB>2</SUB>Ni particles induced the B19 martensite in a Ti–45Ni–5Cu alloy, and consequently transformation occurred in two-stages, i.e., B2–B19–B19′. The change in transformation behaviour was ascribed to strain fields developed around coherent Ti<SUB>2</SUB>Ni particles.</P>
P613 : Exfoliative/Erythrodermic psoriasis after discontinuation of ustekinumab: a case report
( Nam Kyung Roh ),( Min Jung Kim ),( Hae Jeong Youn ),( Soo Young Kim ),( Ho Jung Jung ),( Yu Ri Kim ),( Yu Na Lee ),( Jae Wook Jung ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1
Chemical vapor deposition of graphene on platinum: Growth and substrate interaction
Nam, Jungtae,Kim, Dong-Chul,Yun, Hoyeol,Shin, Dong Hoon,Nam, Seungjin,Lee, Won Ki,Hwang, Jun Yeon,Lee, Sang Wook,Weman, Helge,Kim, Keun Soo Elsevier 2017 Carbon Vol.111 No.-
<P>Low-pressure chemical vapor deposition of graphene has been investigated on various Pt substrates such as e-beam deposited films, sputtered films, and polycrystalline foils. High temperature sputtering is found to be crucial in growing single layer graphene on Pt. It gives highly (111)-oriented crystallization with a significant reduction of dewetting in Pt films, in contrast to e-beam deposited Pt films. Graphene grown on high temperature sputtered Pt films is free of micro-sized multilayer graphene islands normally observed in graphene grown on polycrystalline Pt foils. This indicates that using Pt thin films can effectively suppress the multilayer graphene growth by carbon segregations and precipitations from the Pt bulk. Growth of single layer graphene is demonstrated on Pt films with a thickness down to 25 nm. Effects of the Pt substrates on the as-grown graphene have been investigated. An XY plot of the Raman G and 2D bands in graphene shows a correlation with the surface facet orientations of the Pt substrates measured by electron backscatter diffraction. With a general red shift of the G band distributions, a blue shift of the 2D band distributions is observed, which goes as high as similar to 2750 cm(-1) in graphene grown on Pt (111) films. (C) 2016 Elsevier Ltd. All rights reserved.</P>
Nam, Eun Ji,Lee, Maria,Yim, Ga Won,Kim, Jae Hoon,Kim, Sunghoon,Kim, Sang Wun,Kim, Jae Wook,Kim, Young Tae AlphaMed Press 2013 The oncologist Vol.18 No.7
<P>This study assessed the activity and toxicity of primary carboplatin-based chemoradiotherapy (CarboRT) and compared CarboRT with cisplatin-based chemoradiotherapy (CisRT) in patients with locally advanced cervical cancer and poor general condition. CarboRT was better tolerated than CisRT without compromising tumor response and survival in these patients.</P>