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Role of Additives on the Performance of CsPbI<sub>3</sub> Solar Cells
Heo, Do Yeon,Han, Sang Mok,Woo, Nam Sub,Kim, Young Ju,Kim, Tae-Yoon,Luo, Zhengtang,Kim, Soo Young American Chemical Society 2018 The Journal of Physical Chemistry Part C Vol.122 No.28
<P>The role of additives in the performance of CsPbI<SUB>3</SUB> perovskite solar cells (PSCs) was investigated. Different kinds of cations and anions were used as additives in a <I>N,N</I>-dimethylformamide (DMF) solution containing CsI and PbI<SUB>2</SUB> (1:1 molar ratio). These include HI, HBr, HCl, NH<SUB>4</SUB>I, NH<SUB>4</SUB>Br, and NH<SUB>4</SUB>Cl. Additive cations (H<SUP>+</SUP> and NH<SUB>4</SUB><SUP>+</SUP>) as well as halide ions (I<SUP>-</SUP>, Br<SUP>-</SUP>, and Cl<SUP>-</SUP>) are important for the properties of PSCs. Especially, the addition of iodine ion showed good characteristics compared to Br<SUP>-</SUP> and Cl<SUP>-</SUP>. Among the CsPbI<SUB>3</SUB> layers prepared with different kinds of additives and annealed at different temperatures, the X-ray diffraction peaks of CsPbI<SUB>3</SUB> were clearly found at 14° and 28° for the sample annealed at 150 °C with 50 μL of HI, suggesting the formation of a cubic structure at the low temperature of 150 °C. The field emission scanning electron microscopy images indicate that the surface of the perovskite layer with hydrogen halide additive (“H<SUP>+”</SUP>-based additive) is more uniform than that with ammonium additive. The roughness profiles determined by atomic force microscopy indicate that the CsPbI<SUB>3</SUB> film with HI additive shows the least roughness among the samples with H<SUP>+</SUP>-based additives. Therefore, the best power conversion efficiency (PCE) of 4.72% is obtained for CsPbI<SUB>3</SUB> PSCs annealed at 150 °C with HI (50 μL). The H<SUP>+</SUP>-based additives seem to react with PbI<SUB>2</SUB> in DMF solution, increasing the solubility of PbI<SUB>2</SUB> and thus lowering the processing temperature. Furthermore, the PCE of CH<SUB>3</SUB>NH<SUB>3</SUB>PbI<SUB>3-<I>x</I></SUB>Cl<SUB><I>x</I></SUB> PSCs decreased from 7.45 to 0.23%, whereas that of CsPbI<SUB>3</SUB> PSCs with 50 μL of HI only decreased from 3.55 to 2.78% after exposing the samples to air for 3 h. These results indicate that H<SUP>+</SUP>-based additives, especially HI, have more impact on the CsPbI<SUB>3</SUB> PSCs in terms of lowering the processing temperature and improving the performance.</P> [FIG OMISSION]</BR>
Ju Hyein,Yun HongDuck,Kim YongHwan,Nam Yun Ji,Lee Seungun,Lee Jinwon,Jeong Seon Min,Heo Jinbeom,Kwon Hyungu,Cho You Sook,Jeong Gowun,Ryu Chae-Min,Shin Dong-Myung 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Glutathione (GSH), an abundant nonprotein thiol antioxidant, participates in several biological processes and determines the functionality of stem cells. A detailed understanding of the molecular network mediating GSH dynamics is still lacking. Here, we show that activating transcription factor-2 (ATF2), a cAMP-response element binding protein (CREB), plays a crucial role in maintaining the level and activity of GSH in human mesenchymal stem cells (MSCs) by crosstalking with nuclear factor erythroid-2 like-2 (NRF2), a well-known master regulator of cellular redox homeostasis. Priming with ascorbic acid 2-glucoside (AA2G), a stable vitamin C derivative, increased the expression and activity of ATF2 in MSCs derived from human embryonic stem cells and umbilical cord. Subsequently, activated ATF2 crosstalked with the CREB1-NRF2 pathway to preserve the GSH dynamics of MSCs through the induction of genes involved in GSH synthesis (GCLC and GCLM) and redox cycling (GSR and PRDX1). Accordingly, shRNA-mediated silencing of ATF2 significantly impaired the self-renewal, migratory, proangiogenic, and anti-inflammatory capacities of MSCs, and these defects were rescued by supplementation of the cells with GSH. In addition, silencing ATF2 attenuated the ability of MSCs to alleviate airway inflammatory responses in an ovalbumin-induced mouse model of allergic asthma. Consistently, activation of ATF2 by overexpression or the AA2G-based priming procedure enhanced the core functions of MSCs, improving the in vivo therapeutic efficacy of MSCs for treating asthma. Collectively, our findings suggest that ATF2 is a novel modulator of GSH dynamics that determines the core functionality and therapeutic potency of MSCs used to treat allergic asthma.
부산지역 청년들의 부산에 대한 인식 : 청년 정책을 위한 함의
남성주(외 2명) 신라대학교 부산학연구센터 2016 부산연구 Vol.14 No.-
이 연구는 부산지역 거주 청년 500명을 대상으로 부산시에 대한 인식을 조사하였다. 조사결과 일자리 문제를 제외하고 응답자들은 부산에 대해 대체로 긍정적인 평가를 하는 것으로 나타났으며, 부산의 미래에 대해 낙관적인 기대를 가지고 있었다. 다만 서부산권 거주자들의 만족도가 동부산권 거주자들에 비해 상대적으로 낮았다. 설문조사 결과를 토대로 정책적 함의를 논의 하였다.
Daidzein Activates Choline Acetyltransferase from MC-IXC Cells and Improves Drug-Induced Amnesia
HEO, Ho Jin,SUH, Young-Min,KIM, Mi-Jeong,CHOI, Soo-Jung,MUN, Nam Shik,KIM, Hye-Kyung,KIM, Eunki,KIM, Chang-Ju,CHO, Hong-Yon,KIM, Young Jun,SHIN, Dong-Hoon Japan Society for Bioscience, Biotechnology, and A 2006 Bioscience, Biotechnology, and Biochemistry Vol.70 No.1
<P>The choline acetyltransferase (ChAT) activator, which enhances cholinergic transmission <I>via</I> an augmentation of the enzymatic production of acetylcholine (ACh), is an important factor in the treatment of Alzheimer’s disease (AD). Methanolic extracts from <I>Pueraria thunbergiana</I> exhibited an activation effect (46%) on ChAT <I>in vitro</I>. <I>Via</I> the sequential isolation of <I>Pueraria thunbergiana</I>, the active component was ultimately identified as daidzein (4′,7-dihydroxy-isoflavone). In order to investigate the effects of daidzein from <I>Pueraria thunbergiana</I> on scopolamine-induced impairments of learning and memory, we conducted a series of <I>in vivo</I> tests. Administration of daidzein (4.5 mg/kg body weight) to mice was shown significantly to reverse scopolamine-induced amnesia, according to the results of a Y-maze test. Injections of scopolamine into mice resulted in impaired performance on Y-maze tests (a 37% decreases in alternation behavior). By way of contrast, mice treated with daidzein prior to the scopolamine injections were noticeably protected from this performance impairment (an approximately 12%–21% decrease in alternation behavior). These results indicate that daidzein might play a role in acetylcholine biosynthesis as a ChAT activator, and that it also ameliorates scopolamine-induced amnesia.</P>
Heo Jinbeom,Lee Jinyoung,Nam Yun Ji,Kim YongHwan,Yun HongDuck,Lee Seungun,Ju Hyein,Ryu Chae-Min,Jeong Seon Min,Lee Jinwon,Lim Jisun,Cho Yong Mee,Jeong Eui Man,Hong Bumsik,Son Jaekyoung,Shin Dong-Myung 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Aberrant activation of embryogenesis-related molecular programs in urothelial bladder cancer (BC) is associated with stemness features related to oncogenic dedifferentiation and tumor metastasis. Recently, we reported that overexpression of transcription factor CP2-like protein-1 (TFCP2L1) and its phosphorylation at Thr177 by cyclin-dependent kinase-1 (CDK1) play key roles in regulating bladder carcinogenesis. However, the clinical relevance and therapeutic potential of this novel CDK1-TFCP2L1 molecular network remain elusive. Here, we demonstrated that inhibitor of DNA binding-2 (ID2) functions as a crucial mediator by acting as a direct repressive target of TFCP2L1 to modulate the stemness features and survival of BC cells. Low ID2 and high CDK1 expression were significantly associated with unfavorable clinical characteristics. TFCP2L1 downregulated ID2 by directly binding to its promoter region. Consistent with these findings, ectopic expression of ID2 or treatment with apigenin, a chemical activator of ID2, triggered apoptosis and impaired the proliferation, suppressed the stemness features, and reduced the invasive capacity of BC cells. Combination treatment with the specific CDK1 inhibitor RO-3306 and apigenin significantly suppressed tumor growth in an orthotopic BC xenograft animal model. This study demonstrates the biological role and clinical utility of ID2 as a direct target of the CDK1-TFCP2L1 pathway for modulating the stemness features of BC cells.
Ju Hye Lee,MD,Dong Hyun Kim,MD,Yong Kan Ki,MD,Ji Ho Nam,MD,Jeong Heo,MD,Hyun Young Woo,MD,Dong Won Kim,MD,Won Taek Kim,MD 대한방사선종양학회 2014 Radiation Oncology Journal Vol.32 No.3
Purpose: We sought to evaluate the clinical outcomes of 3-dimensional conformal radiation therapy (3D-CRT) for portal vein tumor thrombosis (PVTT) alone in patients with advanced hepatocellular carcinoma. Materials and Methods: We retrospectively analyzed data on 46 patients who received 3D-CRT for PVTT alone between June 2002 and December 2011. Response was evaluated following the Response Evaluation Criteria in Solid Tumors. Prognostic factors and 1-year survival rates were compared between responders and non-responders. Results: Thirty-seven patients (80.4%) had category B Child-Pugh scores. The Eastern Cooperative Oncology Group performance status score was 2 in 20 patients. Thirty patients (65.2%) had main or bilateral PVTT. The median irradiation dose was 50 Gy (range, 35 to 60 Gy) and the daily median dose was 2 Gy (range, 2.0 to 2.5 Gy). PVTT response was classified as complete response in 3 patients (6.5%), partial response in 12 (26.1%), stable disease in 19 (41.3%), and progressive disease in 12 (26.1%). There were 2 cases of grade 3 toxicities during or 3 months after radiotherapy. Twelve patients in the responder group (15 patients) received at least 50 Gy irradiation, but about 84% of patients in the non-responder group received less than 50 Gy. The 1-year survival rate was 66.8% in responders and 27.4% in non-responders constituting a statistically significant difference (p = 0.008). Conclusion: Conformal radiotherapy for PVTT alone could be chosen as a palliative treatment modality in patients with unfavorable conditions (liver, patient, or tumor factors). However, more than 50 Gy of radiation may be required.
Lee, Ju Hye,Kim, Dong Hyun,Ki, Yong Kan,Nam, Ji Ho,Heo, Jeong,Woo, Hyun Young,Kim, Dong Won,Kim, Won Taek The Korean Society for Radiation Oncology 2014 Radiation Oncology Journal Vol.32 No.3
Purpose: We sought to evaluate the clinical outcomes of 3-dimensional conformal radiation therapy (3D-CRT) for portal vein tumor thrombosis (PVTT) alone in patients with advanced hepatocellular carcinoma. Materials and Methods: We retrospectively analyzed data on 46 patients who received 3D-CRT for PVTT alone between June 2002 and December 2011. Response was evaluated following the Response Evaluation Criteria in Solid Tumors. Prognostic factors and 1-year survival rates were compared between responders and non-responders. Results: Thirty-seven patients (80.4%) had category B Child-Pugh scores. The Eastern Cooperative Oncology Group performance status score was 2 in 20 patients. Thirty patients (65.2%) had main or bilateral PVTT. The median irradiation dose was 50 Gy (range, 35 to 60 Gy) and the daily median dose was 2 Gy (range, 2.0 to 2.5 Gy). PVTT response was classified as complete response in 3 patients (6.5%), partial response in 12 (26.1%), stable disease in 19 (41.3%), and progressive disease in 12 (26.1%). There were 2 cases of grade 3 toxicities during or 3 months after radiotherapy. Twelve patients in the responder group (15 patients) received at least 50 Gy irradiation, but about 84% of patients in the non-responder group received less than 50 Gy. The 1-year survival rate was 66.8% in responders and 27.4% in non-responders constituting a statistically significant difference (p = 0.008). Conclusion: Conformal radiotherapy for PVTT alone could be chosen as a palliative treatment modality in patients with unfavorable conditions (liver, patient, or tumor factors). However, more than 50 Gy of radiation may be required.