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ABELIAN PROPERTY CONCERNING FACTORIZATION MODULO RADICALS
Chae, Dong Hyeon,Choi, Jeong Min,Kim, Dong Hyun,Kim, Jae Eui,Kim, Jae Min,Kim, Tae Hyeong,Lee, Ji Young,Lee, Yang,Lee, You Sun,Noh, Jin Hwan,Ryu, Sung Ju The Kangwon-Kyungki Mathematical Society 2016 한국수학논문집 Vol.24 No.4
In this note we describe some classes of rings in relation to Abelian property of factorizations by nilradicals and Jacobson radical. The ring theoretical structures are investigated for various sorts of such factor rings which occur in the process.
An Effect of Water Vapor on Sulfur Dioxide Removal Property of Potassium-Based Dry Sorbents
Chae Ho Jin(채호진),Lee Soo Chool(이수출),Cho Min Sun(조민선),Jo Seong Bin(조성빈),Kim Tae Young(김태영),Lee Chul Ho(이철호),Kim Hyun Ji(김현지),Ryu Min Young(류민영),Kim Jae Chang(김재창) 한국에너지기후변화학회 2018 한국에너지기후변화학회 학술대회 Vol.2018 No.11
Inhibition of Cytochrome P450 by Propolis in Human Liver Microsomes
Ryu, Chang Seon,Oh, Soo Jin,Oh, Jung Min,Lee, Ji-Yoon,Lee, Sang Yoon,Chae, Jung-woo,Kwon, Kwang-il,Kim, Sang Kyum Korean Society of ToxicologyKorea Environmental Mu 2016 Toxicological Research Vol.32 No.3
Although propolis is one of the most popular functional foods for human health, there have been no comprehensive studies of herb-drug interactions through cytochrome P450 (CYP) inhibition. The purpose of this study was to determine the inhibitory effects of propolis on the activities of CYP1A2, 2A6, 2B6, 2C9, 2C19, 2D6, 2E1 and 3A4 using pooled human liver microsomes (HLMs). Propolis inhibited CYP1A2, CYP2E1 and CYP2C19 with an $IC_{50}$ value of 6.9, 16.8, and $43.1{\mu}g/mL$, respectively, whereas CYP2A6, 2B6, 2C9, 2D6, and 3A4 were unaffected. Based on half-maximal inhibitory concentration shifts between microsomes incubated with and without nicotinamide adenine dinucleotide phosphate, propolis-induced CYP1A2, CYP2C19, and CYP2E1 inhibition was metabolism-independent. To evaluate the interaction potential between propolis and therapeutic drugs, the effects of propolis on metabolism of duloxetine, a serotonin-norepinephrine reuptake inhibitor, were determined in HLMs. CYP1A2 and CYP2D6 are involved in hydroxylation of duloxetine to 4-hydroxy duloxetine, the major metabolite, which was decreased following propolis addition in HLMs. These results raise the possibility of interactions between propolis and therapeutic drugs metabolized by CYP1A2.