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Status of JENDL High Energy File
Y. Watanabe,K. Kosako,S. Kunieda,S. Chiba,R. Fujimoto,H. Harada,M. Kawai,F. Maekawa,T. Murata,H. Nakashima,K. Niita,N. Shigyo,S. Shimakawa,N. Yamano,T. Fukahori 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The present status of the JENDL high-energy file is reported. The recent version (referred to as JENDL/HE-2007) contains neutron and proton cross section data for energies up to 3 GeV for 107 nuclides over the wide mass range from H to Am. The newly evaluated data for 41 nuclides have been added to the first version (JENDL/HE-2004) along with some revisions. The JENDL/HE-2007 includes neutron total cross sections, nucleon elastic scattering cross sections and angular distributions, nonelastic cross sections, production cross sections and double-differential cross sections of secondary light particles (n, p, d, t, ^3He, α, and π) and gamma-rays, isotope production cross sections, and fission cross sections in the ENDF-6 format. The evaluations were performed on the basis of experimental data, nuclear model calculations, and systematics based on measurements. The evaluated cross sections are compared with available experimental data and the other evaluations. Some results of benchmark tests with MCNPX codes are shown.
Amelioration of Atherosclerosis by the New Medicinal Mushroom Grifola gargal Singer
Etsuko Harada,Corina N. D’Alessandro-Gabazza,Masaaki Toda,Toshihiro Morizono,Ayshwarya-Lakshmi Chelakkot-Govindalayathil,Ziaurahman Roeen,Masahito Urawa,Taro Yasuma,Yutaka Yano,Toshimitsu Sumiya,Esteb 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.8
The beneficial effects of edible mushrooms for improving chronic intractable diseases have been documented. However, the antiatherogenic activity of the new medicinal mushroom Grifola gargal is unknown. Therefore, we evaluated whether Grifola gargal can prevent or delay the progression of atherosclerosis. Atherosclerosis was induced in ApoE lipoprotein-deficient mice by subcutaneous infusion of angiotensin II. Grifola gargal extract (GGE) was prepared and intraperitoneally injected. The weight of heart and vessels, dilatation/atheroma formation of thoracic and abdominal aorta, the percentage of peripheral granulocytes, and the blood concentration of MCP-1/CCL2 were significantly reduced in mice treated with GGE compared to untreated mice. By contrast, the percentage of regulatory T cells and the plasma concentration of SDF-1/CXCL12 were significantly increased in mice treated with the mushroom extract compared to untreated mice. In vitro, GGE significantly increased the secretion of SDF-1/CXCL12, VEGF, and TGF-β1 from fibroblasts compared to control. This study demonstrated for the first time that Grifola gargal therapy can enhance regulatory T cells and ameliorate atherosclerosis in mice.
The Medicinal Mushroom, Grifola gargal, Ameliorates Allergic Bronchial Asthma
Etsuko Harada,Corina N. D’Alessandro-Gabazza,Masaaki Toda,Toshihiro Morizono,Toshiaki Totoki,Taro Yasuma,Kota Nishihama,Tetsu Kobayashi,Toshimitsu Sumiya,Hirokazu Kawagishi,Esteban C. Gabazza 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.2
Grifola gargal Singer, a medicinal mushroom, has been found to be effective for the prevention and treatment of various chronic inflammatory diseases. However, the effects of G. gargal on allergic diseases are unknown. The present study investigated the effect of G. gargal extract on allergic bronchial asthma. Asthma was induced in mice by ovalbumin sensitization and inhalation. The grade of asthma was compared between mice fed with chow containing G. gargal extract and mice given standard chow. The human mast cell and eosinophilic cell lines were used for in vitro studies. G. gargal extract significantly reduced airway hyperresponsiveness, lung eosinophilic infiltration, lung interleukin (IL)-13 expression, and plasma IgE level and significantly increased IL-10 plasma levels compared to untreated control mice. Spleen regulatory T cells were significantly increased in mice treated with the G. gargal extract compared with untreated control mice. G. gargal extract significantly suppressed expression of cytokines in mast cells and eosinophils compared with control cells. Overall, these observations show that G. gargal extract augments the lung population of regulatory T cells and ameliorates allergic inflammation and airway hyperresponsiveness in mice with allergic bronchial asthma, suggesting the potential therapeutic benefit of G. gargal extract in allergic diseases.
Oka, T.,Tanabe, Y.,Harada, S.,Abe, K.,Ishii, N.,Maruyama, T.,Sato, T.,Imaizumi, H.,Nishimura, S.,Sengoku, M.,Ohkaw, H. Korean Society for Engineering Education 2010 공학교육연구 Vol.13 No.2
We have constructed three characteristic internship programs which were based on the different aspects of view by the grant in aid from MEXT of Japanese government. The most outstanding program is what we call "Market Internship", where the students directly approach the market in which the engineering technologies are utilized. Then they must find out the problems and advantages of engineering technologies from the view of consumers. The experience would result in the enhancement of motivation to study the engineering technologies. It would be substantially effective in engineering education curriculums that the engineers of private companies in which university students will get their own jobs in near future could take important roles to conduct them. We believe that this activity would effective in reducing gaps they would feel between before and after getting jobs in practical society, and lowering the ratio of unemployment after getting jobs.
The Release of Hepatic Triglyceride Lipase from Rat Monolayered Hepatocytes in Primary Culture
윤대헌(Tai Heon Yoon),Yamada N(Nobuhiro Yamada),Ishibashi S(Shun Ishibashi),Shimano H(Hitoshi Shimano),Gotohda T(Takanari Gotohda),Harada K(Kenji Harada),OAkanuma Y(Yasuo Akanuma),Murase T(Toshio Murase) 한국식품영양과학회 1991 한국식품영양과학회지 Vol.20 No.1
쥐간세포 배양시 간트리글리세리드 lipase의 유리 및 호르몬 조절에 관하여 연구하였다. 배양 2일째 헤파린 첨가구 배양액에 유리된 lipase 활성은 24시간 동안 계속 증가하였다. 반면에 헤파린 무첨가의 lipase활성은 헤파린 첨가가우에 비하여 10%에 지나지 않았다. 간세포를 anti-hepatic triglyceride lipase IgG와 배양시 lipase 활성이 92%까지 저해되었다. Monensin 첨가시 lipase활성 저해는 61%였다. 인슐린은 lipase활성을 20% 상승시켰으며 dexamethasone은 44% 저해시켰다. 이상의 결과로 미루어 보아 간트리글리세리드 lipase는 헤파린 존재하에 분비 및 유리되며 그 분비는 호르몬에 의해 조절됨을 시사한다. The release of hepatic triglyceride lipase from cultured rat hepatocytes and its hormonal regulation were studied. The activity of lipase released into the medium in the presence of heparin was increasing during 24 hours on the 2nd day of culture, while this was 10% in the absence of heparin as compared with the lipase activity in the presense of heparin. When hepatocytes were cultured with anti-hepatic triglyceride lipase IgG, the lipase activity was suppressed by 92%. The results suggest that the enzyme released into culture medium is identical to hepatic triglyceride lipase which can be released only in the presence of heparin, the model of release being similar to that of lipoprotein lipase from adipocytes. The addition of monensin to the medium resulted in the inhibition of lipase secretion by 61%. Insulin enhanced lipase activity only 20%, whereas dexamethasone suppressed the activity by 44%. These data indicated that hepatic triglyceride lipase is secreted and released from hepatocytes in the presence of heparin and its secretion is regulated by hormones.
T. Oka,Y. Tanabe,S. Harada,K. Abe,N. Ishii,T. Maruyama,T. Sato,H. Imaizumi,S. Nishimura,M. Sengoku,H. Ohkaw 한국공학교육학회 2010 공학교육연구 Vol.13 No.2
We have constructed three characteristic internship programs which were based on the different aspects of view by the grant in aid from MEXT of Japanese government. The most outstanding program is what we call “Market Internship”, where the students directly approach the market in which the engineering technologies are utilized. Then they must find out the problems and advantages of engineering technologies from the view of consumers. The experience would result in the enhancement of motivation to study the engineering technologies. It would be substantially effective in engineering education curriculums that the engineers of private companies in which university students will get their own jobs in near future could take important roles to conduct them. We believe that this activity would effective in reducing gaps they would feel between before and after getting jobs in practical society, and lowering the ratio of unemployment after getting jobs
Sea surface temperature and salinity changes near the Soya Strait during the last 19 ka
Bae, S.W.,Lee, K.E.,Park, Y.,Kimoto, K.,Ikehara, K.,Harada, N. Pergamon Press 2014 Quaternary international Vol.344 No.-
Past sea surface temperature (SST) and salinity (SSS) changes in the northeastern East Sea/Japan Sea since 19 cal ka BP have been reconstructed by using an alkenone unsaturation index and the oxygen isotope ratio of planktonic foraminifera Neogloboquadrina pachyderma(s) in Core MR0604-PC03B. Coretop alkenone temperature and calcification temperature correspond to the temperature of seawater in summer and spring at the depth of 10-30 m, respectively. Based on the records from this core and previous studies, spatio-temporal changes in alkenone temperature of the East Sea/Japan Sea have been reconstructed to investigate changes of surface circulations and the subpolar front (SPF) position. During the transitional period from the glacial to the Holocene, the SST was lower (about 2-3 <SUP>o</SUP>C) than that of today and the SSS dramatically increased at that time in the entire East Sea/Japan Sea but it was still lower than that of today. However, the northern SSS was higher than that of the southern part. The source of the cold and saline seawater could have been the Oyashio Current (OY, inflow from the north), not the Tsushima Warm Current (TWC, inflow from the south). Probably, sea level rose rapidly at that time. There might be no strong development of the SPF during the transitional period due to the restricted inflow of the TWC. During the early Holocene, the SST and SSS of the East Sea/Japan Sea increased compared to the transitional period due to increased seawater exchange through straits. The SPF was tilted orienting from southwest to northeast because the inflow of the TWC was not fully developed due to lower sea level. Subsequently, the surface condition of the East Sea/Japan Sea was similar to that of today at 6 cal ka BP. The Forerunner of Soya Warm Water (FSWW) that flowed out through the Soya Strait in early spring did not affect the formation of the Okhotsk Sea Intermediate Water and the North Pacific Intermediate Water during the glacial and interglacial periods.