쓰기활동의 유형분석 및 학습자의 태도 분석

Myungwon Kim(김명원),Jin-young Tak(탁진영) 한국영어학회 2008 영어학 Vol.8 No.2

Association of c-MET with Lymphangiogenic Factors in Colorectal Cancer Patients

Taesung Ahn,MyungWon Son,Hae Il Jeong,Jong Eun Lee,Chang Hwan Lee,Saeng Jin Park,Jong Hyuk Yun,Ji Hyeon Ahn,Moo-Jun Baek 대한종양외과학회 2015 대한임상종양학회 학술대회지 Vol.2015 No.2

수리구조물 표준도 재구축(U-type Canal)

이준구 ( Joongu Lee ),김명원 ( Myungwon Kim ),서동욱 ( Donguk Seo ),진현희 ( Hyunhi Jin ),김영화 ( Younghwa Kim ) 한국농공학회 2018 한국농공학회 학술대회초록집 Vol.2018 No.-

농업생산기반정비사업에 활용되는 농업용수의 급수, 과잉수분의 배제를 위한 배수시설로 활용되는 수리구조물중 개거(U-type)의 표준도면을 콘크리트구조기준(2012)에 따라 작성함으로서 신규 및 개보수사업 설계업무의 효율성 제고 및 설계업무 개방에 따른 대외서비스질을 향상하고자 본 연구를 수행하였다. 개거 표준도 제작을 위한 설계조건은 농업생산기반정비사업 조사·설계실무요령(2011), 농촌용수계획설계편람(1998) 등의 설계기준과 한국농어촌공사내 설계담당자들의 의견을 수렴하여 결정하였으며, 대내·외 설계자문위원들의 기술검토를 통해 확정하였다. 콘크리트 압축강도는 24MPa적용, 토압계수는 정지토압과 주동토압의 평균값적용, 지진하중은 토압에 Monobe-Okabe에 의한 유사정적 해석법 적용, 그리고, 도로에 인접한 개거의 경우를 고려한 활하중을 적용할 수 있도록 하였다. 조립철근의 강성 등 시공성, 생산·시장유통여건을 고려한 최소철근은 D13㎜를 사용하였으며, 2×2m이상의 단면에서는 슬래브나 벽체단면의 압축측에 인장측 주철근의 1/2을 배치하는 것으로 결정함으로서 크리프의 영향에 의한 변형발생을 방지하는 설계기준을 적용하였다.

Acute Phase Protein Lipocalin-2 Is Associated with Formalin-induced Nociception and Pathological Pain

Jha, Mithilesh Kumar,Jeon, Sangmin,Jin, Myungwon,Lee, Won-Ha,Suk, Kyoungho The Korean Association of Immunobiologists 2013 Immune Network Vol.13 No.6

Lipocalin-2 (LCN2) is an acute-phase protein induced by injury, infection, or other inflammatory stimuli. LCN2 binds small hydrophobic ligands and interacts with cell surface receptor to regulate diverse cellular processes. The role of LCN2 as a chemokine inducer in the central nervous system (CNS) has been previously reported. Based on the previous participation of LCN2 in neuroinflammation, we investigated the role of LCN2 in formalin-induced nociception and pathological pain. Formalin-induced nociceptive behaviors (licking/biting) and spinal microglial activation were significantly reduced in the second or late phase of the formalin test in Lcn2 knockout mice. Likewise, antibody-mediated neutralization of spinal LCN2 attenuated the mechanical hypersensitivity induced by peripheral nerve injury in mice. Taken together, our results suggest that LCN2 can be therapeutically targeted, presumably for both prevention and reversal of acute inflammatory pain as well as pathological pain.

데이터마이닝에서 교사학습에 의한 속성 가중치 최적화

강명구(Myung-Ku Kang),차진호(Jin-Ho Cha),김명원(Myungwon Kim) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.1B

최근 군집화와 분류기법이 데이터 마이닝에 중요한 도구로 많은 응용분야에 사용되고 있다. 따라서 이러한 기법을 이용하는데 있어서 각각의 속성의 중요도가 달라 중요하지 않은 속성에 의해 중요한 속성이 왜곡되거나 때로는 마이닝의 결과를 잘못되는 결과를 얻을 수 있으며, 또한 전체 데이터를 사용할 경우 마이닝 과정을 저하시키는 문제로 속성 가중치과 속성선택에 관한 연구가 중요한 연구의 대상이 되고 있다. 최근 연구되고 있는 알고리즘들은 사용자의 의도와는 상관없이 데이터간의 관계에만 의존하여 가중치를 설정하므로 사용자가 마이닝 결과를 쉽게 이해하고 분석할 수 없는 문제점을 안고 있다. 본 논문에서는 클래스 정보가 있는 데이터뿐 아니라 클래스 정보가 없는 데이터를 분석할 경우 사용자의 의도에 따라 학습할 수 있도록 각 가중치를 부여하는 속성가중치 알고리즘을 제안한다. 또한 사용자가 의도한 정보를 이용하여 속성간의 가장 최적화 된 가중치를 찾아주면, Cramer's V²함수를 적합도 함수로 하는 유전자 알고리즘을 사용한다. 알고리즘의 타당성을 검증하기 위해 전자상거래상의 실험 데이터와 몇 가지 벤치마크 데이터를 이용하여 본 논문의 타당성을 보인다.

저온 소결 조제에 따른 PMN-PZ-PT 후막 세라믹 특성

정명원,전대우,김진호,이영진,Jung, Myungwon,Jeon, Dae-Woo,Kim, Jin-Ho,Lee, Youngjin 한국전기전자재료학회 2016 전기전자재료학회논문지 Vol.29 No.8

Convectional PZT based piezoelectric ceramics have to sinter at high temperature about $1,200^{\circ}C$ for their suitable electrical properties. However, some issues: low temperature sintering piezoelectric ceramic composition and reliable internal electrode, have recently attracted a great deal of interest as a highly efficient multi-layered piezoelectric ceramics. In order to optimize low temperature sintering conditions of thick-film PMN-PZ-PT ceramic, it was investigated sintering and piezoelectric properties according to the change of $LiBiO_2$ contents. Thus, the superior piezoelectric properties were found at the pallet type PMN-PZ-PT optimized with low sintering processing at $925^{\circ}C$ including 7 wt% $LiBiO_2$ sintering aid. Consequentially, we successfully manufactured thick-film PMN-PZ-PT ceramics, which had superior piezoelectric and dielectric properties, with 5 wt% of $LiBiO_2$ sintering aid at temperature of $900^{\circ}C$.

Acute Phase Protein Lipocalin-2 Is Associated with Formalin-induced Nociception and Pathological Pain

Mithilesh Kumar Jha,Sangmin Jeon,Myungwon Jin,이원하,석경호 대한면역학회 2013 Immune Network Vol.13 No.6

Lipocalin-2 (LCN2) is an acute-phase protein induced by injury, infection, or other inflammatory stimuli. LCN2 binds small hydrophobic ligands and interacts with cell surface receptor to regulate diverse cellular processes. The role of LCN2 as a chemokine inducer in the central nervous system (CNS) has been previously reported. Based on the previous participation of LCN2 in neuroinflammation, we investigated the role of LCN2 in formalin-induced nociception and pathological pain. Formalin-induced nociceptive behaviors (licking/ biting) and spinal microglial activation were significantly reduced in the second or late phase of the formalin test in Lcn2 knockout mice. Likewise, antibody-mediated neutralization of spinal LCN2 attenuated the mechanical hypersensitivity induced by peripheral nerve injury in mice. Taken together, our results suggest that LCN2 can be therapeutically targeted, presumably for both prevention and reversal of acute inflammatory pain as well as pathological pain.

Computational mechanics and optimization-based prediction of grain orientation in anisotropic media using ultrasonic response

Kim, Munsung,Moon, Seongin,Kang, To,Kim, Kyongmo,Song, Sung-Jin,Suh, Myungwon,Suhr, Jonghwan Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.6

Ultrasonic nondestructive testing is important for monitoring the structural integrity of dissimilar metal welds (DMWs) in pressure vessels and piping in nuclear power plants. However, there is a low probability of crack detection via inspection of DMWs using ultrasonic waves because the grain structures (grain orientations) of the weld area cause distortion and splitting of ultrasonic beams propagating in anisotropic media. To overcome this issue, the grain orientation should be known, and a precise ultrasonic wave simulation technique in anisotropic media is required to model the distortion and splitting of the waves accurately. In this study, a method for nondestructive prediction of the DMW grain orientations is presented for accurate simulation of ultrasonic wave propagation behavior in the weld area. The ultrasonic wave propagation behavior in anisotropic media is simulated via finite-element analysis when ultrasonic waves propagate in a transversely isotropic material. In addition, a methodology to predict the DMW grain orientation is proposed that employs a simulation technique for ultrasonic wave propagation behavior calculation and an optimization technique. The simulated ultrasonic wave behaviors with the grain orientations predicted via the proposed method demonstrate its usefulness. Moreover, the method can be used to determine the focal law in DMWs.

Lipocalin-2 Protein Deficiency Ameliorates Experimental Autoimmune Encephalomyelitis : THE PATHOGENIC ROLE OF LIPOCALIN-2 IN THE CENTRAL NERVOUS SYSTEM AND PERIPHERAL LYMPHOID TISSUES

Nam, Youngpyo,Kim, Jong-Heon,Seo, Minchul,Kim, Jae-Hong,Jin, Myungwon,Jeon, Sangmin,Seo, Jung-wan,Lee, Won-Ha,Bing, So Jin,Jee, Youngheun,Lee, Won Kee,Park, Dong Ho,Kook, Hyun,Suk, Kyoungho American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.24

<P>Lipocalin-2 (LCN2) plays an important role in cellular processes as diverse as cell growth, migration/invasion, differentiation, and death/survival. Furthermore, recent studies indicate that LCN2 expression and secretion by glial cells are induced by inflammatory stimuli in the central nervous system. The present study was undertaken to examine the regulation of LCN2 expression in experimental autoimmune encephalomyelitis (EAE) and to determine the role of LCN2 in the disease process. LCN2 expression was found to be strongly increased in spinal cord and secondary lymphoid tissues after EAE induction. In spinal cords astrocytes and microglia were the major cell types expressing LCN2 and its receptor 24p3R, respectively, whereas in spleens, LCN2 and 24p3R were highly expressed in neutrophils and dendritic cells, respectively. Furthermore, disease severity, inflammatory infiltration, demyelination, glial activation, the expression of inflammatory mediators, and the proliferation of MOG-specific T cells were significantly attenuated in <I>Lcn2</I>-deficient mice as compared with wild-type animals. Myelin oligodendrocyte glycoprotein-specific T cells in culture exhibited an increased expression of <I>Il17a</I>, <I>Ifng</I>, <I>Rorc</I>, and <I>Tbet</I> after treatment with recombinant LCN2 protein. Moreover, LCN2-treated glial cells expressed higher levels of proinflammatory cytokines, chemokines, and MMP-9. Adoptive transfer and recombinant LCN2 protein injection experiments suggested that LCN2 expression in spinal cord and peripheral immune organs contributes to EAE development. Taken together, these results imply LCN2 is a critical mediator of autoimmune inflammation and disease development in EAE and suggest that LCN2 be regarded a potential therapeutic target in multiple sclerosis.</P>

Role of Lipocalin-2-Chemokine Axis in the Development of Neuropathic Pain following Peripheral Nerve Injury

Jeon, Sangmin,Jha, Mithilesh Kumar,Ock, Jiyeon,Seo, Jungwan,Jin, Myungwon,Cho, Heejung,Lee, Won-Ha,Suk, Kyoungho American Society for Biochemistry and Molecular Bi 2013 The Journal of biological chemistry Vol.288 No.33

<P>Lipocalin 2 (LCN2), which is also known as 24p3 and neutrophil gelatinase-associated lipocalin (NGAL), binds small, hydrophobic ligands and interacts with cell surface receptor 24p3R to regulate diverse cellular processes. In the present study, we examined the role of LCN2 in the pathogenesis of neuropathic pain using a mouse model of spared nerve injury (SNI). <I>Lcn2</I> mRNA levels were significantly increased in the dorsal horn of the spinal cord after SNI, and LCN2 protein was mainly localized in neurons of the dorsal and ventral horns. LCN2 receptor 24p3R was expressed in spinal neurons and microglia after SNI. <I>Lcn2</I>-deficient mice exhibited significantly less mechanical pain hypersensitivity during the early phase after SNI, and an intrathecal injection of recombinant LCN2 protein elicited mechanical pain hypersensitivity in naive animals. <I>Lcn2</I> deficiency, however, did not affect acute nociceptive pain. <I>Lcn2</I>-deficient mice showed significantly less microglial activation and proalgesic chemokine (CCL2 and CXCL1) production in the spinal cord after SNI than wild-type mice, and recombinant LCN2 protein induced the expression of these chemokines in cultured neurons. Furthermore, the expression of LCN2 and its receptor was detected in neutrophils and macrophages in the sciatic nerve following SNI, suggesting the potential role of peripheral LCN2 in neuropathic pain. Taken together, our results indicate that LCN2 plays a critical role in the development of pain hypersensitivity following peripheral nerve injury and suggest that LCN2 mediates neuropathic pain by inducing chemokine expression and subsequent microglial activation.</P>