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Lee Myungsu,Chung Jin Wook,Lee Kwang-Hun,Won Jong Yun,Chun Ho Jong,Lee Han Chu,Kim Jin Hyoung,Lee In Joon,허세범,Kim Hyo-Cheol,Kim Yoon Jun,Kim Gyoung Min,Joo Seung-Moon,Oh Jung Suk 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.10
Objective: To assess the two-year treatment outcomes of chemoembolization with drug-eluting embolics (DEE) for nodular hepatocellular carcinoma (HCC). Materials and Methods: This study was a prospective, multicenter, registry-based, single-arm trial conducted at five university hospitals in Korea. Patients were recruited between May 2011 and April 2013, with a target population of 200. A DC Bead loaded with doxorubicin was used as the DEE agent. Patients were followed up for two years. Per-patient and perlesion tumor response analysis, per-patient overall survival (OS) and progression-free survival (PFS) analysis, and per-lesion tumor control analysis were performed. Results: The final study population included 152 patients, with 207 target lesions for the per-lesion analysis. At one-month, six-month, one-year, and two-year per-patient assessments, complete response (CR) rates were 40.1%, 43.0%, 33.3%, and 19.6%, respectively. The objective response (OR) rates were 91.4%, 55.4%, 35.1%, and 19.6%, respectively. The cumulative two-year OS rate was 79.7%. The cumulative two-year PFS rate was 22.4% and the median survival was 9.3 months. In multivariable analysis, the Child-Pugh score (p = 0.019) was an independent predictor of OS, and tumor multiplicity (p < 0.001), tumor size (p = 0.020), and Child-Pugh score (p = 0.006) were independent predictors of PFS. In per-lesion analysis, one-month, six-month, one-year and two-year CR rates were 57.5%, 58.5%, 45.2%, and 33.3%, respectively, and the OR rates were 84.1%, 65.2%, 46.6%, and 33.3%, respectively. The cumulative two-year per-lesion tumor control rate was 36.2%, and the median time was 14.1 months. The Child-Pugh score (p < 0.001) was the only independent predictor of tumor control. Serious adverse events were reported in 11 patients (7.2%). Conclusion: DEE chemoembolization for nodular HCCs in the Korean population showed acceptable survival, tumor response, and safety profiles after a two-year follow-up. Good liver function (Child-Pugh score A5) was a key predictor of per-patient OS, PFS, and per-lesion tumor control.
Lee, In Joon,Lee, Myungsu,Kim, Soo Jin,Kim, You Kyung,Won, Jong Yun,Chung, Jin Wook Elsevier 2018 Journal of Vascular and Interventional Radiology Vol.29 No.8
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>To assess feasibility and efficacy of CKD-516, a vascular disrupting agent, in transarterial chemoembolization in a liver tumor model.</P> <P><B>Materials and Methods</B></P> <P>A VX2 carcinoma strain was implanted in rabbit liver (n = 40) and incubated for 2 weeks. After confirmation of tumor growth using computed tomography, transarterial chemoembolization was performed. CKD-516 was dissolved in ethiodized oil, and animals were allocated to 4 treatment groups (n = 10 in each): group A, ethiodized oil; group B, ethiodized oil/CKD-516; group C, ethiodized oil + doxorubicin; group D, ethiodized oil/CKD-516 + doxorubicin. To assess hepatic damage, serum aspartate transaminase and alanine transaminase levels were measured on day 1, 3, and 7 after delivery. To assess tumor necrosis, animals were euthanized on day 7, and explanted tumors were stained with hematoxylin and eosin and a terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling assay. Percentage areas of viable tumors were calculated using digitalized histopathologic specimen images.</P> <P><B>Results</B></P> <P>Tumor viability rates were 47.1% ± 11.4%, 27.5% ± 13.6%, 14.4% ± 12.5%, and 0.7% ± 1.0% in groups A, B, C, and D (<I>P</I> < .001). Liver enzyme levels were elevated after drug delivery but recovered during follow-up. Significant between-group differences were observed on days 1, 3, and 7 (aspartate transaminase and alanine transaminase: <I>P</I> = .0135 and <I>P</I> = .0134, <I>P</I> = .0390 and <I>P</I> = .0084, and <I>P</I> = .8260 and <I>P</I> = .0440).</P> <P><B>Conclusions</B></P> <P>Treatment with a combination of CKD-516 and conventional transarterial chemoembolization showed therapeutic benefit in a liver tumor model.</P>
Fallback 상황에서의 V2X 기반 자율주행 운행 안전성 확보 방법에 관한 연구
이명수(Myungsu Lee),황영서(Youngseo Hwang),김태형(Taehyeong Kim),김봉섭(Bongsuob Kim),임태호(Taeho Lim) 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.2
본 논문은 Fallback 상황에서의 V2X 기반 자율주행 운행 안전성 확보 방법에 관한 연구로 레벨 4 이상 자율주행 제도적 안전 기준에 있어 DDT Fallback 상황에 대한 MRM과 MRC 등 자율주행 차량의 비상 상황에 대한 대응 체계와 평가방법에 대한 관심이 높아지고 있으나 자율주행 운행환경에 있어 시간에 따른 도로 노면과 구조물 형태의 변화와 날씨와 같은 환경 변화를 예측 대응하기 어렵다. 또한 자율주행 차량 단독으로 Fallback 상황에 대응할 필요가 있으나 시스템의 고장과 성능 한계에 따른 제약이 따르는 문제점이 극복하고자 Fallback 상황에서의 자율주행 운행의 안전성 확보를 위한 방법으로 Fallback 상황에서의 V2X 기반 자율주행 운행 안전성 프로세스와 평가 시나리오 설계 방법를 제안하였다.
차량안정성제어시스템(ESC)장착 차량의 조종안정성 평가방법 표준화에 관한 연구
이명수(Myungsu Lee),민경찬(Kyongchan Min),남궁석완(Sukwan Namkung),권해붕(Haeboung Kwon),최선모(Sunmo Choi) 한국자동차공학회 2008 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
As the ESC become more affordable, the research regarding the performance appraisal method of the ESC is actively advanced. The research was spearheaded by the UN/ECE/WP29 and ISO. Specially, the United States established a ESC efficiency requirements with the FMVSS. And the UN/ECE/WP29 is in the process of propelling the Global Technical Regulation establishment of the ESC. Republic of Korea is the member of U.N. and ISO that participates in the wide range of international meetings. This paper describes vehicle-test results for establishment of the Korean Standards, carrying out actual test to verify the determination of dwell time, Max. steering wheel angle input and the proposed measuring method of lateral displacement and to propose the additional evaluation criteria of ESC efficiency.