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Early-Age Properties of Polymer Fiber-Reinforced Concrete
Myers, Daniel,Kang, Thomas H.K.,Ramseyer, Chris Korea Concrete Institute 2008 International Journal of Concrete Structures and M Vol.2 No.1
The cracking problem in concrete is widespread and complex. This paper reviews the problem and focuses on those parts of the problem that are more readily solved. Polymer fibers are shown to have promise in several important areas of the cracking problem. To investigate one of these areas of the cracking problem more completely, an experimental research program focusing on the early-age properties of fibers was carried out. This study researched the properties of four polymer fibers; two of the fibers were macrofibers, and two were microfibers. Each fiber was tested at several dosage rates to identify optimum dosage levels. Early-age shrinkage, long-term shrinkage, compressive strength, and tensile strength were investigated. Long-term shrinkage and strength impacts from the polymer fibers were minimal; however, the polymer fibers were shown to have a great impact on early-age shrinkage and a moderate impact on early-age strength.
INNOVATIVE STRATEGIES FOR COMPARATIVE AGING RESEARCH
MYERS, GEORGE C. Institute for Social Development and Policy Resear 1995 Korea Journal of Population and Development Vol.24 No.2
After introductory comments on the theme of ‘ageing east and west’, this paper looks at trends in ageing and responses to ageing over time, with particular reference to European experience. The evidence is reviewed in historical, cultural, religious, political and ‘social political’ perspective. Attention in drawn to the different patterns of experience and of policy responses characteristic of the different countries and regions within Europe both past and present. The paper concludes with a review of latest trends and prospects in ‘community care’, which could signal a seeming point of convergence between east and west.
Myers, Amber L.,Harris, Caitlin M.,Choe, Kwang-Min,Brennan, Catherine A. Elsevier 2018 Biochemical and biophysical research communication Vol.505 No.3
<P><B>Abstract</B></P> <P>The production of reactive oxygen species (ROS) is a prominent response to infection among innate immune cells such as macrophages and neutrophils. To better understand the relationship between antimicrobial and regulatory functions of blood cell ROS, we have characterized the ROS response to infection in <I>Drosophila</I> hemocytes. Using fluorescent probes, we find a biphasic hemocyte ROS response to bacterial infection. In the first hour, virtually all hemocytes generate a transient ROS signal, with nonphagocytic cells including prohemocytes and crystal cells displaying exceptionally strong responses. A distinct, and more delayed ROS response starting at 90 min is primarily within cells that have engulfed bacteria, and is sustained for several hours. The early response has a clear regulatory function, as dampening or intensifying the intracellular ROS level has profound effects on plasmatocyte activation. In addition, ROS are necessary and sufficient to activate JNK signalling in crystal cells, and to promote JNK-dependent crystal cell rupture. These findings indicate that <I>Drosophila</I> will be a promising model in which to dissect the mechanisms of ROS stimulation of immune activation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Biphasic hemocyte ROS response to infection in flies. </LI> <LI> Early response high in non-phagocytic prohemocytes and crystal cells. </LI> <LI> Delayed ROS in phagocytic cells. </LI> <LI> ROS activate plasmatocyte spreading and adhesion. </LI> <LI> ROS promote JNK-dependent crystal cell rupture. </LI> </UL> </P>
Myers, Lara,Lee, Seung Woo,Rossi, Robert J.,Lefrancois, Leo,Kwon, Byoung S.,Mittler, Robert S.,Croft, Michael,Vella, Anthony T. Oxford University Press 2006 International immunology Vol.18 No.2
<P>In practice, vaccines should induce lasting and efficacious T cell immunity without promoting deleterious pathological consequences. To accomplish this goal we immunized mice with ovalbumin peptide, polyinosinic–polycytidylic and anti-CD137. Vaccinated mice retained a massive functional CD8 T cell memory pool in lymphoid and non-lymphoid tissues for >1 year. The memory T cells clonally expanded, produced substantial amounts of IFNγ, and responded vigorously to vesicular stomatitis virus infection. To understand how the vaccine might function, we showed that the antigen-specific T cells must bear CD137 in order for optimal priming to occur. Thus, anti-CD137 agonist mAb directly stimulated peptide-specific CD8 T cells and conditioned them to survive. In contrast, CD137-deficient CD8 T cells did not survive despite CD137 expression by antigen presenting cells. Taken together, the data indicate that CD137 and adjuvant combined therapy is an efficacious vaccine strategy for immunization with non-replicating inert antigen.</P>
Microsurgery Training for the Twenty-First Century
Myers, Simon Richard,Froschauer, Stefan,Akelina, Yelena,Tos, Pierluigi,Kim, Jeong Tae,Ghanem, Ali M. Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.4
Current educational interventions and training courses in microsurgery are often predicated on theories of skill acquisition and development that follow a 'practice makes perfect' model. Given the changing landscape of surgical training and advances in educational theories related to skill development, research is needed to assess current training tools in microsurgery education and devise alternative methods that would enhance training. Simulation is an increasingly important tool for educators because, whilst facilitating improved technical proficiency, it provides a way to reduce risks to both trainees and patients. The International Microsurgery Simulation Society has been founded in 2012 in order to consolidate the global effort in promoting excellence in microsurgical training. The society's aim to achieve standarisation of microsurgical training worldwide could be realised through the development of evidence based educational interventions and sharing best practices.
Katherine Myers,Kyle Covington 한국보건의료인국가시험원 2019 보건의료교육평가 Vol.16 No.-
Doctor of physical therapy preparation requires extensive time in precepted clinical education, which involves multiple stakeholders. Student outcomes in clinical education are impacted by many factors, and, in the case of failure, it can be challenging to determine which factors played a primary role in the poor result. Using existing root-cause analysis processes, the authors developed and implemented a framework designed to identify the causes of student failure in clinical education. This framework, when applied to a specific student failure event, can be used to identify the factors that contributed to the situation and to reveal opportunities for improvement in both the clinical and academic environments. A root-cause analysis framework can help to drive change at the programmatic level, and future studies should focus on the framework’s application to a variety of clinical and didactic settings.