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부추와 마늘 바이러스의 分離 同定 및 理化學的 性質에 관한 硏究
노문철,박우원,장무웅 嶺南大學校 基礎科學硏究所 1991 基礎科學硏究 Vol.11 No.-
부추와 마늘은 바이러스 病에 대한 防止策없이 오랬동안 裁培되어온 韓國의 重要한 채소류 중의 하나이다. 따라서 이러한 바이러스 病을 防止하기 위해서는 부추와 마늘의 바이러스에 관한 基本的인 情報가 더욱 必要하다. 이러한 重要性때문에 本 硏究는 부추와 마늘의 바이러스를 分離 同定하여 그 特性을 調査하였다. 그 結果는 다음과 같다. 1. 부추와 마늘의 바이러스는 低速과 高速 遠心分離에 의해 純化되었고, 電子顯微鏡으로 觀察한 結果, 길이 650-700nm의 絲狀 粒子로 確認되었다. 2. 汁液 接種에 의해 感染된 명아주와 잠두의 잎은 局部病斑 症狀을 나타내었다. 3. 부추, 명아주, 잠두의 罹病葉을 초박절편하여 電子 顯微鏡으로 觀察한 결과, 바이러스 粒子는 集團 및 散在像으로 細胞質內에 存在하였다. 4. SDS-PAGE法으로 電氣泳動한 結果, 부추와 마늘의 바이러스의 coat protein의 分子量은 4.12×10⁴dalton으로 確認되었다. 5. 1.4% agarose gel 造成으로 水平電氣泳動한 結果, 부추와 마늘의 바이러스의 RNA의 分子量은 2.85×?? dalton으로 確認되었다. 6. GLV의 항혈청을 이용한 혈청학적 실험(면역전기영동법, 면역전자현미경법)에서 CCLV와 GLV가 동일한 반응을 나타냈었다. Chinese chive(Allium tuberosum) and garlic(Allium sativum) are an important vegetable crops for the korean people and have long been cultivated extensively in Korea. Because of this importance. studies were initiated to isolate and characterize the chinese chive latent virus(CCLV) and garlic latent virus(GLV). Result of these studies are summarized as follows: 1. CCMV and GLV were purified by alternate high and low speed centrifugation of chinese chive leaf or garlic leaf extracts. 2. Electron microscopic examination of CCLV and GLV revealed rod shaped. These paticles are measured about 650-700nm in length. 3. In manual inoculation, these viruses induced local lesion on Chenopodium album and broad bean. 4. In ultrathin section, Particles of CCLV and GLV were often found aggregate or scatered in the cytoplasm. 5. The molecular weight of the coat protein of CCLV and GLV were estimated by polyacrylamade gel electrophoresis in the presence of sodium dodecyl sulfate. Coat protein subunit of CCLV and GLV estimated about about 4.12×10⁴ daltons. 6. The moleculat weight of the nucleic acid of CCLV and GLV estimated about 2.85×?? daltons. 7. By the method of immunoelectrophoresis and immunosorbent electron microscope it has been proved that CCLV is identical to GLV.
Pheophorbide A-methyl Ester, Acyl-CoA: Cholesterol Acyltransferase Inhibitor from Diospyros kaki
Rho, Mun-Chual,Chung, Mi-Yeon,Song, Hye-Young,Kwon, Oh-Eok,Lee, Seung-Woong,Baek, Jin-Ah,Jeune, Kyung-Hee,Kim, Koan-Hoi,Lee, Hyun-Sun,Kim, Young-Kook The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.9
In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an $IC_{50}$ value of 1.85 $\mu$ g/mL.
Jin, Ying-Lan,Rho, Mun-Chual,Gajulapati, Kondaji,Jung, Hwa-Young,Boovanahalli, Shanthaveerappa K.,Lee, Jee-Hyun,Song, Gyu-Yong,Choi, Jung-Ho,Kim, Young-Kook,Lee, Kyeong,Choi, Yong-Seok Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.6
A novel series of imidazo[1,2-$\alpha$]pyridines was designed, synthesized, and tested for their ability to inhibit acyl- CoA:cholesterol acyltransferase. Preliminary lead optimization efforts resulted in the identification of ACAT inhibitors represented by analogues 5b, 5c, 6a, 6c, 7b, and 7c. The ACAT inhibitory activity of these compounds was further established by potent inhibition of cholesteryl ester formation in HepG2 cells by a representative analogue 7b.
Choi, Jung-Ho,Rho, Mun-Chual,Lee, Seung-Woong,Choi, Ji-Na,Kim, Koan-Hoi,Song, Gyu-Young,Kim, Young-Kook 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification and plays important roles in intestinal absorption of cholesterol, hepatic production of lipoproteins and accumulation of cholesteryl ester within macrophages and smooth muscle cells. Ethanol extract of Psoralea corylifolia showed a significant inhibition of ACAT enzyme. Via bioactivity-guided fractionation of the ethanol extract of Psoralea corylifolia, two prenylated flavonoids were isolated. Their structures were determined as bavachin (1) and isobavachalcone (2) by spectroscopic analysis ($^1H-$, ${13}C$-NMR, 2D-NMR, and ESI-MS). The $IC_{50}$ values were 86.0 (1) and 48.0 (2) ${\mu}M$ in the ACAT assay system using rat liver microsome. Compound 2 also decreased cholesteryl ester formations in HepG2 cells. In addition, this compound showed a noncompetitive type of inhibition of ACAT.
호장근의 쿠마린에 의한 RAW 264.7 세포주의 nitric oxide 생성 저해활성
노태철,최희철,이승웅,김영호,노문철,김영국,이현선,Rho, Tae-Cheol,Choi, Hee-Cheol,Lee, Seung-Woong,Kim, Young-Ho,Rho, Mun-Chual,Kim, Young-Kook,Lee, Hyun-Sun 한국생약학회 2001 생약학회지 Vol.32 No.3
During the screening for inhibitors of nitric oxide production in LPS-activated macrophage, RAW 264.7 cells, two coumarins were isolated from chloroform extract of the root of Polygonum cuspidatum. They were identified as decursin (1) and decursinol angelate (2) on the basis of spectroscopic methods. The $IC_{50}$ values of these compounds on NO production were $0.76\;{\mu}M$ (1) and $2.6\;{\mu}M$ (2), respectively. However, the iNOS activity was not inhibited by treatment with these compounds. Their inhibitory effect on NO production seems to result from the suppression of iNOS induction through the suppression of NF-kB activity.
Synthesis of Thienopyrimidine Derivatives as Inhibitors of STAT3 Activation Induced by IL-6
( Hyun-jae Jang ),( Sung Min Kim ),( Mun-chual Rho ),( Seung Woong Lee ),( Yang-heon Song ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.6
A series of thienopyrimidine compounds (6Aa-g and 6Ba-d) were synthesized and characterized by NMR spectroscopy and mass spectrometry. These compounds (6Aa-g and 6Ba-d) potently inhibited STAT3 expression induced by IL-6 in a dose-dependent manner with IC<sub>50</sub> values of 5.73-0.32 μM. Among the prepared thienopyrimidine derivatives, 6Aa, 6Ab, 6Ba and 6Bc significantly suppressed the phosphorylation of STAT3 and ERK1/2 stimulated by IL-6 in Hep3B cells. Furthermore, the synthesized compounds might be useful remedies for the treatment of inflammatory diseases by inhibiting the action of IL-6.
The Inhibition of Diacylglycerol Acyltransferase by Terpenoids from Youngia koidzumiana
Dat Nguyen Tien,Cai Xing Fu,Rho Mun-Chual,Lee Hyun Sun,Bae KiHwan,Kim Young Ho The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.2
The EtOAc extract of Youngia koidzumiana significantly inhibited the diacylglycerol acyltransferase (DGAT) from rat liver microsomes. Bioactivity-guided fractionation led to the isolation of nine compounds, the structures of which were established using physicochemical and spectral data. Of the isolated compounds, oleanolic acid (2), methyl ursolate (7) and corosolic aicd (8) inhibited DGAT, with $IC_{50}$ values of 31.7, 26.4, and $44.3{\mu}M$, respectively. However, sesquit-erpenoids showed only weak inhibitory effects toward DGAT.