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Tin,Copper,Silicon-Phthalocyanine과 그 유도체의 합성에 관한 연구(Organic Semiconductor의 개발Ⅰ)
오응주,송양헌 明知大學校 産業技術硏究所 1984 産業技術硏究所論文集 Vol.3 No.-
Tin, Copper, Silicon-Phthalocyanine and its derivatives which seems to possess semiconductivities were synthesized by various methods to develop the new organic semiconductors. The most desirable starting materials for the syntheses were o-cyanobenzamide. Electrical Conductivities of Tin, Copper, Silicon-Phthalocyanine were ?? at room temperature, respectively.
Selective Oxidation of Benzylic and Allylic Alcohols using Benzyldimethyltelluronium Dichromate
Song, Yang Heon 목원대학교 자연과학연구소 1993 自然科學 硏究論文集 Vol.2 No.1
벤질디메틸텔루로늄 디크로메이트는 포화 지방족알콜의 존재하에서 벤질, 알릴 알코올만을 해당 알데히드나 케톤으로 산화시키는 선택적인 새로운 산화제임을 알 수 있었다. Benzyldimethyltelluronium dichromate selectively oxidizes benzylic, allylic alcohols to the corresponding aldehydes or ketones in the presence of saturated aliphatic alcohols.
Selective Oxidation of Alcohols By Ytterbium(Ⅲ) Nitrate
Song,Yang-Heon 牧園大學校 1990 論文集 - 牧園大學校 Vol.18 No.-
Ytterbium(Ⅲ) nitrate was an efficient oxidizing agent for the selective oxidation of benzylic alcohols. Oxidation of alcohols by nitrate has not attracted much attention mainly because several excellent transition metal oxidizing agents have been available for that purpose. Recently, Laszlo reported oxidation of alcohols by clay-supported cupric nitrite and iron nitrate. However, the condition employed by Laszlo did not show the selectivity for oxidation of alcohols. As continuation of our search for the selective oxidizing agent for alcohols, we, therefore, investigated the oxidizing ability of ytterbium nitrate under the condition which was different from Laszlo's condition. In addition, to the best of our knowledge, no examples of oxidation of alcohol with ytterbium nitrate have been reported. Herein we report a ytterbium nitrate in solvent mixture of water-dioxane as an efficient and selective oxidizing agent for oxidation of alcohols. In a typical oxidation, to a solution of an alcohol (1mmol) in dioxane (5 mL) was added a ytterbium nitrate pentahydrate (0.2 mmol) dissolved in water (5 mL) and concentrated hydrochloric acid (0.5 mL). The mixture was strirred at room temperature. The reaction mixture was extracted with CH₂Cl₂(3×10 mL). The organic extracts were washed with NaHCO₃and with water, dried over MgSO₄, evaporated to dryness and analyzed by GLC. The experimental results are summarized In Table 1. Table 1. Oxidation of Alcohols by Yb(NO₃)₃ a : determined by GLC (Hewlett-packard 5890 A equipped with a 6ft, 0.25 in. column packed with 10% SE-30 silicon rubber gum on Chromosorb p) The reaction of benzyl alcohol with oxidizing agent, Yb(NO₃)₃, gave benzaldehyde in 1h in quantitative yield. Other benzylic alcohols were similarity transformed into the corresponding aldehyde or ketone in high yields as shown in table 1. Oxidation of cinnamyl alcohol, however, produced cinnamaldehyde in 30% yield together with several unidentified by-products. Allylic alcohol containing an isolated double bond, namely geraniol, was oxidized to correspondig aldehyde with side product. Therefore, oxidation of allylic alcohols with this oxidizing agent was not effective. Saturated primary and secondary alcohols under same condition were oxidized in low yield or not oxidized. For example, oxidation of cyclohexanol by same reagent gave cyclohexanone only in 5% yield in 24h and 1-dodecanol was not oxidized. When the mixture of benzyl alcohol and l-dodecanol was treated with Yb(NO₃)₃, benzyl alcohol was selectively oxidized to benzaldehyde. It is noteworthy that good selectrivety was observed in the selective oxidation of benzyl alcohol in the presence of satruated aliphatic alcohol. The further examination of the selectivity of this oxidizing agent to the oxidation of polyhydroxy compounds is under way. In conclusion, the good selectivity and efficiency of ytterbium nitrate, Yb(NO₃)₃, indicates that this oxidizing agent would prove to be a useful alternative to other regents in the selective oxidation of benzylic alcohols.
Bis(2-oxo-3-oxazolidinyl)phosphinic Chloride As a New Thiol Protective Reagent
Song, Yang,-Heon 牧園大學校 1989 論文集 - 牧園大學校 Vol.16 No.-
An effective method for the protection of thiol group using bis(2-oxo-3-oxazolidinyl) phosphinic chloride was developed. This protective group of thiols could be readily removed by use of KF/benzyltriethylammonium chloride in a solvent mixture of water-chloroform whereas it was stable under acidic condition.
Convenient Synthesis of Novel Phenylpyrimido[1,2-c]thienopyrimidinones as IL-6/STAT3 Inhibitors
Song, Yang-Heon,Hoo Park, Jae,Young Hong, So,Kim, Jungah,Joo Lee, Hyuck,Ho Lee, Hyun,Young Kim, Ka,Woong Lee, Seung,Oh, Hyun-Mee,Rho, Mun-Chul,Lee, Beom-Gyu Japan Institute of Heterocyclic Chemistry 2015 Heterocycles Vol.91 No.4
<P>New phenylpyrimido[1,2-c]thienopyrimidinones 4A and 4B were easily prepared in good yields by the one-pot reaction of formamidine derivatives 2 of 4-aminothienopyrimidine 1 with phenylacetyl chlorides. The application of this convenient and reliable method could be used for the synthesis of a variety of pyrimido[1,2-c]thienopyrimidinone derivatives of biological importance. Some of the compounds synthesized showed strong IL-6/STAT3 inhibition.</P>
Song, Yang-Heon 牧園大學校 1987 論文集 - 牧園大學校 Vol.13 No.-
K₂FeO₄ adsorbed on basic alumina was found to be an effective oxidizing agent for the conversion of benzylic, allylic alcohol to the corresponding aldehyde or ketone whereas the oxidation of saturated aliphatic alcohol with same reagent was very sluggish.
Song, Yang Heon 목원대학교 자연과학연구소 1994 自然科學 硏究論文集 Vol.3 No.1
디엔에이에 결합하는 단백질의 광친화제로서 이용될 수 있는 5-아지도-2'-디옥시유리딘을 세단계에 걸쳐 성공적으로 합성하였다. The first synthesis of 5-azido-2'-deoxyuridine as a photoaffinity label for DNA-binding proteins has been achieved in three steps.
A Facile Synthesis of 4-(Phenylamino)thieno[3,2-d]pyrimidines
SONG, Yang-Heon 목원대학교 자연과학연구소 2000 自然科學 硏究論文集 Vol.9 No.1
4-(Phenylamino)thieno[3,2-d]pyrimidines were obtained in high yield by the reaction between aniline derivatives and 4-chlorothieno[3,2-d]pyrimidine prepared from 3-amino-2-carbamoylthiophene.