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Moon, S.M.,Kim, J.S.,Kim, H.J.,Choi, M.S.,Park, B.R.,Kim, S.G.,Ahn, H.,Chun, H.S.,Shin, Y.K.,Kim, J.J.,Kim, D.K.,Lee, S.Y.,Seo, Y.W.,Kim, Y.H.,Kim, C.S. Society for Bioscience and Bioengineering, Japan ; 2014 Journal of bioscience and bioengineering Vol.117 No.5
A novel fibrinolytic enzyme was purified from Lyophyllum shimeji, a popular edible mushroom in Asia. The enzyme was purified using combination of anion exchange chromatography on a Mono Q 5/5 column and size exclusion gel filtration chromatography on Superdex 200 100/300 column. This purification protocol resulted 80.9-fold purification of the enzyme and a final yield of 5.7%. The molecular weight of the purified enzyme was estimated to be 21 kDa by SDS-PAGE and size exclusion gel filtration. The N-terminal amino acid sequence was found to be ITFQSASP, which is dissimilar from that of known fibrinolytic enzymes. The purified enzyme was a neutral protease with an optimal reaction pH and temperature of 8.0 and 37<SUP>o</SUP>C, respectively. Enzymatic activity was inhibited by Cu<SUP>2+</SUP> and Co<SUP>2+</SUP>. It was also significantly inhibited by PMSF and TPCK. Furthermore, it was found to exhibit a higher specificity for S-7388, a well-known chymotrypsin chromogenic substrate, indicating chymotrypsin like serine metalloprotease. The relative fibrinolytic activity of 5 μg purified enzyme have two fold more activity than 1 unit/ml of plasmin on fibrin plate. Furthermore, purified enzyme preferentially hydrolyzed the Aα-chain followed by the Bβ- and γ-chain of fibrinogen, which is precursor of fibrin. Therefore, these data suggests that the fibrinolytic enzyme derived from edible mushroom, L. shimeji, might be useful for thrombolytic therapy and preventing thrombotic disease.
Kang, H.w.,Song, P.H.,Ha, Y.S.,Kim, W.T.,Kim, Y.J.,Yun, S.J.,Lee, S.C.,Choi, Y.H.,Moon, S.K.,Kim, W.J. Pergamon Press 2013 European journal of cancer Vol.49 No.14
Background: We investigated whether genetic polymorphisms in the glutathione S transferase mu (GSTM1) and theta (GSTT1) genes modulated risk, disease progression and survival in primary muscle invasive bladder cancer (MIBC). Methods: GSTM1 and GSTT1 polymorphisms were analysed by multiplex polymerase chain reaction (PCR) using blood genomic DNA in 110 MIBC patients and 220 gender- and age-matched healthy controls. The influence of the genetic polymorphisms on patient survival was evaluated by Kaplan-Meier survival curves and Cox Proportional Hazard models. We also evaluated whether cigarette smoking and treatment modality modified the association between genotype and prognosis. Results: GSTM1-null individuals exhibited increased risk for MIBC and an association with cigarette smoking. GSTT1-null subjects showed significant disease progression and cancer-specific death. In the combined analysis, GSTT1-null genotype was an independent risk factor for disease progression and cancer specific death regardless of GSTM1 genotype. Significant differences in progression-free survival (PFS) and cancer-specific survival (CSS) were seen based on GSTT1 genotype. The survival impact of the GSTT1 genotype was only valid for smokers. The GSTT1-null genotype was an independent prognostic factor for shorter PFS in patients who received chemotherapy and those who did not undergo radical cystectomy. By multivariate Cox regression analysis, GSTT1-null genotype was a predictive factor for disease progression and cancer specific survival regardless of treatment modality. Conclusions: The GSTM1-null genotype plays an important role in genetic susceptibility to MIBC and the GSTT1-null genotype is associated with disease progression and shorter survival in MIBC.
1970年 慶北 聞慶地域에 發生한 腸티브스 疫學調査報告
李元榮,韓王洙,洪在雄,李京男,金貞順,文玉綸 서울大學校 保建大學院 1973 公衆保健雜誌 Vol.10 No.1
Epidemiology team, School of Public Health, Seoul National University, was commissioned to investigate an outbreak of unknown febrile disease occurred in Moon Kyung area from Ministry of Health. The team investigated the outbreak and collected specimens of rectal swab and sera; bacteriological study was done in National Institute of Health and serological test in the serology laboratory in the School of Public Health. Followings are the results obtained: 1. The entity of unknown febrile disease was identified as Salmonella typhi, D group. 2. Most common symptoms were headache and fever. The symptoms appeared to be quite severe in the begining of the epidemic which gradually became milder as the epidemic progressed to from of walking typhoid, probably being resulted from gradual development of population immunity. 3. It was an explosive outbreak among school children; the incidence of the disease per 1000 was 619.3 for school children whereas average incidence in four villages surveyed was 170.1. 4. The source of infection was common, open well in a corner of school ground for school children, however, the source of infection for general population was either personal contact or contaminated food in the family. 5. Distribution of date of onset and diffuse case distribution among villagers other than school children strongly suggested that these were secondary cases infected from the school children who delivered the agent to their family and/or neighbours. 6. A route of spread was assumed as follow: a beautician who travelled around extensively from one village to another for weddings was the first patient so far we could trace. She got sick in the begining of March and went home where her only brother followed her and died. she got out home and lost because of her brother's death. In the middle of March the beautician's two neighbours who shared open well contracted the disease. One of these two had such sever symptoms like delirium and aphasia that she was hospitalized in a private hospital for seven days and singed out the hospital and went her mother's home. In the begining of April her mother and one of her old classmates who was principal's son became ill. The principal lived in the school campus near the well, and thus the well got contaminated. The principal was the one who brought attention to health center because of unusually high absenteeism of the school children.