Patterns of Impaired Neurocognitive Performance on the Global Neuropsychological Assessment, and Their Brain Structural Correlates in Recent-onset and Chronic Schizophrenia

Vineeth Mohan(Vineeth Mohan ),Pravesh Parekh(Pravesh Parekh ),Ammu Lukose(Ammu Lukose ),Sydney Moirangthem(Sydney Moirangthem ),Jitender Saini(Jitender Saini ),David J. Schretlen(David J. Schretlen ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2

Objective: Schizophrenia is associated with impairment in multiple cognitive domains. There is a paucity of research on the effect of prolonged illness duration (≥ 15 years) on cognitive performance along multiple domains. In this pilot study, we used the Global Neuropsychological Assessment (GNA), a brief cognitive battery, to explore the patterns of cognitive impairment in recent-onset (≤ 2 years) compared to chronic schizophrenia (≥ 15 years), and correlate cognitive performance with brain morphometry in patients and healthy adults. Methods: We assessed cognitive performance in patients with recent-onset (n = 17, illness duration ≤ 2 years) and chronic schizophrenia (n = 14, duration ≥ 15 years), and healthy adults (n = 16) using the GNA and examined correlations between cognitive scores and gray matter volumes computed from T1-weighted magnetic resonance imaging images. Results: We observed cognitive deficits affecting multiple domains in the schizophrenia samples. Selectively greater impairment of perceptual comparison speed was found in adults with chronic schizophrenia (p = 0.009, η2 partial = 0.25). In the full sample (n = 47), perceptual comparison speed correlated significantly with gray matter volumes in the anterior and medial temporal lobes (TFCE, FWE p < 0.01). Conclusion: Along with generalized deficit across multiple cognitive domains, selectively greater impairment of perceptual comparison speed appears to characterize chronic schizophrenia. This pattern might indicate an accelerated or premature cognitive aging. Anterior-medial temporal gray matter volumes especially of the left hemisphere might underlie the impairment noted in this domain in schizophrenia.

Effect of inducible co-overexpression of protein disulfide isomerase and endoplasmic reticulum oxidoreductase on the specific antibody productivity of recombinant Chinese hamster ovary cells

Mohan, Chaya,Lee, Gyun Min Wiley Subscription Services, Inc., A Wiley Company 2010 Biotechnology and bioengineering Vol.107 No.2

<P>To enhance specific antibody (Ab) productivity (q<SUB>Ab</SUB>) of recombinant Chinese hamster ovary (rCHO) cells, post-translational limitations in the endoplasmic reticulum during antibody production should be relieved. Previously, we reported that overexpression of protein disulfide isomerase (PDI), which catalyzes disulfide bond exchanges and assists in protein folding of newly synthesized proteins, enhanced q<SUB>Ab</SUB> of rCHO cells by about 27% (Mohan et al., 2007, Biotechnol Bioeng 98:611–615) . Since the rate limiting step in disulfide bond formation is found to be the regeneration of oxidized PDI, the oxidation state of PDI, as well as the amount of PDI, might be important. Endoplasmic reticulum oxidoreductase (ERO1L) maintains PDI in an oxidized state so that disulfide bond formation occurs. Here, PDI and its helper protein, ERO1L were overexpressed in rCHO cells producing an Ab in an attempt to ease the bottleneck in disulfide bond formation, and hence, Ab folding and secretion. Transient expression of ERO1L alone and with PDI resulted in enhanced q<SUB>Ab</SUB> by 37% and 55%, respectively. In contrast, under stable inducible co-overexpression of PDI and ERO1L, the q<SUB>Ab</SUB> was unaffected or negatively affected by varying degrees, depending on the individual expression levels of these genes. In stable clones with altered oxidation state of PDI due to co-overexpression of PDI and ERO1L, secretion of Ab was hindered and PDI-associated retention of Ab was seen in the cells. Under transient gene expression, secretion of Ab was not compromised. The data presented here suggests a possible mechanism of PDI/ERO1L interaction with the target Ab and shows how the expression levels of these proteins could affect the q<SUB>Ab</SUB> of this Ab-producing rCHO cell line. Biotechnol. Bioeng. 2010;107: 337–346. © 2010 Wiley Periodicals, Inc.</P>

Quantum Sensing Research: A Scientometric Assessment of Global Publications during 1991-2020

Brij Mohan Gupta,Surinder Mohan Dhawan,Ghouse Modin Mamdapur 건국대학교 GLOCAL(글로컬)캠퍼스 지식콘텐츠연구소 2022 International Journal of Knowledge Content Develop Vol.12 No.3

The study presents a global research scenario in the domain of quantum sensing in quantitative and qualitative terms. The study is based on an analysis of 588 global publications in the field, sourced from the Scopus database for the period 1991-2020. The study identified key countries, organizations and authors, network collaborative linkages at national, institutional, and author level. In addition, it identified broad subject areas intersecting quantum sensing research, key journals for research communications, and broad characteristics of highly-cited papers. The study finds that the USA and Germany lead the world ranking in quantum sensing research with a combined share of 50% to the global output. The USA, Germany, and Italy are the home countries to 13 of the top 15 most productive organizations, and also the home countries to 14 of the top 15 most productive authors in the subject. The top journals publishing most research publications are Physical Review A, Physical Review Letters and New Journal of Physics. However, in the most cited journals list in the subject, Agriculture & Forest Meterology, Science and Physical Review A tops the list.

Application of a Lateral Misalignments Detection Mechanism for Roadway Powered Electric Vehicle

Krishna G. Mohan,Pulluri Harish,Merugu Kavitha,Mohan Reddy D.,Anil Kumar T. 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.5

Wireless power transfer (WPT) is emerging as an eminent means of the electric vehicle charging system. A perfectly aligned transmitter–receiver set of WPT system vintages a quick and autonomous charging of the vehicle. However, practically, misalignment is inevitable, and a minor deviation between the transmitter–receiver makes a diff erential fall in the desired output power. So, the system requires a proper mechanism to detect and correct these misalignments. In this paper, an experimental study on lateral misalignments is performed at diff erent ground clearances. Of the many detection techniques present, a 10bit R-2R ladder based lateral misalignment detection mechanism is proposed, and the signifi cant results are presented. This mechanism is a digital-to-analog converter, which induces multiple combinations of outputs. These outputs signify the precise position of the vehicle in the charging lane. Further, an interactive driver assistance system is suggested to attain the desired output power by instructing the EV driver to proceed for perfect alignment. This system eff ectively communicates the data such as state of alignment, measurement of speed, percentage of state-of-charge, and control over the charging process.

The role of rectal diclofenac and aggressive hydration with Ringer's lactate in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients

Sharma Vivek Mohan,Mathur Amit,Goyal Mohan Babu,Jat Shankar Lal 소화기인터벤션의학회 2023 International journal of gastrointestinal interven Vol.12 No.2

Background: Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is a common complication of therapeutic endoscopy. The aim of this trial was to determine whether a combination of rectal diclofenac and vigorous hydration with Ringer’s lactate is superior to the correspond-ing individual treatments for preventing PEP in high-risk patients. Methods: This randomized, open-label, controlled trial was conducted from August 2020 to January 2022. We included patients who were at high risk of developing PEP. Three intervention groups were made: group A, diclofenac sodium suppository (100 mg); group B, aggressive hydration with Ringer’s lactate; group C, a combination of diclofenac and aggressive hydration. PEP was defined as a serum amylase level > 3 times the upper limit of normal with epigastric pain within 24 hours after endoscopic retrograde cholangiopancreatography.Results: A total of 144 patients were included and 48 cases were randomized to each intervention group. The incidence of PEP was 8.3%, 10.4%, and 8.3% in groups A, B, and C, respectively. A personal history of alcohol consumption and more than one pancreatic duct guidewire cannulation were significantly associated with the development of PEP.Conclusion: No difference in the incidence of PEP was observed with or without the use of aggressive hydration. Combining aggressive hydration with a rectal nonsteroidal anti-inflammatory drug for preventing PEP cannot be recommended.

Electrochemical studies on two-dimensional ZnInO nanoplates for organic–inorganic hybrid photodiode related applications

Mohan Kumar, G.,Madhan Kumar, A.,Ilanchezhiyan, P.,Kang, T.W. Elsevier 2015 JOURNAL OF ALLOYS AND COMPOUNDS Vol.619 No.-

<P><B>Abstract</B></P> <P>An ultra low cost route has been established to fabricate organic–inorganic hybrid <I>p</I> <I>–</I> <I>n</I> junctions <I>via</I> chemical <I>in-situ</I> polymerization of organic monomers on traditionally drop casted inorganic deposits. In this regard, ZnInO nanoplate-like structures were synthesized through a facile solution based chemical approach and their structural property was studied using X-ray diffraction patterns. The nature of charge carriers and donor density in ZnInO made electrodes were studied using electrochemical impedance spectroscopy. The dissemination of polymer matrices on the ZnInO nanoplates was examined through scanning electron microscopy. The current–voltage characteristics obtained across the polypyrrole/ZnInO made hybrid structures revealed an improved rectifying behaviour under illuminated conditions. The mechanism behind the drastic decrease in resistance values that substantiates the improved electron transfer characteristics across the organic–inorganic structures was studied through cyclic voltammetric measurements.</P>

A two-photon fluorescent probe for near-membrane calcium ions in live cells and tissues

Mohan, Palathurai Subramaniam,Lim, Chang Su,Tian, Yu Shun,Roh, Won Young,Lee, Jun Han,Cho, Bong Rae Royal Society of Chemistry 2009 Chemical communications Vol.2009 No.36

<P>A two-photon fluorescent probe (ACaL) is reported that can be excited by 780 nm fs pulses, shows high photostability and negligible toxicity, and can visualize near-membrane Ca<SUP>2+</SUP> in live cells and deep inside live tissues by two-photon microscopy.</P> <P>Graphic Abstract</P><P>A two-photon fluorescent probe (ACaL) has been developed that can be excited by 780 nm fs laser pulses, shows high photostability and negligible toxicity, and can visualize near-membrane Ca<SUP>2+</SUP> in live cells and deep inside live tissues by two-photon microscopy. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b911337a'> </P>

Securing Australia: From Alliances to Agreements

( Mohan Malik ) 한국국방연구원 1998 The Korean Journal of Defense Analysis Vol.10 No.1

Security alliances have always played a central role in the maintenance of regional and international security and have therefore served as a major instrument of Australia`s national security. The strong emphasis on security alliances and pacts in Australian defense planning can be attributed to the belief that Australia needs to team up with major powers to secure its place in the Asia-Pacific. In the post-Cold War era, since there is no clearly identifiable common threat, the "threat oriented" alliances forged during the Cold War may well be an anachronism. This paper therefore argues that the Cold War era threat oriented military alliances must transform themselves into "order oriented" alliances to meet the security challenges of the next century. The objective should be to make these order-oriented security arrangements the basis of an Asia-Pacific security community founded on shared interests, shared values and shared responsibility. This security community would maintain stability and tranquility in a multipolar setting and would not allow the domination of the region by any single state. This paper provides a conceptual framework for the new type of post-Cold War flexible, purpose-specific, loose, order-oriented security arrangements which are likely to be more widespread in the foreseeable future. Over the last few years, Australia has taken a lead in establishing order-oriented new type of flexible, purpose-specific, loose, order oriented security arrangements with regional countries. Such security arrangements, characterized by adaptability, flexibility and ambiguity, are likely to prove more adaptable and therefore will be more widespread in the foreseeable future. The conclusion of new order oriented security arrangements such as the security agreement with Indonesia, strategic partnership with Japan and political-military dialogues with Korea, China, Vietnam, the Philippines, Thailand and India constitute an integral part of Australia`s "regional defense" strategy. Regional defense is a variant of forward defense just as "defense of Australia" was a variant of "fortress Australia." As in the past, Australian defense policy in the 21st century is likely to be a mixture of the two strategies-self-reliance and forward defense. This mixture will remain the basis of Australia`s regional defense strategy based on a ring of order-oriented security arrangements and political military dialogues with regional countries.

Blessing Of Sky Lanterns

Mohan Wang,Xiaoqing Ma,Miao Zhang 한국콘텐츠학회 2015 ICCC International Digital Design Invitation Exhib Vol.2015 No.7

Effect of process parameters on 3-hydroxypropionic acid production from glycerol using a recombinant Escherichia coli

Mohan Raj, Subramanian,Rathnasingh, Chelladurai,Jung, Woo-Chel,Park, Sunghoon Springer-Verlag 2009 Applied microbiology and biotechnology Vol.84 No.4