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손미라 ( Son¸ Mira ),김신향 ( Kim¸ Sinhyang ) 한국간호과학회 정신간호학회(구 대한간호학회정신간호학회) 2021 정신간호학회지 Vol.30 No.1
Purpose: The purpose of this study was to explore the experience of self-awareness of nursing students through a short-term overseas language study. Methods: Study subjects were 10 nursing students, and collected data were analyzed with open coding, axial coding, selective coding, and process analysis based on Strauss and Corbin's grounded theory (1998). Results: In total, 23 sub-categories and 12 categories were generated. The 12 categories included "Longing for a bigger world", "Don't want to be intimidated", "Interest in English", "Tension about local classes", "Feeling of pushing the limit", "Getting along with natives", “Making Korean American University students a role model", "Self-observe confronting unfamiliarity", "Self-encourage about enduring hardships", "Self-expansion for a better self", "Recognize self-transformation", "Focusing on the reality". Nursing students' self-awareness experience through a short-term overseas language study was a process of solving the phenomenon of 'feeling of pushing the limit', and a derived core category was 'surpass the feeling of pushing the limit and take a step forward'. Conclusion: Study participants experienced self-awareness. These results will not only expand our understanding about self-awareness of nursing students and educators but will also provide information for developing a short-term overseas study program.
송우정,Mira Choi,Dong Hun Lee,Jae-Woo Kwon,Gun-Woo Kim,Myung Hwa Kim,Mi-Ae Kim,Min-Hye Kim,Byung-Keun Kim,Sujeong Kim,Joung Soo Kim,Jung Eun Kim,Ju Young Kim,Joo Hee Kim,Hyun Jung Kim,Hye One Kim,Hyo-Bin 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.4
Chronic spontaneous urticaria (CSU) is defined as the occurrence of spontaneous wheals, angioedema, or both for >6 weeks in the absence of specific causes. It is a common condition associated with substantial disease burden both for affected individuals and societies in many countries, including Korea. CSU frequently persists for several years and requires high-intensity treatment; therefore, patients experience deteriorations in quality of life and medication-associated complications. During the last decade, there have been major advances in the pharmacological treatment of CSU and there is an outstanding need for evidence-based guidelines that reflect clinical practice in Korea. The guidelines reported here represent a joint initiative of the Korean Academy of Asthma, Allergy and Clinical Immunology and the Korean Dermatological Association, and aim to provide evidence-based guidance for the management of CSU in Korean adults and children. In Part 1, disease definition, guideline scope and development methodology as well as evidence-based recommendations on the use of antihistamines and corticosteroids are summarized.
Kim, Mirae,Cha, Chaenyung Butterworth Scientific Ltd. etc. 2018 Polymer Vol. No.
<P><B>Abstract</B></P> <P>Michael addition is extensively utilized to fabricate hydrogels for biomedical applications, due their ability to undergo crosslinking reaction under physiological conditions without the need of a catalyst. Herein, mechanical properties and degradation behavior of in situ crosslinkable poly (ethylene glycol) diacrylate (PEGDA)-polyethyleneimine (PEI) hydrogels are explored. PEGDA and PEI, having acrylate and amine groups respectively, undergo crosslinking reaction via Michael addition to form hydrogels. The mechanical properties are controlled in a wide range by varying their concentrations and the molecular weight of PEGDA. In addition, the hydrogels are all shown to undergo degradation due to the expedited hydrolysis of ester linkages by the presence of unreacted amine groups on PEI. With this interesting combination of tunable mechanical properties and degradation, the PEGDA-PEI hydrogel system display a dual-mode drug release kinetics in which the drug release was governed by swelling-controlled and degradation-controlled mechanisms in sequence, which demonstrates the potential for drug delivery applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> In situ forming hydrogel via Michael addition between PEGDA and PEI is presented. </LI> <LI> Mechanical properties and degradation behavior are tuned by reactant parameters. </LI> <LI> Drug release kinetics are governed by “dual-mode” mechanisms. </LI> <LI> Swelling- and degradation-controlled drug release mechanisms occur in series. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Derivation of putative brain endothelial cells from porcine induced pluripotent stem cells
Mirae Kim,Sang-Hwan Hyun 한국수정란이식학회 2017 한국수정란이식학회 학술대회 Vol.2017 No.05
The use of pigs in neuroscience has increased over the past years because the pigs are closely related to humans in terms of anatomy and physiology. Especially, the blood-brain barrier (BBB) maintains the homeostatic microenvironment in the central nervous system (CNS) and they can provide a valuable tool for studying the neurobiology. However, only a few putative blood-brain barrier (BBB) models have been generated by co-culture of porcine primary cells. The fundamental problem is that they lose some of their phenotypes when maintained in vitro for long-term culture. To establish improved in vitro porcine BBB models, we differentiated novel brain microvascular endothelial cells (BMECs) from porcine induced pluripotent stem cells (iPSCs) using a modified human-based protocol. Briefly, the dissociated single cells from iPSCs were seeded in Geltrex. For differentiation, cells were maintained for 3 days of expansion and then switched to unconditioned medium (UM) lacking bFGF for 6-7 days. Then, we subcultured cells onto collagen/fibronectin coated plates and changed BMEC medium for 2-3 weeks. About two weeks later, we observed a cluster of round cells surrounded by spindle shaped adherent cells termed as colony-forming units (CFU) of putative BMECs. Over time, the cluster of cells disappears and remained adherent spindle-shaped cells showed properties of endothelial cells. Although further studies will be needed, this study would be a great comparative analysis of the porcine and human in vitro BBB model.
Estimation of Supply and Demand for Cardiologists in Korea
Mira Kim,Kyunghee Chae,Ju Mee Wang,Arum Choi,Jang-Whan Bae,Keon-Woong Moon,Sukil Kim 대한심장학회 2024 Korean Circulation Journal Vol.54 No.1
Background and Objectives: The objective of this study was to estimate the supply and demand for cardiologists in Korea and provide evidence for healthcare policy to ensure a stable and adequate workforce for optimal cardiovascular disease management. Methods: Past trends of inflow and outflow of cardiologists were used to make crude projections, which were then adjusted based on demands of services to obtain final projections. Inflow of cardiologists was estimated using second-order polynomial regression and demand for cardiology care was estimated using linear regression. Results: There were 1,139 active cardiologists who were under the age of 65 in clinical practice in Korea. The estimated number of cardiologists from 2022 to 2040 showed that the number of cardiologists would peak at 1,344 in 2032 and gradually decrease thereafter. We also estimated an increase of 947,811 cases of heart-related procedures annually from 2023 to 2032. The number of heart-related procedures per cardiologist would increase 1.4 times from 12,964 in 2023 to 17,862 in 2032. The estimated number of emergency patients per cardiologist under 50 years old would almost double from 544 in 2022 to 987 in 2032. Conclusions: We expect significant shortage of cardiologists in Korea within the next 10 years. The number of emergency patients per cardiologist will increase by nearly 50%, leading to high individual workload for cardiologists. To prevent this imbalance between supply and demand, an organized and collective approach by the specialty of cardiology is imperative to produce a balanced workforce.
Synthesis of Vinyl Sulfone-tethered Proline Derivatives as Highly Selective Cathepsin S Inhibitors
Mira Kim,Jiyoung Jeon,Jongouk Baek,Jaeyul Choi,Eun Ju Park,Jiyeon Song,Hyojeong Bang,Kwee-Hyun Suh,Young Hoon Kim,Jongmin Kim,Doran Kim,민경훈,Kwang-Ok Lee 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
Kim, Mirae,Li, Yongzeng,Peng, Di,Yeom, Eunseop,Kim, Kyung Chun Elsevier 2019 Experimental thermal and fluid science Vol.105 No.-
<P><B>Abstract</B></P> <P>When the circular jet impinges onto a cylinder, the three-dimensional (3D) curved wall jet was attached to the wall due to the Coanda effect and the flow separation was delayed with increasing Reynolds number and impinging angle. These interesting phenomena can be studied in depth through a variety of parameters and measurement methods. Time-resolved stereo PIV measurement was conducted to investigate the 3D flow characteristics with instantaneous velocity and vorticity fields. Pressure sensitive paint (PSP) method was used to examine the pressure distribution on the cylinder surface when a circular jet impinges on it. The effects of the impingement angle, Reynolds number, and diameter ratio between the jet nozzle and the cylinder (d/D) were examined at a fixed nozzle to wall distance ratio of two (H/d = 2). Experimental results show that the pressure gradient in the flow direction decreases and the separation is delayed when the Reynolds number and impingement angle are increased at the same distance ratio. As the diameter ratio decreases with the same impingement angle and Reynolds number, the maximum suction pressure increases, and the pressure gradient in the wall jet flow direction increases. The three-dimensional nature of the surface pressure distribution changes with the flow parameters, which are well explained with three-dimensional flow field measurements in the curved 3D wall jet due to the Coanda effect.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Surface pressure distribution was measured when a circular jet impinges on a cylinder. </LI> <LI> Effects of the impingement angle, Reynolds number, and diameter ratio were examined. </LI> <LI> Pressure gradient in flow direction decreases when the impingement angle increases. </LI> <LI> The three-dimensional nature of the surface pressure changes with the flow parameters. </LI> </UL> </P>