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( Minjoo Kim ),( Eun-mi Kim ),( Phil-sun Oh ),( Seok Tae Lim ),( Myung-hee Sohn ),( Eun-kee Song ),( Keon Uk Park ),( Jin Young Kim ),( Kyoung Sook Won ),( Hwan-jeong Jeong ) 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.4
Background: Pharmacological and non-pharmacological therapies have been used to treat patients with chemotherapy-induced peripheral neuropathy (CIPN). However, the effect of therapies in cancer patients has yet to be investigated comprehensively. We hypothesized that cyclic thermal therapy would improve blood flow and microcirculation and improve the symptoms driven by CIPN. Methods: The criteria of assessment were blood volume in region of interest (ROI) in the images, and European Organization for Research and Treatment of Cancer- Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy 20 questionnaire scores. The blood volume was quantified by using red blood cell (RBC) scintigraphy. All patients were treated 10 times during 10 days. The thermal stimulations, between 15° and 41°, were repeatedly delivered to the patient’s hands. Results: The total score of the questionnaires, the score of questions related to the upper limbs, the score of questions closely related to the upper limbs, and the score excluding the upper limbs questions was decreased. The blood volume was decreased, and the variance of blood volume was decreased. During cooling stimulation, the blood volume was decreased, and its variance was decreased. During warming stimulation, the blood volume was decreased, and its variance was decreased. Conclusions: We suggest that cyclic thermal therapy is useful to alleviate CIPN symptoms by blood circulation improvement. RBC scintigraphy can provide the quantitative information on blood volume under certain conditions such as stress, as well as rest, in peripheral tissue.
Choi, Ji Hae,Oh, Doori,Kim, In Sun,Kim, Hyeon-Soo,Kim, Minjoo,Kim, Eun-Mi,Lim, Seok Tae,Sohn, Myung-Hee,Kim, Dong Hyun,Jeong, Hwan-Jeong Hindawi 2018 Contrast media and molecular imaging Vol.2018 No.-
<P>Novel probe development for positron emission tomography (PET) is leading to expanding the scope of molecular imaging. To begin responding to challenges, several biomaterials such as natural products and small molecules, peptides, engineered proteins including affibodies, and antibodies have been used in the development of targeted molecular imaging probes. To prepare radiotracers, a few bioactive materials are unique challenges to radiolabelling because of their complex structure, poor stability, poor solubility in aqueous or chemical organic solutions, and sensitivity to temperature and nonphysiological pH. To overcome these challenges, we developed a new radiolabelling strategy based on photoactivated 1,3-dipolar cycloaddition between alkene dipolarophile and tetrazole moiety containing compounds. Herein, we describe a light-triggered radiochemical synthesis via photoactivated click reaction to prepare <SUP>18</SUP>F-radiolabelled PET tracers using small molecular and RGD peptide.</P>
The Applicability of the Cultural Management Studies for International Tourism Researches
Minjoo Kim,Yeonjin Jang 관광경영학회 2002 관광경영연구 Vol.14 No.-
국제관광은 오래 전부터 관광학 연구의 주요분야로 인식되어 왔으나 아직 학적 체계를 이루지 못하고 있다. 기존에 수행된 국제관광 연구는 국제관광의 경제적 효과나 문화간 접촉에 따른 충격, 문화 변용 등의 한정된 관심에 머무르고 있으며, 관광경영 분야에는 몇몇 연구가 수행된 바 있으나 국내외적으로 주목할만한 연구를 찾아보기 어려운 실정이다. 본 연구는 이러한 문제의식 하에 국제화라는 시대적 조류 속에서 관광경영 연구가 실천적 유용성을 갖기 위한 지향점과 답보상태에 있는 국제관광 연구의 활로를 모색하기 위하여, 심리학, 경영학 등 다른 학문분야에서 이루어진 다문화 연구의 적용가능성을 탐색하였다. 그 동안에 축적된 다문화 또는 비교문화 연구들은 국제관광 현상을 설명하는 이론적 준거틀로 사용할만한 여지가 충분히 있으며, 국제관광의 거래 과정이 문화간 접촉을 수반한다는 점에서 관광산업의 조직행동 및 소비자행동 연구에 공헌할 수 있을 것으로 판단된다. 본 연구에서는 관광학 연구에 적용가능하며 다양한 명제를 도출할 수 있는 문화 연구들을 정리하기 위하여 기존의 문화 연구 중에서 다문화간 커뮤니케이션, 고유문화가 소비자 행동과 조직행동에 미치는 영향 등 비교적 미시적인 초점 하에 이루어진 연구들을 소개하고 응용가능성을 논의하였으며, 관광경영 분야에서 다루어진 비교문화 관련 연구도 요약 정리하였다. 본 연구는 광범위한 영역을 다루고 있어서 문화연구의 관광 분야 적용 가능성에 대한 세부전공별 논의가 미흡하고 실증적 연구가 아니라는 점에서 탐색적 연구들이 흔히 갖는 한계를 지닌다. 향후 이 분야에 관련하여 보다 진전된 연구들을 기대한다.
Kim, Minkyung,Kim, Minjoo,Kang, Miso,Yoo, Hye Jin,Kim, Min Sun,Ahn, Young-Tae,Sim, Jae-Hun,Jee, Sun Ha,Lee, Jong Ho The Royal Society of Chemistry 2017 Food & Function Vol.8 No.1
<P>Our previous study showed that supplementation with a combination of<I>Lactobacillus curvatus</I>(<I>L. curvatus</I>) HY7601 and<I>Lactobacillus plantarum</I>(<I>L. plantarum</I>) KY1032 reduced the body weight, body fat percentage, body fat mass and L1 subcutaneous fat area in overweight subjects. We aimed to evaluate whether the changes in adiposity after supplementation with<I>Lactobacillus</I>strains were associated with metabolic intermediates. A randomized, double-blind, placebo-controlled study was conducted on 66 non-diabetic and overweight individuals. Over a 12-week period, the probiotic group consumed 2 g of probiotic powder, whereas the placebo group consumed the same product without the probiotics. To investigate metabolic alterations, we performed plasma metabolomics using ultra-performance liquid chromatography and mass spectrometry (UPLC-LTQ/Orbitrap MS). Probiotic supplementation significantly increased the levels of octenoylcarnitine (C8:1), tetradecenoylcarnitine (C14:1), decanoylcarnitine (C10) and dodecenoylcarnitine (C12:1) compared with the levels from placebo supplementation. In the probiotic group, the changes in the body weight, body fat percentage, body fat mass and L1 subcutaneous fat area were negatively associated with changes in the levels of C8:1, C14:1, C10 and C12:1 acylcarnitines. In overweight individuals, probiotic-induced weight loss and adiposity reduction from the probiotic supplementation were associated with an increase in medium-chain acylcarnitines.</P>
Kim Minjoo,Moon Aree 한국독성학회 2022 Toxicological Research Vol.38 No.1
Triple-negative breast cancer (TNBC) is one of the most aggressive types of breast cancer with poor outcomes. Patients with TNBC cannot benefit from targeted therapies such as Tamoxifen and Herceptin. The aim of the present study was to seek a preventive or therapeutic agent with a potential inhibitory effect on aggressive progression of TNBC. Anticancer effect of a natural compound curcumin have been demonstrated, however, development of more effective curcumin analogs with better bioavailability is needed. We investigated if a curcumin analog CA-5f could inhibit the invasive phenotype of TNBC cell lines in the present study. Treatment with CA-5f inhibited the viability of MDA‑MB‑231 and Hs578T TNBC cells, possible by inducing apoptosis. The invasive phenotypes of these cells were inhibited by CA-5f in a concentration-dependent manner. Protein expression of urokinase-type plasminogen activator (uPA), a serine protease known to degrade the extracellular matrix and lead to invasion, was markedly decreased by CA-5f in Hs578T cells. However, mRNA level of uPA was not altered by CA-5f, implicating that the effect of CA-5f was not through transcriptional regulation. Of note, CA-5f upregulated plasminogen activator inhibitor type (PAI)-1, which is known to inhibit uPA by interacting with urokinase-type plasminogen receptor, in TNBC cells. Taken together, these results demonstrated that CA-5f significantly inhibited the invasive phenotype of TNBC cells, possibly by decreasing the protein level of uPA through upregulating PAI-1. Our results may provide useful information on developing CA-5f as a potential therapeutic agent against malignant progression of TNBC.