Robotic single-site tubal reanastomosis: Initial experience

( Minjeong Kwak ),( Sunhee Cha ) 대한산부인과학회 2023 대한산부인과학회 학술대회 Vol.109 No.-

Synthesis and preparation of FITC labeled SiO₂ nanoparticles for reliable cytotoxicity testing

Minjeong KWAK,Min Beom HEO,Ja Young PARK,Nam Woong SONG 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

코비드19 진단키트의 사용자 경험에 대한 탐색적 연구

곽민정(Minjeong Kwak),허정윤(Jeongyun Heo) 대한인간공학회 2022 대한인간공학회 학술대회논문집 Vol.2022 No.4

서비스 스케이프를 활용한 코로나19 검사 프로세스 경험 개선에 대한 연구

곽민정(Minjeong Kwak),허정윤(Jeongyun Heo) 한국디자인학회 2021 한국디자인학회 학술발표대회 논문집 Vol.2021 No.5

귀환 재외동포의 한국에서의 삶 연구에 관한 질적 메타분석

곽민정(Minjeong Kwak),함보연(Boyeon Ham) 한국문화융합학회 2023 문화와 융합 Vol.45 No.10

본 연구의 목적은 이미 발표된 귀한 재외동포의 한국에서 삶의 경험에 관한 질적 연구를 메타분석 함으로 이들의 삶의 실상을 파악하는 데 있다. 연구 대상은 2012년부터 2022년까지 국내 학술지에 게재된 6편의 논문이다. 본 연구는 자료코딩, 범주화, 문헌 간 분석, 결론 도출 과정을 거쳐 진행했다. 연구결과는 5개의 범주와 17개의 개념어로 나타났다. '귀환 이주 동기'에는 고향으로 귀환, 취업을 위한 귀환이 도출됐다. '사회·경제적 어려움'에는 가족 이산, 언어를 배울 곳이 부족함, 한국어 능력 부족으로기초 생활 시설 이용이 어려움, 의료비·생활비 부족, 사망·장례식에 관한 걱정이 도출됐다. '사회 인프라 및 지원의 취약'에는 과한 근무 시간, 불안전한 근로환경, 주거·여가 공간 지원 취약, 체류 자격의어려움, 육아 돌봄 지원 부족이 도출됐다. '지역사회 커뮤니티 활동'에는 재외동포 간의 교류, 문화차이로 인한 한국인과 교류의 어려움, 한국인과 교류, 종교활동이 도출됐다. '정체성'에는 한국인으로서 정체성, 초국적 정체성이 도출됐다. 이를 바탕으로 귀환 재외동포의 한국에서 삶의 경험과 그 의미를 논의했다. The purpose of this study was to examine the experiences of repatriated overseas Koreans in Korea, as reported in six qualitative articles published in domestic academic journals from 2012 to 2022. The research identified five key themes and 17 sub-concepts, including motivations for repatriation, social and economic challenges, vulnerabilities in social infrastructure, community activities, and identity issues among repatriated individuals. This analysis provides a comprehensive understanding of the repatriated overseas Koreans' experiences in Korea.

Two gene prognostic model with ERCC1 and BRCA1 in non-small-cell lung cancer patients treated with platinum doublets

( Minjeong Kim ),( Jeong-seon Ryu ),( Eun-soon Shin ),( Yeon-kyeong Yoo ),( Seung-min Kwak ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Effective lung cancer pharmacogenomics relies on identifying NSCLC patients that may benefit from DNA-damaging agents, such as platinum. Since individual variations in DNA repair capacity influence the efficiency of DNA-damaging agents, DNA repair pathway genes have generated great interest as potential biomarkers. Accordingly, genes such as ERCC1, BRCA1, ERCC2 and XRCC1, which are involved in DNA repair, have been focused on potential biomarkers to predict the effects of platinum-based chemotherapy in NSCLC patients. BRCA1 and ERCC1 also plays a central role in DNA repair via transcription- coupled nucleotide excision repair. BRCA1 originally described in terms of its involvement in other repair processes, including homologous recombination repair, nonhomologous end joining, and mismatch repair, as well as in the regulation of mitotic spindle assembly. Recent study has identified differential BRCA1 expression as a reliable predictive/ prognostic marker for platinum-based neoadjuvant chemotherapy in NSCLC patients. We found that Germline variation of ERCC1 codon 118 or a haplotype of BRCA1 was associated with differences in outcome in NSCLC Pts. treated with platinum doublets (Lung Cancer 2004; J Clin Oncol 2008). Approach with multiple genes could be able to generate a more robust and useful model for clinicians to potentially utilize as a guide in patient assignment. Therefore, we set out this study to demonstrate whether genetic effects of both genes on the survival can be synergistically augmented

Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells

Kwak, Seung-Hwa,Shin, Seungheon,Lee, Ji-Hyun,Shim, Jin-Kyoung,Kim, Minjeong,Lee, So-Deok,Lee, Aram,Bae, Jinsu,Park, Jin-Hee,Abdelrahman, Aliaa,Mü,ller, Christa E.,Cho, Steve K.,Kang, Seok-Gu,Bae, S.E.C.T. [etc.] 2018 European Journal of Medicinal Chemistry Vol. No.

<P><B>Abstract</B></P> <P>Screening a compound library of quinolinone derivatives identified compound <B>11a</B> as a new P2X7 receptor antagonist. To optimize its activity, we assessed structure-activity relationships (SAR) at three different positions, R<SUB>1</SUB>, R<SUB>2</SUB> and R<SUB>3</SUB>, of the quinolinone scaffold. SAR analysis suggested that a carboxylic acid ethyl ester group at the R<SUB>1</SUB> position, an adamantyl carboxamide group at R<SUB>2</SUB> and a 4-methoxy substitution at the R<SUB>3</SUB> position are the best substituents for the antagonism of P2X7R activity. However, because most of the quinolinone derivatives showed low inhibitory effects in an IL-1β ELISA assay, the core structure was further modified to a quinoline skeleton with chloride or substituted phenyl groups. The optimized antagonists with the quinoline scaffold included 2-chloro-5-adamantyl-quinoline derivative (<B>16c</B>) and 2-(4-hydroxymethylphenyl)-5-adamantyl-quinoline derivative (<B>17k</B>), with IC<SUB>50</SUB> values of 4 and 3 nM, respectively. In contrast to the quinolinone derivatives, the antagonistic effects of the quinoline compounds (<B>16c</B> and <B>17k</B>) were paralleled by their ability to inhibit the release of the pro-inflammatory cytokine, IL-1β, from LPS/IFN-γ/BzATP-stimulated THP-1 cells (IC<SUB>50</SUB> of 7 and 12 nM, respectively). In addition, potent P2X7R antagonists significantly inhibited the sphere size of TS15-88 glioblastoma cells.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Quinoline derivatives were developed as P2X7 receptor antagonists. </LI> <LI> We performed the introduction of various substituents at the R<SUB>3</SUB> position of the quinoline structure. </LI> <LI> Compounds <B>16c</B>, <B>17b</B>−<B>c</B> and <B>17h</B>−<B>k</B> showed potent antagonistic effects (EtBr IC<SUB>50</SUB> = 3–18 nM). </LI> <LI> Also, compounds <B>16c</B>, <B>17b</B>−<B>c</B> and <B>17h</B>−<B>k</B> exhibited highly potent functional activities (IL-1β IC<SUB>50</SUB> = 7–33 nM). </LI> <LI> <B>16c</B> has an acceptable in vitro anti-cancer activities against the glioblastoma cells, in which P2X7Rs are overexpressed. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered.</P> <P>[DISPLAY OMISSION]</P>

귀환 재외동포 노인 여가 취향 개념화 연구

곽민정(Kwak,Minjeong),김민규(Kim,Minkyu) 한국여가문화학회 2024 여가학연구 Vol.22 No.3

본 연구는 귀환 재외동포 노인의 여가 취향을 개념화하고, 이들의 여가 취향을 형성하는 요인을 탐색하는 데 목적이 있다. 이를 위해 노인, 여가, 재외동포 전문가 10명으로 자문위원을 구성하고 델파이조사를 시행하였다. 1차 델파이조사는 개방형 설문으로 자문위원의 자유로운 의견을 수집하였으며, 2, 3차 델파이조사는 1차 조사를 바탕으로 구성한 폐쇄형 설문으로 개념 정의와 요인의 타당성을 검증하였다. 문항의 타당성을 검증하기 위하여 기술통계치, 집중경향치, 긍정률을 사용하였다. 연구 결과, 귀환 재외동포 노인의 여가 취향 개념은 ‘과거의 향수를 상기시킬 수 있는, 이전 거주국의 문화와 한국문화의 융합 속에서 새로운 여가 활동 참여를 결정하게 하는 요인’으로 정의되었다. 귀환 재외동포 노인의 여가 취향을 형성하는 요인은 건강 상태와 여가를 위한 배경을 ‘개인적 요인’, 생활 여가 인프라와 여가를 함께하는 주요 타자를 ‘사회적 요인’, 기존의 국적국 여가문화와 귀환 후 한국에서의 여가문화를 ‘문화적 요인’, 여가에 관한 지식과 생애 시기에 따라 축적된 경험적 정보를 ‘정보적 요인’으로 정리하였다. 본 연구에서는 개인 내적동기와 체류 자격이 고려되지 않았다는 점에서 제한점이 있으며, 이를 바탕으로 한 후속 연구가 필요하다는 점을 제언하였다. 본 연구는 귀환 재외동포 노인의 여가 취향에 관한 개념과 요인을 정의함으로써 이들을 위한 여가정책과 프로그램 설계의 기초 자료로 활용될 수 있다는 점에 의의가 있다. This study aims to conceptualize the leisure tastes of returning elderly overseas Koreans and explore the factors shaping these tastes. To this end, a Delphi survey was conducted with a panel of 10 experts in the fields of elderly care, leisure, and overseas Koreans. The first round of the Delphi survey used open-ended questions to gather the free opinions of the panel members, while the second and third rounds used closed-ended questionnaires based on the first round to validate the conceptual definitions and factors. Descriptive statistics, central tendency measures, and approval rates were used to verify the validity of the items. The results of the study defined the concept of leisure tastes of returning elderly overseas Koreans as "factors that influence the decision to participate in new leisure activities through a fusion of the culture of their previous residence and Korean culture, evoking nostalgia from their past." The factors shaping the leisure tastes of these individuals were categorized into 'personal factors' such as health status and background for leisure, 'social factors' such as living leisure infrastructure and key companions for leisure, 'cultural factors' such as the leisure culture of their former country and that of Korea after their return, and 'informational factors' such as knowledge about leisure and empirically accumulated information over their lifetime. The study acknowledged limitations, including the exclusion of personal intrinsic motivation and residency status, suggesting the need for follow-up research based on these aspects. The significance of this study lies in its definition of the concepts and factors related to the leisure tastes of returning elderly overseas Koreans, providing foundational data for designing leisure policies and programs for this demographic.

Usefulness of noninvasive positive-pressure ventilation delivered by helmet versus facial mask in patients with postextubational respiratory distress

박미화,( Minjeong Kim ),( Hong-lyeol Lee ),( Seung-min Kwak ),( Jeong-seon Ryu ),( Hae Sung Nam ),( Jung Soo Kim ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.0

Background: Extubation failure is common in intensive care unit. We hypothesize the significant reduction of reintubation rates in the patients with NIPPV delivered by helmet would be expected. Method: Between March 1, 2017 and April 30, 2018, Thirty-nine patients with respiratory failure within two hours after extubation and applied by NIPPV were retrospectively collected in a medical ICU in an academic, tertiary care hospital. Results: 39 patients were collected and 18 of them applied NIPPV by helmet. Respiratory failure due to hypercapnea occurred in 16 patients, hypoxemia occurred in 19 patients, and postextubational stridor was observed in 5 patients. Comparing the NIPPV delivered facial mask with helmet, there was no difference in the rate of reintubation or ICU mortality, duration of NIPPV and removal rate of CO2 in blood. According to the cause of respiratory failure, comparing the difference in the rate of reintubation, ICU mortality and removal of carbon dioxide, there was no differences between delivered by facial mask and helmet. Although there was no statistical significance, the severity was higher in the patients with delivered by helmet. Conclusion: NIPPV delivered by helmet than facial mask significantly reduced the intubation rate among ARDS patients. However, in this study, the effect of NIPPV delivered by helmet was not significant in patients with postextubation respiratory distress. The severity of the patients would be distorted by the small number of patients might influence our outcomes. Thus, we will collect more cases and analyze again each year.

통신산업과 디지털콘텐츠산업 간 갈등 현안 및 관리 방안 : 한국의 갈등 사례에 대한 정성적 고찰을 중심으로

함민정(Minjeong Ham),김재원(Jaewon Kim),박소언(Soeon Park),곽규태(Kyu Tae Kwak) 한국정보사회학회 2024 정보사회와 미디어 Vol.25 No.1

본 연구는 국내 인터넷서비스사업자(ISP)와 국내외 콘텐츠제공사업자(CP) 사이에 발생하는 갈등 현안을 심층적으로 고찰하고 주요한 갈등 현안을 관리하는 방안을 모색하기 위해 통신산업 및 디지털콘텐츠산업 관련 전문가들을 대상으로 심층 인터뷰를 시행한 후 그 결과를 제시하였다. 연구 결과, ISP와 CP 간의 갈등 요소 중 가장 주요한 현안은 망 이용료 문제로 나타났고 이의해결을 위한 핵심적인 갈등 관리 방안은 국내외 CP의 망 이용료 합리화와 관련한 제도 개선으로 거론되었다. 이와 함께 ISP와 CP 간 갈등 관리를 위해서는 갈등 당사자 상호 간의 이해와 협력, 그리고 정부의 적극적인 중재 역할이 필수적인 것으로 확인되었다. 본 연구는 통신산업과 디지털콘텐츠산업 간에 형성된 갈등의 본질 및 관리 특성을 유형화하고 실무적 해결방안을 모색했다는 데 그 의의가 있다.