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Lee, Dahee,Choi, Eunji,Lee, Jaewon,Oh, Jungju,Lee, Seonyeong,Lee, Minhyung THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2018 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.67 No.-
<P><B>Abstract</B></P> <P>Receptor for advanced glycation end-products (RAGE) is overexpressed in various cancer cells. In this study, a RAGE-binding peptide (RBP) was conjugated to polyethylenimine (25kDa, PEI). RBP-conjugated PEI (PEI-RBP) was characterized as a dual-functional reagent, a RAGE-mediated gene carrier and an anti-angiogenic reagent. As a gene carrier, PEI-RBP had higher transfection efficiency to the C6 glioblastoma cells than PEI. As an anti-angiogenic reagent, the pEmpty/PEI-RBP complex reduced RAGE expression on the surface of the C6 glioblastoma cells. Also, the complex reduced the VEGF expression and tube formation of endothelial cells. Therefore, PEI-RBP may be useful for development of glioblastoma therapy.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Seasonal abundance of mosquito species in diverse habitat types in Gyeonggi-do, South Korea
Minhyung Jung,Po-Hyun Park,Young-Ran Joo,Lee-Hyeon Sin,Uk-Gyo LeeUk-Gyo Lee,Doo-Hyung Lee 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10
Mosquitoes are vectors of many human diseases such as Japanese encephalitis, vivax malaria, west nile fever, dengue fever and yellow fever. However, factors affecting the abundance and distribution of mosquitoes are not well-understood. Moreover, the global climate change makes it even more difficult to address and predict the population dynamics of mosquitoes. Therefore, it is important to monitor this medically-important pest throughout landscapes over a long period of time. This study was conducted as a part of the nation-wide surveillance program to monitor insect vectors. In 2015, mosquitoes were collected using black light traps and BG-Sentinel traps in Gyeonggi-do at every two weeks from April to September. Three types of potential mosquito habitats were selected for surveillance: urban area (Suwon), cattle shed (Yongin) and wild bird refuge (Gwangju). Among the three habitats, female mosquitoes were first caught on April 4 by BG-Sentinel trap in the urban area. The highest density of female mosquitoes in the traps was recorded in July in the urban area (134 ± 84 per trap); the highest density was observed in June in the cattle shed (2473 ± 1319) and wild bird refuge (21 ± 15) (mean ± SE). The dominant mosquito species were Culex pipens pallens (91%), Aedes vexans nipponii (79%) and Anopheles sinensis (33%) in the urban area, cattle shed and wild bird refuge, respectively. The results of this study indicate that female mosquitoes were most abundant in the cattle shed habitat type. It is also noteworthy that the dominant mosquito species varied among the habitat types surveyed. This nation-wide monitoring program for medical pests will provide fundamental basis to develop effective management strategy under the global climate change environment.
Minhyung Jung,Po-Hyun Park,Young-Ran Joo,Lee-Hyeon Sin,Uk-Gyo Lee,Doo-Hyung Lee 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04
Seasonal abundance and distribution of mosquitoes and chigger mites are important for human populations. However, factors affecting the abundance and distribution of vector species are not well - understood. Furthermore, global climate change makes it difficult to predict the population dynamics of vector species. Therefore, it is important to monitor this vector species over a long period of time. In 2015, mosquitoes were collected from three potential mosquito habitats using black light trap and BG-Sentinel trap in Gyeongi-do in April through October. Also, we collected chigger mite using sherman live traps in Cheorwon, Gangwon-do in April, September and October. From the survey, we collected a total of 11,649 mosquitoes in three potential mosquito habitats, and a total of 3,656 chigger mites from 54 wild rodents. In the samples, dominant mosquito species were Aedes vexans nipponii (Species Ratio 70%), Culex pipens pallens (SR 9.8%) in Gyeonggi area and dominant chigger mite species was Leptotrombidium pallidium (SR 59%) in Cheorwon. The results of this study can serve as provide fundamental basis to develop effective management strategy under the global climate change environment.
BES를 이용한 연동형 온실의 냉 · 난방 부하 산정 및 PV 시스템 발전 성능 분석
이민형(Minhyung Lee),이인복(In-Bok Lee),하태환(Tae-Hwan Ha),김락우(Rack-Woo Kim),여욱현(Uk-Hyeon Yeo),이상연(Sang-Yeon Lee),박관용(Gwanyong Park),김준규(Jun-Gyu Kim) (사)한국생물환경조절학회 2017 생물환경조절학회지 Vol.26 No.4
The price competitiveness of photovoltaic system (PV system) has risen recently due to the growth of industries, however, it is rarely applied to the greenhouse compared to other renewable energy. In order to evaluate the application of PV system in the greenhouse, power generation and optimal installation area of PV panels should be analyzed. For this purpose, the prediction of the heating and cooling loads of the greenhouse is necessary at first. Therefore, periodic and maximum energy loads of a multi-span greenhouse were estimated using Building Energy Simulation(BES) and optimal installation area of PV panels was derived in this study. 5 parameter equivalent circuit model was applied to analyzed power generation of PV system under different installation angle and the optimal installation condition of the PV system was derived. As a result of the energy simulation, the average cooling load and heating load of the greenhouse were 627,516MJ and 1,652,050MJ respectively when the ventilation rate was 60AE·hr<SUP>-1</SUP>. The highest electric power production of the PV system was generated when the installation angle was set to 30°. Also, adjustable PV system produced about 6% more electric power than the fixed PV system. Optimal installation area of the PV panels was derived with consideration of the estimated energy loads. As a result, optimal installation area of PV panels for fixed PV system and adjustable PV system were 521m² and 494m² respectively.
천리안 위성 자료를 활용한 합성곱 순환 신경망 기반 태풍 최대풍속 산출
이민형(Minhyung Lee),이수봉(Soobong Lee),이정환(Junghwan Lee),한성원(Sung Won Han) 대한산업공학회 2019 대한산업공학회지 Vol.45 No.4
It is crucial to predict the intensity of typhoons since they cause massive casualties and damage in property. We propose a model for estimating the maximum wind speed of typhoons using Convolutional Recurrent Neural Network (CRNN). Compared to the current method in investigating typhoons which is fully subjected to the meteorologist’s analyzing skill and domain knowledge, the proposed model assists meteorologists to obtain the objective analysis of typhoons. In previous studies, they construct the model utilizing only CNN. However, our suggested model is built with CNN followed by LSTM to consider the fact that the typhoons occur sequentially. We train the model by using each single channel in COMS satellite data composed of IR1, IR2, WV, and SWIR. As a result, the CRNN model trained on WV shows the lowest RMSE error, which is 9.84knot.
Instability of Electrically Driven Polymer Liquid Jets
Minhyung Lee,Seung Baik Kang,Joo Hyuk Park 대한기계학회 2006 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.20 No.3
Polymer nanofibers can be generated by a electrospinning process. The process involves electrically charged jet of polymer solutions evolving from a droplet. The jet stretches in vertical direction due to the difference between charged particle and constant current located at the collector, while the Coulomb and viscoelastic forces start to contribute to radial and azimuthal (torsional stretching. In this paper, the unstable dynamics of the liquid polymer jet is examined experimentally and theoretically. A complex viscoelastic rheological model has been adopted to analyze the behavior of a charged liquid jet. The model includes complex phenomena of stress relaxation of the liquid jet resulting from the competing force components. The experimental data of the jet paths captured by high-speed videocamera also confirm the similar behavior with the predictions.
Vortex-Induced Vibrations of a Circular Cylinder at Low Reynolds Numbers
Minhyung Lee,Sung-Yeoul Lee 대한기계학회 2003 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.17 No.11
The vortex-induced vibrations of a circular cylinder at low Reynolds (Re) numbers are simulated by applying a method of the two-dimensional computational fluid dynamics coupled with the structural dynamics based on the multi-physics. The fluid solver is first tested on the case of a fixed cylinder at Re≤160, and shows a good agreement with the previous highresolution numerical results. The present study then reports on the detailed findings concerning the vibrations of an elastic cylinder with two degrees of translational freedom for a number of cases in which Re is fixed at 200, a reduced damping parameter Sg=O.O1. 0.1. 1.0, 10.0 and the mass ratio M^* = I, 10.
Lee, GeonHui,Jun, Yesl,Jang, HeeYeong,Yoon, Junghyo,Lee, JaeSeo,Hong, MinHyung,Chung, Seok,Kim, Dong-Hwee,Lee, SangHoon Elsevier Science B.V. Amsterdam 2018 ACTA BIOMATERIALIA Vol. No.
<P><B>Abstract</B></P> <P>Oxygen availability is a critical factor in regulating cell viability that ultimately contributes to the normal morphogenesis and functionality of human tissues. Among various cell culture platforms, construction of 3D multicellular spheroids based on microwell arrays has been extensively applied to reconstitute <I>in vitro</I> human tissue models due to its precise control of tissue culture conditions as well as simple fabrication processes. However, an adequate supply of oxygen into the spheroidal cellular aggregation still remains one of the main challenges to producing healthy <I>in vitro</I> spheroidal tissue models. Here, we present a novel design for controlling the oxygen distribution in concave microwell arrays. We show that oxygen permeability into the microwell is tightly regulated by varying the poly-dimethylsiloxane (PDMS) bottom thickness of the concave microwells. Moreover, we validate the enhanced performance of the engineered microwell arrays by culturing non-proliferated primary rat pancreatic islet spheroids on varying bottom thickness from 10 μm to 1050 μm. Morphological and functional analyses performed on the pancreatic islet spheroids grown for 14 days prove the long-term stability, enhanced viability, and increased hormone secretion under the sufficient oxygen delivery conditions. We expect our results could provide knowledge on oxygen distribution in 3-dimensional spheroidal cell structures and critical design concept for tissue engineering applications.</P> <P><B>Statement of Significance</B></P> <P>In this study, we present a noble design to control the oxygen distribution in concave microwell arrays for the formation of highly functional pancreatic islet spheroids by engineering the bottom of the microwells. Our new platform significantly enhanced oxygen permeability that turned out to improve cell viability and spheroidal functionality compared to the conventional thick-bottomed 3-D culture system. Therefore, we believe that this could be a promising medical biotechnology platform to further develop high-throughput tissue screening system as well as <I>in vivo</I>-mimicking customised 3-D tissue culture systems.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>