Design of a Fresnel Lens for a Solar End-pumped Solid-state Laser

Mingyu Ou,Pian Hu,Lanling Lan,Yan Liu,Jun Zhou,Xiaotao Shi 한국광학회 2020 Current Optics and Photonics Vol.4 No.5

A novel design for a Fresnel lens for a solar end-pumped laser is demonstrated in this paper. The new hybrid Fresnel lens includes two parts, inner and outer. The inner part is a twice-total-internal-reflection and vertical-transmission lens. The outer part is a once-total-reflection and vertical-transmission lens. The radius of the Fresnel lens is 600 mm, and its focal length is 750 mm. The concentrating performance of the Fresnel lens is examined using TracePro. The results show that the concentration efficiency has been greatly improved. The total concentration efficiency of the hybrid Fresnel lens reaches 73.2% when the radius of the laser rod is 3 mm. This design can simplify the concentration system of a solar endpumped solid-state laser.

Identification of genomic diversity and selection signatures in Luxi cattle using whole-genome sequencing data

Hu Mingyue,Shi Lulu,Yi Wenfeng,Li Feng,Yan Shouqing 아세아·태평양축산학회 2024 Animal Bioscience Vol.37 No.3

Objective: The objective of this study was to investigate the genetic diversity, population structure and whole-genome selection signatures of Luxi cattle to reveal its genomic characteristics in terms of meat and carcass traits, skeletal muscle development, body size, and other traits. Methods: To further analyze the genomic characteristics of Luxi cattle, this study sequenced the whole-genome of 16 individuals from the core conservation farm in Shandong region, and collected 174 published genomes of cattle for conjoint analysis. Furthermore, three different statistics (pi, Fst, and XP-EHH) were used to detect potential positive selection signatures related to selection in Luxi cattle. Moreover, gene ontology and Kyoto encyclopedia of genes and genomes pathway enrichment analyses were performed to reveal the potential biological function of candidate genes harbored in selected regions. Results: The results showed that Luxi cattle had high genomic diversity and low inbreeding levels. Using three complementary methods (pi, Fst, and XP-EHH) to detect the signatures of selection in the Luxi cattle genome, there were 2,941, 2,221 and 1,304 potentially selected genes identified, respectively. Furthermore, there were 45 genes annotated in common overlapping genomic regions covered 0.723 Mb, including PLAG1 zinc finger (PLAG1), dedicator of cytokinesis 3 (DOCK3), ephrin A2 (EFNA2), DAZ associated protein 1 (DAZAP1), Ral GTPase activating protein catalytic subunit alpha 1 (RALGAPA1), mediator complex subunit 13 (MED13), and decaprenyl diphosphate synthase subunit 2 (PDSS2), most of which were enriched in pathways related to muscle growth and differentiation and immunity. Conclusion: In this study, we provided a series of genes associated with important economic traits were found in positive selection regions, and a scientific basis for the scientific conservation and genetic improvement of Luxi cattle.

병보천 지점분석 및 오염총량 삭감을 위한 개선방향 연구

최민규 ( Mingyu Choi ),이덕찬 ( Dukchan Lee ),최수연 ( Sooyeon Choi ),정동열 ( Dongyeol Jung ),허세준 ( Sejoon Hu ),윤정민 ( Jungmin Yoon ),박지철 ( Jicheol Park ) 한국물환경학회(구 한국수질보전학회) 2019 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2019 No.-

중국의 해외직접투자(OFDI)가 국가 이미지를 향상 시키는가?

후스첸(Shiqian Hu),레이밍웨(Mingyu Lei),정승안(Seungan Jung) 지역사회학회 2024 지역사회학 Vol.25 No.1

국가 이미지 구축은 중국 소프트파워 구축의 핵심이다. 본 논문은 PEW 리서치 센터의 설문 조사 데이터를 중국의 국가 이미지 평가 데이터로 삼고, 2009년부터 2019년까지의 해외직접투자(OFDI) 데이터를 활용하여 OFDI와 중국의 국가 이미지 향상 간의 관계와 OFDI가 국가 이미지에 미치는 영향 메커니즘을 실증적으로 분석하였다. 연구결과는 OFDI가 중국의 국가 이미지 향상을 촉진하는 데 중요한 역할을 한다는 것을 보여주며, 강건성 테스트(robustness test)는 관련 결론을 추가로 검증하였다. 메커니즘 검증에서는 OFDI가 경제 및 사회 발전의 촉진 효과, 사회적 책임 효과 및 여론 개선을 통해 중국의 국가 이미지 개선을 촉진하는 데 기여하고 있음을 발견하였다. 추가 분석에 따르면 OFDI가 국가 이미지 향상에 미치는 영향에는 ‘이질적인 투자 동기’, ‘투자 단계’, ‘투자 계약 및 정치적 친화성’이 있으며, 국가 이미지 향상에는 ‘시간 효과’ 및 ‘거리적 효과’가 있다. 본 논문의 연구 성과는 중국의 국가이미지 구축 및 개선을 위한 기준과 의사결정의 근거를 제공하는 데 기여할 수 있을 것이며, 중국의 대외적 이미지 개선과 교착상태에 있는 한중관계를 개선하는 데 있어서 정책적 기여를 할 수 있을 것으로 기대된다. Building the national image is the core of building China's soft power. This paper used the survey data of the PEW Research Center as the data for evaluating China's national image, and used the foreign direct investment (OFDI) data from 2009 to 2019 to empirically analyze the relationship between OFDI and the improvement of China's national image and the mechanism by which OFDI affects the national image. The research results show that OFDI plays an important role in promoting the improvement of China's national image, and the robustness test further verified related conclusions. In the mechanism verification, it was found that OFDI contributes to promoting the improvement of China's national image through the promotion effect of economic and social development, the effect of social responsibility, and the improvement of public opinion. According to additional analysis, OFDI's effects on improving the national image include ‘heterogeneous investment motivation’, ‘investment stage’, and ‘investment contracts and political affinity’, and ‘time effect’ and ‘distance effect’ on improving the national image. The research results of this paper are expected to contribute to providing the basis for standards and decision-making for building and improving China's national image, and to make a policy contribution to improving China's external image and deadlocked Korea-China relations.

Pituitary P62 deficiency leads to female infertility by impairing luteinizing hormone production

Li Xing,Zhou Ling,Peng Guiliang,Liao Mingyu,Zhang Linlin,Hu Hua,Long Ling,Tang Xuefeng,Qu Hua,Shao Jiaqing,Zheng Hongting,Long Min 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

P62 is a protein adaptor for various metabolic processes. Mice that lack p62 develop adult-onset obesity. However, investigations on p62 in reproductive dysfunction are rare. In the present study, we explored the effect of p62 on the reproductive system. P62 deficiency-induced reproductive dysfunction occurred at a young age (8 week old). Young systemic p62 knockout (p62 -/- ) and pituitary-specific p62 knockout (p62 flox/flox αGSU cre ) mice both presented a normal metabolic state, whereas they displayed infertility phenotypes (attenuated breeding success rates, impaired folliculogenesis and ovulation, etc.) with decreased luteinizing hormone (LH) expression and production. Consistently, in an infertility model of polycystic ovary syndrome (PCOS), pituitary p62 mRNA was positively correlated with LH levels. Mechanistically, p62 -/- pituitary RNA sequencing showed a significant downregulation of the mitochondrial oxidative phosphorylation (OXPHOS) pathway. In vitro experiments using the pituitary gonadotroph cell line LβT2 and siRNA/shRNA/plasmid confirmed that p62 modulated LH synthesis and secretion via mitochondrial OXPHOS function, especially Ndufa2, a component molecule of mitochondrial complex I, as verified by Seahorse and rescue tests. After screening OXPHOS markers, Ndufa2 was found to positively regulate LH production in LβT2 cells. Furthermore, the gonadotropin-releasing hormone (GnRH)-stimulating test in p62 flox/flox αGSU cre mice and LβT2 cells illustrated that p62 is a modulator of the GnRH-LH axis, which is dependent on intracellular calcium and ATP. These findings demonstrated that p62 deficiency in the pituitary impaired LH production via mitochondrial OXPHOS signaling and led to female infertility, thus providing the GnRH-p62-OXPHOS(Ndufa2)-Ca 2+ /ATP-LH pathway in gonadotropic cells as a new theoretical basis for investigating female reproductive dysfunction.

miR-148b-3p, miR-190b, and miR-429 Regulate Cell Progression and Act as Potential Biomarkers for Breast Cancer

Wenzhu Dai,Jixiang He,Ling Zheng,Mingyu Bi,Fei Hu,Minju Chen,Heng Niu,Jingyu Yang,Ying Luo,Wenru Tang,Miaomiao Sheng 한국유방암학회 2019 Journal of breast cancer Vol.22 No.2

Purpose: Breast cancer is the most frequently diagnosed malignancy in women worldwide. MicroRNAs (miRNAs) are thought to serve as potential biomarkers in various cancers, including breast cancer. Methods: We evaluated the miRNA expression profiles in 1,083 breast cancer samples and 104 normal breast tissues from The Cancer Genome Atlas database. We used the edgeR package of R software to analyze the differentially expressed miRNAs in normal and cancer tissues, and screened survival-related miRNAs by Kaplan-Meier analysis. A receiver operating characteristic curve was generated to evaluate the accuracy of these miRNAs as molecular markers for breast cancer diagnosis. Furthermore, the functional role of these miRNAs was verified using cell experiments. Targets of candidate miRNAs were predicted using 9 online databases, and Gene Ontology (GO) functional annotation and pathway analyses were conducted using Database for Annotation, Visualization and Integrated Discovery online tool. Results: A total of 68 miRNAs showed significantly different expression patterns between the groups (p < 0.001), and 13 of these miRNAs were significantly associated with poor survival (p < 0.05). Three miRNAs with high specificity and sensitivity, namely, miR-148b-3p, miR-190b, and miR-429, were selected. In vitro experiments showed that the overexpression of these 3 miRNAs significantly promoted the proliferation and migration of MDA-MB-468 and T47D cells and reduced the apoptosis of T47D cells. GO and pathway enrichment analyses revealed that the targets of these dysregulated miRNAs were involved in many critical cancer-related biological processes and pathways. Conclusion: The miR-148b-3p, miR-190b, and miR-429 may serve as potential diagnostic and prognostic markers for breast cancer. This study demonstrated the roles of these 3 miRNAs in the initiation and progression of breast cancer.

Influence of Microstructure and Mechanical Properties on Formability in High Strain Rate Rolled AZ31 Magnesium Alloy Sheets

Fubao Liu,Xiao Liu,Biwu Zhu,Hui Yang,Gang Xiao,Mingyue Hu 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.6

High strain-rate rolling (≥ 10 s−1) has been successfully employed to produce AZ31 magnesium alloy sheets to a high reductionof 82% with a fine grain structure in a single pass. The rolled sheets inevitably undertake various forming processessuch as press and deep forming in the fabrication stage. To investigate the formability, the Erichsen tests were carried out onhigh strain rate rolled AZ31 magnesium alloy sheets at room temperature. The relationship among mechanical properties,microstructure and formability were investigated. The crack behavior during Erichsen tests was also studied. It was foundthat the formability was related to the lowest in-plane tensile strengthen and dislocation density of initial microstructure. The competitive relationship between micro-crack and twinning/shear bands would also influence the formability of highstrain rate rolled magnesium alloy sheets. Deformed shear band with substaintial twins prohibits the crack extension andenhances strengthen of materials in front of crack tip.

Efficiency of gerAa, tupA and ca transformation in Bacillus subtilis for self-healing of concrete cracks

Hanxing He,Gefei Li,Jiantao Zhang,Jinlong Zhang,Mingyue Luo,Wenkai Hu,Yamin Lin,Ziyu Deng,Zhicheng Liu,Weizhao Chen,Xu Deng 한양대학교 세라믹연구소 2019 Journal of Ceramic Processing Research Vol.20 No.5

A genetic approach was proposed to modify the characteristics of Bacillus subtilis strain WB800 (B. subtilis WB800) for selfhealing of concrete cracks. Three genes, namely gerAa which encodes germination receptors activated by L-alanine, tupA which is responsible for the synthesis of teichuronopeptide, and ca which encodes carbonic anhydrase (CA) catalyzing the synthesis of carbonate ion, were separately transformed into WB800. To protect bacterial cells from being squeezed, microspheres were produced with microcrystal cellulose (MCC) before the introduction of bacteria into the specimens. The results showed that the modified B. subtilis expressing GerA achieved 39.9% of germination ratio compared to 17% by the original host cells. With the transformation of tupA, the modified strain demonstrated higher resistance to alkaline environments, tolerating pH as high as 11, while the original strain only tolerated pH 9. The modified strain expressing CA induced more calcium carbonate than the original cells. Energy dispersive spectroscopy (EDS) identified the produced precipitate to be calcite (CaCO3). Moreover, a mathematical model was developed to optimize the influential factors of calcium precipitation process. Finally, based on the above results, an effective self-healing of concrete crack was achieved. This study may provide a promising strategy to improve the efficiency of bacterial self-healing of concrete cracks.

고분자 전해질형 연료전지 내 수분의 원활 배출을 위한 소수-친수 패턴을 갖는 기체확산층의 에어브러싱 기반 수월 제작 기술

이민영(Minyoung Lee),김용태(Yongtae Kim),전현수(Hyunsoo Chun),김민욱(Minwook Kim),김민규(Mingyu Kim),박재원(Jaewon Park),한별(Byeol Han),김광준(Kwangjun Kim),이우승(Useung Lee),송정근(Jungkeun Song),한인희(Inhui Han),허종원(Jong Won Hu 대한전기학회 2020 대한전기학회 학술대회 논문집 Vol.2020 No.7