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Link Prediction Algorithm for Signed Social Networks Based on Local and Global Tightness
( Miao-miao Liu ),( Qing-cui Hu ),( Jing-feng Guo ),( Jing Chen ) 한국정보처리학회 2021 Journal of information processing systems Vol.17 No.2
Given that most of the link prediction algorithms for signed social networks can only complete sign prediction, a novel algorithm is proposed aiming to achieve both link prediction and sign prediction in signed networks. Based on the structural balance theory, the local link tightness and global link tightness are defined respectively by using the structural information of paths with the step size of 2 and 3 between the two nodes. Then the total similarity of the node pair can be obtained by combining them. Its absolute value measures the possibility of the two nodes to establish a link, and its sign is the sign prediction result of the predicted link. The effectiveness and correctness of the proposed algorithm are verified on six typical datasets. Comparison and analysis are also carried out with the classical prediction algorithms in signed networks such as CN-Predict, ICN-Predict, and PSNBS (prediction in signed networks based on balance and similarity) using the evaluation indexes like area under the curve (AUC), Precision, improved AUC′, improved Accuracy′, and so on. Results show that the proposed algorithm achieves good performance in both link prediction and sign prediction, and its accuracy is higher than other algorithms. Moreover, it can achieve a good balance between prediction accuracy and computational complexity.
Chemical Components of Dendrobium polyanthum
Hu, Jiang-Miao,Zhao, You-Xing,Miao, Ze-Hong,Zhou, Jun Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.9
A new tetrahydroanthracene, 3,6,9-trihydroxy-3,4-dihydroanthracen-1(2H)-one (1), six phenolics, moscatilin (2), gigantol (3), batatasin (4), moscatin (5), 9,10-dihydromoscatin (6), 10-dihydrophenanthrene-2,4,7-triol (7), and a sesquiterpenoid, corchoionoside C (8), together with two sterols $\beta$-sitosterol (9) and daucosterol (10), were isolated from the stems of Dendrobium polyanthum. Compounds 1 and 2 were assessed for cytotoxic activity against two human tumor cell lines (A549 and HL-60).
Chemical Components of Dendrobium polyanthum
Jiang-Miao Hu,You-Xing Zhao,Ze-Hong Miao,Jun Zhou 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.9
A new tetrahydroanthracene, 3,6,9-trihydroxy-3,4-dihydroanthracen-1(2H)-one (1), six phenolics, moscatilin (2), gigantol (3), batatasin (4), moscatin (5), 9,10-dihydromoscatin (6), 10-dihydrophenanthrene-2,4,7-triol (7), and a sesquiterpenoid, corchoionoside C (8), together with two sterols β-sitosterol (9) and daucosterol (10), were isolated from the stems of Dendrobium polyanthum. Compounds 1 and 2 were assessed for cytotoxic activity against two human tumor cell lines (A549 and HL-60).
Hu, Yan-Xia,Li, Min,Jia, Xiao-Hui,Du, Qu-Xiao,Miao, Feng-Tai,Yao, Li,Shen, Ji-Duo Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
There is increasing evidence that natural killer (NK) cells play an important role in antitumor immunity following dendritic cell (DC) vaccination. Little is known, however, about the optimal stimulation of DCs by epitopes and NK interactions for cytotoxicity in tumors. In this study, DC cells activated by the HPV16E7.49-57 epitope and LPS were co-cultured with NK cells in vitro, and then used ot immunize mice to study CTL activity of TC-1, which constitutively expresses HPV16E6E7, with an LDH release assay. Cytotoxicity in mice immunized with DC loaded with epitope HPVE7.49-57 vaccine co-cultured with NK was enhanced significantly (p<0.01). In conclusion, talk-across between DC and NK cells enhances their functions, also improving cytotoxicity againsttumor cells, suggesting that activated DC-NK by epitopes has potential application for cancer-specific immuno-cellular therapy.
Miao Wang,Zhiyong Xiong,Liang Xu,Lihua Zhang,Cheng Gong,Yi Hu,Yi Lin 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.3
The electromagnetic anomaly observations before earthquake, have been confirmed by many cases of strong earthquakes. The analysis of earthquake magnetic anomaly is an effective approach for seismo-precursor detection. Traditional frequent mining methods for electromagnetic matrix datasets analysis often find the co-related items. However, these methods may miss the items which are differential co-related patters under different datasets. Mining these differential co-related patterns is more valuable for inferring potential knowledge. In this paper, we develop an algorithm, MSPattern, to mine maximal subspace differential co-expression patterns. MSPattern constructs a weighted undirected item-item relational graph firstly. Then all the maximal co-related patterns would be mined using item-growth method in above graph. MSPattern also utilizes several techniques for producing maximal patterns without candidate patterns maintenance. Evaluated by real electromagnetic matrix datasets and the gene expression datasets, the experimental results show our algorithm can find some potential knowledge for earthquake analysis, and MSPattern algorithm is more efficient than traditional ones. The performance of MSPattern is also evaluated by empirical p-value and gene ontology, the results show our algorithm can find statistical significant and biological differential co-expression patterns.
Miao Li,Shenfei Long,Qianqian Wang,Lianhua Zhang,Jiangxu Hu,Jie Yang,Zhibin Cheng,Xiang Shu Piao 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.6
Objective: The objective of this study was to investigate effects of mixed organic acids (MOA) on nutrient digestibility, volatile fatty acids composition and intestinal microbiota in growing-finishing pigs fed high wheat bran diet. Methods: Six crossbred barrows (Duroc×Landrace×Yorkshire), with an average body weight 78.8±4.21 kg, fitted with T-cannulas at the distal ileum, were allotted to a double 3×3 Latin square design with 3 periods and 3 diets. Each period consisted of a 5-d adjustment period followed by a 2-d total collection of feces and then a 2-d collection of ileal digesta. The dietary treatments included a corn-soybean-wheat bran basal diet (CTR), mixed organic acid 1 diet (MOA1; CTR+3,000 mg/kg OA1), mixed organic acid 2 diet (MOA2; CTR+2,000 mg/kg OA2). Results: Pigs fed MOA (MOA1 or MOA2) showed improved (p<0.05) apparent total tract digestibility (ATTD) of gross energy, dry matter and organic matter, and pigs fed MOA2 had increased (p<0.05) ATTD of neutral detergent fiber compared to CTR. Dietary MOA supplementation decreased (p<0.05) pH value, and improved (p<0.01) concentrations of lactic acid and total volatile fatty acids (TVFA) in ileum compared to CTR. Pigs fed MOA showed higher (p<0.05) concentration of acetic acid, and lower (p<0.05) content of formic acid in feces compared to CTR. Pigs fed MOA1 had increased (p<0.05) concentration of TVFA and butyric acid in feces. Pigs fed MOA1 showed higher concentration of Lactobacillus and lower concentration of Escherichia in feces compared to CTR. Conclusion: Dietary supplementation of MOA 1 or 2 could improve nutrients digestibility, TVFA concentration and intestinal flora in growing-finishing pigs fed high fiber diet.
Hu, Xiaoyi,Miao, Jiyu,Zhang, Min,Wang, Xiaofei,Wang, Zhenzhen,Han, Jia,Tong, Dongdong,Huang, Chen Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.5
Studies have revealed that miR-103a-3p contributes to tumor growth in several human cancers, and high miR-103a-3p expression is associated with poor prognosis in advanced gastric cancer (GC) patients. Moreover, bioinformatics analysis has shown that miR-103a-3p is upregulated in The Cancer Genome Atlas (TCGA) stomach cancer cohort. These results suggest that miR-103a-3p may function as an oncogene in GC. The present study aimed to investigate the role of miR-103a-3p in human GC. miR-103a-3p expression levels were increased in 33 clinical GC specimens compared with adjacent nontumor stomach tissues. Gain- and loss-of-function studies were performed to identify the correlation between miR-103a-3p and tumorigenesis in human GC. Inhibiting miR-103a-3p suppressed GC cell proliferation and blocked the S-G2/M transition in MKN-45/SGC-7901 cells, whereas miR-103a-3p overexpression improved GC cell proliferation and promoted the S-G2/M transition in vitro. Bioinformatics and dual-luciferase reporter assays confirmed that ATF7 is a direct target of miR-103a-3p. Analysis of the TCGA stomach cancer cohort further revealed that miR-103a-3p expression was inversely correlated with ATF7 expression. Notably, silencing ATF7 showed similar cellular and molecular effects as miR-103a-3p overexpression, namely, increased GC cell proliferation, improved CDK2 expression and decreased P27 expression. ATF7 overexpression eliminated the effects of miR-103a-3p expression. These findings indicate that miR-103a-3p promotes the proliferation of GC cell by targeting and suppressing ATF7 in vitro.
Hu Wan,Miao Yuan,Hong You,Jianhong Li,진병래 한국응용곤충학회 2012 Journal of Asia-Pacific Entomology Vol.15 No.3
The leaf beetle, Gastrophysa atrocyanea, diapause-specific peptide (DSP), which plays a role in diapause,inhibits Ca2+ channels and has antifungal activity. Here, we show the molecular cloning and characterization of a diapause-specific peptide in the beet armyworm Spodoptera exigua. The S. exigua diapause-specific peptide (SeDSP) gene consists of only one exon encoding 63 amino acid residues. A comparative analysis showed that mature SeDSP consists of 40 amino acid residues including six cysteines, which are similar to those of S. littoralis Spodomicin and G. atrocyanea DSP. The SeDSP was expressed as a 4.5 kDa peptide in baculovirusinfected insect cells. SeDSP was constitutively expressed in the epidermis of S. exigua larvae and pupae after molting and metamorphosis. In addition, recombinant SeDSP showed antibacterial activity against Bacillus megaterium