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Meka, Phanni bhushann,Jarjapu, Sarika,Nanchari, Santhoshi Rani,Vishwakarma, Sandeep Kumar,Edathara, Prajitha Mohandas,Gorre, Manjula,Cingeetham, Anuradha,Vuree, Sugunakar,Annamaneni, Sandhya,Dunna, Na Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12
LCN2 (Lipocalin 2) is a 25 KD secreted acute phase protein, reported to be a novel regulator of angiogenesis in breast cancer. Up regulation of LCN2 had been observed in multiple cancers including breast cancer, pancreatic cancer and ovarian cancer. However, the role of LCN2 promoter methylation in the formation of microvessels is poorly understood. The aim of this study was to analyze the association of LCN 2 promoter methylation with microvessel formation and tumor cell proliferation in breast cancer patients. The LCN2 promoter methylation status was studied in 64 breast cancer tumors by methylation specific PCR (MSP). Evaluation of microvessel density (MVD) and Ki67 cell proliferation index was achieved by immunohistochemical staining using CD34 and MIB-1 antibodies, respectively. LCN2 promoter unmethylation status was observed in 43 (67.2%) of breast cancer patients whereas LCN2 methylation status was seen in 21 (32.8%). Further, LCN2 promoter unmethylation status was associated with aggressive tumor phenotype and elevated mean MVD in breast cancer patients.
( Youran Gao ),( Meka Uffenheimer ),( Michael Ashamallah ),( Gregory Grimaldi ),( Arun Swaminath ),( Keith Sultan ) 대한장연구학회 2020 Intestinal Research Vol.18 No.3
Background/Aims: Inflammatory bowel disease (IBD) involves chronic inflammation of the colon with ulcerative colitis (UC), and the colon and/or small intestine with Crohn’s disease (CD). Pneumatosis intestinalis (PI), characterized by compromise of the intestinal wall with gas-filled cysts, has rarely been reported with IBD. The presentation, best management and outcomes of PI with IBD are poorly defined. Methods: We conducted a search for PI in all abdominal computed tomography (CT) reports at 2 large tertiary care hospitals from January 1, 2010 to December 31, 2017, cross referenced to ICD codes for IBD. CT and chart review was performed to confirm PI and IBD respectively. A systematic review excluding case reports was performed for PI with IBD for comparison. Results: Of 5,990 patients with a CT abdomen report mentioning PI, we identified 11 cases of PI with IBD, 4 UC, 6 CD, and 1 indeterminate colitis. PI was limited to the small bowel in 5 patients, the right colon in 5, and small bowel and colonic in 1. All 3 mortalities had CD, small intestinal PI and portal/mesenteric venous gas. The systematic literature search identified 9 articles describing 58 patients with IBD and PI. These cases were mostly included in larger cohorts of PI patients without extractable data on presentation or outcomes in the IBD subpopulation. Conclusions: Ours appears to be the first reporting of presentations and outcomes, outside of case reports, for those with PI and IBD. The high mortality for those with CD and PI of the small bowel appears to define a group requiring more than supportive medical care. (Intest Res 2020;18:289- 296)
Incubation time for iron-nitride layer formation upon gaseous nitriding of iron-based alloys
Jung, Minsu,Meka, Sai Ramudu,Mittemeijer, Eric Jan Abingdon; Taylor & Francis Ltd 2016 PHILOSOPHICAL MAGAZINE Vol.96 No.14
<P>A model was developed to predict quantitatively the influence of alloying element (Me) dissolved in the ferrite (alpha) matrix on the incubation time for iron-nitride layer formation upon gaseous nitriding of iron-based alloys. The model incorporates the coupled, concurrent processes of inward diffusion of nitrogen and the depth dependency of the time dependency of the precipitation of alloying-element nitride particles in the a matrix. Experimental results were obtained by gaseous nitriding of an Fe-2.23 at.% V alloy. The incubation time for iron-nitride formation on Fe-Me alloy is generally much larger than that for iron-nitride formation on pure iron due to a pronouncedly lesser rate of increase of dissolved N content at the surface of Fe-Me alloy. The extent of segregation of N at the MeN/alpha-Fe interfaces has distinct influence on the incubation time.</P>
Kirat Rawal,Manish Dixit,Meka Srinivasarao,Manish Kumar Mishra 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.4
The catalytic application of sulfated zirconia as solid Brønsted acid catalyst was explored for cross aldol condensation reactions (Claisen Schmidt reaction). The synthesized catalyst was highly active for solvent free synthesis of a,a9 -bis(arylidene)cycloalkanones by cross aldol condensation of aromatic aldehydes with cycloalkanones. The microwave assisted synthesis resulted increased yields of the products (79–99%) at significantly lower reaction temperature (120–140 8C) and reaction time (20 min) as compared to the synthesis by thermal heating (63–96% yield at 170 8C after 4 h). The microwave irradiation afforded selectively cross aldol products. The catalyst could be easily regenerated and reused several times with similar efficiency.
Removal of Orange G from aqueous solution by hematite: Isotherm and mass transfer studies
Monoj Kumar Mondal,Sudama Singh,Meka Umareddy,Betty Dasgupta 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.6
The efficiency of hematite for the removal of Orange G from aqueous solution has been studied at various concentrations as a function of time, temperatures and pH. It was found that the low initial concentration, low temperature and low pH favor the removal process. The maximum adsorption of the dye on hematite has been recorded at 25 mg/l concentration, 303 K temperature and pH 3. The negative values of change in free energy and enthalpy indicate the spontaneous and exothermic nature of the process, respectively. Fixation and immobilization of the dye molecules at the surface of hematite as a result of adsorption are responsible for the negative entropy effect. The effect of pH was described by considering coulombic attraction and aqua complex formation approaches. The applicability of various adsorption isotherms--Langmuir, Freundlich and Jossens--was tested in order to find the most suitable isotherm. The Freundlich isotherm was fitted with the data of the present study.
A practical approach for kinetic analysis of hydrogenation of complex mineral base oil
Modi Siddharth,Tiwari Anand Kumar,Rao Meka Srinivasa,Snigdha Thummalapalli,Saritha Thummalapalli,Gupta Thummalapalli Chandra Sekhara Manik,Kumar Ajay 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.7
The mineral base oil contains paraffins, naphthenes and aromatic hydrocarbons (AH) with carbon chains ranging from C14 to C60. The presence of AH in base oil affects the performance of the product in many industrially oriented applications. The base oil considered in this work had AH around 14% w/w that needed to be reduced below 5% w/w for some applications and ideally 0% w/w. This paper demonstrates the practical approach for hydrogenation of complex mineral base oil for reducing AH. The mineral base oil rich in C20 was taken as the representative component. The hydrogen solubility in the oil was estimated using NRTL model. The semi-batch hydrogenation experiments were performed at different conditions and conversion of AH as high as 79% (i.e. 3% w/w) could be achieved. A second-order pseudo-homogeneous reaction kinetic model was proposed and validated. The conditions for reaction kinetics were optimized to achieve desirable conversion using Aspen Plus. To develop a continuous process for hydrogenation of AH, experiments were performed in a lab scale fixed bed reactor and the applicability of the kinetic model was validated. The kinetics was observed to be free of internal and external mass transfer limitations under lab scale conditions.
Role of the MDM2 Promoter Polymorphism (-309T>G) in Acute Myeloid Leukemia Development
Cingeetham, Anuradha,Vuree, Sugunakar,Jiwatani, Sangeeta,Kagita, Sailaja,Dunna, Nageswara Rao,Meka, Phanni Bhushann,Gorre, Manjula,Annamaneni, Sandhya,Digumarti, Raghunadharao,Sinha, Sudha,Satti, Vish Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7
Background: The human homologue of the mouse double minute 2 (MDM2) gene is a negative regulator of Tp53. MDM2-309T>G a functional promoter polymorphism was found to be associated with overexpression thereby attenuation of Tp53 stress response and increased cancer susceptibility. We have planned to evaluate the possible role of MDM2-309T>G polymorphism with risk and response to chemotherapy in AML. Materials and Methods: A total of 223 de novo AML cases and 304 age and sex matched healthy controls were genotyped for the MDM2-309T>G polymorphism through the tetra-primer amplification refractory mutation system (ARMS)-PCR method. In order to assess the functional relationship of -309T>G SNP with MDM2 expression level, we quantified MDM2 mRNA in 30 primary AML blood samples through quantitative RT-PCR. Both the (-309T>G) genotypes and the MDM2 expression were correlated with disease free survival (DFS) rates among patients who have achieved complete remission (CR) after first induction chemotherapy. Results: MDM2-309T>G polymorphism was significantly associated with AML development (p<0.0001). The presence of either GG genotype or G allele at MDM2-309 confered 1.79 (95% CI: 1.12-2.86; p<0.001) and 1.46 fold (95%CI: 1.14-1.86; p= 0.003) increased AML risk. Survival analysis revealed that CR+ve cases with GG genotype had significantly increased DFS rates (16months, p=0.05) compared to CR+ve TT (11 months) and TG (9 months) genotype groups. Further, MDM2 expression was also found to be significantly elevated in GG genotype patients (p=0.0039) and among CR+ve cases (p=0.0036). Conclusions: The MDM2-309T>G polymorphism might be involved in AML development and also serve as a good prognostic indicator.
Chika J. Okwor,Kayode S. Adedapo,Oluwasomidoyin O. Bello,Ijeoma A. Meka,Chukwuemeka V. Okwor,Chukwuemelie Z. Uche,Chiebonam E. Nwajiobi,Uloaku A. Nto-Ezimah,Chisom E. Uchechukwu,Ekene J. Arum 대한고혈압학회 2022 Clinical Hypertension Vol.28 No.-
Hypertensive disorders of pregnancy including preexisting (or chronic) hypertension are the most common complication encountered during pregnancy that contribute significantly to maternal and perinatal morbidity and mortality. Brain natriuretic peptide (BNP) and copeptin have been investigated as biomarkers in various hypertensive disorders, but studies of their clinical value in chronic hypertensive pregnant women are sparce. This study aimed to assess the levels of BNP and copeptin in chronic hypertensive pregnant women and investigate their correlation with blood pressure (BP) in chronic hypertensive pregnant women in South Western Nigeria. One hundred and sixty consenting pregnant women in their third trimester of pregnancy, grouped into those with chronic hypertension ( n = 80) and normotensive ( n = 80), were recruited for this cross-sectional study. Age and clinical characteristics were obtained, and blood was aseptically drawn for BNP and copeptin measurement using enzyme-linked immunosorbent assay. Data was analyzed with IBM SPSS ver. 20.0. Data was analyzed using Student t-test, chi-square, and Pearson correlation test as appropriate. Statistical significance was set at P < 0.05. The mean systolic BP (SBP) and diastolic BP (DBP) were significantly higher in pregnant women with chronic hypertension (158.30 ± 3.51 and 105.08 ± 2.47 mmHg, respectively) compared with normotensive pregnant women (100.72 ± 3.02 and 70.29 ± 1.96 mmHg, respectively). The mean levels of BNP and copeptin were higher in pregnant women with chronic hypertension (57.26 ± 3.65 pg/mL and 12.44 ± 1.02 pmol/L, respectively) compared with normotensive pregnant women (49.85 ± 2.44 pg/mL and 10.25 ± 1.50 pmol/L, respectively) though not statistically significant. Correlations observed between SBP and DBP with levels of BNP ( r = 0.204, P = 0.200; r = 0.142, P = 0.478) and copeptin ( r = − 0.058, P = 0.288; r = 0.045, P = 0.907) were not statistically significant. There was no association between BP and the levels of BNP and copeptin in pregnant women with chronic hypertension who were already on antihypertensive treatment, with the implication that antihypertensive treatment may modulate BNP and copeptin release despite significantly elevated BP levels.
Controlled Release Chitosan Microspheres of Mirtazapine: In Vitro and In Vivo Evaluation
Om Prakash Ranjan,Gopal Venkatesh Shavi,Usha Yogendra Nayak,Karthik Arumugam,Ranjith Kumar Averineni,Pandey Sureshwar,Sreenivasa Reddy Meka 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11
The purpose of the study was to formulate and evaluate controlled release chitosan microspheres of mirtazapine (MTZ) to improve the bioavailability by altering the pharmacokinetic profiles of the drug. Chitosan microspheres were prepared to prolong the release of the drug into the systemic circulation. Microspheres were prepared by a single water in oil (w/o) emulsion technique varying the chitosan/drug ratio, stirring speed and concentration of the crosslinking agent (glutaraldehyde). Drug-polymer compatibility studies were carried out using fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). The microspheres were evaluated for encapsulation efficiency, particle size, surface morphology, swelling index, in vitro release, as well as erosion and in vivo studies in rats. The FT-IR and DSC studies revealed no interaction between drug and polymer. The encapsulation efficiency of different formulation varied from 53 ± 1.2% to 78 ± 1.5%. The mean particle size of the optimized formulation F-14 was 106.4 ± 0.5 μm. Surface morphology revealed that chitosan microspheres were discrete and spherical in shape with a porous surface. The release of MTZ from chitosan microspheres was rapid up to 4 h, and then it was continuously and slowly released up to 48 h. Optimized formulation (F-14) was found to be stable under accelerated storage conditions based on International Conference on Harmonisation guidelines. Pharmacokinetic studies revealed that the optimized formulation showed significant increases in systemic exposure (AUC = 177.70 ± 7.39 μg·h/mL), half-life (4.72 ± 0.46 h) and reduced clearance (0.009 ± 0.0001 L/h) compared to pure drug administration. Hence, the present study demonstrates that controlled release formulation of MTZ microspheres using chitosan can improve pharmacokinetic profiles of MTZ.