Fabrication and Mechanical Properties of Porous Ti/HA Composites for Bone Fixation Devices

Nomura, Naoyuki,Sakamoto, Kozue,Takahashi, Katsuya,Kato, Seiji,Abe, Yasunori,Doi, Hisashi,Tsutsumi, Yusuke,Kobayashi, Masahiro,Kobayashi, Equo,Kim, Woo-Jong,Kim, Kyo-Han,Hanawa, Takao The Japan Institute of Metals 2010 MATERIALS TRANSACTIONS Vol.51 No.8

<P>Porous Ti (pTi)/hydroxylapatite (HA) composites were fabricated by an infiltration method in a vacuum and sintering. The Young’s modulus of the composites was evaluated before and after the immersion in Hanks’ solution. The strength of the composites was also evaluated by four-point bending test. The Young’s modulus of the compacts was governed by the porosity and was comparable to the human bone in the porosity range from 24 to 34%. The Young’s modulus of sintered pTi/HA composites was larger than that of pTi. The Young’s modulus of the sintered pTi/HA composites decreased after immersion in Hanks’ solution. The proof and bending strengths of the sintered pTi/HA composites were larger than those of pTi. Solid solution hardening of Ti by oxygen contributed the increase of the proof strength.</P>

Underwater Endoscopic Mucosal Resection without Submucosal Injection Facilitates En bloc Resection of Colon Adenomas Extending into a Diverticulum

Yoshikazu Hayashi,Masahiro Okada,Takaaki Morikawa,Tatsuma Nomura,Hisashi Fukuda,Takahito Takezawa,Alan Kawarai Lefor,Hironori Yamamoto 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.3

Superficial colonic neoplasms sometimes extend into a diverticulum. Conventional endoscopic mucosal resection of these lesionsis considered challenging because colonic diverticula do not have a muscularis propria and are deeply inverted. Even if the solutionis carefully injected below the mucosa at the bottom of the diverticulum, the mucosa is rarely elevated from the diverticular orifice,and it is usually just narrowed. Although endoscopic submucosal dissection or full-thickness resection with an over-the-scope clipdevice enables the complete resection of these lesions, it is still challenging, time consuming and expensive. Underwater endoscopicmucosal resection without submucosal injection (UEMR) is an innovative technique enabling en bloc resection of superficial colonlesions. We report three patients with colon adenomas extending into a diverticulum treated with successful UEMR. UEMR enabledrapid and safe en bloc resection of colon lesions extending into a diverticulum.

Impact of Tumor Location on the Quality of Life of Patients Undergoing Total or Proximal Gastrectomy

Fujisaki Muneharu,Nomura Takashi,Yamashita Hiroharu,Uenosono Yoshikazu,Fukunaga Tetsu,Otsuji Eigo,Takahashi Masahiro,Matsumoto Hideo,Oshio Atsushi,Nakada Koji 대한위암학회 2022 Journal of gastric cancer Vol.22 No.3

Purpose Most studies have investigated the differences in postgastrectomy quality of life (QOL) based on the surgical procedure or reconstruction method adopted; only a few studies have compared QOL based on tumor location. This large-scale study aims to investigate the differences in QOL between patients with esophagogastric junction cancer (EGJC) and those with upper third gastric cancer (UGC) undergoing the same gastrectomy procedure to evaluate the impact of tumor location on postoperative QOL. Methods The Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45) questionnaire was distributed in 70 institutions to 2,364 patients who underwent gastrectomy for EGJC or UGC. A total of 1,909 patients were eligible for the study, and 1,744 patients who underwent total gastrectomy (TG) or proximal gastrectomy (PG) were selected for the final analysis. These patients were divided into EGJC and UGC groups; thereafter, the PGSAS-45 main outcome measures (MOMs) were compared between the two groups for each type of gastrectomy. Results Among the post-TG patients, only one MOM was significantly better in the UGC group than in the EGJC group. Conversely, among the post-PG patients, postoperative QOL was significantly better in 6 out of 19 MOMs in the UGC group than in the EGJC group. Conclusions Tumor location had a minimal effect on the postoperative QOL of post-TG patients, whereas among post-PG patients, there were definite differences in postoperative QOL between the two groups. It seems reasonable to conservatively estimate the benefits of PG in patients with EGJC compared to those in patients with UGC. Purpose Most studies have investigated the differences in postgastrectomy quality of life (QOL) based on the surgical procedure or reconstruction method adopted; only a few studies have compared QOL based on tumor location. This large-scale study aims to investigate the differences in QOL between patients with esophagogastric junction cancer (EGJC) and those with upper third gastric cancer (UGC) undergoing the same gastrectomy procedure to evaluate the impact of tumor location on postoperative QOL. Methods The Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45) questionnaire was distributed in 70 institutions to 2,364 patients who underwent gastrectomy for EGJC or UGC. A total of 1,909 patients were eligible for the study, and 1,744 patients who underwent total gastrectomy (TG) or proximal gastrectomy (PG) were selected for the final analysis. These patients were divided into EGJC and UGC groups; thereafter, the PGSAS-45 main outcome measures (MOMs) were compared between the two groups for each type of gastrectomy. Results Among the post-TG patients, only one MOM was significantly better in the UGC group than in the EGJC group. Conversely, among the post-PG patients, postoperative QOL was significantly better in 6 out of 19 MOMs in the UGC group than in the EGJC group. Conclusions Tumor location had a minimal effect on the postoperative QOL of post-TG patients, whereas among post-PG patients, there were definite differences in postoperative QOL between the two groups. It seems reasonable to conservatively estimate the benefits of PG in patients with EGJC compared to those in patients with UGC.

2층 HVAC 시스템의 오프 사이클 연비 효과 결정 방법에 대한 연구

Forrest Jehlik,Netsanet Chevers,Matthew Moniot,Yuanpei Song,Hidekazu Hirabayashi,Masahiro Nomura,Eric Wood,김원일 한국자동차공학회 2020 한국자동차공학회 부문종합 학술대회 Vol.2020 No.7

이 연구는 히터코어의 환기 및 열 손실을 감소시키는 2층 HVAC 시스템의 오프 사이클 연비 효과를 결정하는 방법론을 제시하였다. 이 테스트는 2016 Lexus RX350(3.5L, 8단 자동 변속기) 차량으로 다양한 외기 온도 조건에서 EPA 주행 모드를 이용하여, 2층 HAVC 기술 유무에 대해 엔진 예열 변화에 따른 엔진 효율의 차이를 측정하기 위해 수행되었습니다. (2층 HVAC 기술 미적용 : 외기 모드) 이 실험 데이터들은 열에 대한 함수로 차량 효율을 예측하는 단순화된 반응 표면 및 집중 용량 차량 열 모델을 개발하는데 사용되었다. 이 차량 모델은 도로 주행 테스트에서 측정한 데이터 베이스로 통합되었고, 수십만 번의 주행 사이클 동안 계절별 열 부하 및 구동 조건에서 차량 효율을 시뮬레이션 하기 위해 미국의 기상 데이터와 결합하였다.

Additive effect of rikkunshito, an herbal medicine, on chemotherapy-induced nausea, vomiting, and anorexia in uterine cervical or corpus cancer patients treated with cisplatin and paclitaxel: results of a randomized phase II study (JORTC KMP-02)

Shunsuke Ohnishi,Hidemichi Watari,Maki Kanno,Yoko Ohba,Satoshi Takeuchi,Tempei Miyaji,Shunsuke Oyamada,Eiji Nomura,Hidenori Kato,Toru Sugiyama,Masahiro Asaka,Noriaki Sakuragi,Takuhiro Yamaguchi,Yasuhi 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5

Objective: Rikkunshito, an herbal medicine, is widely prescribed in Japan for the treatmentof anorexia and functional dyspepsia, and has been reported to recover reductions in foodintake caused by cisplatin. We investigated whether rikkunshito could improve chemotherapyinducednausea and vomiting (CINV) and anorexia in patients treated with cisplatin. Methods: Patients with uterine cervical or corpus cancer who were to receive cisplatin (50 mg/m2day 1) and paclitaxel (135 mg/m2day 0) as first-line chemotherapy were randomly assignedto the rikkunshito group receiving oral administration on days 0–13 with standard antiemetics,or the control group receiving antiemetics only. The primary endpoint was the rate of completecontrol (CC: no emesis, no rescue medication, and no significant nausea) in the overall phase(0–120 hours). Two-tailed p<0.20 was considered significant in the planned analysis. Results: The CC rate in the overall phase was significantly higher in the rikkunshito groupthan in the control group (57.9% vs. 35.3%, p=0.175), as were the secondary endpoints:the CC rate in the delayed phase (24–120 hours), and the complete response (CR) rates(no emesis and no rescue medication) in the overall and delayed phases (63.2% vs. 35.3%, p=0.095; 84.2% vs. 52.9%, p=0.042; 84.2% vs. 52.9%, p=0.042, respectively), and time totreatment failure (p=0.059). Appetite assessed by visual analogue scale (VAS) appeared to besuperior in the rikkunshito group from day 2 through day 6. Conclusion: Rikkunshito provided additive effect for the prevention of CINV and anorexia