On the tangent space of a weighted homogeneous plane curve singularity

Mario Canon Mario,Julien Sebag 대한수학회 2020 대한수학회지 Vol.57 No.1

Let $k$ be a field of characteristic 0. Let $ \scr C=\Spec(k[x,y]/\langle f\rangle)$ be a weighted homogeneous plane curve singularity with tangent space $\pi_\scr C\colon T_{\scr C/k}\rightarrow \scr C$. In this article, we study, from a computational point of view, the Zariski closure $\scr G(\scr C)$ of the set of the 1-jets on $\scr C$ which define formal solutions (in $F[[t]]^2$ for field extensions $F$ of $k$) of the equation $f=0$. We produce Groebner bases of the ideal $\mathcal{N}_1(\scr C)$ defining $\scr G(\scr C)$ as a reduced closed subscheme of $T_{\scr C/k}$ and obtain applications in terms of logarithmic differential operators (in the plane) along $ \scr C$.

El Cielo a Dentelladas o De La Mentalidad Hispánica En El Siglo XVI

Mario Alonso Arango M.(마리오 알론소 아랑고 M.) 부산외국어대학교 중남미지역원 2007 이베로아메리카 Vol.9 No.1

Within Social Sciences, the study of the colonial subject in terms of analysis and the disclosure of the mentalities (perception mechanisms, assessment and conceptualization of the other) have gathered strength in the last few years. At the end of the XV century and the beginning of the XVI, Latin America underwent the vicissitudes of the expansionistic force of the European world carrying along multiple consequences for its indigenous inhabitants, their descendants and for those who occupy that territory nowadays. The different points of view about how this first encounter was carried out have generated multiple viewpoints, some of them somewhat in discordance. Nevertheless, what is unequivocal is that the study of the minority groups (natives, mestizo and other marginal groups) has barely begun research on. Many have taken on the task of revealing such mechanisms through historical investigation and research. The Mexican writer Antonio Sarabia with his work, El cielo a dentelladas registers this tendency: he delves to these imaginary logics and reveals to us through literary realism that other anti-hegemonic discourses that began to develop from the earliest point of this encounter.

ABO-incompatible renal transplantation: From saline flushes to antigen-specific immunoadsorption-Tools to overcome the barrier

Mario Schiffer,Jan T. Kielstein 대한혈액학회 2011 Blood Research Vol.46 No.3

On April 23, 1951, a 30-year-old woman received the first intentional ABOi (ABO incompatible) renal transplantation in Boston. At that time, it was commonly believed that intensely rinsing the graft to remove blood would be sufficient to overcome any immunological problems associated with blood type incompatibility. However, when the abovementioned patient and another ABOi transplant recipient died within a month, Humes and colleagues arrived at the same conclusion: “We do not feel that renal transplantation in the presence of blood incompatibility is wise.” In the decades that followed, we learned that the oligosaccharide surface antigens representing the ABO- blood group antigens are expressed not only on erythrocytes but also on cells from various tissues, including the vascular endothelium. The growing gap between organ demand and availability has sparked efforts to overcome the ABO barrier. After its disappointing results in the early 1970s, Japan became the leader of this endeavor in the 1980s. All protocols are based on 2 strategies: removal of preformed antibodies with extracorporeal techniques and inhibition of ongoing antibody production. Successful ABOi renal transplantation became possible with the advent of splenectomy, new immunosuppressive drugs (e.g., rituximab, a monoclonal antibody against CD20), and extracorporeal methods such as antigen-specific immunoadsorption. This review summarizes the underlying pathophysiology of ABOi transplantation and the different protocols available. Further, we briefly touch potential short- and long-term problems, particularly the incidence of infectious complications and malignancies, that can arise with high-intensity immunosuppressive therapy.

The Combination of Naproxen and Citral Reduces Nociception and Gastric Damage in Rats

Mario I. Ortiz,Martha L. Ramírez-Montiel,Martha P. González-García,Héctor A. Ponce-Monter,Gilberto Castañeda-Hernández,Raquel Cariño-Cortés 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.10

It has been shown that the association of non-steroidal anti-inflammatory drugs with plant extracts can increase their antinociceptive activity, allowing the use of lower doses and, thus, limiting side effects. Therefore, the aim of this study was to examine the effects of the interaction between naproxen and citral on nociception and gastric injury in rats. Naproxen, citral, or combinations of naproxen and citral produced an antinociceptive effect. The administration of naproxen produced significant gastric damage, but this effect was not obtained with either citral or the naproxen-citral combination. The ED50 value was estimated for the individual drugs and an isobologram was constructed. The derived theoretical ED50 for the antinociceptive effect (423.8 mg/kg) was not significantly different from the observed experimental value (359.0 mg/kg); hence, the interaction between naproxen and citral mediating the antinociceptive effect is additive. These data suggest that the naproxen-citral combination interacts at the systemic level, produces minor gastric damage, and potentially has therapeutic advantages for the clinical treatment of inflammatory pain.

C1-STABLY SHADOWABLE CONSERVATIVE DIFFEOMORPHISMS ARE ANOSOV

Mario Bessa 대한수학회 2013 대한수학회보 Vol.50 No.5

In this short note we prove that if a symplectomorphism f is C1-stably shadowable, then f is Anosov. The same result is obtained for volume-preserving diffeomorphisms.

PIXELRAIN

Mario Fuentes 한국콘텐츠학회 2017 한국콘텐츠학회 ICCC 논문집 Vol.2017 No.12

Articles : Regional Integration in Latin America: Experience and Outlook

( Mario I. Blejer ) 세종대학교 경제통합연구소 1988 Journal of Economic Integration Vol.3 No.2

Risk factors for unrecognized invasive carcinoma in patients with vulvar high­grade squamous intraepithelial lesion at vulvoscopy­directed biopsy

Mario Preti,Lauro Bucchi,Bruno Ghiringhello,Silvana Privitera,Valentina Frau,Elisabetta Corvetto,Chiara Benedetto,Leonardo Micheletti 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.4

Objective: To evaluate the prevalence and risk factors for unrecognized invasive carcinomain a series of patients undergoing surgical excision after an office biopsy of vulvar high-gradesquamous intraepithelial lesion (VHSIL). Methods: Two hundred and sixteen consecutive patients treated in a tertiary-level referralcenter for vulvar disease in north-western Italy were recruited. Patients' records werereviewed by trained personnel. Factors showing a statistically significant (p<0.05) associationwith detection of stromal invasion at excisional surgery in univariate analysis were furtherexamined in a backward stepwise multiple logistic regression model. Results: The median patient age was 50 years (range, 19–88). More than 25% patients withVHSIL at biopsy had associated cervical/vaginal intraepithelial neoplasia, and more than 35%had a multifocal lesion. Invasive carcinoma was detected in surgical specimens from 24 patients(11%). The depth of stromal invasion varied between 0.1 mm and 3.0 mm with a median of 0.5mm. In multivariate analysis, the risk of invasive carcinoma detection was greater for patients inthe highest tertile of age (p=0.008), for patients with a lesion ≥20 mm in size (p=0.013) and withclitoral involvement (p<0.001), and for patients presenting with a nodular lesion (p=0.078). Conclusion: Our study suggests that patient age, lesion size, clitoral involvement andnodular appearance in patients with VHSIL at vulvoscopy-directed biopsy are independentlyassociated with the risk of unrecognized invasive carcinoma.

De la región en el epistolario y la obra crítica de Tomás Carrasquilla

Mario A. Arango Morales 서울대학교 라틴아메리카연구소 2011 이베로아메리카硏究 Vol.22 No.2

The work of Colombian writer Tomás Carrasquilla evidences the authenticity of a narrator who, in the process of cultural evolution of Colombian and Latin American literature, establishes a historical framework: in his quest for self-expression, he turned his vision to America, particularly to the characters and situations of the people of Antioquia, his home province. His writing also becomes the first to offer a broad array of historical and fictional literary worlds,expanded and elaborated by later generation of well-known authors such as German Espinosa, Gabriel García Márquez and Álvaro Mutis who, in their unique styles, were able to turn the “complex cultural sides” of Colombian society into something more universal and widely recognizable. But the work of Tomás Carrasquilla is not only confined to his fictional world. In fact, through the letters (epistles) and various critical essays published by the writer in magazines and newspapers at the time, he reveals a tension that allows us to understand a unique and very personal aesthetic outlook where local or regional elements do not suffice as literary qualifier or leitmotif. The letters and the critical essays allow us to trace the clear and coherent vision between his theories and the assumption of a writing style that we don’t find in any other author until the mid-twentieth century. The tension generated by the political period known as “Regeneration” and the position taken by “centralists”that the country’s capital (Bogotá) should be the center of administrative power as well as that of aesthetic ideas are, in part, the basis for Tomás Carrasquilla’s refreshing attitude. This article focuses on the revelation of his artistic principles and also on some intricacies of the said “regenerative project”, essential to understanding the work and life of the author.

Rhizobium etli bacteroids engineered for Vitreoscilla hemoglobin expression alleviate oxidative stress in common bean nodules that reprogramme global gene expression

Mario Ramirez,Luis P. Iniguez,Gabriela Guerrero,Francesca Sparvoli,Georgina Hernandez 한국식물생명공학회 2016 Plant biotechnology reports Vol.10 No.6

The common bean (Phaseolus vulgaris L.)– Rhizobium etli symbiosis and crop productivity are highly affected by adverse environmental conditions that cause oxidative stress. Based on the improved symbiosis of common bean inoculated with engineered R. etli expressing the Vitreoscilla hemoglobin (VHb) (Ramı ´rez et al., Mol Plant Microbe Interact 12:1008–1015, 1999), in this work we analyzed the effect of this strain in plants exposed to the herbicide paraquat (PQ) which generates oxidative stress. PQ-treated plants inoculated with the engineered (VHb) R. etli strain showed higher nitrogenase activity and ureide content than plants inoculated with the wild type strain. We performed microarray transcriptomic analysis to identify PQ-responsive genes in nodules elicited by engineered vs wild type strains. An evident reprogramming of the transcriptional profile was observed in PQ-treated nodules, and the global changes in gene expression were different between nodules elicited with each strain. The most relevant difference was the increased number of up-regulated PQ-responsive genes in wild type strain nodules as compared to VHb-expressing nodules. The majority of these genes were classified into biological processes/functional categories related to defense, response to abiotic stress or signaling, as revealed by Gene Ontology and MapMan analysis. Taken together our analysis suggests that the expression of VHb in R. etli bacteroids contributes to buffering the damage caused by increased reactive oxygen species, and this is reflected in nodule cells that showed decreased sensitivity to oxidative stress and response of stress-related genes. Biotechnological applications of VHbexpressing rhizobia inoculants could be further explored.